Bicculine (BioDeep_00000859957)

Main id: BioDeep_00000000317

 

PANOMIX_OTCML-2023


代谢物信息卡片


Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-

化学式: C20H17NO6 (367.1055822)
中文名称: 右旋比扣扣灵碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
InChI: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018756 - GABA Antagonists
Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) [1][2][3].
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice[1][2][3][4].
Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) [1][2][3].

同义名列表

36 个代谢物同义名

Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-; Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [R-(R*,S*)]-; (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one; WLN: T C566 DO FO KN EH&&TJ K1 J- ET B565 CVO JO LO EH KHJ; 4-27-00-06900 (Beilstein Handbook Reference); Prestwick0_000589; Prestwick1_000589; Prestwick2_000589; Prestwick3_000589; Biomol-NT_000252; EINECS 207-619-7; Bicuculline (+); (+)-Bicuculline; ()-Bicuculline; Lopac0_000234; BSPBio_000438; BPBio1_000482; BPBio1_000794; d-Bicuculline; DivK1c_000609; Prestwick_96; PDSP2_000138; NINDS_000609; SPBio_002657; KBio1_000609; BRN 0098786; Bicuculline; 14340_FLUKA; IDI1_000609; Bicucullin; NSC 32192; Bicculine; 485-49-4; ST057559; NSC32192; C09364



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

63 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Weikang Chen, Yangbin Zheng, Yanyan Zhu, Dehong Liu, Lianghui Zhu. Pharmacokinetics, tissue distribution, and plasma protein binding ratio of bicuculline following intragastric and intravenous administration in rats using ultra-high-performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2023 Dec; ?(?):e5802. doi: 10.1002/bmc.5802. [PMID: 38110194]
  • John Cowgill, Chen Fan, Nandan Haloi, Victor Tobiasson, Yuxuan Zhuang, Rebecca J Howard, Erik Lindahl. Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor. Neuron. 2023 Aug; ?(?):. doi: 10.1016/j.neuron.2023.08.006. [PMID: 37659407]
  • Ya-Yue Yang, Li-Xia Du, Jian-Yu Zhu, Ting Yi, Ya-Chen Yang, Zheng Qiao, Qi-Liang Maoying, Yu-Xia Chu, Yan-Qing Wang, Wen-Li Mi. Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 119(?):154969. doi: 10.1016/j.phymed.2023.154969. [PMID: 37516088]
  • Shana Wuken, Junjun Li, Xiaoli Gao, Shungang Jiao, Xiaojing Ma, Suyile Chen, Pengfei Tu, Luqi Huang, Xingyun Chai. Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system. Journal of ethnopharmacology. 2023 Jan; 301(?):115813. doi: 10.1016/j.jep.2022.115813. [PMID: 36220513]
  • Rodrigo Vargas-Ruiz, Rosa Mariana Montiel-Ruiz, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Maribel Lucila Herrera-Ruiz, Jaqueline Molina-Cabrera, María Cruz Juárez-Aragón, Francisco Javier Flores-Murrieta. Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception. Journal of ethnopharmacology. 2023 Jan; 300(?):115756. doi: 10.1016/j.jep.2022.115756. [PMID: 36170958]
  • Vivek Jain, Ashutosh Pareek, Yashumati Ratan Bhardwaj, Saurabh Kumar Sinha, Madan Mohan Gupta, Nirmal Singh. Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition. Nutritional neuroscience. 2022 Oct; 25(10):2149-2166. doi: 10.1080/1028415x.2021.1954293. [PMID: 34369317]
  • Yasumi Ohta, Takaaki E Murakami, Mamiko Kawahara, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta, Metin Akay, Yasemin M Akay. Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031114. [PMID: 35163036]
  • Amjad Ali, Abdul Nasir, Syed Wadood Ali Shah, Atif Ali Khan Khalil, Mi-Jeong Ahn, Syed Muhammad Mukarram Shah, Fazli Subhan, Muhammad Faheem, Wasim Sajjad, Mohammad Shoaib, Saeed Ahmad, Nausheen Nazir, Mohammad Nisar. Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice. BMC complementary medicine and therapies. 2021 Jul; 21(1):184. doi: 10.1186/s12906-021-03357-4. [PMID: 34210323]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Magdalena Olga Ciechanowska, Magdalena Łapot, Marek Kowalczyk, Tadeusz Malewski, Marek Brytan, Bożena Antkowiak, Franciszek Przekop. Does kisspeptin participate in GABA-mediated modulation of GnRH and GnRH receptor biosynthesis in the hypothalamic-pituitary unit of follicular-phase ewes?. Pharmacological reports : PR. 2019 Aug; 71(4):636-643. doi: 10.1016/j.pharep.2019.02.019. [PMID: 31176893]
  • Jorge Maícas Royo, Gareth Leng, Duncan J MacGregor. The spiking and secretory activity of oxytocin neurones in response to osmotic stimulation: a computational model. The Journal of physiology. 2019 07; 597(14):3657-3671. doi: 10.1113/jp278045. [PMID: 31111496]
  • Vijay P Sonar, Benedetta Fois, Simona Distinto, Elias Maccioni, Rita Meleddu, Filippo Cottiglia, Elio Acquas, Sanjay Kasture, Costantino Floris, Daniele Colombo, Claudia Sissi, Enrico Sanna, Giuseppe Talani. Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABAA Receptor Modulators. Journal of natural products. 2019 05; 82(5):1250-1257. doi: 10.1021/acs.jnatprod.8b01023. [PMID: 30998355]
  • Simonas Masiulis, Rooma Desai, Tomasz Uchański, Itziar Serna Martin, Duncan Laverty, Dimple Karia, Tomas Malinauskas, Jasenko Zivanov, Els Pardon, Abhay Kotecha, Jan Steyaert, Keith W Miller, A Radu Aricescu. GABAA receptor signalling mechanisms revealed by structural pharmacology. Nature. 2019 01; 565(7740):454-459. doi: 10.1038/s41586-018-0832-5. [PMID: 30602790]
  • Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li, Qing Zhu. Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. European journal of pharmacology. 2018 Mar; 823(?):105-109. doi: 10.1016/j.ejphar.2018.01.044. [PMID: 29408089]
  • Gisele Claudine Nkamguie Nkantchoua, Jacqueline Stephanie Kameni Njapdounke, Jean Jules Fifen, Germain Sotoing Taiwe, Lucie Josiane Ojong, Antoine Kavaye Kandeda, Elisabeth Ngo Bum. Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock. Journal of ethnopharmacology. 2018 Feb; 212(?):18-28. doi: 10.1016/j.jep.2017.09.042. [PMID: 28986332]
  • Zsuzsanna Bardóczi, Balázs Pál, Áron Kőszeghy, Tamás Wilheim, Masahiko Watanabe, László Záborszky, Zsolt Liposits, Imre Kalló. Glycinergic Input to the Mouse Basal Forebrain Cholinergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 09; 37(39):9534-9549. doi: 10.1523/jneurosci.3348-16.2017. [PMID: 28874448]
  • Frank Richter, Annett Eitner, Johannes Leuchtweis, Reinhard Bauer, Alfred Lehmenkühler, Hans-Georg Schaible. Effects of interleukin-1ß on cortical spreading depolarization and cerebral vasculature. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2017 May; 37(5):1791-1802. doi: 10.1177/0271678x16641127. [PMID: 27037093]
  • M S Gastón, M P Cid, N A Salvatierra. Bicuculline, a GABAA-receptor antagonist, blocked HPA axis activation induced by ghrelin under an acute stress. Behavioural brain research. 2017 03; 320(?):464-472. doi: 10.1016/j.bbr.2016.10.035. [PMID: 27780724]
  • Ezia Guatteo, Francesca Romana Rizzo, Mauro Federici, Alberto Cordella, Ada Ledonne, Laura Latini, Annalisa Nobili, Maria Teresa Viscomi, Filippo Biamonte, Kerstin K Landrock, Alessandro Martini, Daniela Aversa, Chiara Schepisi, Marcello D'Amelio, Nicola Berretta, Nicola B Mercuri. Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats. Experimental neurology. 2017 Jan; 287(Pt 1):21-33. doi: 10.1016/j.expneurol.2016.10.009. [PMID: 27771352]
  • Yanil Hepp, Angeles Salles, Martin Carbo-Tano, Maria Eugenia Pedreira, Ramiro Freudenthal. Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata. Learning & memory (Cold Spring Harbor, N.Y.). 2016 08; 23(8):427-34. doi: 10.1101/lm.041707.116. [PMID: 27421895]
  • Marwa Y Sallam, Sahar M El-Gowilly, Abdel-Galil A Abdel-Galil, Mahmoud M El-Mas. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn-Schmiedeberg's archives of pharmacology. 2016 Mar; 389(3):279-88. doi: 10.1007/s00210-015-1201-7. [PMID: 26685896]
  • T S Gan'shina, E V Kurza, I N Kurdyumov, D V Maslennikov, R S Mirzoyan. [PECULIARITIES OF THE CEREBROVASCULAR EFFECTS OF GLUTAMIC ACID]. Eksperimental'naia i klinicheskaia farmakologiia. 2016; 79(3):9-12. doi: ". [PMID: 27455572]
  • Arianna Allio, Chiara Calorio, Claudio Franchino, Daniela Gavello, Emilio Carbone, Andrea Marcantoni. Bud extracts from Tilia tomentosa Moench inhibit hippocampal neuronal firing through GABAA and benzodiazepine receptors activation. Journal of ethnopharmacology. 2015 Aug; 172(?):288-96. doi: 10.1016/j.jep.2015.06.016. [PMID: 26144285]
  • Sunita A Ramesh, Stephen D Tyerman, Bo Xu, Jayakumar Bose, Satwinder Kaur, Vanessa Conn, Patricia Domingos, Sana Ullah, Stefanie Wege, Sergey Shabala, José A Feijó, Peter R Ryan, Matthew Gilliham. GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters. Nature communications. 2015 Jul; 6(?):7879. doi: 10.1038/ncomms8879. [PMID: 26219411]
  • Ken'ichi Yamaguchi. Evaluation for roles of neurosteroids in modulating forebrain mechanisms controlling vasopressin secretion and related phenomena in conscious rats. Neuroscience research. 2015 Jun; 95(?):38-50. doi: 10.1016/j.neures.2015.01.002. [PMID: 25598212]
  • Shuhei Kobuchi, Ryosuke Tanaka, Takuya Shintani, Rie Suzuki, Hidenobu Tsutsui, Mamoru Ohkita, Yasuo Matsumura, Kazuhide Ayajiki. Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats. Clinical and experimental pharmacology & physiology. 2015 Mar; 42(3):278-86. doi: 10.1111/1440-1681.12350. [PMID: 25482107]
  • G C Vaz, A P C O Bahia, F C de Figueiredo Müller-Ribeiro, C H Xavier, K P Patel, R A S Santos, F A Moreira, F Frézard, M A P Fontes. Cardiovascular and behavioral effects produced by administration of liposome-entrapped GABA into the rat central nervous system. Neuroscience. 2015 Jan; 285(?):60-9. doi: 10.1016/j.neuroscience.2014.10.067. [PMID: 25446344]
  • Adriana Pétriz, Daniel Reyes-Haro, María Alejandra González-González, Ricardo Miledi, Ataúlfo Martínez-Torres. GABAρ subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec; 111(49):17522-7. doi: 10.1073/pnas.1419632111. [PMID: 25422464]
  • M J Kenney. Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats. Autonomic neuroscience : basic & clinical. 2014 Dec; 186(?):32-7. doi: 10.1016/j.autneu.2014.09.003. [PMID: 25262958]
  • Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Spinal mechanism of micturition reflex inhibition by naftopidil in rats. Life sciences. 2014 Oct; 116(2):106-11. doi: 10.1016/j.lfs.2014.09.008. [PMID: 25258114]
  • Christopher D Schmoutz, Glenn F Guerin, Nicholas E Goeders. Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction. Behavioural brain research. 2014 Sep; 271(?):269-76. doi: 10.1016/j.bbr.2014.06.032. [PMID: 24959859]
  • Juliana C Perry, Cássia T Bergamaschi, Ruy R Campos, Adilson M Silva, Sergio Tufik. Interconnectivity of sympathetic and sleep networks is mediated through reduction of gamma aminobutyric acidergic inhibition in the paraventricular nucleus. Journal of sleep research. 2014 Apr; 23(2):168-75. doi: 10.1111/jsr.12110. [PMID: 24283672]
  • Jianshe Ma, Chongliang Lin, Congcong Wen, Zheng Xiang, Xuezhi Yang, Xianqin Wang. Determination of bicuculline in rat plasma by liquid chromatography mass spectrometry and its application in a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Mar; 953-954(?):143-6. doi: 10.1016/j.jchromb.2014.02.006. [PMID: 24607696]
  • R S Mirzoian, T S Gan'shina, N A Khaĭlov, A V Gnezdilova, D V Maslennikov, I N Kurdiumov, M A Lebedeva, A A Gorbunov. [Cerebrovascular pharmacology of separate and combined vascular pathology of brain and heart]. Eksperimental'naia i klinicheskaia farmakologiia. 2014; 77(3):3-8. doi: ". [PMID: 24800517]
  • Tomohide Hori, Lindsay B Gardner, Toshiyuki Hata, Feng Chen, Ann-Marie T Baine, Shinji Uemoto, Justin H Nguyen. Pretreatment of liver grafts in vivo by γ-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat. Annals of transplantation. 2013 Jun; 18(?):299-313. doi: 10.12659/aot.883955. [PMID: 23792534]
  • Audrey Dagorn, Annelise Chapalain, Lily Mijouin, Mélanie Hillion, Cécile Duclairoir-Poc, Sylvie Chevalier, Laure Taupin, Nicole Orange, Marc G J Feuilloley. Effect of GABA, a bacterial metabolite, on Pseudomonas fluorescens surface properties and cytotoxicity. International journal of molecular sciences. 2013 Jun; 14(6):12186-204. doi: 10.3390/ijms140612186. [PMID: 23743829]
  • Bozena Kuzniewska, Emilia Rejmak, Anna R Malik, Jacek Jaworski, Leszek Kaczmarek, Katarzyna Kalita. Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor/c-Fos pathway. Molecular and cellular biology. 2013 Jun; 33(11):2149-62. doi: 10.1128/mcb.00008-13. [PMID: 23508111]
  • Morteza Kosari-Nasab, Shirin Babri, Laleh Fatehi-Gharehlar, Mohammad-Hossein Doosti, Sara Pakzad. Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects of Scrophularia striata extract in rats. Pharmaceutical biology. 2013 May; 51(5):581-8. doi: 10.3109/13880209.2012.749924. [PMID: 23373710]
  • Rohit Ramchandra, Sally G Hood, Robert Frithiof, Michael J McKinley, Clive N May. The role of the paraventricular nucleus of the hypothalamus in the regulation of cardiac and renal sympathetic nerve activity in conscious normal and heart failure sheep. The Journal of physiology. 2013 Jan; 591(1):93-107. doi: 10.1113/jphysiol.2012.236059. [PMID: 22615431]
  • Mohammad Hadi Gharedaghi, Mehrak Javadi-Paydar, Yashar Yousefzadeh-Fard, Mohammad Salehi-Sadaghiani, Pouya Javadian, Nahid Fakhraei, Seyed Mohammad Tavangar, Ahmad Reza Dehpour. Muscimol delays lipopolysaccharide-induced preterm delivery in mice: role of GABA(A) receptors and nitric oxide. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2013 Jan; 26(1):36-43. doi: 10.3109/14767058.2012.722715. [PMID: 22913283]
  • Hui-Feng Chen, Hui-Min Su. Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. The Journal of nutritional biochemistry. 2013 Jan; 24(1):70-80. doi: 10.1016/j.jnutbio.2012.02.006. [PMID: 22818715]
  • Kamon Iigaya, Flávia Camargos de Figueirêdo Müller-Ribeiro, Jouji Horiuchi, Lachlan M McDowall, Eugene Nalivaiko, Marco A P Fontes, Roger A L Dampney. Synchronized activation of sympathetic vasomotor, cardiac, and respiratory outputs by neurons in the midbrain colliculi. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Sep; 303(6):R599-610. doi: 10.1152/ajpregu.00205.2012. [PMID: 22814668]
  • Doris P Molina, Olusegun J Ariwodola, Constance Linville, William E Sonntag, Jeff L Weiner, Judy K Brunso-Bechtold, Michelle M Adams. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiology of aging. 2012 Sep; 33(9):1938-49. doi: 10.1016/j.neurobiolaging.2011.09.014. [PMID: 22015312]
  • Germain Sotoing Taïwe, Elisabeth Ngo Bum, Emmanuel Talla, Amadou Dawe, Fleur Clarisse Okomolo Moto, Gwladys Temkou Ngoupaye, Neteydji Sidiki, Bernard Dabole, Paul Désiré Djomeni Dzeufiet, Théophile Dimo, Michel De Waard. Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents. Journal of ethnopharmacology. 2012 Aug; 143(1):213-20. doi: 10.1016/j.jep.2012.06.026. [PMID: 22750453]
  • Phurpa Wangchuk, Paul A Keller, Stephen G Pyne, Anthony C Willis, Sumalee Kamchonwongpaisan. Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia. Journal of ethnopharmacology. 2012 Aug; 143(1):310-3. doi: 10.1016/j.jep.2012.06.037. [PMID: 22796506]
  • Qin Chen, Peter D Yim, Nina Yuan, Juliette Johnson, James M Cook, Steve Smith, Cristian Ionescu-Zanetti, Zhi-Jian Wang, Leggy A Arnold, Charles W Emala. Comparison of cell expression formats for the characterization of GABA(A) channels using a microfluidic patch clamp system. Assay and drug development technologies. 2012 Aug; 10(4):325-35. doi: 10.1089/adt.2011.415. [PMID: 22574655]
  • M R Laconi, C Chavez, J C Cavicchia, M Fóscolo, Z Sosa, R F Yunes, R J Cabrera. Allopregnanolone alters the luteinizing hormone, prolactin, and progesterone serum levels interfering with the regression and apoptosis in rat corpus luteum. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2012 Jul; 44(8):632-8. doi: 10.1055/s-0032-1314834. [PMID: 22674474]
  • Ganesan L Kamatchi, Palaniswami Rathanaswami. Inhibition of deprivation-induced food intake by GABA(A) antagonists: roles of the hypothalamic, endocrine and alimentary mechanisms. Journal of clinical biochemistry and nutrition. 2012 Jul; 51(1):19-26. doi: 10.3164/jcbn.11-85. [PMID: 22798708]
  • J M Numata, J F M van Brederode, A J Berger. Lack of an endogenous GABAA receptor-mediated tonic current in hypoglossal motoneurons. The Journal of physiology. 2012 Jul; 590(13):2965-76. doi: 10.1113/jphysiol.2012.231944. [PMID: 22495589]
  • Yun Li, Brittany D Roy, Wei Wang, Li Zhang, Lifeng Zhang, Stephen B Sampson, Yupeng Yang, Da-Ting Lin. Identification of two functionally distinct endosomal recycling pathways for dopamine D₂ receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 May; 32(21):7178-90. doi: 10.1523/jneurosci.0008-12.2012. [PMID: 22623662]
  • Chihiro Miyamoto, Mariko Yoshida, Masaaki Yoshikawa, Takafumi Mizushige, Kousaku Ohinata. Complement C5a exhibits anxiolytic-like activity via the prostaglandin D2-DP1 receptor system coupled to adenosine A2A and GABAA receptors. Prostaglandins & other lipid mediators. 2012 May; 98(1-2):17-22. doi: 10.1016/j.prostaglandins.2012.03.004. [PMID: 22503964]
  • Phurpa Wangchuk, Paul A Keller, Stephen G Pyne, Thanapat Sastraruji, Malai Taweechotipatr, Roonglawan Rattanajak, Aunchalee Tonsomboon, Sumalee Kamchonwongpaisan. Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa. Natural product communications. 2012 May; 7(5):575-80. doi: . [PMID: 22799079]
  • Najeeb-ur-Rehman, Malik Hassan Mehmood, Adnan J Al-Rehaily, Ramzi A A Mothana, Anwar H Gilani. Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora. BMC complementary and alternative medicine. 2012 Mar; 12(?):16. doi: 10.1186/1472-6882-12-16. [PMID: 22405321]
  • Jobin Mathew, Savitha Balakrishnan, Sherin Antony, Pretty Mary Abraham, C S Paulose. Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. Journal of biomedical science. 2012 Feb; 19(?):25. doi: 10.1186/1423-0127-19-25. [PMID: 22364254]
  • Tamra Llewellyn, Hong Zheng, Xuefei Liu, Bo Xu, Kaushik P Patel. Median preoptic nucleus and subfornical organ drive renal sympathetic nerve activity via a glutamatergic mechanism within the paraventricular nucleus. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Feb; 302(4):R424-32. doi: 10.1152/ajpregu.00403.2011. [PMID: 22160544]
  • M N Nasir, J Abdullah, M Habsah, R I Ghani, G Rammes. Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Feb; 19(3-4):311-6. doi: 10.1016/j.phymed.2011.10.004. [PMID: 22112723]
  • Ana Elisa Gonçalves, Cristiani Bürger, Solomon K S Amoah, Rogério Tolardo, Maique W Biavatti, Márcia M de Souza. The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: evidence for the involvement of adrenergic, dopaminergic and serotonergic systems. European journal of pharmacology. 2012 Jan; 674(2-3):307-14. doi: 10.1016/j.ejphar.2011.11.009. [PMID: 22115892]
  • H Steve White, Anitha B Alex, Amanda Pollock, Naama Hen, Tawfeeq Shekh-Ahmad, Karen S Wilcox, John H McDonough, James P Stables, Dan Kaufmann, Boris Yagen, Meir Bialer. A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia. 2012 Jan; 53(1):134-46. doi: 10.1111/j.1528-1167.2011.03338.x. [PMID: 22150444]
  • Hui Wang, Yoshiyuki Tanaka, Akihiro Kawauchi, Tsuneharu Miki, Yukihiko Kayama, Yoshimasa Koyama. Acupuncture of the sacral vertebrae suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center. Neuroscience research. 2012 Jan; 72(1):43-9. doi: 10.1016/j.neures.2011.09.007. [PMID: 22001760]
  • Masaaki Nishihara, Yoshitaka Hirooka, Ryuichi Matsukawa, Takuya Kishi, Kenji Sunagawa. Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats. Journal of hypertension. 2012 Jan; 30(1):97-106. doi: 10.1097/hjh.0b013e32834e1df4. [PMID: 22157590]
  • Hardeep Kataria, Renu Wadhwa, Sunil C Kaul, Gurcharan Kaur. Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. PloS one. 2012; 7(5):e37080. doi: 10.1371/journal.pone.0037080. [PMID: 22606332]
  • Xin Zhang, Bin Cheng, Xianghong Jing, Yongfa Qiao, Xinyan Gao, Huijuan Yu, Bing Zhu, Haifa Qiao. NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21). Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):583479. doi: 10.1155/2012/583479. [PMID: 22654955]
  • Spencer D Watts, Katherine L Suchland, Susan G Amara, Susan L Ingram. A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. PloS one. 2012; 7(4):e35373. doi: 10.1371/journal.pone.0035373. [PMID: 22506078]
  • Mathilde Chivet, Fiona Hemming, Karin Pernet-Gallay, Sandrine Fraboulet, Rémy Sadoul. Emerging role of neuronal exosomes in the central nervous system. Frontiers in physiology. 2012; 3(?):145. doi: 10.3389/fphys.2012.00145. [PMID: 22654762]
  • Keisuke Shinohara, Yoshitaka Hirooka, Takuya Kishi, Kenji Sunagawa. Reduction of nitric oxide-mediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats. Circulation journal : official journal of the Japanese Circulation Society. 2012; 76(12):2814-21. doi: 10.1253/circj.cj-12-0399. [PMID: 22972304]
  • Eiji Shigetomi, Xiaoping Tong, Kelvin Y Kwan, David P Corey, Baljit S Khakh. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nature neuroscience. 2011 Dec; 15(1):70-80. doi: 10.1038/nn.3000. [PMID: 22158513]
  • Maribel Herrera-Ruiz, Adolfo González-Carranza, Alejandro Zamilpa, Enrique Jiménez-Ferrer, Maira Huerta-Reyes, Víctor M Navarro-García. The standardized extract of Loeselia mexicana possesses anxiolytic activity through the γ-amino butyric acid mechanism. Journal of ethnopharmacology. 2011 Nov; 138(2):261-7. doi: 10.1016/j.jep.2011.09.010. [PMID: 21979412]
  • S A Menzikov, M N Karpova, M V Kalinina. Effect of HCO3(-) ions on the ATP-dependent GABA(A) receptor-coupled Cl(-) channel in rat brain plasma membranes. Bulletin of experimental biology and medicine. 2011 Nov; 152(1):38-42. doi: 10.1007/s10517-011-1448-z. [PMID: 22803035]
  • Keisuke Migita, Masahiko Tomiyama, Junko Yamada, Masashi Fukuzawa, Takashi Kanematsu, Masato Hirata, Shinya Ueno. Phenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice. Molecular pain. 2011 Oct; 7(?):79. doi: 10.1186/1744-8069-7-79. [PMID: 22008183]
  • Jouji Horiuchi, Alp Atik, Kamon Iigaya, Lachlan M McDowall, Suzanne Killinger, Roger A L Dampney. Activation of 5-hydroxytryptamine-1A receptors suppresses cardiovascular responses evoked from the paraventricular nucleus. American journal of physiology. Regulatory, integrative and comparative physiology. 2011 Oct; 301(4):R1088-97. doi: 10.1152/ajpregu.00144.2011. [PMID: 21753144]
  • Jeong Sook Kim, Woong Bin Kim, Young-Beom Kim, Yeon Lee, Yoon Sik Kim, Feng-Yan Shen, Seung Won Lee, Dawon Park, Hee-Joo Choi, Jinyoung Hur, Joong Jean Park, Hee Chul Han, Christopher S Colwell, Young-Wuk Cho, Yang In Kim. Chronic hyperosmotic stress converts GABAergic inhibition into excitation in vasopressin and oxytocin neurons in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Sep; 31(37):13312-22. doi: 10.1523/jneurosci.1440-11.2011. [PMID: 21917814]
  • Shuhei Kobuchi, Ryosuke Tanaka, Takuya Shintani, Rie Suzuki, Hidenobu Tsutsui, Mamoru Ohkita, Kazuhide Ayajiki, Yasuo Matsumura. Mechanisms underlying the renoprotective effect of GABA against ischemia/reperfusion-induced renal injury in rats. The Journal of pharmacology and experimental therapeutics. 2011 Sep; 338(3):767-74. doi: 10.1124/jpet.111.180174. [PMID: 21632868]
  • Patrick J Mueller, Nicholas A Mischel, Tadeusz J Scislo. Differential activation of adrenal, renal, and lumbar sympathetic nerves following stimulation of the rostral ventrolateral medulla of the rat. American journal of physiology. Regulatory, integrative and comparative physiology. 2011 May; 300(5):R1230-40. doi: 10.1152/ajpregu.00713.2010. [PMID: 21346240]
  • Tomoko Nakamoto, Kanji Matsukawa, Nan Liang, Rie Wakasugi, L Britt Wilson, Jouji Horiuchi. Coactivation of renal sympathetic neurons and somatic motor neurons by chemical stimulation of the midbrain ventral tegmental area. Journal of applied physiology (Bethesda, Md. : 1985). 2011 May; 110(5):1342-53. doi: 10.1152/japplphysiol.01233.2010. [PMID: 21393462]
  • E Stone, J H Coote, J Allard, T A Lovick. GABAergic control of micturition within the periaqueductal grey matter of the male rat. The Journal of physiology. 2011 Apr; 589(Pt 8):2065-78. doi: 10.1113/jphysiol.2010.202614. [PMID: 21486804]
  • Xiao-Tao Jin, Jean-Francois Paré, Yoland Smith. Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus. The European journal of neuroscience. 2011 Apr; 33(8):1504-18. doi: 10.1111/j.1460-9568.2011.07636.x. [PMID: 21410779]
  • M F Cano-Abad, I Herrera-Peco, R G Sola, J Pastor, E García-Navarrete, R Carrasco Moro, P Pizzo, A Ruiz-Nuño. New insights on culture and calcium signalling in neurons and astrocytes from epileptic patients. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2011 Apr; 29(2):121-9. doi: 10.1016/j.ijdevneu.2010.12.006. [PMID: 21238565]
  • Silmara Aparecida Faggion, Alexandra Olimpio Siqueira Cunha, Helene Aparecida Fachim, Amanda Salomão Gavin, Wagner Ferreira dos Santos, Ana Maria Soares Pereira, Renê Oliveira Beleboni. Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae). Epilepsy & behavior : E&B. 2011 Mar; 20(3):441-6. doi: 10.1016/j.yebeh.2010.12.037. [PMID: 21277832]
  • Oleg V Lobanov, Yuan B Peng. Differential contribution of electrically evoked dorsal root reflexes to peripheral vasodilatation and plasma extravasation. Journal of neuroinflammation. 2011 Feb; 8(?):20. doi: 10.1186/1742-2094-8-20. [PMID: 21356101]
  • Christian Geis, Andreas Weishaupt, Benedikt Grünewald, Thomas Wultsch, Andreas Reif, Manfred Gerlach, Ron Dirkx, Michele Solimena, Daniela Perani, Manfred Heckmann, Klaus V Toyka, Franco Folli, Claudia Sommer. Human stiff-person syndrome IgG induces anxious behavior in rats. PloS one. 2011 Feb; 6(2):e16775. doi: 10.1371/journal.pone.0016775. [PMID: 21346811]
  • Jun-Feng Peng, Zhao-Tang Wu, Yang-Kai Wang, Wen-Jun Yuan, Tao Sun, Xin Ni, Ding-Feng Su, Wei Wang, Ming-Juan Xu, Wei-Zhong Wang. GABAergic mechanism in the rostral ventrolateral medulla contributes to the hypotension of moxonidine. Cardiovascular research. 2011 Feb; 89(2):473-81. doi: 10.1093/cvr/cvq289. [PMID: 20829217]
  • Andrew J Thompson, Gavin E Jarvis, Rujee K Duke, Graham A R Johnston, Sarah C R Lummis. Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 2011 Feb; 60(2-3):488-95. doi: 10.1016/j.neuropharm.2010.11.003. [PMID: 21059362]
  • Woosik Eom, Jung Min Lee, Jeongmi Park, Kyungho Choi, Sung-Jun Jung, Hee-Soo Kim. The effects of midazolam and sevoflurane on the GABA(A) receptors with alternatively spliced variants of the γ2 subunit. Korean journal of anesthesiology. 2011 Feb; 60(2):109-18. doi: 10.4097/kjae.2011.60.2.109. [PMID: 21390166]
  • Shan Jiang, Bei Miao, Xuejun Song, Zhenglin Jiang. Inactivation of GABA(A) receptor reduces ginsenoside Rb3 neuroprotection in mouse hippocampal slices after oxygen-glucose deprivation. Journal of ethnopharmacology. 2011 Jan; 133(2):914-6. doi: 10.1016/j.jep.2010.10.030. [PMID: 20969942]
  • Roman Tyzio, Camille Allene, Romain Nardou, Michel A Picardo, Sumii Yamamoto, Sudhir Sivakumaran, Maddalena D Caiati, Sylvain Rheims, Marat Minlebaev, Mathieu Milh, Pascal Ferré, Rustem Khazipov, Jean-Louis Romette, Jean Lorquin, Rosa Cossart, Ilgam Khalilov, Astrid Nehlig, Enrico Cherubini, Yehezkel Ben-Ari. Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Jan; 31(1):34-45. doi: 10.1523/jneurosci.3314-10.2011. [PMID: 21209187]
  • Ilgam Khalilov, Geneviève Chazal, Ilona Chudotvorova, Christophe Pellegrino, Séverine Corby, Nadine Ferrand, Olena Gubkina, Romain Nardou, Roman Tyzio, Sumii Yamamoto, Thomas J Jentsch, Christian A Hübner, Jean-Luc Gaiarsa, Yehezkel Ben-Ari, Igor Medina. Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus. Frontiers in cellular neuroscience. 2011; 5(?):23. doi: 10.3389/fncel.2011.00023. [PMID: 22065950]
  • Ken'ichi Yamaguchi, Hitoshi Hama. Changes in vasopressin release and autonomic function induced by manipulating forebrain GABAergic signaling under euvolemia and hypovolemia in conscious rats. Endocrine journal. 2011; 58(7):559-73. doi: 10.1507/endocrj.k11e-002. [PMID: 21532213]
  • Ronald W Irwin, Jun Ming Wang, Shuhua Chen, Roberta Diaz Brinton. Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Frontiers in endocrinology. 2011; 2(?):117. doi: 10.3389/fendo.2011.00117. [PMID: 22654847]
  • Alice F Viana, Izaque S Maciel, Emerson M Motta, Paulo C Leal, Luiz Pianowski, Maria M Campos, João B Calixto. Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):120820. doi: 10.1093/ecam/nep144. [PMID: 19815648]
  • Kalpana Gupta, Amitabha Chakrabarti, Sonia Rana, Ritu Ramdeo, Bryan L Roth, Munna L Agarwal, William Tse, Mukesh K Agarwal, David N Wald. Securinine, a myeloid differentiation agent with therapeutic potential for AML. PloS one. 2011; 6(6):e21203. doi: 10.1371/journal.pone.0021203. [PMID: 21731671]
  • Candy Flores-Gracia, Avril Nuche-Bricaire, Minerva Crespo-Ramírez, Ricardo Miledi, Kjell Fuxe, Miguel Pérez de la Mora. GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety. Psychopharmacology. 2010 Dec; 212(4):475-84. doi: 10.1007/s00213-010-1973-x. [PMID: 20689940]
  • Felix L Yeh, Min Dong, Jun Yao, William H Tepp, Guangyun Lin, Eric A Johnson, Edwin R Chapman. SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS pathogens. 2010 Nov; 6(11):e1001207. doi: 10.1371/journal.ppat.1001207. [PMID: 21124874]
  • Markus Rauchenzauner, Gerhard Luef. Update on treatment of partial onset epilepsy: role of eslicarbazepine. Neuropsychiatric disease and treatment. 2010 Nov; 6(?):723-30. doi: 10.2147/ndt.s5840. [PMID: 21127691]
  • Tadachika Koganezawa, Yuri Shimomura, Naohito Terui. The viscerosympathetic response in rabbits is mediated by GABAergic and glutamatergic inputs into the sympathetic premotor neurons of the rostral ventrolateral medulla. Experimental physiology. 2010 Nov; 95(11):1061-70. doi: 10.1113/expphysiol.2010.054668. [PMID: 20729268]
  • A J M Verberne, D M Sartor. Rostroventrolateral medullary neurons modulate glucose homeostasis in the rat. American journal of physiology. Endocrinology and metabolism. 2010 Nov; 299(5):E802-7. doi: 10.1152/ajpendo.00466.2010. [PMID: 20807841]
  • Wagner L Reis, Wilson A Saad, Luiz A Camargo, Lucila Lk Elias, José Antunes-Rodrigues. Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II. Behavioral and brain functions : BBF. 2010 Oct; 6(?):64. doi: 10.1186/1744-9081-6-64. [PMID: 20974001]
  • Adam W Hantman, Thomas M Jessell. Clarke's column neurons as the focus of a corticospinal corollary circuit. Nature neuroscience. 2010 Oct; 13(10):1233-9. doi: 10.1038/nn.2637. [PMID: 20835249]
  • Joel S Goldberg. Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions. Perspectives in medicinal chemistry. 2010 Aug; 4(?):23-31. doi: 10.4137/pmc.s5490. [PMID: 20703328]
  • Janardhan P Bhattarai, Seon Ah Park, Seong Kyu Han. The methanolic extract of Withania somnifera ACTS on GABAA receptors in gonadotropin releasing hormone (GnRH) neurons in mice. Phytotherapy research : PTR. 2010 Aug; 24(8):1147-50. doi: 10.1002/ptr.3088. [PMID: 20044800]