Combretastatin_A-4 (BioDeep_00000000868)
Secondary id: BioDeep_00000177624, BioDeep_00000180142, BioDeep_00000600702
PANOMIX_OTCML-2023
代谢物信息卡片
phenol, 2-methoxy-5-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-,1-(dihydrogen phosphate)
化学式: C18H20O5 (316.1311)
中文名称: 考布他汀A4, 康普瑞汀, (Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 78.13%
分子结构信息
SMILES: c1(c(c(cc(c1)/C=C\c1ccc(c(c1)O)OC)OC)OC)OC
InChI: InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
描述信息
Combretastatin A4 is a stilbenoid.
Combretastatin A4 is a natural product found in Combretum caffrum with data available.
Combretastatin A-4 is an inhibitor of microtubule polymerization derived from the South African willow bush which causes mitotic arrest and selectively targets and reduces or destroys existing blood vessels, causing decreased tumor blood supply.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D000970 - Antineoplastic Agents
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.
同义名列表
56 个代谢物同义名
phenol, 2-methoxy-5-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-,1-(dihydrogen phosphate); phenol, 2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, dihydrogen phosphate; 2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenyl dihydrogen phosphate; (combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol; (combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol; 5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol; Phenol, 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)ethenyl)-, (Z)-; 1-(3,4,5-trimethoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethene; Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-; 2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol; 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol; 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol; 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol; [3,4,5-trimethoxy-3-hydroxy-4-methoxy-(z)-stilbene]; (Z)-2-METHOXY-5-(3,4,5-TRIMETHOXYSTYRYL)PHENOL; (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol; 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene; 3-Hydroxy-3,4,4,5-tetramethoxy-cis-stilbene; 5-(3,4,5-trimethoxystyryl)-2-methoxyphenol; 2-methoxy-5-(3,4,5-trimethoxystyryl)phenol; (Z)-3-hydroxy-3,4,4,5-tetramethoxystilbene; Combretastatin A4, >=98\\% (HPLC), powder; Phenol,4,5-trimethoxyphenyl)ethenyl]-; combretastatin A-4 disodium phosphate; combretastatin A4 phosphate; COMBRETASTATIN A4 [WHO-DD]; combretastatin A-4, (CSA4); 2-deoxycombretastatin A1; deoxycombretastatin A-4; COMBRETASTATIN A-4 [MI]; isocombretastatin A-4; Z-Combretastatin A-4; Combretastastin A-4; combretastatin A-4; combretastatin-A-4; combretastatin A4; Combretastatin-A4; Combretastin A-4; Combretastatin 4; Combrestatin A-4; Combrestatin A4; combretastin A4; UNII-16U6OP69RQ; fosbretabulin; 16U6OP69RQ; CRC 87-09; CRC-98-09; CHEMBL67; CA4DP; CA-4; CA 4; CA4; 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; 3-Hydroxy-3,4,45-tetramethoxystilbene
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:181391
- KEGG: C20268
- PubChem: 5351344
- PubChem: 72686
- DrugBank: DB14680
- ChEMBL: CHEMBL67
- Wikipedia: Combretastatin_A-4
- MeSH: fosbretabulin
- ChemIDplus: 0117048596
- KNApSAcK: C00015429
- CAS: 117048-59-6
- medchemexpress: HY-N2146
- PMhub: MS000027772
- PubChem: 163312008
- PDB-CCD: 7BA
- LOTUS: LTS0271753
- wikidata: Q105110565
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 507393 - Combretum caffrum:
- 507393 - Combretum caffrum: 10.1097/00001813-199302000-00002
- 507406 - Combretum erythrophyllum: 10.1021/NP9904410
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hangqi Zhang, Ming Li, Xueming Zhou, Li Tang, Guangying Chen, Yongmin Zhang. Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells.
European journal of medicinal chemistry.
2024 Jun; 272(?):116497. doi:
10.1016/j.ejmech.2024.116497. [PMID: 38759453] - Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D'Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.
Journal of medicinal chemistry.
2022 12; 65(23):15805-15818. doi:
10.1021/acs.jmedchem.2c01457. [PMID: 36395526] - Honglu Yin, Yuepeng Chen, Qiu Zhong, Shilong Zheng, Guangdi Wang, Ling He. Design, synthesis, and antitumor study of a series of novel 1-Oxa-4-azaspironenone derivatives.
Bioorganic & medicinal chemistry letters.
2022 10; 74(?):128925. doi:
10.1016/j.bmcl.2022.128925. [PMID: 35944852] - Bin Li, Mingli Hu, Chen Chen, Honglu Yin, Yan Deng, Haibo Li, Jing Zhang, Ling He. Synthesis and antitumor activity of a series of novel N-aryl-5-(2,2,2-trifluoroethoxy)-1,5-dihydro-2H-pyrrol-2-ones derivatives.
Bioorganic & medicinal chemistry letters.
2022 10; 73(?):128919. doi:
10.1016/j.bmcl.2022.128919. [PMID: 35931243] - Jingjing Jia, Honglu Yin, Chen Chen, Mingli Hu, Qiu Zhong, Shilong Zheng, Wei Zhang, Haibo Li, Liang Xu, Guangdi Wang, Ling He. Design, synthesis, and evaluation of a novel series of mono-indolylbenzoquinones derivatives for the potential treatment of breast cancer.
European journal of medicinal chemistry.
2022 Jul; 237(?):114375. doi:
10.1016/j.ejmech.2022.114375. [PMID: 35477142] - Chen Chen, Yang Luo, Honglu Yin, Qiu Zhong, Shilong Zheng, Rui Liu, Chong Zhao, Guangdi Wang, Ling He. Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones.
Bioorganic & medicinal chemistry.
2022 04; 60(?):116626. doi:
10.1016/j.bmc.2022.116626. [PMID: 35255412] - Xiang Qiu, Lv Zhu, Huan Wang, Yan Tan, Zhuang Yang, Linyu Yang, Li Wan. From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.
Bioorganic & medicinal chemistry.
2021 12; 52(?):116510. doi:
10.1016/j.bmc.2021.116510. [PMID: 34826681] - Qizhen Wu, Qian Wang, Yixuan Wang, Jingqiu Huang, Yalin Fang, Weiyi Wu, Wenying Wu, Fanhong Wu, Xiaodong Yu, Yan Sun. A high-throughput and simultaneous determination of combretastatin A-4 phosphate and its metabolites in human plasma using HPLC-MS/MS: Application to a clinical pharmacokinetic study.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5204. doi:
10.1002/bmc.5204. [PMID: 34165810] - Michela Puxeddu, Hongliang Shen, Ruoli Bai, Antonio Coluccia, Marianna Bufano, Marianna Nalli, Jessica Sebastiani, Diego Brancaccio, Eleonora Da Pozzo, Chiara Tremolanti, Claudia Martini, Viviana Orlando, Stefano Biagioni, Maria Stefania Sinicropi, Jessica Ceramella, Domenico Iacopetta, Addolorata Maria Luce Coluccia, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina. Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.
European journal of medicinal chemistry.
2021 Oct; 221(?):113532. doi:
10.1016/j.ejmech.2021.113532. [PMID: 34052717] - Kun Wang, Hui Zhong, Na Li, Nairong Yu, Yujin Wang, Li Chen, Jianbo Sun. Discovery of Novel Anti-Breast-Cancer Inhibitors by Synergistically Antagonizing Microtubule Polymerization and Aryl Hydrocarbon Receptor Expression.
Journal of medicinal chemistry.
2021 09; 64(17):12964-12977. doi:
10.1021/acs.jmedchem.1c01099. [PMID: 34428056] - Antonia Charalambous, Victoria Mico, Laura E McVeigh, Gemma Marston, Nicola Ingram, Milène Volpato, Sally A Peyman, James R McLaughlan, Antonia Wierzbicki, Paul M Loadman, Richard J Bushby, Alexander F Markham, Stephen D Evans, P Louise Coletta. Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, combretastatin A4.
Nanomedicine : nanotechnology, biology, and medicine.
2021 08; 36(?):102401. doi:
10.1016/j.nano.2021.102401. [PMID: 33894396] - Bonan Zhao, Zhipeng Dong, Weixing Liu, Fangning Lou, Qiyan Wang, Hao Hong, Yue Wang. Co-administration of combretastatin A4 nanoparticles and anti-PD-L1 for synergistic therapy of hepatocellular carcinoma.
Journal of nanobiotechnology.
2021 May; 19(1):124. doi:
10.1186/s12951-021-00865-w. [PMID: 33933077] - Libang Zhang, Dongjian Zhang, Meng Gao, Qiaomei Jin, Cuihua Jiang, Tianze Wu, Yuanbo Feng, Yicheng Ni, Zhiqi Yin, Jian Zhang. Design and Evaluation of Rhein-Based MRI Contrast Agents for Visualization of Tumor Necrosis Induced by Combretastatin A-4 Disodium Phosphate.
Molecular imaging and biology.
2021 04; 23(2):220-229. doi:
10.1007/s11307-020-01551-3. [PMID: 33048270] - Lan Luo, Jing Jing Jia, Qiu Zhong, Xue Zhong, Shilong Zheng, Guangdi Wang, Ling He. Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones.
European journal of medicinal chemistry.
2021 Mar; 213(?):113039. doi:
10.1016/j.ejmech.2020.113039. [PMID: 33261898] - Xinxiu Yang, Meng Gao, Mengqi Miao, Cuihua Jiang, Dongjian Zhang, Zhiqi Yin, Yicheng Ni, Jing Chen, Jian Zhang. Combining combretastatin A4 phosphate with ginsenoside Rd synergistically inhibited hepatocellular carcinoma by reducing HIF-1α via PI3K/AKT/mTOR signalling pathway.
The Journal of pharmacy and pharmacology.
2021 Mar; 73(2):263-271. doi:
10.1093/jpp/rgaa006. [PMID: 33793802] - Nham-Linh Nguyen, Thanh-Hoa Vo, Yu-Chi Lin, Chia-Ching Liaw, Mei-Kuang Lu, Jing-Jy Cheng, Mei-Chuan Chen, Yao-Haur Kuo. Arenarosides A-G, Polyhydroxylated Oleanane-Type Saponins from Polycarpaea arenaria and their Cytotoxic and Antiangiogenic Activities.
Journal of natural products.
2021 02; 84(2):259-267. doi:
10.1021/acs.jnatprod.0c00919. [PMID: 33459007] - Weifeng Ma, Peng Chen, Xiansen Huo, Yufeng Ma, Yanhong Li, Pengcheng Diao, Fang Yang, Shengquan Zheng, Mengjin Hu, Wenwei You, Peiliang Zhao. Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study.
European journal of medicinal chemistry.
2020 Dec; 208(?):112847. doi:
10.1016/j.ejmech.2020.112847. [PMID: 33022479] - Ying-Jie Cui, Chao Liu, Chen-Chen Ma, Ya-Ting Ji, Yi-Li Yao, Long-Qian Tang, Cheng-Mei Zhang, Jing-De Wu, Zhao-Peng Liu. SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors.
Journal of medicinal chemistry.
2020 12; 63(23):14840-14866. doi:
10.1021/acs.jmedchem.0c01345. [PMID: 33201714] - Dinaer Mulatihan, Tao Guo, Yanjun Zhao. Azobenzene Photoswitch for Isomerization-Dependent Cancer Therapy via Azo-Combretastatin A4 and Phototrexate.
Photochemistry and photobiology.
2020 11; 96(6):1163-1168. doi:
10.1111/php.13292. [PMID: 32521572] - Fang Yang, Xie-Er Jian, Peng-Cheng Diao, Xian-Sen Huo, Wen-Wei You, Pei-Liang Zhao. Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors.
European journal of medicinal chemistry.
2020 Oct; 204(?):112625. doi:
10.1016/j.ejmech.2020.112625. [PMID: 32717486] - Libang Zhang, Lichao Liu, Dongjian Zhang, Qiaomei Jin, Meng Gao, Tianze Wu, Yuanbo Feng, Yicheng Ni, Zhiqi Yin, Jian Zhang. Synthesis and Evaluation of Diindole-Based MRI Contrast Agent for In Vivo Visualization of Necrosis.
Molecular imaging and biology.
2020 06; 22(3):593-601. doi:
10.1007/s11307-019-01399-2. [PMID: 31332630] - Aimi Zhang, Tianze Wu, Li Bian, Panli Li, Qiufang Liu, Dongjian Zhang, Qiaomei Jin, Jian Zhang, Gang Huang, Shaoli Song. Synthesis and Evaluation of Ga-68-Labeled Rhein for Early Assessment of Treatment-Induced Tumor Necrosis.
Molecular imaging and biology.
2020 06; 22(3):515-525. doi:
10.1007/s11307-019-01365-y. [PMID: 31250330] - Thomas Wong, Silpa Narayanan, David P Brown, Zhe-Sheng Chen. Synthesis and Cytotoxicity Studies of Stilbene Long-Chain Fatty Acid Conjugates.
Journal of natural products.
2020 05; 83(5):1563-1570. doi:
10.1021/acs.jnatprod.0c00027. [PMID: 32243160] - Ying-Jie Cui, Chen-Chen Ma, Cheng-Mei Zhang, Long-Qian Tang, Zhao-Peng Liu. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo.
European journal of medicinal chemistry.
2020 Feb; 187(?):111968. doi:
10.1016/j.ejmech.2019.111968. [PMID: 31865012] - Meng Gao, Dongjian Zhang, Nan Yao, Qiaomei Jin, Cuihua Jiang, Jian Zhang, Feng Wang. Enhancing intratumoral biodistribution and antitumor activity of nab-paclitaxel through combination with a vascular disrupting agent, combretastatin A-4-phosphate.
Cancer chemotherapy and pharmacology.
2019 12; 84(6):1187-1194. doi:
10.1007/s00280-019-03953-9. [PMID: 31520101] - Qiang Zeng, Yali Liu, Yonggui Song, Bingwei Feng, Pengfei Xu, Baixi Shan, Zhou Liao, Kuangyi Liu, Youbao Zhong, Lai Chen, Dan Su. A UHPLC-MS/MS method coupled with simple and efficient alkaline hydrolysis for free and total determination of conjugate nanomedicine: Pharmacokinetic and biodistribution study of poly (l-glutamic acid)-graft-methoxy poly (ethylene glycol)/combretastatin A4.
Journal of pharmaceutical and biomedical analysis.
2019 May; 169(?):215-224. doi:
10.1016/j.jpba.2019.03.001. [PMID: 30877933] - Ya-Liang Zhang, Bo-Yan Li, Rong Yang, Lin-Ying Xia, A-Li Fan, Yi-Chun Chu, Lin-Jian Wang, Zhong-Chang Wang, Ai-Qin Jiang, Hai-Liang Zhu. A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
European journal of medicinal chemistry.
2019 Feb; 163(?):896-910. doi:
10.1016/j.ejmech.2018.12.030. [PMID: 30580241] - Yongwei Gu, Juanjuan Ma, Zhiqin Fu, Youfa Xu, Baoan Gao, Jianzhong Yao, Wei Xu, Kedan Chu, Jianming Chen. Development Of Novel Liposome-Encapsulated Combretastatin A4 Acylated Derivatives: Prodrug Approach For Improving Antitumor Efficacy.
International journal of nanomedicine.
2019; 14(?):8805-8818. doi:
10.2147/ijn.s210938. [PMID: 31806973] - Fredrick O Ojike, Nathalie Lavignac, Maxwell A Casely-Hayford. Synthesis and in Vitro Bioactivity of Polyunsaturated Fatty Acid Conjugates of Combretastatin A-4.
Journal of natural products.
2018 09; 81(9):2101-2105. doi:
10.1021/acs.jnatprod.7b01062. [PMID: 30230828] - Qinhuai Lai, Yuxi Wang, Ruixue Wang, Weirong Lai, Liangze Tang, Yiran Tao, Yu Liu, Ruirui Zhang, Luyi Huang, Haotian Xiang, Shaoxue Zeng, Lantu Gou, Hao Chen, Yuqin Yao, Jinliang Yang. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
European journal of medicinal chemistry.
2018 Aug; 156(?):162-179. doi:
10.1016/j.ejmech.2018.05.010. [PMID: 30006162] - E Ragozin, A Hesin, A Bazylevich, H Tuchinsky, A Bovina, T Shekhter Zahavi, M Oron-Herman, G Kostenich, M A Firer, T Rubinek, I Wolf, G Luboshits, M Y Sherman, G Gellerman. New somatostatin-drug conjugates for effective targeting pancreatic cancer.
Bioorganic & medicinal chemistry.
2018 07; 26(13):3825-3836. doi:
10.1016/j.bmc.2018.06.032. [PMID: 30017114] - Irfan Khan, Koteswara Rao Garikapati, Anver Basha Shaik, Venkata Krishna Kanth Makani, Abdul Rahim, Mohd Adil Shareef, V Ganga Reddy, Manika Pal-Bhadra, Ahmed Kamal, C Ganesh Kumar. Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis.
European journal of medicinal chemistry.
2018 Jan; 144(?):104-115. doi:
10.1016/j.ejmech.2017.12.010. [PMID: 29268127] - Dongjian Zhang, Meng Gao, Nan Yao, Cuihua Jiang, Wei Liu, Tiannv Li, Shaoli Song, Dejian Huang, Zhiqi Yin, Yunliang Qiu, Qiaomei Jin. Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents.
Contrast media & molecular imaging.
2018; 2018(?):5237950. doi:
10.1155/2018/5237950. [PMID: 29681781] - B Poornima, Bandi Siva, A Venkanna, G Shankaraiah, Nishant Jain, Dharmendra Kumar Yadav, Sanjeev Misra, K Suresh Babu. Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies.
European journal of medicinal chemistry.
2017 Oct; 139(?):441-453. doi:
10.1016/j.ejmech.2017.07.076. [PMID: 28818768] - Yurun Shen, Liping Wu, Liyan Qiu. Water-Soluble Combretastatin A4 Phosphate Orally Delivered via Composite Nanoparticles With Improved Inhibition Effect Toward S180 Tumors.
Journal of pharmaceutical sciences.
2017 10; 106(10):3076-3083. doi:
10.1016/j.xphs.2017.05.031. [PMID: 28619603] - Hongsheng Wang, Wen Li, Jing Xu, Tao Zhang, Dongqing Zuo, Zifei Zhou, Binhui Lin, Gangyang Wang, Zhuoying Wang, Wei Sun, Mengxiong Sun, Shimin Chang, Zhengdong Cai, Yingqi Hua. NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
Cell death & disease.
2017 09; 8(9):e3048. doi:
10.1038/cddis.2017.438. [PMID: 28906492] - Victoria Mico, Antonia Charalambous, Sally A Peyman, Radwa H Abou-Saleh, Alexander F Markham, P Louise Coletta, Stephen D Evans. Evaluation of lipid-stabilised tripropionin nanodroplets as a delivery route for combretastatin A4.
International journal of pharmaceutics.
2017 Jun; 526(1-2):547-555. doi:
10.1016/j.ijpharm.2017.05.009. [PMID: 28495582] - Tianzhou Liu, Dawei Zhang, Wantong Song, Zhaohui Tang, Jiaming Zhu, Zhiming Ma, Xudong Wang, Xuesi Chen, Ti Tong. A poly(l-glutamic acid)-combretastatin A4 conjugate for solid tumor therapy: Markedly improved therapeutic efficiency through its low tissue penetration in solid tumor.
Acta biomaterialia.
2017 04; 53(?):179-189. doi:
10.1016/j.actbio.2017.02.001. [PMID: 28167300] - Meng Gao, Dongjian Zhang, Qiaomei Jin, Cuihua Jiang, Cong Wang, Jindian Li, Fei Peng, Dejian Huang, Jian Zhang, Shaoli Song. Combretastatin-A4 phosphate improves the distribution and antitumor efficacy of albumin-bound paclitaxel in W256 breast carcinoma model.
Oncotarget.
2016 09; 7(36):58133-58141. doi:
10.18632/oncotarget.11249. [PMID: 27531898] - Florence Colliez, Anne-Catherine Fruytier, Julie Magat, Marie-Aline Neveu, Patrice D Cani, Bernard Gallez, Bénédicte F Jordan. Monitoring Combretastatin A4-induced tumor hypoxia and hemodynamic changes using endogenous MR contrast and DCE-MRI.
Magnetic resonance in medicine.
2016 Feb; 75(2):866-72. doi:
10.1002/mrm.25642. [PMID: 25765253] - Qingen Ke, Mohammed A Samad, Soochan Bae, David J Chaplin, Peter M Kang. Exaggerated hypertensive response to combretastatin A-4 phosphate in hypertensive rats: Effective pharmacological inhibition by diltiazem.
Vascular pharmacology.
2015 Nov; 74(?):73-79. doi:
10.1016/j.vph.2015.05.004. [PMID: 25989107] - Nan Yao, Ke Ren, Cuihua Jiang, Meng Gao, Dejian Huang, Xiao Lu, Bin Lou, Fei Peng, Aizhen Yang, Xiaoning Wang, Yicheng Ni, Jian Zhang. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2015 Nov; 36(11):8499-510. doi:
10.1007/s13277-015-3508-x. [PMID: 26026583] - Xuejiao Liu, Cuihua Jiang, Dongjian Zhang, Meng Gao, Fei Peng, Dejian Huang, Ziping Sun, Yicheng Ni, Jian Zhang, Zhiqi Yin. Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model.
Oncotarget.
2015 Sep; 6(28):26400-10. doi:
10.18632/oncotarget.4568. [PMID: 26305548] - Meng Gao, Nan Yao, Dejian Huang, Cuihua Jiang, Yuanbo Feng, Yue Li, Bin Lou, Fei Peng, Ziping Sun, Yicheng Ni, Jian Zhang. Trapping effect on a small molecular drug with vascular-disrupting agent CA4P in rodent H22 hepatic tumor model: in vivo magnetic resonance imaging and postmortem inductively coupled plasma atomic emission spectroscopy.
Journal of drug targeting.
2015 Jun; 23(5):436-43. doi:
10.3109/1061186x.2014.1002789. [PMID: 25582132] - Linh H Mai, Guy G Chabot, Philippe Grellier, Lionel Quentin, Vincent Dumontet, Cyril Poulain, Laila S Espindola, Sylvie Michel, Hue T B Vo, Brigitte Deguin, Raphaël Grougnet. Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
European journal of medicinal chemistry.
2015 Mar; 93(?):93-100. doi:
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Anti-cancer drugs.
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Bioorganic & medicinal chemistry.
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Bioorganic & medicinal chemistry letters.
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Bioorganic & medicinal chemistry.
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