Yageine (BioDeep_00000866797)

Main id: BioDeep_00000324323

 

PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


InChI=1\C13H12N2O\c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13\h3-7,15H,1-2H

化学式: C13H12N2O (212.095)
中文名称: 哈尔碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
InChI: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D006213 - Hallucinogens
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

同义名列表

65 个代谢物同义名

InChI=1\C13H12N2O\c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13\h3-7,15H,1-2H; 5-23-12-00237 (Beilstein Handbook Reference); 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-; 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole; 7-Methoxy-1-methyl-9H-beta-carboline; 7-methoxy-1-methyl-9H-$b-carboline; 1-Methyl-7-methoxy-beta-carboline; SDCCGMLS-0066733.P001; 442-51-3 (FREE base); Prestwick0_000613; Prestwick3_000613; Prestwick1_000613; Prestwick2_000613; Spectrum2_000568; Spectrum4_001004; Spectrum5_001914; Spectrum3_000906; EINECS 207-131-4; Spectrum_001128; NCGC00094869-05; NCGC00094869-02; 6-Methoxyharman; NCGC00094869-01; NCGC00094869-03; SpecPlus_000611; NCGC00016435-01; SPECTRUM1500867; 343-27-1 (HCL); 286044_ALDRICH; DivK1c_006707; MEGxp0_001875; Oprea1_596686; KBioSS_001608; BPBio1_000602; KBioGR_001467; BSPBio_000546; KBio2_001608; KBio2_006744; KBio1_001651; BAS 00654992; ZINC00058177; ACon0_001194; Leucoharmine; ACon1_000061; KBio2_004176; KBio3_001852; SPBio_002765; SPBio_000356; CAS-343-27-1; BRN 0178813; Telepathine; 51400_FLUKA; Banisterine; AIDS-109052; AIDS109052; ST069315; 442-51-3; Yageine; Harmine; Yajeine; C06538; Harmine; Harmine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

61 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, BCL2, BDNF, CASP3, DYRK1A, MTOR, PIK3CA, PRKX, PTGS2, TP53, VEGFA
Peripheral membrane protein 3 ACHE, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HSP90B1, MTOR, PTGS2
Mitochondrion membrane 1 MAOA
Nucleus 11 ACHE, AKT1, BCL2, CASP3, DYRK1A, HSP90B1, MTOR, PARP1, PRKX, TP53, VEGFA
cytosol 9 AKT1, BCL2, CASP3, HSP90B1, MAOA, MTOR, PARP1, PIK3CA, TP53
dendrite 3 BDNF, DYRK1A, MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 1 TP53
nucleoplasm 7 AKT1, CASP3, DYRK1A, MTOR, PARP1, PRKX, TP53
Cell membrane 4 ACHE, AKT1, SLC1A2, TNF
Cytoplasmic side 2 MAOA, MTOR
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 SLC1A2
Golgi apparatus membrane 1 MTOR
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 4 ACHE, SLC1A2, TNF, VEGFA
glutamatergic synapse 3 AKT1, CASP3, SLC1A2
Golgi apparatus 2 ACHE, VEGFA
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
presynaptic membrane 1 SLC1A2
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 PARP1
Lysosome 1 MTOR
plasma membrane 5 ACHE, AKT1, PIK3CA, SLC1A2, TNF
Membrane 11 ACHE, AKT1, BCL2, BDNF, HSP90B1, MAOA, MTOR, PARP1, SLC1A2, TP53, VEGFA
axon 3 BDNF, CCK, DYRK1A
caveola 1 PTGS2
extracellular exosome 2 BMP3, HSP90B1
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, HSP90B1, PTGS2, TP53, VEGFA
extracellular space 7 ACHE, BDNF, BMP3, CCK, INS, TNF, VEGFA
perinuclear region of cytoplasm 4 ACHE, BDNF, HSP90B1, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, MAOA, PARP1, TP53
protein-containing complex 6 AKT1, BCL2, HSP90B1, PARP1, PTGS2, TP53
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 6 ACHE, BDNF, BMP3, CCK, INS, VEGFA
extracellular region 8 ACHE, BDNF, BMP3, CCK, HSP90B1, INS, TNF, VEGFA
Mitochondrion outer membrane 3 BCL2, MAOA, MTOR
Single-pass membrane protein 2 BCL2, MAOA
mitochondrial outer membrane 3 BCL2, MAOA, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ACHE
transcription regulator complex 2 PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 2 PARP1, TP53
midbody 1 HSP90B1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, SLC1A2
Membrane raft 2 SLC1A2, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 HSP90B1
spindle 1 AKT1
axolemma 1 SLC1A2
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 VEGFA
nuclear speck 1 DYRK1A
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 PARP1, TP53
phagocytic cup 1 TNF
Chromosome 1 PARP1
cytoskeleton 1 DYRK1A
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 2 PARP1, TP53
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
endosome lumen 1 INS
Melanosome 1 HSP90B1
Nucleus speckle 1 DYRK1A
cell body 1 SLC1A2
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BDNF, HSP90B1, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 MAOA
Sarcoplasmic reticulum lumen 1 HSP90B1
ribonucleoprotein complex 1 DYRK1A
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
astrocyte projection 1 SLC1A2
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endoplasmic reticulum chaperone complex 1 HSP90B1
neuron projection terminus 1 SLC1A2
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
membrane protein complex 1 SLC1A2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Eleanor White, Tom Kennedy, Simon Ruffell, Daniel Perkins, Jerome Sarris. Ayahuasca and Dimethyltryptamine Adverse Events and Toxicity Analysis: A Systematic Thematic Review. International journal of toxicology. 2024 May; 43(3):327-339. doi: 10.1177/10915818241230916. [PMID: 38363085]
  • Ya-Li Guo, Jing-Wen Yu, Yan Cao, Ke-Xin Cheng, Suo-Nan-Mu Dong-Zhi, Yan-Fei Zhang, Qing-Jia Ren, Yong Yin, Cao-Long Li. Design, synthesis, and biological evaluation of harmine derivatives as topoisomerase I inhibitors for cancer treatment. European journal of medicinal chemistry. 2024 Feb; 265(?):116061. doi: 10.1016/j.ejmech.2023.116061. [PMID: 38154256]
  • Phumudzo P Tshikhudo, Tafadzwanashe Mabhaudhi, Neil A Koorbanally, Fhatuwani N Mudau, Edgardo Oscar Avendaño Caceres, Dragos Popa, Daniela Calina, Javad Sharifi-Rad. Anticancer Potential of β-Carboline Alkaloids: An Updated Mechanistic Overview. Chemistry & biodiversity. 2023 Dec; ?(?):e202301263. doi: 10.1002/cbdv.202301263. [PMID: 38108650]
  • Ahmed H Abdelazim, Majed A Algarni, Atiah H Almalki. Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices. Scientific reports. 2023 11; 13(1):19951. doi: 10.1038/s41598-023-46041-y. [PMID: 37968310]
  • Bao Tan Nguyen, Nguyen Thi Hai Yen, Ninh Khac Thanh Tung, Gil-Saeng Jeong, Jong Seong Kang, Nguyen Phuoc Long, Hyung Min Kim. Lipid class-dependent alterations of Caenorhabditis elegans under harmane exposure. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 231(?):115401. doi: 10.1016/j.jpba.2023.115401. [PMID: 37105045]
  • Yuanyuan Wang, Maofeng Dong, Limin Guo, Yamin Zhu, Qingqing Jiang, Jianbo Xiao, Mingfu Wang, Yueliang Zhao. Effect of acrolein on the formation of harman and norharman in chemical models and roast beef patties. Food research international (Ottawa, Ont.). 2023 02; 164(?):112465. doi: 10.1016/j.foodres.2023.112465. [PMID: 36738015]
  • Summya Rashid, Maryam Sameti, Mohammed H Alqarni, Fatma M Abdel Bar. In vivo investigation of the inhibitory effect of Peganum harmala L. and its major alkaloids on ethylene glycol-induced urolithiasis in rats. Journal of ethnopharmacology. 2023 Jan; 300(?):115752. doi: 10.1016/j.jep.2022.115752. [PMID: 36174807]
  • Dongyan Hu, Guangtian Han, Huazhong Ren, Xinwei Li, Xi'an Li, Lirong Yue, Jiao Xu, Jiafu Feng, Li Guo. Synthesis, biological evaluation and preliminary mechanisms of 6-amino substituted harmine derivatives as potential antitumor agents. Fitoterapia. 2022 Nov; 163(?):105329. doi: 10.1016/j.fitote.2022.105329. [PMID: 36209955]
  • Albert Katchborian-Neto, Mário Ferreira Conceição Santos, Diego Fernandes Vilas-Boas, Elda Gonçalves Dos Santos, Márcia Paranho Veloso, Paula Carolina Pires Bueno, Ivo Santana Caldas, Marisi Gomes Soares, Danielle Ferreira Dias, Daniela Aparecida Chagas-Paula. Immunological Modulation and Control of Parasitaemia by Ayahuasca Compounds: Therapeutic Potential for Chagas's Disease. Chemistry & biodiversity. 2022 Oct; 19(10):e202200409. doi: 10.1002/cbdv.202200409. [PMID: 36163588]
  • Lucia Jimenez, Andreia Silva, Giampaolo Calissi, Inês Grenho, Rita Monteiro, Victor Mayoral-Varo, Carmen Blanco-Aparicio, Joaquin Pastor, Victor Bustos, Franz Bracher, Diego Megías, Bibiana I Ferreira, Wolfgang Link. Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3. The journals of gerontology. Series A, Biological sciences and medical sciences. 2022 08; 77(8):1485-1493. doi: 10.1093/gerona/glab265. [PMID: 34508571]
  • Zhezhe Li, Yipaerguli Apizi, Chengzhong Zhang, Zhaozhi Wang, Hongji He, Xiaoya Li, Yina Zhu, Jishun Yang, Liang Xiao, Mei Wang. Synthesis of harmine-nitric oxide donor derivatives as potential antitumor agents. Bioorganic & medicinal chemistry letters. 2022 06; 65(?):128698. doi: 10.1016/j.bmcl.2022.128698. [PMID: 35341920]
  • Caizhi Tian, Shuoqi Huang, Zihua Xu, Wenwu Liu, Deping Li, Mingyue Liu, Chengze Zhu, Limeng Wu, Xiaowen Jiang, Huaiwei Ding, Qingchun Zhao. Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects. Bioorganic & medicinal chemistry letters. 2022 05; 64(?):128663. doi: 10.1016/j.bmcl.2022.128663. [PMID: 35272009]
  • Soching Luikham, Mavani A, Jhimli Bhattacharyya. Deciphering binding affinity, energetics, and base specificity of plant alkaloid Harmane with AT and GC hairpin duplex DNA. Luminescence : the journal of biological and chemical luminescence. 2022 May; 37(5):691-701. doi: 10.1002/bio.4210. [PMID: 35156295]
  • Shi-Ming Huang, Shu-Bei Li, Hong-Tao Deng, Qing-Qing Jiang, Yi-Bo Gu, Xue Ying. [Preparation and effect against cervical cancer invasion in vitro of harmine-loaded photosensitive liposomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(10):2643-2651. doi: 10.19540/j.cnki.cjcmm.20210520.301. [PMID: 35718482]
  • Beatriz Werneck Lopes Santos, Daniel Carneiro Moreira, Tatiana Karla Dos Santos Borges, Eloisa Dutra Caldas. Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells. Molecules (Basel, Switzerland). 2022 Apr; 27(8):. doi: 10.3390/molecules27082500. [PMID: 35458698]
  • You-Xu Wang, Ning Cao, Hui-Da Guan, Xue-Mei Cheng, Chang-Hong Wang. Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine. Chinese journal of natural medicines. 2022 Mar; 20(3):194-201. doi: 10.1016/s1875-5364(22)60151-1. [PMID: 35369963]
  • Weiyi Qu, Ze Chen, Xing Hu, Toujun Zou, Yongping Huang, Yanyan Zhang, Yufeng Hu, Song Tian, Juan Wan, Rufang Liao, Lan Bai, Jinhua Xue, Yi Ding, Manli Hu, Xiao-Jing Zhang, Xin Zhang, Jingjing Zhao, Xu Cheng, Zhi-Gang She, Hongliang Li. Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model. Frontiers in endocrinology. 2022; 13(?):849060. doi: 10.3389/fendo.2022.849060. [PMID: 35620391]
  • Limin Liu, Xiaoxuan Ning, Lei Wei, Ying Zhou, Lijuan Zhao, Feng Ma, Ming Bai, Xiaoxia Yang, Di Wang, Shiren Sun. Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis. Theranostics. 2022; 12(8):3758-3775. doi: 10.7150/thno.71722. [PMID: 35664054]
  • Wei Liu, Zhaoyu Yang, Lili Shi, Ziyu Cui, Yun Li. Degradation of β-Carbolines Harman and Norharman in Edible Oils during Heating. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26227018. [PMID: 34834111]
  • Bo Luo, Xinqiang Song. A comprehensive overview of β-carbolines and its derivatives as anticancer agents. European journal of medicinal chemistry. 2021 Nov; 224(?):113688. doi: 10.1016/j.ejmech.2021.113688. [PMID: 34332400]
  • Cheng-Peng Sun, Jing Yi, Fan Wei, Xia Lv, Sa Deng, Bao-Jing Zhang, Wen-Yu Zhao, Xiao-Chi Ma. UV-light-driven photooxidation of harmaline catalyzed by riboflavin: Product characterization and mechanisms. Fitoterapia. 2021 Nov; 155(?):105054. doi: 10.1016/j.fitote.2021.105054. [PMID: 34626737]
  • Andrew B Hawkey, Julia Hoeng, Manuel C Peitsch, Edward D Levin, Kyoko Koshibu. Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish. Pharmacology, biochemistry, and behavior. 2021 08; 207(?):173223. doi: 10.1016/j.pbb.2021.173223. [PMID: 34197843]
  • Abde El-Galil E Amr, Ayman H Kamel, Abdulrahman A Almehizia, Ahmed Y A Sayed, Hisham S M Abd-Rabboh. Solid-Contact Potentiometric Sensors Based on Main-Tailored Bio-Mimics for Trace Detection of Harmine Hallucinogen in Urine Specimens. Molecules (Basel, Switzerland). 2021 Jan; 26(2):. doi: 10.3390/molecules26020324. [PMID: 33435196]
  • Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice. The Journal of toxicological sciences. 2021; 46(6):289-301. doi: 10.2131/jts.46.289. [PMID: 34078836]
  • Jared P Taylor, Lucas H Armitage, Daniel L Aldridge, Melanie N Cash, Mark A Wallet. Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA. Biology open. 2020 12; 9(12):. doi: 10.1242/bio.052969. [PMID: 33234703]
  • Vivek Lawana, Se Young Um, Rachel M Foguth, Jason R Cannon. Neuromelanin formation exacerbates HAA-induced mitochondrial toxicity and mitophagy impairments. Neurotoxicology. 2020 12; 81(?):147-160. doi: 10.1016/j.neuro.2020.10.005. [PMID: 33058929]
  • Liang Zhang, Dengchang Li, Shenglan Yu. Pharmacological effects of harmine and its derivatives: a review. Archives of pharmacal research. 2020 Dec; 43(12):1259-1275. doi: 10.1007/s12272-020-01283-6. [PMID: 33206346]
  • Simon Ruffell, Nige Netzband, Catherine Bird, Allan H Young, Mario F Juruena. The pharmacological interaction of compounds in ayahuasca: a systematic review. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2020 Nov; 42(6):646-656. doi: 10.1590/1516-4446-2020-0884. [PMID: 32638916]
  • Chen-Xia Zhang, Jun Xi, Tian-Pei Zhao, Yu-Xiang Ma, Xue-De Wang. β-carbolines norharman and harman in vegetable oils in China. Food additives & contaminants. Part B, Surveillance. 2020 Sep; 13(3):193-199. doi: 10.1080/19393210.2020.1759701. [PMID: 32364007]
  • Renata Zawirska-Wojtasiak, Agnieszka Fedoruk-Wyszomirska, Paulina Piechowska, Sylwia Mildner-Szkudlarz, Joanna Bajerska, Elżbieta Wojtowicz, Krzysztof Przygoński, Dorota Gurda, Wiktoria Kubicka, Eliza Wyszko. β-Carbolines in Experiments on Laboratory Animals. International journal of molecular sciences. 2020 Jul; 21(15):. doi: 10.3390/ijms21155245. [PMID: 32722000]
  • Laura Lewerenz, Tahani Hijazin, Sara Abouzeid, Robert Hänsch, Dirk Selmar. Pilot study on the uptake and modification of harmaline in acceptor plants: An innovative approach to visualize the interspecific transfer of natural products. Phytochemistry. 2020 Jun; 174(?):112362. doi: 10.1016/j.phytochem.2020.112362. [PMID: 32229335]
  • Haiqi Wang, Hongjian Song. Synthesis of Four Optical Isomers of Antiviral Agent NK0209 and Determination of Their Configurations and Activities against a Plant Virus. Journal of agricultural and food chemistry. 2020 Mar; 68(9):2631-2638. doi: 10.1021/acs.jafc.9b07694. [PMID: 32023057]
  • Jizong Jiang, Tingyun Ma, Liuhong Zhang, Xuemei Cheng, Changhong Wang. The transdermal performance, pharmacokinetics, and anti-inflammatory pharmacodynamics evaluation of harmine-loaded ethosomes. Drug development and industrial pharmacy. 2020 Jan; 46(1):101-108. doi: 10.1080/03639045.2019.1706549. [PMID: 31851523]
  • Zhi Xu, Shi-Jia Zhao, Yi Liu. 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. European journal of medicinal chemistry. 2019 Dec; 183(?):111700. doi: 10.1016/j.ejmech.2019.111700. [PMID: 31546197]
  • Bo Jiang, Liyuan Meng, Nan Zou, Hanxue Wang, Shuping Li, Lifeng Huang, Xuemei Cheng, Zhengtao Wang, Wansheng Chen, Changhong Wang. Mechanism-based pharmacokinetics-pharmacodynamics studies of harmine and harmaline on neurotransmitters regulatory effects in healthy rats: Challenge on monoamine oxidase and acetylcholinesterase inhibition. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Sep; 62(?):152967. doi: 10.1016/j.phymed.2019.152967. [PMID: 31154274]
  • Rita C Z Souza, Flávia S Zandonadi, Donizete P Freitas, Luís F F Tófoli, Alessandra Sussulini. Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):197-203. doi: 10.1016/j.jchromb.2019.06.014. [PMID: 31220748]
  • Yu Ding, Jinrong He, Juan Huang, Tong Yu, Xiaoyan Shi, Tianzhu Zhang, Ge Yan, Shanshan Chen, Caixia Peng. Harmine induces anticancer activity in breast cancer cells via targeting TAZ. International journal of oncology. 2019 Jun; 54(6):1995-2004. doi: 10.3892/ijo.2019.4777. [PMID: 31081045]
  • Falco Beer, Felix Urbat, Charles M A P Franz, Melanie Huch, Sabine E Kulling, Mirko Bunzel, Diana Bunzel. The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations. Molecular nutrition & food research. 2019 05; 63(10):e1801177. doi: 10.1002/mnfr.201801177. [PMID: 30815965]
  • Xiaofeng Niu, Qing Yao, Weifeng Li, Lulu Zang, Wenqi Li, Jinmeng Zhao, Fang Liu, Wenbing Zhi. Harmine mitigates LPS-induced acute kidney injury through inhibition of the TLR4-NF-κB/NLRP3 inflammasome signalling pathway in mice. European journal of pharmacology. 2019 Apr; 849(?):160-169. doi: 10.1016/j.ejphar.2019.01.062. [PMID: 30716318]
  • Yunpeng Zhang, Shuping Li, Youxu Wang, Gang Deng, Ning Cao, Chao Wu, Wenzheng Ding, Yuwen Wang, Xuemei Cheng, Changhong Wang. Potential Pharmacokinetic Drug⁻Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist. Molecules (Basel, Switzerland). 2019 Apr; 24(7):. doi: 10.3390/molecules24071430. [PMID: 30978991]
  • Paulina Piechowska, Renata Zawirska-Wojtasiak, Sylwia Mildner-Szkudlarz. Bioactive β-Carbolines in Food: A Review. Nutrients. 2019 Apr; 11(4):. doi: 10.3390/nu11040814. [PMID: 30978920]
  • Fábio Kummrow, Bianca S Maselli, Rafael Lanaro, José Luis Costa, Gisela A Umbuzeiro, Alessandra Linardi. Mutagenicity of Ayahuasca and Their Constituents to the Salmonella/Microsome Assay. Environmental and molecular mutagenesis. 2019 04; 60(3):269-276. doi: 10.1002/em.22263. [PMID: 30488498]
  • Sueli Moreira Mello, Paula Christiane Soubhia, Gabriela Silveira, Nelson Francisco Corrêa-Neto, Rafael Lanaro, José Luiz Costa, Alessandra Linardi. Effect of Ritualistic Consumption of Ayahuasca on Hepatic Function in Chronic Users. Journal of psychoactive drugs. 2019 Jan; 51(1):3-11. doi: 10.1080/02791072.2018.1557355. [PMID: 30582439]
  • Vikalp Vishwakarma, Jacob New, Dhruv Kumar, Vusala Snyder, Levi Arnold, Emily Nissen, Qingting Hu, Nikki Cheng, David Miller, Ahia Rael Thomas, Yelizaveta Shnayder, Kiran Kakarala, Terance Ted Tsue, Douglas A Girod, Sufi Mary Thomas. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Scientific reports. 2018 08; 8(1):12163. doi: 10.1038/s41598-018-29683-1. [PMID: 30111862]
  • Ram B Jain. Concentrations of selected heterocyclic aromatic amines among US population aged ≥ 6 years: data from NHANES 2013-2014. Environmental science and pollution research international. 2018 Jul; 25(20):19859-19874. doi: 10.1007/s11356-018-2210-0. [PMID: 29737487]
  • Deyan Chen, Xiaoyan Tian, Xue Zou, Shijie Xu, Huanru Wang, Nan Zheng, Zhiwei Wu. Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-κB pathway. International immunopharmacology. 2018 Jul; 60(?):111-120. doi: 10.1016/j.intimp.2018.04.050. [PMID: 29730555]
  • Xinran Geng, Yichang Ren, Fangfang Wang, Danmei Tian, Xinsheng Yao, Youwei Zhang, Jinshan Tang. Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy. Biochemical and biophysical research communications. 2018 03; 498(1):99-104. doi: 10.1016/j.bbrc.2018.02.205. [PMID: 29501493]
  • Roudaina Benzekri, Lamjed Bouslama, Adele Papetti, Majdi Hammami, Abderrazak Smaoui, Ferid Limam. Anti HSV-2 activity of Peganum harmala (L.) and isolation of the active compound. Microbial pathogenesis. 2018 Jan; 114(?):291-298. doi: 10.1016/j.micpath.2017.12.017. [PMID: 29223449]
  • Tomás Herraiz, Hugo Guillén. Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. BioMed research international. 2018; 2018(?):4810394. doi: 10.1155/2018/4810394. [PMID: 29568754]
  • Monaj Karar, Suvendu Paul, Arabinda Mallick, Tapas Majumdar. Shipment of a photodynamic therapy agent into model membrane and its controlled release: A photophysical approach. Chemistry and physics of lipids. 2018 01; 210(?):122-128. doi: 10.1016/j.chemphyslip.2017.10.005. [PMID: 29056528]
  • Nan Zou, Yue Wei, Fenghua Li, Yang Yang, Xuemei Cheng, Changhong Wang. The inhibitory effects of compound Muniziqi granule against B16 cells and harmine induced autophagy and apoptosis by inhibiting Akt/mTOR pathway. BMC complementary and alternative medicine. 2017 Dec; 17(1):517. doi: 10.1186/s12906-017-2017-4. [PMID: 29197358]
  • Xin Liu, Mingxia Li, Si Tan, Changhong Wang, Shengjie Fan, Cheng Huang. Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling. Biochemical and biophysical research communications. 2017 07; 489(3):332-338. doi: 10.1016/j.bbrc.2017.05.126. [PMID: 28551404]
  • Jose A Morales-García, Mario de la Fuente Revenga, Sandra Alonso-Gil, María Isabel Rodríguez-Franco, Amanda Feilding, Ana Perez-Castillo, Jordi Riba. The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro. Scientific reports. 2017 07; 7(1):5309. doi: 10.1038/s41598-017-05407-9. [PMID: 28706205]
  • M A Tabari, M R Youssefi, A A Moghadamnia. Antitrichomonal activity of Peganum harmala alkaloid extract against trichomoniasis in pigeon (Columba livia domestica). British poultry science. 2017 Jun; 58(3):236-241. doi: 10.1080/00071668.2017.1280725. [PMID: 28084792]
  • Shuping Li, Liang Teng, Wei Liu, Xuemei Cheng, Bo Jiang, Zhengtao Wang, Changhong Wang. Interspecies metabolic diversity of harmaline and harmine in in vitro 11 mammalian liver microsomes. Drug testing and analysis. 2017 May; 9(5):754-768. doi: 10.1002/dta.2028. [PMID: 27377954]
  • Marcos Tascón, Fernando Benavente, Nora M Vizioli, Leonardo G Gagliardi. A rapid and simple method for the determination of psychoactive alkaloids by CE-UV: application to Peganum Harmala seed infusions. Drug testing and analysis. 2017 Apr; 9(4):596-602. doi: 10.1002/dta.1989. [PMID: 27377797]
  • Haroon Khan, Seema Patel, Mohammad A Kamal. Pharmacological and Toxicological Profile of Harmane-β-Carboline Alkaloid: Friend or Foe. Current drug metabolism. 2017; 18(9):853-857. doi: 10.2174/1389200218666170607100947. [PMID: 28595532]
  • Xiaofei Shang, Xiao Guo, Bing Li, Hu Pan, Jiyu Zhang, Yu Zhang, Xiaolou Miao. Microwave-assisted extraction of three bioactive alkaloids from Peganum harmala L. and their acaricidal activity against Psoroptes cuniculi in vitro. Journal of ethnopharmacology. 2016 Nov; 192(?):350-361. doi: 10.1016/j.jep.2016.07.057. [PMID: 27452655]
  • Shuping Li, Liang Teng, Wei Liu, Xuemei Cheng, Bo Jiang, Zhengtao Wang, Chang-Hong Wang. Pharmacokinetic study of harmane and its 10 metabolites in rat after intravenous and oral administration by UPLC-ESI-MS/MS. Pharmaceutical biology. 2016 Sep; 54(9):1768-81. doi: 10.3109/13880209.2015.1127978. [PMID: 26730489]
  • Frecska Ede, Kovács Attila, Szabó Attila, Ferencz Csaba, Móré Csaba. Basics of the medical use of ayahuasca: physiology of dimethyltryptamine. Lege artis medicinae : uj magyar orvosi hirmondo. 2016 Sep; 26(9-10):413. doi: . [PMID: 29537778]
  • Hongtao Du, Shan Tian, Juncheng Chen, Hongling Gu, Na Li, Junru Wang. Synthesis and biological evaluation of N(9)-substituted harmine derivatives as potential anticancer agents. Bioorganic & medicinal chemistry letters. 2016 08; 26(16):4015-9. doi: 10.1016/j.bmcl.2016.06.087. [PMID: 27397495]
  • Ercument Dirice, Deepika Walpita, Amedeo Vetere, Bennett C Meier, Sevim Kahraman, Jiang Hu, Vlado Dančík, Sean M Burns, Tamara J Gilbert, David E Olson, Paul A Clemons, Rohit N Kulkarni, Bridget K Wagner. Inhibition of DYRK1A Stimulates Human β-Cell Proliferation. Diabetes. 2016 06; 65(6):1660-71. doi: 10.2337/db15-1127. [PMID: 26953159]
  • Marica Mariano, Rolf W Hartmann, Matthias Engel. Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2. European journal of medicinal chemistry. 2016 Apr; 112(?):209-216. doi: 10.1016/j.ejmech.2016.02.017. [PMID: 26896709]
  • Wei-Liang Chen, Zhi-Qiang Yuan, Yang Liu, Shu-di Yang, Chun-ge Zhang, Ji-Zhao Li, Wen-jing Zhu, Fang Li, Xiao-feng Zhou, Yi-mei Lin, Xue-nong Zhang. Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro. International journal of nanomedicine. 2016; 11(?):325-36. doi: 10.2147/ijn.s95540. [PMID: 26855571]
  • Dandan He, Hui Wu, Yue Wei, Wei Liu, Fei Huang, Hailian Shi, Beibei Zhang, Xiaojun Wu, Changhong Wang. Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP/PS1 transgenic mice and scopolamine-induced memory impairment mice. European journal of pharmacology. 2015 Dec; 768(?):96-107. doi: 10.1016/j.ejphar.2015.10.037. [PMID: 26526348]
  • Simone Maschauer, Adelina Haller, Patrick J Riss, Torsten Kuwert, Olaf Prante, Paul Cumming. Specific binding of [(18)F]fluoroethyl-harmol to monoamine oxidase A in rat brain cryostat sections, and compartmental analysis of binding in living brain. Journal of neurochemistry. 2015 Dec; 135(5):908-17. doi: 10.1111/jnc.13370. [PMID: 26386360]
  • L H Gu, L P Liao, H J Hu, S W Annie Bligh, C H Wang, G X Chou, Z T Wang. A thin-layer chromatography-bioautographic method for detecting dipeptidyl peptidase IV inhibitors in plants. Journal of chromatography. A. 2015 Sep; 1411(?):116-22. doi: 10.1016/j.chroma.2015.07.123. [PMID: 26283532]
  • Siwen Li, Aqin Wang, Fan Gu, Zhaohui Wang, Caiping Tian, Zhiyu Qian, Liping Tang, Yueqing Gu. Novel harmine derivatives for tumor targeted therapy. Oncotarget. 2015 Apr; 6(11):8988-9001. doi: 10.18632/oncotarget.3276. [PMID: 25940702]
  • Pengfei Yue, Changhong Wang, Jixiu Dan, Wei Liu, Zhenfeng Wu, Ming Yang. The importance of solidification stress on the redispersibility of solid nanocrystals loaded with harmine. International journal of pharmaceutics. 2015 Mar; 480(1-2):107-15. doi: 10.1016/j.ijpharm.2015.01.037. [PMID: 25617675]
  • Mohammad Amjadi, Leila Farzampour. Selective turn-on fluorescence assay of 6-thioguanine by using harmine-modified silver nanoparticles. Luminescence : the journal of biological and chemical luminescence. 2014 Sep; 29(6):689-94. doi: 10.1002/bio.2612. [PMID: 24288350]
  • Tomás Herraiz, Juan Galisteo. Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases. Biochemical and biophysical research communications. 2014 Aug; 451(1):42-7. doi: 10.1016/j.bbrc.2014.07.047. [PMID: 25035927]
  • Sudhakar Manda, Shabana I Khan, Surendra K Jain, Shabber Mohammed, Babu L Tekwani, Ikhlas A Khan, Ram A Vishwakarma, Sandip B Bharate. Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines. Bioorganic & medicinal chemistry letters. 2014 Aug; 24(15):3247-50. doi: 10.1016/j.bmcl.2014.06.030. [PMID: 24980054]
  • Shuping Li, Wei Liu, Liang Teng, Xuemei Cheng, Zhengtao Wang, Changhong Wang. Metabolites identification of harmane in vitro/in vivo in rats by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2014 Apr; 92(?):53-62. doi: 10.1016/j.jpba.2014.01.003. [PMID: 24486683]
  • Hao Zhang, Kun Sun, Jing Ding, Huae Xu, Lingjun Zhu, Kai Zhang, Xiaolin Li, Weihao Sun. Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb; 21(3):348-55. doi: 10.1016/j.phymed.2013.09.007. [PMID: 24176842]
  • Celesztina Domonkos, Ilona Fitos, Júlia Visy, Ferenc Zsila. Fatty acid modulated human serum albumin binding of the β-carboline alkaloids norharmane and harmane. Molecular pharmaceutics. 2013 Dec; 10(12):4706-16. doi: 10.1021/mp400531n. [PMID: 24171410]
  • S M Biradar, Hanumanthachar Joshi, K C Tarak. Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice. Pakistan journal of biological sciences : PJBS. 2013 Dec; 16(23):1687-97. doi: 10.3923/pjbs.2013.1687.1697. [PMID: 24506035]
  • Lei Zhang, Liang Teng, Can Gong, Wei Liu, Xuemei Cheng, Shenghua Gu, Zhongping Deng, Zhengtao Wang, Changhong Wang. Simultaneous determination of harmine, harmaline and their metabolites harmol and harmalol in beagle dog plasma by UPLC-ESI-MS/MS and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2013 Nov; 85(?):162-8. doi: 10.1016/j.jpba.2013.07.019. [PMID: 23948761]
  • Akihisa Abe, Hiroko Kokuba. Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin. Oncology reports. 2013 Apr; 29(4):1333-42. doi: 10.3892/or.2013.2242. [PMID: 23338618]
  • Hua Shao, Xiaoli Huang, Yuanming Zhang, Chi Zhang. Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops. Molecules (Basel, Switzerland). 2013 Feb; 18(3):2623-34. doi: 10.3390/molecules18032623. [PMID: 23446919]
  • Karen L Smith, Gemma K Ford, David S Jessop, David P Finn. Behavioural, neurochemical and neuroendocrine effects of the endogenous β-carboline harmane in fear-conditioned rats. Journal of psychopharmacology (Oxford, England). 2013 Feb; 27(2):162-70. doi: 10.1177/0269881112460108. [PMID: 23015542]
  • Mohammad Nasehi, Morteza Piri, Mojgan Abdollahian, Mohammad Reza Zarrindast. Involvement of nitrergic system of CA1in harmane induced learning and memory deficits. Physiology & behavior. 2013 Jan; 109(?):23-32. doi: 10.1016/j.physbeh.2012.10.006. [PMID: 23103833]
  • G- B Zhang, B Zhang, X- X Zhang, F- H Bing. Homonojirimycin, an alkaloid from dayflower inhibits the growth of influenza A virus in vitro. Acta virologica. 2013; 57(1):85-6. doi: 10.4149/av_2013_01_85. [PMID: 23530829]
  • Tania Tahtouh, Jonathan M Elkins, Panagis Filippakopoulos, Meera Soundararajan, Guillaume Burgy, Emilie Durieu, Claude Cochet, Ralf S Schmid, Donald C Lo, Florent Delhommel, Anselm E Oberholzer, Laurence H Pearl, François Carreaux, Jean-Pierre Bazureau, Stefan Knapp, Laurent Meijer. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. Journal of medicinal chemistry. 2012 Nov; 55(21):9312-30. doi: 10.1021/jm301034u. [PMID: 22998443]
  • Ting Zhao, Shan-Song Zheng, Bin-Feng Zhang, Yuan-Yuan Li, S W Annie Bligh, Chang-Hong Wang, Zheng-Tao Wang. Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy. Food chemistry. 2012 Sep; 134(2):1096-105. doi: 10.1016/j.foodchem.2012.03.024. [PMID: 23107733]
  • Bharathi Avula, Yan-Hong Wang, Chidananda Swamy Rumalla, Troy J Smillie, Ikhlas A Khan. Simultaneous determination of alkaloids and flavonoids from aerial parts of Passiflora species and dietary supplements using UPLC-UV-MS and HPTLC. Natural product communications. 2012 Sep; 7(9):1177-80. doi: . [PMID: 23074901]
  • Mohammad Nasehi, Shahrbano Sharifi, Mohammad Reza Zarrindast. Involvement of the cholinergic system of CA1 on harmane-induced amnesia in the step-down passive avoidance test. Journal of psychopharmacology (Oxford, England). 2012 Aug; 26(8):1151-61. doi: 10.1177/0269881111421972. [PMID: 21965190]
  • Jordi Riba, Ethan H McIlhenny, Marta Valle, José Carlos Bouso, Steven A Barker. Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca. Drug testing and analysis. 2012 Jul; 4(7-8):610-6. doi: 10.1002/dta.1344. [PMID: 22514127]
  • Patrick Grabher, Emilie Durieu, Eirini Kouloura, Maria Halabalaki, Leandros A Skaltsounis, Laurent Meijer, Matthias Hamburger, Olivier Potterat. Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts. Planta medica. 2012 Jun; 78(10):951-6. doi: 10.1055/s-0031-1298625. [PMID: 22673832]
  • Bijan Kumar Paul, Nikhil Guchhait. Differential interactions of a biological photosensitizer with liposome membranes having varying surface charges. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2012 Apr; 11(4):661-73. doi: 10.1039/c2pp05346b. [PMID: 22266915]
  • Christophe Noll, Asma Tlili, Clémentine Ripoll, Ludovic Mallet, Jean-Louis Paul, Jean-Maurice Delabar, Nathalie Janel. Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism. Molecular genetics and metabolism. 2012 Mar; 105(3):484-8. doi: 10.1016/j.ymgme.2011.11.194. [PMID: 22178546]
  • Guilherme A Behr, José C F Moreira, Benicio N Frey. Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder. Oxidative medicine and cellular longevity. 2012; 2012(?):609421. doi: 10.1155/2012/609421. [PMID: 22693652]
  • José Carlos Bouso, Débora González, Sabela Fondevila, Marta Cutchet, Xavier Fernández, Paulo César Ribeiro Barbosa, Miguel Ángel Alcázar-Córcoles, Wladimyr Sena Araújo, Manel J Barbanoj, Josep Maria Fábregas, Jordi Riba. Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of Ayahuasca: a longitudinal study. PloS one. 2012; 7(8):e42421. doi: 10.1371/journal.pone.0042421. [PMID: 22905130]
  • Ting Zhao, Yu-qi He, Jun Wang, Ke-min Ding, Chang-hong Wang, Zheng-tao Wang. Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-carboline alkaloids, harmine derivatives. Phytotherapy research : PTR. 2011 Nov; 25(11):1671-7. doi: 10.1002/ptr.3458. [PMID: 21433154]
  • Bin Liu. [Study on chemical constituents of Peganum multisectum]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Nov; 34(11):1719-21. doi: . [PMID: 22506396]
  • Julia Sacher, Sylvain Houle, Jun Parkes, Pablo Rusjan, Sandra Sagrati, Alan A Wilson, Jeffrey H Meyer. Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study. Journal of psychiatry & neuroscience : JPN. 2011 Nov; 36(6):375-82. doi: 10.1503/jpn.100117. [PMID: 21463543]
  • Marcelo F de Araújo, Ivo J Curcino Vieira, Raimundo Braz-Filho, Mário G de Carvalho. Simiranes A and B: erythroxylanes diterpenes and other compounds from Simira eliezeriana (Rubiaceae). Natural product research. 2011 Oct; 25(18):1713-9. doi: 10.1080/14786419.2011.560575. [PMID: 21936665]
  • Hironori Waki, Masahiro Nakamura, Toshimasa Yamauchi, Ken-ichi Wakabayashi, Jing Yu, Lisa Hirose-Yotsuya, Kazumi Take, Wei Sun, Masato Iwabu, Miki Okada-Iwabu, Takanori Fujita, Tomohisa Aoyama, Shuichi Tsutsumi, Kohjiro Ueki, Tatsuhiko Kodama, Juro Sakai, Hiroyuki Aburatani, Takashi Kadowaki. Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation. PLoS genetics. 2011 Oct; 7(10):e1002311. doi: 10.1371/journal.pgen.1002311. [PMID: 22028663]
  • Bijan Kumar Paul, Nikhil Guchhait. Modulation of prototropic activity and rotational relaxation dynamics of a cationic biological photosensitizer within the motionally constrained bio-environment of a protein. The journal of physical chemistry. B. 2011 Sep; 115(34):10322-34. doi: 10.1021/jp2015275. [PMID: 21790166]
  • Hamid-Reza Adhami, Hassan Farsam, Liselotte Krenn. Screening of medicinal plants from Iranian traditional medicine for acetylcholinesterase inhibition. Phytotherapy research : PTR. 2011 Aug; 25(8):1148-52. doi: 10.1002/ptr.3409. [PMID: 21287652]