143-25-9 (BioDeep_00000869031)

Main id: BioDeep_00000009097

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(11E)-octadec-11-enoic acid

化学式: C18H34O2 (282.2559)
中文名称: 反式-11-十八烯酸, 反式十八烷酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCC/C=C/CCCCCCCCCC(=O)O
InChI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/b8-7+

描述信息

trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated linoleic acid (CLA) at the tissue level.
trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated linoleic acid (CLA) at the tissue level.

同义名列表

21 个代谢物同义名

(11E)-octadec-11-enoic acid; trans-11-octadecenoic acid; (E)-Octadec-11-enoic acid; (e)-11-Octadecenoic acid; 11-Octadecen-1-ol, (Z)-; (11E)-Octadecenoic acid; 11-Octadecenoyl alcohol; 11E-octadecenoic acid; cis-Vaccenoyl alcohol; octadec-11-enoic acid; 11-Octadecenoic acid; trans-Vaccenic acid; VACCENIC ACID; LMFA01030077; CHEBI:28727; 62972-93-4; 2545-72-4; 143-25-9; 693-72-1; C08367; (11E)-Octadecenoic acid



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

105 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 APOB, BCL2, FASN, GNPDA1, PPARG, SREBF1
Endosome membrane 2 APOB, LDLR
Endoplasmic reticulum membrane 8 APOB, BCL2, ELOVL5, FADS1, FADS2, SCD, SCD5, SREBF1
Nucleus 4 BCL2, PPARA, PPARG, SREBF1
cytosol 7 APOB, BCL2, FASN, GNPDA1, LEP, PPARG, SREBF1
dendrite 1 ELOVL5
nucleoplasm 3 PPARA, PPARG, SREBF1
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 2 LDLR, TNF
Multi-pass membrane protein 6 ELOVL5, FADS1, FADS2, SCD, SCD5, SREBF1
Golgi apparatus membrane 1 SREBF1
cell surface 2 LDLR, TNF
Golgi apparatus 2 FASN, LDLR
Golgi membrane 2 INS, SREBF1
neuronal cell body 3 APOB, ELOVL5, TNF
smooth endoplasmic reticulum 1 APOB
Lysosome 1 LDLR
plasma membrane 5 APOB, FADS2, FASN, LDLR, TNF
Membrane 8 BCL2, ELOVL5, FADS1, FADS2, FASN, LDLR, SCD, SCD5
basolateral plasma membrane 1 LDLR
extracellular exosome 3 APOB, FASN, GNPDA1
endoplasmic reticulum 4 BCL2, ELOVL5, SCD, SREBF1
extracellular space 8 APOB, CRP, CXCL8, IL10, IL2, INS, LEP, TNF
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 1 PPARG
mitochondrion 2 BCL2, FADS1
protein-containing complex 2 BCL2, SREBF1
intracellular membrane-bounded organelle 3 APOB, FADS1, PPARG
Single-pass type I membrane protein 1 LDLR
Secreted 7 APOB, CRP, CXCL8, IL10, IL2, INS, LEP
extracellular region 8 APOB, CRP, CXCL8, IL10, IL2, INS, LEP, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, LDLR
mitochondrial outer membrane 1 BCL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 LDLR, TNF
chylomicron 1 APOB
low-density lipoprotein particle 2 APOB, LDLR
very-low-density lipoprotein particle 1 APOB
nucleolus 1 SCD
Early endosome 2 APOB, LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
Late endosome 1 LDLR
receptor complex 2 LDLR, PPARG
chromatin 3 PPARA, PPARG, SREBF1
phagocytic cup 1 TNF
nuclear envelope 1 SREBF1
Endomembrane system 1 LDLR
endosome lumen 2 APOB, INS
sorting endosome 1 LDLR
Lipid droplet 1 APOB
[Isoform 1]: Endoplasmic reticulum membrane 1 FADS1
Cytoplasmic vesicle membrane 1 SREBF1
Cell projection, dendrite 1 ELOVL5
Melanosome 1 FASN
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 APOB, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
ER to Golgi transport vesicle membrane 1 SREBF1
clathrin-coated endocytic vesicle membrane 2 APOB, LDLR
endolysosome membrane 1 LDLR
somatodendritic compartment 1 LDLR
[Isoform 2]: Endoplasmic reticulum membrane 1 FADS1
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
endocytic vesicle lumen 1 APOB
PCSK9-LDLR complex 1 LDLR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
mature chylomicron 1 APOB
BAD-BCL-2 complex 1 BCL2
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1
dendritic tree 1 ELOVL5
glycogen granule 1 FASN
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Genlai Dong, Shijie Xu, Shuobo Shi. De Novo Biosynthesis of Free Vaccenic Acid with a Low Content of Oleic Acid in Saccharomyces cerevisiae. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16204-16211. doi: 10.1021/acs.jafc.3c04793. [PMID: 37856078]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
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  • Ye Wang, Maria M Jacome-Sosa, Megan R Ruth, Yan Lu, Jianheng Shen, Martin J Reaney, Shannon L Scott, Michael E R Dugan, Hope D Anderson, Catherine J Field, Spencer D Proctor, Donna F Vine. The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor-α and -γ in a rodent model of dyslipidemia and the metabolic syndrome. Molecular nutrition & food research. 2012 Aug; 56(8):1234-46. doi: 10.1002/mnfr.201100517. [PMID: 22714958]
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  • Enrico Girardi, Esther Dawen Yu, Yali Li, Norihito Tarumoto, Bo Pei, Jing Wang, Petr Illarionov, Yuki Kinjo, Mitchell Kronenberg, Dirk M Zajonc. Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. PLoS biology. 2011 Nov; 9(11):e1001189. doi: 10.1371/journal.pbio.1001189. [PMID: 22069376]
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  • Zhen-Yu Du, Pascal Degrace, Joseph Gresti, Olivier Loreau, Pierre Clouet. Vaccenic and elaidic acid equally esterify into triacylglycerols, but differently into phospholipids of fed rat liver cells. Lipids. 2011 Jul; 46(7):647-57. doi: 10.1007/s11745-011-3569-6. [PMID: 21614647]
  • Laurence Bernard, Julien Mouriot, Jacques Rouel, Frédéric Glasser, Pierre Capitan, Estelle Pujos-Guillot, Jean-Michel Chardigny, Yves Chilliard. Effects of fish oil and starch added to a diet containing sunflower-seed oil on dairy goat performance, milk fatty acid composition and in vivo delta9-desaturation of [13C]vaccenic acid. The British journal of nutrition. 2010 Aug; 104(3):346-54. doi: 10.1017/s0007114510000486. [PMID: 20307350]
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