Tetrachlorobisphenol A (BioDeep_00000858495)

   


代谢物信息卡片


Phenol,4,4-(1-methylethylidene)bis[2,6-dichloro-

化学式: C15H12Cl4O2 (363.9591)
中文名称: 4-[(3-甲基苯基)氨基] -3-吡啶磺酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C1=CC(=C(C(=C1)Cl)O)Cl)C2=CC(=C(C(=C2)Cl)O)Cl
InChI: InChI=1S/C15H12Cl4O2/c1-15(2,7-3-9(16)13(20)10(17)4-7)8-5-11(18)14(21)12(19)6-8/h3-6,20-21H,1-2H3



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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AR, DCTN4, EGFR, ESR1, GPER1, MAPK3, PGR, PIK3C3, PIK3CA, PPARG, SCARB1, TNK1
Peripheral membrane protein 3 CYP11A1, ESR1, TNK1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 6 CYP17A1, EGFR, GPER1, HSD17B3, UGT1A1, UGT1A9
Mitochondrion membrane 2 CYP11A1, GPER1
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 8 AR, DCTN4, EGFR, ESR1, GPER1, MAPK3, PGR, PPARG
autophagosome 1 PIK3C3
cytosol 10 AR, DCTN4, ESR1, GPER1, MAPK3, MYL4, PGR, PIK3C3, PIK3CA, PPARG
dendrite 1 GPER1
mitochondrial membrane 1 GPER1
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
trans-Golgi network 1 GPER1
centrosome 1 DCTN4
nucleoplasm 6 AR, ESR1, GPER1, MAPK3, PGR, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 EGFR, ESR1, LHCGR, SCARB1
Cytoplasmic side 1 ESR1
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Cell projection, axon 1 GPER1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 GPER1, LHCGR, SCARB1
Golgi apparatus membrane 1 GPER1
cell cortex 1 DCTN4
cell junction 1 EGFR
cell surface 2 EGFR, SCARB1
dendritic shaft 1 GPER1
glutamatergic synapse 3 EGFR, MAPK3, PIK3C3
Golgi apparatus 3 ESR1, GPER1, MAPK3
Golgi membrane 2 EGFR, GPER1
lysosomal membrane 1 SCARB1
mitochondrial inner membrane 1 CYP11A1
neuronal cell body 1 CYP17A1
presynaptic membrane 1 GPER1
Lysosome 1 SCARB1
endosome 3 EGFR, LHCGR, PIK3C3
plasma membrane 11 AR, EGFR, ESR1, GPER1, LHCGR, MAPK3, PGR, PIK3CA, SCARB1, TNK1, UGT1A1
presynaptic active zone 1 GPER1
Membrane 10 AR, CYP11A1, EGFR, ESR1, GPER1, PIK3C3, SCARB1, TNK1, UGT1A1, UGT1A9
apical plasma membrane 1 EGFR
axon 2 CYP17A1, GPER1
basolateral plasma membrane 1 EGFR
caveola 2 MAPK3, SCARB1
extracellular exosome 1 SCARB1
endoplasmic reticulum 5 CYP17A1, GPER1, HSD17B3, UGT1A1, UGT1A9
extracellular space 3 EGFR, INSL3, LHCGR
perinuclear region of cytoplasm 6 EGFR, GPER1, INSL3, PIK3CA, PPARG, UGT1A1
intercalated disc 1 PIK3CA
mitochondrion 2 CYP11A1, MAPK3
protein-containing complex 3 AR, EGFR, ESR1
intracellular membrane-bounded organelle 4 GPER1, HSD17B3, PPARG, SCARB1
Microsome membrane 1 CYP17A1
postsynaptic density 1 GPER1
Single-pass type I membrane protein 1 EGFR
Secreted 1 INSL3
extracellular region 1 INSL3
Single-pass membrane protein 2 UGT1A1, UGT1A9
mitochondrial outer membrane 1 PGR
hippocampal mossy fiber to CA3 synapse 1 GPER1
mitochondrial matrix 1 CYP11A1
transcription regulator complex 1 ESR1
centriolar satellite 1 LHCGR
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 DCTN4
nuclear membrane 1 EGFR
nucleolus 1 GPER1
midbody 1 PIK3C3
Early endosome 2 GPER1, MAPK3
recycling endosome 1 GPER1
Cytoplasm, perinuclear region 1 UGT1A1
Mitochondrion inner membrane 1 CYP11A1
Membrane raft 1 EGFR
Cell junction, focal adhesion 1 MAPK3
Cytoplasm, cytoskeleton 1 DCTN4
focal adhesion 3 DCTN4, EGFR, MAPK3
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
intracellular vesicle 1 EGFR
axoneme 1 PIK3C3
nuclear speck 1 AR
Cytoplasm, myofibril, sarcomere 1 DCTN4
Late endosome 2 MAPK3, PIK3C3
sarcomere 1 DCTN4
receptor complex 3 EGFR, LHCGR, PPARG
chromatin 4 AR, ESR1, PGR, PPARG
phagocytic vesicle membrane 1 PIK3C3
cytoskeleton 1 MAPK3
spindle pole 1 DCTN4
Cytoplasm, cell cortex 1 DCTN4
myosin II complex 1 MYL4
nuclear envelope 2 GPER1, MAPK3
Membrane, caveola 2 MAPK3, SCARB1
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasmic vesicle membrane 1 GPER1
Cell projection, dendrite 1 GPER1
euchromatin 1 ESR1
pseudopodium 1 MAPK3
stress fiber 1 DCTN4
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 1 MAPK3
axon terminus 1 GPER1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
dynactin complex 1 DCTN4
kinetochore 1 DCTN4
endocytic vesicle membrane 1 SCARB1
cytoplasmic dynein complex 1 DCTN4
presynaptic endosome 1 PIK3C3
clathrin-coated endocytic vesicle membrane 1 EGFR
Cytoplasm, cytoskeleton, stress fiber 1 DCTN4
A band 1 MYL4
[Isoform 1]: Nucleus 1 ESR1
keratin filament 1 GPER1
dendritic spine head 1 GPER1
Cell projection, dendritic spine membrane 1 GPER1
dendritic spine membrane 1 GPER1
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Autolysosome 1 PIK3C3
[Isoform 4]: Mitochondrion outer membrane 1 PGR
endoplasmic reticulum chaperone complex 1 UGT1A1
cytochrome complex 1 UGT1A1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Vanessa Cheng, David C Volz. Halogenated bisphenol a analogues induce PPARγ-independent toxicity within human hepatocellular carcinoma cells. Current research in toxicology. 2022; 3(?):100079. doi: 10.1016/j.crtox.2022.100079. [PMID: 35734227]
  • Yinan Wang, Wenjuan Zhang, Aijing Li, Maoyong Song. Tetrachlorobisphenol A induced immunosuppression and uterine injury in mice. Ecotoxicology and environmental safety. 2021 Jan; 207(?):111527. doi: 10.1016/j.ecoenv.2020.111527. [PMID: 33254397]
  • P Pawlicki, M Duliban, R Tuz, A Ptak, A Milon, E Gorowska-Wojtowicz, W Tworzydlo, B J Płachno, B Bilinska, K Knapczyk-Stwora, M Kotula-Balak. Do G-protein coupled estrogen receptor and bisphenol A analogs influence on Leydig cell epigenetic regulation in immature boar testis ex vivo?. Animal reproduction science. 2019 Aug; 207(?):21-35. doi: 10.1016/j.anireprosci.2019.06.006. [PMID: 31266599]
  • Hangjun Zhang, Wenli Liu, Bin Chen, Jianbo He, Feifei Chen, Xiaodong Shan, Qiongxia Du, Ning Li, Xiuying Jia, Juan Tang. Differences in reproductive toxicity of TBBPA and TCBPA exposure in male Rana nigromaculata. Environmental pollution (Barking, Essex : 1987). 2018 Dec; 243(Pt A):394-403. doi: 10.1016/j.envpol.2018.08.086. [PMID: 30199813]
  • Zhihua Ji, Yaxian Zhang, Juan Tian, Fengbang Wang, Maoyong Song, Hao Li. Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells. Ecotoxicology and environmental safety. 2018 10; 161(?):1-7. doi: 10.1016/j.ecoenv.2018.05.070. [PMID: 29857228]
  • Guozhu Ye, Yajie Chen, Hong-Ou Wang, Ting Ye, Yi Lin, Qiansheng Huang, Yulang Chi, Sijun Dong. Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol A and tetrachlorobisphenol A. Scientific reports. 2016 10; 6(?):35257. doi: 10.1038/srep35257. [PMID: 27734936]
  • Huangshi Luo, Chunya Li, Huaifang Fang, Xian Wang. Comparative study of the interactions between bisphenol analogues and serum albumins by electrospray mass spectrometry and fluorescence spectroscopy. Rapid communications in mass spectrometry : RCM. 2016 08; 30 Suppl 1(?):162-7. doi: 10.1002/rcm.7633. [PMID: 27539432]
  • Anne Riu, Catherine W McCollum, Caroline L Pinto, Marina Grimaldi, Anne Hillenweck, Elisabeth Perdu, Daniel Zalko, Laure Bernard, Vincent Laudet, Patrick Balaguer, Maria Bondesson, Jan-Ake Gustafsson. Halogenated bisphenol-A analogs act as obesogens in zebrafish larvae (Danio rerio). Toxicological sciences : an official journal of the Society of Toxicology. 2014 May; 139(1):48-58. doi: 10.1093/toxsci/kfu036. [PMID: 24591153]
  • Hong Sun, Ou-Xi Shen, Xin-Ru Wang, Lian Zhou, Shi-Qi Zhen, Xiao-Dong Chen. Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay. Toxicology in vitro : an international journal published in association with BIBRA. 2009 Aug; 23(5):950-4. doi: 10.1016/j.tiv.2009.05.004. [PMID: 19457453]