Biapenem (BioDeep_00000008570)
代谢物信息卡片
CLI 86815;L 627;LJC 10627
化学式: C15H18N4O4S (350.1049)
中文名称: 比阿培南
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(O)C1C(=O)N2C(C(=O)[O-])=C(SC3Cn4cnc[n+]4C3)C(C)C12
InChI: InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DH - Carbapenems
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Same as: D01057
同义名列表
3 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:3089
- KEGG: C11268
- KEGGdrug: D01057
- PubChem: 71339
- PubChem: 4488114
- Metlin: METLIN68951
- DrugBank: DB13028
- ChEMBL: CHEMBL285347
- CAS: 120410-24-4
- PMhub: MS000022200
- MetaboLights: MTBLC3089
- PubChem: 13445
- NIKKAJI: J550.678F
- RefMet: Biapenem
- KNApSAcK: 3089
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuichi Ichimura, Natsumi Kudoh, Takashi Murabe, Takumi Akao, Sho Watanuki, Takanao Suzuki, Toshihide Saito, Masako Oda, Hiroshi Saitoh. Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats.
Drug metabolism and pharmacokinetics.
2021 Oct; 40(?):100406. doi:
10.1016/j.dmpk.2021.100406. [PMID: 34352708] - Wenyan Li, Zheng Jiao, Yanhui Liu, Jiacheng Yao, Guodong Li, Jing Dong. Role of organic anion transporter 3 in the renal excretion of biapenem and potential drug-drug interactions.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Jul; 162(?):105814. doi:
10.1016/j.ejps.2021.105814. [PMID: 33753216] - Jaehong Kim, Samyeol Choo, Hyunchae Sim, Moon-Chang Baek, Jong-Sup Bae. Biapenem reduces sepsis mortality via barrier protective pathways against HMGB1-mediated septic responses.
Pharmacological reports : PR.
2021 Jun; 73(3):786-795. doi:
10.1007/s43440-020-00212-0. [PMID: 33515401] - Wonhwa Lee, Moon-Chang Baek, Kyung-Min Kim, Jong-Sup Bae. Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury.
International journal of molecular sciences.
2020 Feb; 21(4):. doi:
10.3390/ijms21041462. [PMID: 32098061] - Yongfu Hang, Yafang Chen, Ling Xue, Shusen Sun, Long Liu, Jie Gao, Cheng Xie, Xianfeng Zhang, Jianguo Zhu, Jun Jin, Liyan Miao. Evaluating biapenem dosage regimens in intensive care unit patients with Pseudomonas aeruginosa infections: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation.
International journal of antimicrobial agents.
2018 Mar; 51(3):484-487. doi:
10.1016/j.ijantimicag.2017.07.005. [PMID: 28709989] - Jing Dong, Wei Xiong, Yuancheng Chen, Yunfeng Zhao, Yang Lu, Di Zhao, Wenyan Li, Yanhui Liu, Xijing Chen. Optimal dosing regimen of biapenem in Chinese patients with lower respiratory tract infections based on population pharmacokinetic/pharmacodynamic modelling and Monte Carlo simulation.
International journal of antimicrobial agents.
2016 Mar; 47(3):202-9. doi:
10.1016/j.ijantimicag.2015.12.018. [PMID: 26895604] - Yinfang Zhu, Shunli Ji, Shaohui Li, Cheng Li, Feifang Zhang, Xinmiao Liang. [Analysis of carbapenems by hydrophilic interaction chromatography and its application].
Se pu = Chinese journal of chromatography.
2015 Sep; 33(9):946-50. doi:
10.3724/sp.j.1123.2015.05005. [PMID: 26753282] - Sangeetha Rajenderan, Veeraraghavan Balaji, Shalini Anandan, Rani Diana Sahni, Giannoula S Tansarli, Matthew E Falagas. Determination of MIC distribution of arbekacin, cefminox, fosfomycin, biapenem and other antibiotics against gram-negative clinical isolates in South India: a prospective study.
PloS one.
2014; 9(7):e103253. doi:
10.1371/journal.pone.0103253. [PMID: 25068396] - Koichi Yamada, Katsunori Yanagihara, Norihito Kaku, Yosuke Harada, Yohei Migiyama, Kentaro Nagaoka, Yoshitomo Morinaga, Shigeki Nakamura, Yoshifumi Imamura, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Kakeya, Hiroo Hasegawa, Akira Yasuoka, Shigeru Kohno. In vivo efficacy of biapenem with ME1071, a novel metallo-β-lactamase (MBL) inhibitor, in a murine model mimicking ventilator-associated pneumonia caused by MBL-producing Pseudomonas aeruginosa.
International journal of antimicrobial agents.
2013 Sep; 42(3):238-43. doi:
10.1016/j.ijantimicag.2013.05.016. [PMID: 23891525] - Y Liu, Z Li, C Yang, H Zheng, Y Lv, H Chen, Y Zhang, S Shi. Tolerability and pharmacokinetics of biapenem following single and multiple intravenous administrations in healthy Chinese subjects: an open-label, randomized, single-center study.
Drug research.
2013 Aug; 63(8):396-403. doi:
10.1055/s-0033-1341498. [PMID: 23585303] - Fumi Karino, Naoko Deguchi, Hibiki Kanda, Miki Ohe, Keiichi Kondo, Mitsuhiro Tada, Takashige Kuraki, Nobuhiro Nishimura, Hidehiko Moriyama, Kazuro Ikawa, Norifumi Morikawa, Takeshi Isobe. Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2013 Feb; 19(1):98-102. doi:
10.1007/s10156-012-0463-y. [PMID: 22926665] - Koichi Yamada, Yoshihiro Yamamoto, Katsunori Yanagihara, Nobuko Araki, Yosuke Harada, Yoshitomo Morinaga, Koichi Izumikawa, Hiroshi Kakeya, Hiroo Hasegawa, Shigeru Kohno, Shimeru Kamihira. In vivo efficacy and pharmacokinetics of biapenem in a murine model of ventilator-associated pneumonia with Pseudomonas aeruginosa.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2012 Aug; 18(4):472-8. doi:
10.1007/s10156-011-0359-2. [PMID: 22215228] - Kazuro Ikawa, Akira Nakashima, Norifumi Morikawa, Kayo Ikeda, Yoshiaki Murakami, Hiroki Ohge, Hartmut Derendorf, Taijiro Sueda. Clinical pharmacokinetics of meropenem and biapenem in bile and dosing considerations for biliary tract infections based on site-specific pharmacodynamic target attainment.
Antimicrobial agents and chemotherapy.
2011 Dec; 55(12):5609-15. doi:
10.1128/aac.00497-11. [PMID: 21947393] - Qin Yu, Mao-Zhi Liang, Jin Xiang, Yong-Ping Qin, Feng Nan. [Determination of biapenem in human plasma by high performance liquid chromatography].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2011 Jul; 42(4):564-6. doi:
NULL. [PMID: 21866650] - Libo Zhao, Yi Liu, Zhibin Kou, Aidijie Bayasi, Huan Cai, Chunyan Zhang, Qian Wang, Yuzhen Li, Yi Fang. Improved RP-HPLC method to determine biapenem in human plasma/urine and its application to a pharmacokinetic study.
Arzneimittel-Forschung.
2011; 61(3):197-204. doi:
10.1055/s-0031-1296189. [PMID: 21528646] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Eiki Kikuchi, Junko Kikuchi, Yasuyuki Nasuhara, Satoshi Oizumi, Akitoshi Ishizaka, Masaharu Nishimura. Comparison of the pharmacodynamics of biapenem in bronchial epithelial lining fluid in healthy volunteers given half-hour and three-hour intravenous infusions.
Antimicrobial agents and chemotherapy.
2009 Jul; 53(7):2799-803. doi:
10.1128/aac.01578-08. [PMID: 19380601] - Keiko Kameda, Mizuka Miki, Kazuro Ikawa, Norifumi Morikawa, Masao Kobayashi. [Dosing regimen rationalization of biapenem in pediatric patients: use of Monte Carlo simulation].
The Japanese journal of antibiotics.
2009 Feb; 62(1):1-8. doi:
NULL. [PMID: 19378765] - Hidemichi Suyama, Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Yoshihiro Fujiue, Shingo Morikawa, Kotaro Kaneko, Masao Kuwabara, Takao Yamanoue. Pharmacokinetics and pharmacodynamics of biapenem in critically ill patients under continuous venovenous hemodiafiltration.
The Japanese journal of antibiotics.
2008 Oct; 61(5):303-13. doi:
. [PMID: 19260350] - Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Hiroki Ohge, Taijiro Sueda. Pharmacodynamic evaluation of biapenem in peritoneal fluid using population pharmacokinetic modelling and Monte Carlo simulation.
International journal of antimicrobial agents.
2008 Oct; 32(4):339-43. doi:
10.1016/j.ijantimicag.2008.03.011. [PMID: 18602798] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - K Ikawa, N Morikawa, K Ikeda, M Miki, S Nishimura, M Kobayashi. Population pharmacokinetics and pharmacodynamics of biapenem in paediatric patients.
Journal of clinical pharmacy and therapeutics.
2008 Apr; 33(2):203-10. doi:
10.1111/j.1365-2710.2008.00908.x. [PMID: 18315787] - Yuko Muto, Yukio Mikami, Shiro Sakakibara, Atsuyuki Shimizu, Masashi Niida, Hiroshi Kataoka, Fumi Ito, Katsuyoshi Suzuki, Koji Kijima, Kazunori Maebashi, Toshihiko Takata, Muneo Hikida, Kazunori Takeda, Michiaki Unno. Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis.
Pancreas.
2008 Mar; 36(2):125-32. doi:
10.1097/mpa.0b013e3181568ed7. [PMID: 18376302] - Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Hidemichi Suyama. Pharmacokinetic modeling and dosage adaptation of biapenem in Japanese patients during continuous venovenous hemodiafiltration.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2008 Feb; 14(1):35-9. doi:
10.1007/s10156-007-0572-1. [PMID: 18297447] - Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Hiroki Ohge, Taijiro Sueda, Hidemichi Suyama, Masao Doi, Masao Kuwabara. Pharmacokinetic-pharmacodynamic target attainment analysis of biapenem in adult patients: a dosing strategy.
Chemotherapy.
2008; 54(5):386-94. doi:
10.1159/000152459. [PMID: 18769027] - Kayo Ikeda, Kazuro Ikawa, Aki Ikeda, Yoshimi Nishikawa, Norifumi Morikawa. A simple and rapid determination of biapenem in plasma by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Nov; 844(1):148-52. doi:
10.1016/j.jchromb.2006.06.023. [PMID: 16875889] - Yaeko Watanabe, Yoshihiro Fujiue, Sintarou Yano, Satomi Shimizu, Kunio Muroki, Masao Doi, Masao Kuwabara. [Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from urine at one hospital to mainly carbapenem and fluoroquinolone drugs].
The Japanese journal of antibiotics.
2006 Apr; 59(2):65-71. doi:
. [PMID: 16805317] - Toshihiko Takata, Kazumasa Aizawa, Atsuyuki Shimizu, Shiro Sakakibara, Hiroomi Watabe, Kyoichi Totsuka. Optimization of dose and dose regimen of biapenem based on pharmacokinetic and pharmacodynamic analysis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2004 Apr; 10(2):76-85. doi:
10.1007/s10156-003-0292-0. [PMID: 15160299] - Akiko Aoki, Takako Sato, Toshihisa Igarashi. [Clinical evaluation on biapenem for respiratory infections in elderly patients: safety for renal function].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
2003 Jul; 40(4):402-3. doi:
10.3143/geriatrics.40.402. [PMID: 12934573] - S Nagashima, O Kozawa, T Otsuka, K Kohno, M Minamoto, M Yokokawa, M Kanamaru, T Uematsu. Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis.
The Journal of antimicrobial chemotherapy.
2000 Nov; 46(5):839-42. doi:
10.1093/jac/46.5.839. [PMID: 11062211] - K Hara, S Baba, F Matsumoto, M Ooishi, Y Kawada, J Arata, N Shinagawa, J Sasaki, K Hayasi, T Sugihara, S Matsuda. [Clinical evaluation of biapenem in various infectious diseases].
The Japanese journal of antibiotics.
1999 Nov; 52(11):629-60. doi:
. [PMID: 10659441] - O Kozawa, T Uematsu, H Matsuno, M Niwa, Y Takiguchi, S Matsumoto, M Minamoto, Y Niida, M Yokokawa, S Nagashima, M Kanamaru. Pharmacokinetics and safety of a new parenteral carbapenem antibiotic, biapenem (L-627), in elderly subjects.
Antimicrobial agents and chemotherapy.
1998 Jun; 42(6):1433-6. doi:
10.1128/aac.42.6.1433. [PMID: 9624490] - P Koeppe, D Höffler, B Fitzen. Biapenem pharmacokinetics in healthy volunteers and in patients with impaired renal function.
Arzneimittel-Forschung.
1997 Nov; 47(11):1250-6. doi:
NULL. [PMID: 9428983] - S Iwata, K Yamamoto, E Isohata, Y Kin, T Yokota, Y Kusumoto, Y Sato, H Akita, S Nanri, T Oikawa. [Effect of biapenem (L-627) on fecal flora in gnotobiotic mice and children].
The Japanese journal of antibiotics.
1994 Dec; 47(12):1668-84. doi:
. [PMID: 7877249] - Y Toynaga, T Ishihara, T Tezuka, T Sano, K Kawada, H Nakamura, H Chiba. [Pharmacokinetic and clinical studies on biapenem (L-627) in the pediatric field].
The Japanese journal of antibiotics.
1994 Dec; 47(12):1691-705. doi:
. [PMID: 7877251] - T Motohiro, S Handa, S Yamada, S Oki, Y Yoshinaga, K Oda, Y Sakata, H Kato, F Yamashita, S Imai. [Bacteriological, pharmacokinetic and clinical studies on biapenem (L-627) in the pediatric field].
The Japanese journal of antibiotics.
1994 Dec; 47(12):1728-52. doi:
. [PMID: 7877254] - T Haruta, S Kuroki, K Okura, H Nikami, T Nishio, Y Kobayashi. [Transferability of biapenem (L-627) to cerebrospinal fluid in rabbits with meningitis caused by Staphylococcus aureus].
The Japanese journal of antibiotics.
1994 Jul; 47(7):869-72. doi:
. [PMID: 7933519] - K Kuno, A Ogawa, F Hayakawa, M Kondo, A Okumura, H Takahashi. [Laboratory and clinical studies on biapenem (L-627) in the field of pediatrics].
The Japanese journal of antibiotics.
1994 Jul; 47(7):932-9. doi:
. [PMID: 7933528] - Y Kusumoto, H Akita, Y Sato, S Iwata, Y Takeuchi, T Abe, K Sunakawa, T Yokota. [Bacteriological and clinical studies of biapenem (L-627) in pediatrics].
The Japanese journal of antibiotics.
1994 Jul; 47(7):921-31. doi:
NULL. [PMID: 7933527] - Y Kakizaki, M Yokoyama, N Tsushima. [Clinical studies on and pharmacokinetics of a new carbapenem antibiotic, biapenem (L-627), in the pediatric field].
The Japanese journal of antibiotics.
1994 Jul; 47(7):889-95. doi:
. [PMID: 7933523] - K Fujita, M Yoshikawa, K Murono, S Maruyama, H Sakata, F Inyaku, S Takahashi, T Saino. [Clinical evaluation of biapenem (L-627) in children].
The Japanese journal of antibiotics.
1994 Jul; 47(7):873-7. doi:
. [PMID: 7933520] - T Tajima, R Niimi, M Kobayashi, S Kobayashi-Negishi, Y Kondo, E Nakayama-Esaki, S Nishimura, N Hagiwara, T Abe. [Pharmacokinetic, bacteriological and clinical studies on biapenem (L-627) in children].
The Japanese journal of antibiotics.
1994 Jul; 47(7):896-902. doi:
. [PMID: 7933524] - R Fujii, K Fujita, M Yoshikawa, K Murono, S Maruyama, H Sakata, F Inyaku, S Takahashi, T Saino, S Chiba. [Pharmacokinetic and clinical studies with L-627 (biapenem) in the pediatric field. Pediatric study group of L-627].
The Japanese journal of antibiotics.
1994 May; 47(5):530-52. doi:
NULL. [PMID: 8051795] - A K Houston, R N Jones. Post-antibiotic effect of FK-037 and biapenem tested against five bacterial species.
Journal of chemotherapy (Florence, Italy).
1994 Feb; 6(1):12-4. doi:
10.1080/1120009x.1994.11741121. [PMID: 8071670] - M Nakashima, T Uematsu, K Ueno, S Nagashima, H Inaba, M Nakano, K Kosuge, M Kitamura, T Sasaki. Phase 1 study of L-627, biapenem, a new parenteral carbapenem antibiotic.
International journal of clinical pharmacology, therapy, and toxicology.
1993 Feb; 31(2):70-6. doi:
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Antimicrobial agents and chemotherapy.
1992 Sep; 36(9):1928-34. doi:
10.1128/aac.36.9.1928. [PMID: 1416883] - H C Neu, J W Gu, W Fang, N X Chin. In vitro activity and beta-lactamase stability of LJC 10,627.
Antimicrobial agents and chemotherapy.
1992 Jul; 36(7):1418-23. doi:
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Antimicrobial agents and chemotherapy.
1992 Feb; 36(2):481-3. doi:
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Antimicrobial agents and chemotherapy.
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