Biacalein (BioDeep_00000861663)

Main id: BioDeep_00000229862

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one

化学式: C15H10O5 (270.0528)
中文名称: 黄芩苷元, 黄芩素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O
InChI: InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists
D020011 - Protective Agents > D000975 - Antioxidants
COVID info from PDB, Protein Data Bank
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.

同义名列表

51 个代谢物同义名

5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one; 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one; 5,6,7-Trihydroxy-2-phenyl-chroman-4-one; 5,6,7-trihydroxy-2-phenyl-chromen-4-one; 5,6,7-trihydroxy-2-phenyl-4-chromenone; 5,6,7-trihydroxy-2-phenylchromen-4-one; 5,6,7-trihydroxy-2-phenyl-chromone; 5,6,7-Trihydroxyflavone; SDCCGMLS-0066744.P001; Spectrum5_001418; Spectrum3_001608; Spectrum2_000466; Spectrum4_000537; NCGC00025282-01; NCGC00017236-01; NCGC00025282-03; SPECTRUM1504002; NCGC00025282-02; Spectrum_000427; SpecPlus_000758; 465119_ALDRICH; KBioGR_001173; Oprea1_765614; KBioSS_000907; DivK1c_006854; BSPBio_003215; SPBio_000572; KBio2_003475; ZINC00017881; KBio3_002435; Sho-saiko-to; KBio2_000907; KBio2_006043; KBio1_001798; 11712_FLUKA; SMP1_000037; AIDS-000731; Tocris-1761; CHEBI:2979; NSC 661431; AIDS000731; Biacalein; Baicalein; NSC661431; NSC729192; TNP00121; 491-67-8; ST057152; C10023; S00113; Baicalein



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANG, CASP3, CASP9, EGFR, JAK2, MAPK1, MAPK14, PPARG, PRKAA2, PTGS2, SNCA
Peripheral membrane protein 3 ALOX15, JAK2, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, PTGS2
Nucleus 10 ANG, CASP3, CASP9, EGFR, JAK2, MAPK1, MAPK14, PPARG, PRKAA2, SNCA
cytosol 11 ALOX15, ANG, CASP3, CASP9, IL1B, JAK2, MAPK1, MAPK14, PPARG, PRKAA2, SNCA
dendrite 1 PRKAA2
centrosome 1 MAPK1
nucleoplasm 6 CASP3, JAK2, MAPK1, MAPK14, PPARG, PRKAA2
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 3 ALOX15, EGFR, MGAM
ruffle membrane 1 EGFR
Cell projection, axon 1 SNCA
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCC2
Synapse 2 MAPK1, SNCA
cell cortex 1 SNCA
cell junction 1 EGFR
cell surface 2 ABCC2, EGFR
glutamatergic synapse 4 CASP3, EGFR, JAK2, MAPK14
Golgi apparatus 2 MAPK1, PRKAA2
Golgi membrane 2 EGFR, INS
growth cone 2 ANG, SNCA
neuronal cell body 4 ANG, CASP3, PRKAA2, SNCA
postsynapse 2 JAK2, SNCA
Cytoplasm, cytosol 2 ALOX15, IL1B
Lysosome 2 IL1B, SNCA
endosome 1 EGFR
plasma membrane 8 ABCC2, ALOX15, EGFR, IFNLR1, JAK2, MAPK1, MGAM, SNCA
synaptic vesicle membrane 1 SNCA
Membrane 8 ABCC2, ALOX15, EGFR, IFNLR1, JAK2, MGAM, PRKAA2, SNCA
apical plasma membrane 3 ABCC2, EGFR, MGAM
axon 3 CCK, PRKAA2, SNCA
basolateral plasma membrane 1 EGFR
caveola 3 JAK2, MAPK1, PTGS2
extracellular exosome 2 MGAM, MMP9
endoplasmic reticulum 1 PTGS2
extracellular space 8 ANG, CCK, CXCL8, EGFR, IL1B, INS, MMP9, SNCA
perinuclear region of cytoplasm 3 EGFR, PPARG, SNCA
intercellular canaliculus 1 ABCC2
mitochondrion 4 CASP9, MAPK1, MAPK14, SNCA
protein-containing complex 4 CASP9, EGFR, PTGS2, SNCA
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 EGFR, IFNLR1
Secreted 7 ANG, CCK, CXCL8, IL1B, INS, MGAM, SNCA
extracellular region 10 ANG, CCK, CXCL8, IL1B, INS, MAPK1, MAPK14, MGAM, MMP9, SNCA
cytoplasmic side of plasma membrane 2 ALOX15, JAK2
Single-pass membrane protein 1 MGAM
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAPK1
nuclear membrane 1 EGFR
Secreted, extracellular space, extracellular matrix 1 MMP9
actin cytoskeleton 2 ANG, SNCA
nucleolus 1 ANG
Early endosome 1 MAPK1
Apical cell membrane 1 ABCC2
Membrane raft 2 EGFR, JAK2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 3 EGFR, JAK2, MAPK1
spindle 1 MAPK1
basement membrane 1 ANG
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 MMP9
secretory granule 1 IL1B
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK1
receptor complex 2 EGFR, PPARG
neuron projection 1 PTGS2
chromatin 1 PPARG
mitotic spindle 1 MAPK1
supramolecular fiber 1 SNCA
Chromosome 1 ANG
cytoskeleton 2 JAK2, MAPK1
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
Endomembrane system 1 JAK2
endosome lumen 2 INS, JAK2
Lipid droplet 1 ALOX15
Membrane, caveola 1 MAPK1
tertiary granule membrane 1 MGAM
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 JAK2
pseudopodium 1 MAPK1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 3 MAPK1, MAPK14, MMP9
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 INS, MAPK1, PTGS2
axon terminus 1 SNCA
tertiary granule lumen 1 MMP9
endocytic vesicle 1 ANG
transport vesicle 1 INS
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 1 MAPK1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 1 EGFR
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
ficolin-1-rich granule membrane 1 MGAM
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
angiogenin-PRI complex 1 ANG
inclusion body 1 SNCA
caspase complex 1 CASP9
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Yanqin Luo, Bo Lin, Peng Yu, Di Zhang, Yingfan Hu, Xianli Meng, Li Xiang. Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155706. doi: 10.1016/j.phymed.2024.155706. [PMID: 38723528]
  • Ying-Ying Li, Yi-Qiu Peng, Yu-Xi Yang, Ting-Juan Shi, Rui-Xia Liu, Ying-Yi Luan, Cheng-Hong Yin. Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155423. doi: 10.1016/j.phymed.2024.155423. [PMID: 38518646]
  • Juyeong Cho, Eun-Bin Hong, Young-Sik Kim, Jungbin Song, Yeon Ha Ju, Hyunjin Kim, Hyowon Lee, Hocheol Kim, Min-Ho Nam. Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes. CNS neuroscience & therapeutics. 2024 05; 30(5):e14740. doi: 10.1111/cns.14740. [PMID: 38715318]
  • Weifan Huang, Yihan Qian, Jiacheng Lin, Fang Wang, Xiaoni Kong, Weifeng Tan. Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner. Biochemical and biophysical research communications. 2024 Apr; 705(?):149670. doi: 10.1016/j.bbrc.2024.149670. [PMID: 38442444]
  • Xi Qin, Yali Wu, Ya Zhao, Shangshang Qin, Qiuru Ji, Jinhao Jia, Mengqi Huo, Xiaoyu Zhao, Qing Ma, Xiaoyan Wang, Xiaofei Chen, Hui Zhang, Mingliang Zhang, Liuqing Yang, Weixia Li, Jinfa Tang. Revealing active constituents within traditional Chinese Medicine used for treating bacterial pneumonia, with emphasis on the mechanism of baicalein against multi-drug resistant Klebsiella pneumoniae. Journal of ethnopharmacology. 2024 Mar; 321(?):117488. doi: 10.1016/j.jep.2023.117488. [PMID: 38008277]
  • Nan Hu, Fang-Yin Jin, Miao-Miao Gao, Lian-Jie Liu, Jin-Hui Wang, Bao-Feng Yang, Chun-Li Li. Baicalein improves Na2SeO3 induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat. Journal of ethnopharmacology. 2024 Feb; 320(?):117433. doi: 10.1016/j.jep.2023.117433. [PMID: 37979815]
  • Wang Peng, Qinxuan Xia, Yue Zhang, Danfeng Cao, Xiangrong Zheng. VEGF and EGFR signaling pathways are involved in the baicalein attenuation of OVA-induced airway inflammation and airway remodeling in mice. Respiratory research. 2024 Jan; 25(1):10. doi: 10.1186/s12931-023-02637-6. [PMID: 38178132]
  • Ruolei Wang, Chunyan Wang, Lianheng Lu, Fuwen Yuan, Feng He. Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives. Pharmacological research. 2024 Jan; 199(?):107032. doi: 10.1016/j.phrs.2023.107032. [PMID: 38061594]
  • Yuan Ji-Hong, Ma Yu, Yuan Ling-Hong, Gong Jing-Jing, Xu Ling-Li, Wang Lv, Jin Yong-Mei. Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression. Pharmaceutical biology. 2023 Dec; 61(1):288-297. doi: 10.1080/13880209.2022.2160767. [PMID: 36815239]
  • Jingbo Pei, Yuanyuan Zou, Wenying Zhou, Yakun Wang. Baicalein, a component of banxia xiexin decoction, alleviates CPT-11-induced gastrointestinal dysfunction by inhibiting ALOX15-mediated ferroptosis. Chemical biology & drug design. 2023 Sep; ?(?):. doi: 10.1111/cbdd.14349. [PMID: 37735740]
  • Meiling Yu, Hongyu Li, Boying Wang, Zhenxiang Wu, Sheng Wu, Guojun Jiang, Huaxue Wang, Yingying Huang. Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation. Chemico-biological interactions. 2023 Sep; 382(?):110607. doi: 10.1016/j.cbi.2023.110607. [PMID: 37354967]
  • Jing Yang, Aner Chen, Xiaobo He, Shuangji Lu. Fabrication of baicalein-encapsulated zeolitic imidazole framework as a novel nanocomposited wound closure material to persuade pH-responsive healing efficacy in post-caesarean section wound care. International wound journal. 2023 Aug; 20(6):1921-1933. doi: 10.1111/iwj.14052. [PMID: 36572003]
  • Saswat Kumar Mohanty, Kitlangki Suchiang. Baicalein mitigates oxidative stress and enhances lifespan through modulation of Wnt ligands and GATA factor: ELT-3 in Caenorhabditis elegans. Life sciences. 2023 Jul; 329(?):121946. doi: 10.1016/j.lfs.2023.121946. [PMID: 37463652]
  • Mingxiao Liu, Di Zhang, Dongqiang Wang, Xiaodong Wu, Ying Zhang, Jigang Yin, Guan Zhu. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad243. [PMID: 37418629]
  • Shuna Zhang, Ying Wang, Jiaojiao Shan, Xueju Qi, Qun Liu. Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System. Current drug delivery. 2023 Jun; ?(?):. doi: 10.2174/1567201820666230606163452. [PMID: 37282637]
  • Li Gao, Yu-Xin Liu, Yu-Zhi Zhou, Xue-Mei Qin. Baicalein Attenuates Neuroinflammation in LPS-Treated BV-2 Cells by Inhibiting Glycolysis via STAT3/c-Myc Pathway. Neurochemical research. 2023 Jun; ?(?):. doi: 10.1007/s11064-023-03961-5. [PMID: 37277556]
  • Hanlin Shi, Lingling Deng, Yaolong Zhou, Hang Yu, Xi Huang, Mengmeng Chen, Yang Lei, Jingcheng Dong. Network pharmacology and experiments in vivo and in vitro reveal that the Jia-Wei-Bu-Shen-Yi-Qi formula (JWBSYQF) and its active ingredient baicalein ameliorate BLM-induced lung fibrosis in mice via PI3K/Akt signaling pathway. Journal of ethnopharmacology. 2023 May; 315(?):116691. doi: 10.1016/j.jep.2023.116691. [PMID: 37247682]
  • Bangzuo Ning, Jingjing Shen, Fanglin Liu, Hemin Zhang, Xin Jiang. Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy. Microbiology spectrum. 2023 May; ?(?):e0471122. doi: 10.1128/spectrum.04711-22. [PMID: 37125940]
  • Xin-Mei Xie, Jiao-Jiao Hao, Jun-Zhuo Shi, Yun-Feng Zhou, Peng-Fei Liu, Feng Wang, Xiao-Ming Zheng, Xiu-Ying Yu, Chen-Chen Wang, Yi Yan, Guan-Hua Du, Jun-Ke Song, Yang-Yang He, Xiao-Bin Pang. Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model. International immunopharmacology. 2023 May; 118(?):109994. doi: 10.1016/j.intimp.2023.109994. [PMID: 37098656]
  • Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
  • Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li. Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline. Microbiology spectrum. 2023 Apr; ?(?):e0470222. doi: 10.1128/spectrum.04702-22. [PMID: 37070985]
  • Shuya Xue, Min Shi, Jinye Wang, Jiapeng Li, Guanwei Peng, Jingkun Xu, Yansha Gao, Xuemin Duan, Limin Lu. TiO2-MXene/PEDOT:PSS Composite as a Novel Electrochemical Sensing Platform for Sensitive Detection of Baicalein. Molecules (Basel, Switzerland). 2023 Apr; 28(7):. doi: 10.3390/molecules28073262. [PMID: 37050025]
  • Tiansheng Zheng, Haipeng Liu, Yifan Hong, Yajuan Cao, Qing Xia, Chengge Qin, Ming Li, Russel J Reiter, Yidong Bai, Lihong Fan. Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis. Signal transduction and targeted therapy. 2023 Mar; 8(1):133. doi: 10.1038/s41392-023-01326-6. [PMID: 36944610]
  • Xiaomeng Zhang, Jingcong Xie, Shiping Cao, Haiyan Zhang, Jianjun Pei, Su Bu, Linguo Zhao. Efficient production of the glycosylated derivatives of baicalein in engineered Escherichia coli. Applied microbiology and biotechnology. 2023 Mar; ?(?):. doi: 10.1007/s00253-023-12464-w. [PMID: 36930276]
  • I-Chieh Wang, Jian-Hong Lin, Wen-Sen Lee, Chin-Hung Liu, Ting-Yuan Lin, Kun-Ta Yang. Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocytes. International journal of cardiology. 2023 03; 375(?):74-86. doi: 10.1016/j.ijcard.2022.12.018. [PMID: 36513286]
  • Xiao Han, Jiayan Huang, Jia Lu, Feng He, Fang Wang, Shuangfeng Li, Hao Zhong, Haiyang Yu, Weiling Pu. Active compounds and potential targets of Shuganning injection in the treatment of hepatocellular carcinoma by network pharmacology and in vitro validation. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Mar; ?(?):. doi: 10.1007/s00210-023-02432-6. [PMID: 36869905]
  • Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan. Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors. Progress in neuro-psychopharmacology & biological psychiatry. 2023 03; 122(?):110689. doi: 10.1016/j.pnpbp.2022.110689. [PMID: 36462602]
  • Marcelina Chmiel, Monika Stompor-Gorący. Promising Role of the Scutellaria baicalensis Root Hydroxyflavone-Baicalein in the Prevention and Treatment of Human Diseases. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054732. [PMID: 36902160]
  • Bohan Tang, Yue Dong. Network pharmacology and bioinformatics analysis on the underlying mechanisms of baicalein against oral squamous cell carcinoma. The journal of gene medicine. 2023 Feb; ?(?):e3490. doi: 10.1002/jgm.3490. [PMID: 36843559]
  • Chunyu Guo, Qingjun Li, Rihong Chen, Wenhui Fan, Xin Zhang, Yuqian Zhang, Lanping Guo, Xiao Wang, Xinyan Qu, Hongjing Dong. Baicalein alleviates non-alcoholic fatty liver disease in mice by ameliorating intestinal barrier dysfunction. Food & function. 2023 Feb; 14(4):2138-2148. doi: 10.1039/d2fo03015b. [PMID: 36752061]
  • Yunpeng Wan, Kai Shen, Haiyang Yu, Weimin Fan. Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis. Free radical biology & medicine. 2023 02; 196(?):108-120. doi: 10.1016/j.freeradbiomed.2023.01.006. [PMID: 36657732]
  • Hao Wang, Yantong Sun, Wei Guo, Jing Wang, Jingyi Gao, Wenwen Peng, Jingkai Gu. Identification and high-throughput quantification of baicalein and its metabolites in plasma and urine. Journal of ethnopharmacology. 2023 Jan; 301(?):115853. doi: 10.1016/j.jep.2022.115853. [PMID: 36272493]
  • Sai Ying, Haihao Yang, Qianlan Gu, Zhao Wu, Nanting Zou, Chong-Zhi Wang, Chunping Wan, Chun-Su Yuan. The Small-Molecule compound baicalein alleviates experimental autoimmune encephalomyelitis by suppressing pathogenetic CXCR6+ CD4 cells. International immunopharmacology. 2023 Jan; 114(?):109562. doi: 10.1016/j.intimp.2022.109562. [PMID: 36508914]
  • Md Reyad-Ul-Ferdous, Yongfeng Song. Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies. International journal of biological macromolecules. 2022 Dec; 222(Pt B):1963-1973. doi: 10.1016/j.ijbiomac.2022.09.285. [PMID: 36252624]
  • Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh. Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2022 Dec; 30(2):351-366. doi: 10.1007/s40199-022-00443-x. [PMID: 35870110]
  • Xiaoran Ma, Shuang Wang, Chenglin Li, Xihui Jia, Tiantian Wang, Zhe Leng, Ran Lu, Xiaowen Kong, Jinyu Zhang, Ling Li. Baicalein inhibits the polarization of microglia/macrophages to the M1 phenotype by targeting STAT1 in EAE mice. International immunopharmacology. 2022 Dec; 113(Pt A):109373. doi: 10.1016/j.intimp.2022.109373. [PMID: 36279665]
  • Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh. Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review. Naunyn-Schmiedeberg's archives of pharmacology. 2022 11; 395(11):1297-1329. doi: 10.1007/s00210-022-02258-8. [PMID: 35676380]
  • Shambhoo Sharan Tripathi, Raushan Kumar, Akalabya Bissoyi, Syed Ibrahim Rizvi. Baicalein maintains redox balance in experimental hyperlipidemic rats. Archives of physiology and biochemistry. 2022 Oct; 128(5):1156-1164. doi: 10.1080/13813455.2020.1760890. [PMID: 32393069]
  • Ming Li, Zhaoli Meng, Shichao Yu, Jiarui Li, Yupeng Wang, Wei Yang, Hui Wu. Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis. Chemico-biological interactions. 2022 Oct; 366(?):110137. doi: 10.1016/j.cbi.2022.110137. [PMID: 36055377]
  • Zi-Zhen Zhang, Xiao-Hua Yu, Wei-Hua Tan. Baicalein inhibits macrophage lipid accumulation and inflammatory response by activating the PPARγ/LXRα pathway. Clinical and experimental immunology. 2022 09; 209(3):316-325. doi: 10.1093/cei/uxac062. [PMID: 35749304]
  • Xi-Jing Qian, He-Yang Zhou, Yan Liu, Jia-Xiao Dong, Wan-Da Tang, Ping Zhao, Hai-Lin Tang, Yong-Sheng Jin. Synthesis of baicalein derivatives and evaluation of their antiviral activity against arboviruses. Bioorganic & medicinal chemistry letters. 2022 09; 72(?):128863. doi: 10.1016/j.bmcl.2022.128863. [PMID: 35738350]
  • Caiyun Chen, Gaotian Li, Long Dai, Huijuan Zhao, Ning Li, Wei Mi, Shuying Yin, Shaoping Wang, Jiayu Zhang. Simultaneous separation of glycyrrhizic acid, baicalein and wogonin from Radix Glycyrrhizae and Radix Scutellariae using foam fractionation and in vitro activity evaluation. Journal of the science of food and agriculture. 2022 Sep; 102(12):5200-5209. doi: 10.1002/jsfa.11872. [PMID: 35289954]
  • Naveenkumar Chandrashekar, Anandakumar Pandi. Baicalein: A review on its anti-cancer effects and mechanisms in lung carcinoma. Journal of food biochemistry. 2022 09; 46(9):e14230. doi: 10.1111/jfbc.14230. [PMID: 35543192]
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  • Lin Wang, Ting Feng, Zhilian Su, Chao Pi, Yumeng Wei, Ling Zhao. Latest research progress on anticancer effect of baicalin and its aglycone baicalein. Archives of pharmacal research. 2022 Aug; 45(8):535-557. doi: 10.1007/s12272-022-01397-z. [PMID: 35908250]
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