4-HPA (BioDeep_00000862189)

Main id: BioDeep_00000000855

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


InChI=1\C8H8O3\c9-7-3-1-6(2-4-7)5-8(10)11\h1-4,9H,5H2,(H,10,11

化学式: C8H8O3 (152.0473418)
中文名称: 对羟基苯乙酸, 4-羟基苯乙酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1CC(=O)O)O
InChI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

描述信息

D009676 - Noxae > D002273 - Carcinogens
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

同义名列表

37 个代谢物同义名

InChI=1\C8H8O3\c9-7-3-1-6(2-4-7)5-8(10)11\h1-4,9H,5H2,(H,10,11; 4-10-00-00543 (Beilstein Handbook Reference); 2-(4-hydroxyphenyl)ethanoic acid; Acetic acid, (p-hydroxyphenyl)-; 2-(4-hydroxyphenyl)acetic acid; benzeneacetic acid, 4-hydroxy-; Parahydroxy phenylacetic acid; (4-Hydroxyphenyl)acetic acid; (p-Hydroxyphenyl)acetic acid; 4-Hydroxybenzeneacetic acid; p-Hydroxyphenyl acetic acid; 4-Hydroxyphenylacetic acid; p-hydroxyphenylacetic acid; 4-hydroxyphenylacetate; 4-Carboxymethylphenol; EINECS 205-851-3; AM-814\41090691; ChemDiv3_005483; H50004_ALDRICH; SMR000020068; MLS001066398; CHEBI:18101; IDI1_023393; 56140_FLUKA; BRN 1448766; EU-0016214; NSC 25066; AI3-17755; 156-38-7; T5354939; NSC27460; NSC25066; C00642; 4-HPA; 4HP; 4-Hydroxyphenylacetic acid; 4-Hydroxyphenylacetate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shaoshuai Xin, Mengqi Zhang, Peihai Li, Lizhen Wang, Xuanming Zhang, Shanshan Zhang, Zhenqiang Mu, Houwen Lin, Xiaobin Li, Kechun Liu. Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Marine drugs. 2024 Mar; 22(4):. doi: 10.3390/md22040148. [PMID: 38667765]
  • Sheng An, Yi Yao, Junjie Wu, Hongbin Hu, Jie Wu, Maomao Sun, Jiaxin Li, Yaoyuan Zhang, Lulan Li, Weihuang Qiu, Yuying Li, Zhiya Deng, Haihong Fang, Shenhai Gong, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng. Gut-derived 4-hydroxyphenylacetic acid attenuates sepsis-induced acute kidney injury by upregulating ARC to inhibit necroptosis. Biochimica et biophysica acta. Molecular basis of disease. 2023 Sep; 1870(1):166876. doi: 10.1016/j.bbadis.2023.166876. [PMID: 37714058]
  • Yu-Ping Shen, Yuyang Pan, Fu-Xing Niu, Yu-Ling Liao, Mingtao Huang, Jian-Zhong Liu. Biosensor-assisted evolution for high-level production of 4-hydroxyphenylacetic acid in Escherichia coli. Metabolic engineering. 2022 03; 70(?):1-11. doi: 10.1016/j.ymben.2021.12.008. [PMID: 34965469]
  • Danny Orabi, Lucas J Osborn, Kevin Fung, William Massey, Anthony J Horak, Federico Aucejo, Ibrahim Choucair, Beckey DeLucia, Zeneng Wang, Jan Claesen, J Mark Brown. A surgical method for continuous intraportal infusion of gut microbial metabolites in mice. JCI insight. 2021 05; 6(9):. doi: 10.1172/jci.insight.145607. [PMID: 33986195]
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  • James Cartwright, Richard M Green. Tyrosine-derived 4-hydroxyphenylpyruvate reacts with ketone test fields of 3 commercially available urine dipsticks. Veterinary clinical pathology. 2010 Sep; 39(3):354-7. doi: 10.1111/j.1939-165x.2010.00231.x. [PMID: 20487432]
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