Tetrabenazine (BioDeep_00000008526)
Secondary id: BioDeep_00000858452
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one
化学式: C19H27NO3 (317.1990832)
中文名称: 丁苯那嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 4.9%
分子结构信息
SMILES: CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
InChI: InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3
描述信息
A drug formerly used as an antipsychotic but now used primarily in the treatment of various movement disorders including tardive dyskinesia. Tetrabenazine blocks uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system. [PubChem]
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
N - Nervous system
Same as: D08575
同义名列表
17 个代谢物同义名
9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one; 2-oxo-3-Isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11BH-benzo[a]quinolizine; 1,2,4,6,7,11b-Hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one; 2-oxo-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine; Cambridge laboratories brand OF tetrabenazine; Orphan brand OF tetrabenazine; Roche brand OF tetrabenazine; Shire brand OF tetrabenazine; Tetrabenazine orphan brand; Tetra benazin; TETRABENAZINE; Tetrabenzaine; Tetrabenzine; Ro 1-9569; Xenazine; Nitoman; TBZ
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:64028
- ChEBI: CHEBI:9467
- KEGG: C11168
- PubChem: 6018
- HMDB: HMDB0015592
- Metlin: METLIN2800
- DrugBank: DB04844
- ChEMBL: CHEMBL117785
- Wikipedia: Tetrabenazine
- MeSH: Tetrabenazine
- chemspider: 5796
- CAS: 718635-93-9
- CAS: 58-46-8
- PMhub: MS000022152
- PubChem: 13350
- NIKKAJI: J4.592F
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sangram Nag, Mahabuba Jahan, Miklós Tóth, Ryuji Nakao, Andrea Varrone, Christer Halldin. PET Imaging of VMAT2 with the Novel Radioligand [18F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [11C]DTBZ and [18F]FE-DTBZ.
ACS chemical neuroscience.
2021 12; 12(24):4580-4586. doi:
10.1021/acschemneuro.1c00651. [PMID: 34813272] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Renee A Rotolo, Rose E Presby, Olivia Tracy, Sokaina Asar, Jen-Hau Yang, Merce Correa, Fraser Murray, John D Salamone. The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology.
Neuropharmacology.
2021 02; 183(?):108325. doi:
10.1016/j.neuropharm.2020.108325. [PMID: 32956676] - Renee A Rotolo, Predrag Kalaba, Vladimir Dragacevic, Rose E Presby, Julia Neri, Emily Robertson, Jen-Hau Yang, Merce Correa, Vasiliy Bakulev, Natalia N Volkova, Christian Pifl, Gert Lubec, John D Salamone. Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding.
Psychopharmacology.
2020 Nov; 237(11):3459-3470. doi:
10.1007/s00213-020-05625-6. [PMID: 32770257] - Hugo Cruces-Solis, Wiebke Nissen, Boris Ferger, Roberto Arban. Whole-brain signatures of functional connectivity after bidirectional modulation of the dopaminergic system in mice.
Neuropharmacology.
2020 11; 178(?):108246. doi:
10.1016/j.neuropharm.2020.108246. [PMID: 32771528] - Manish Kumar, Nirmal Singh, Amteshwar Singh Jaggi. Exploring the anti-stress effects of imatinib and tetrabenazine in cold-water immersion-induced acute stress in mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 09; 393(9):1625-1634. doi:
10.1007/s00210-020-01862-w. [PMID: 32291496] - Anmol Arora, Shobhit Kumar, Javed Ali, Sanjula Baboota. Intranasal delivery of tetrabenazine nanoemulsion via olfactory region for better treatment of hyperkinetic movement associated with Huntington's disease: Pharmacokinetic and brain delivery study.
Chemistry and physics of lipids.
2020 08; 230(?):104917. doi:
10.1016/j.chemphyslip.2020.104917. [PMID: 32439327] - Frank Schneider, Margaret Bradbury, Thomas A Baillie, David Stamler, Edward Hellriegel, Donna S Cox, Pippa S Loupe, Juha-Matti Savola, Laura Rabinovich-Guilatt. Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers.
Clinical and translational science.
2020 07; 13(4):707-717. doi:
10.1111/cts.12754. [PMID: 32155315] - Fatma Tuğçe Gürağaç Dereli, Haroon Khan, Eduardo Sobarzo-Sánchez, Esra Küpeli Akkol. Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach.
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061299. [PMID: 32178424] - Fatma Tuğçe Gürağaç Dereli, Mert Ilhan, Esra Küpeli Akkol. Identification of the main active antidepressant constituents in a traditional Turkish medicinal plant, Centaurea kurdica Reichardt.
Journal of ethnopharmacology.
2020 Mar; 249(?):112373. doi:
10.1016/j.jep.2019.112373. [PMID: 31689479] - Byoung Seok Ye, Sangwon Lee, Hansoo Yoo, Seok Jong Chung, Yang Hyun Lee, Yonghoon Choi, Phil Hyu Lee, Young H Sohn, Mijin Yun. Distinguishing between dementia with Lewy bodies and Alzheimer's disease using metabolic patterns.
Neurobiology of aging.
2020 03; 87(?):11-17. doi:
10.1016/j.neurobiolaging.2019.10.020. [PMID: 31791660] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Fatma Tuğçe Gürağaç Dereli, Mert Ilhan, Esra Küpeli Akkol. Discovery of new antidepressant agents: In vivo study on Anthemis wiedemanniana Fisch. & Mey.
Journal of ethnopharmacology.
2018 Nov; 226(?):11-16. doi:
10.1016/j.jep.2018.07.019. [PMID: 30031141] - Karla Soares-Weiser, John Rathbone, Yusuke Ogawa, Kiyomi Shinohara, Hanna Bergman. Miscellaneous treatments for antipsychotic-induced tardive dyskinesia.
The Cochrane database of systematic reviews.
2018 03; 3(?):CD000208. doi:
10.1002/14651858.cd000208.pub2. [PMID: 29552749] - Futao Liu, Seok Rye Choi, Zhihao Zha, Karl Ploessl, Lin Zhu, Hank F Kung. Deuterated 18F-9-O-hexadeutero-3-fluoropropoxyl-(+)-dihydrotetrabenazine (D6-FP-(+)-DTBZ): A vesicular monoamine transporter 2 (VMAT2) imaging agent.
Nuclear medicine and biology.
2018 02; 57(?):42-49. doi:
10.1016/j.nucmedbio.2017.11.009. [PMID: 29306111] - Heather Skor, Evan B Smith, Gordon Loewen, Christopher F O'Brien, Dimitri E Grigoriadis, Haig Bozigian. Differences in Dihydrotetrabenazine Isomer Concentrations Following Administration of Tetrabenazine and Valbenazine.
Drugs in R&D.
2017 Sep; 17(3):449-459. doi:
10.1007/s40268-017-0202-z. [PMID: 28776237] - Rosa Luo, Haig Bozigian, Roland Jimenez, Gordon Loewen, Christopher F O'Brien. Single Dose and Repeat Once-Daily Dose Safety, Tolerability and Pharmacokinetics of Valbenazine in Healthy Male Subjects.
Psychopharmacology bulletin.
2017 08; 47(3):44-52. doi:
NULL. [PMID: 28839339] - D M Paton. Deutetrabenazine: Treatment of hyperkinetic aspects of Huntington's disease, tardive dyskinesia and Tourette syndrome.
Drugs of today (Barcelona, Spain : 1998).
2017 Feb; 53(2):89-102. doi:
10.1358/dot.2017.53.2.2589164. [PMID: 28387387] - Jonathan M Meyer. Forgotten but not gone: new developments in the understanding and treatment of tardive dyskinesia.
CNS spectrums.
2016 12; 21(S1):13-24. doi:
10.1017/s1092852916000730. [PMID: 28044943] - Mika Naganawa, Shu-Fei Lin, Keunpoong Lim, David Labaree, Jim Ropchan, Paul Harris, Yiyun Huang, Masanori Ichise, Richard E Carson, Gary W Cline. Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons.
Nuclear medicine and biology.
2016 Dec; 43(12):743-751. doi:
10.1016/j.nucmedbio.2016.08.018. [PMID: 27673755] - Xueshi Hao, Qihui Jin, Porino Va, Chun Li, Weijun Shen, Bryan Laffitte, Tom Y-H Wu. Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules.
ChemMedChem.
2016 06; 11(11):1129-32. doi:
10.1002/cmdc.201600116. [PMID: 27095073] - Xianying Wu, Xue Zhou, Shuxian Zhang, Yan Zhang, Aifang Deng, Jie Han, Lin Zhu, Hank F Kung, Jinping Qiao. Brain uptake of a non-radioactive pseudo-carrier and its effect on the biodistribution of [(18)F]AV-133 in mouse brain.
Nuclear medicine and biology.
2015 Jul; 42(7):630-6. doi:
10.1016/j.nucmedbio.2015.03.009. [PMID: 25910857] - Paul P Lerner, Chanoch Miodownik, Vladimir Lerner. Tardive dyskinesia (syndrome): Current concept and modern approaches to its management.
Psychiatry and clinical neurosciences.
2015 Jun; 69(6):321-34. doi:
10.1111/pcn.12270. [PMID: 25556809] - Francisco Molinet-Dronda, Belén Gago, Ana Quiroga-Varela, Carlos Juri, María Collantes, Mercedes Delgado, Elena Prieto, Margarita Ecay, Elena Iglesias, Concepció Marín, Iván Peñuelas, José A Obeso. Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study.
Neurobiology of disease.
2015 May; 77(?):165-72. doi:
10.1016/j.nbd.2015.01.007. [PMID: 25681534] - Aifang Deng, Xianying Wu, Xue Zhou, Yan Zhang, Wei Yin, Jinping Qiao, Lin Zhu. Mapping the target localization and biodistribution of non-radiolabeled VMAT2 ligands in rat brain.
The AAPS journal.
2014 May; 16(3):592-9. doi:
10.1208/s12248-014-9584-9. [PMID: 24706374] - Surbhi Gupta, Bhupesh Sharma. Pharmacological benefit of I(1)-imidazoline receptors activation and nuclear factor kappa-B (NF-κB) modulation in experimental Huntington's disease.
Brain research bulletin.
2014 Mar; 102(?):57-68. doi:
10.1016/j.brainresbull.2014.02.007. [PMID: 24582883] - Chung Chan, Xiao Jin, Edward K Fung, Mika Naganawa, Tim Mulnix, Richard E Carson, Chi Liu. Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation.
Medical physics.
2013 Nov; 40(11):112507. doi:
10.1118/1.4826165. [PMID: 24320466] - Venkata Ramu Derangula, Nageswara Rao Pilli, Siva Kumar Nadavala, Vinayender Adireddy, Jaswanth Kumar Inamadugu, Venkateswarlu Ponneri. Liquid chromatography-tandem mass spectrometric assay for the determination of tetrabenazine and its active metabolites in human plasma: a pharmacokinetic study.
Biomedical chromatography : BMC.
2013 Jun; 27(6):792-801. doi:
10.1002/bmc.2862. [PMID: 23339053] - Ryuji Nakao, Christer Halldin. 'Mixed' anionic and non-ionic micellar liquid chromatography for high-speed radiometabolite analysis of positron emission tomography radioligands.
Journal of chromatography. A.
2013 Mar; 1281(?):54-9. doi:
10.1016/j.chroma.2013.01.071. [PMID: 23399000] - Norman Simpson, Antonella Maffei, Matthew Freeby, Steven Burroughs, Zachary Freyberg, Jonathan Javitch, Rudolph L Leibel, Paul E Harris. Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.
Molecular endocrinology (Baltimore, Md.).
2012 Oct; 26(10):1757-72. doi:
10.1210/me.2012-1101. [PMID: 22915827] - Alison I Bernstein, Kristen A Stout, Gary W Miller. A fluorescent-based assay for live cell, spatially resolved assessment of vesicular monoamine transporter 2-mediated neurotransmitter transport.
Journal of neuroscience methods.
2012 Aug; 209(2):357-66. doi:
10.1016/j.jneumeth.2012.06.002. [PMID: 22698664] - Carlos Singer. Comprehensive treatment of Huntington disease and other choreic disorders.
Cleveland Clinic journal of medicine.
2012 Jul; 79 Suppl 2(?):S30-4. doi:
10.3949/ccjm.79.s2a.06. [PMID: 22761268] - Marc D Normandin, Kitt F Petersen, Yu-Shin Ding, Shu-Fei Lin, Sarita Naik, Krista Fowles, Daniel M Skovronsky, Kevan C Herold, Timothy J McCarthy, Roberto A Calle, Richard E Carson, Judith L Treadway, Gary W Cline. In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 Jun; 53(6):908-16. doi:
10.2967/jnumed.111.100545. [PMID: 22573821] - Catarina A Owesson-White, Mitchell F Roitman, Leslie A Sombers, Anna M Belle, Richard B Keithley, Jessica L Peele, Regina M Carelli, R Mark Wightman. Sources contributing to the average extracellular concentration of dopamine in the nucleus accumbens.
Journal of neurochemistry.
2012 Apr; 121(2):252-62. doi:
10.1111/j.1471-4159.2012.07677.x. [PMID: 22296263] - Erik G Puffenberger, Robert N Jinks, Carrie Sougnez, Kristian Cibulskis, Rebecca A Willert, Nathan P Achilly, Ryan P Cassidy, Christopher J Fiorentini, Kory F Heiken, Johnny J Lawrence, Molly H Mahoney, Christopher J Miller, Devika T Nair, Kristin A Politi, Kimberly N Worcester, Roni A Setton, Rosa Dipiazza, Eric A Sherman, James T Eastman, Christopher Francklyn, Susan Robey-Bond, Nicholas L Rider, Stacey Gabriel, D Holmes Morton, Kevin A Strauss. Genetic mapping and exome sequencing identify variants associated with five novel diseases.
PloS one.
2012; 7(1):e28936. doi:
10.1371/journal.pone.0028936. [PMID: 22279524] - LinLin Tian, Morvarid Karimi, Susan K Loftin, Chris A Brown, HuChuan Xia, JinBin Xu, Robert H Mach, Joel S Perlmutter. No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease.
PloS one.
2012; 7(2):e31439. doi:
10.1371/journal.pone.0031439. [PMID: 22359591] - Mélanie Bourque, Bin Liu, Dean E Dluzen, Thérèse Di Paolo. Sex differences in methamphetamine toxicity in mice: effect on brain dopamine signaling pathways.
Psychoneuroendocrinology.
2011 Aug; 36(7):955-69. doi:
10.1016/j.psyneuen.2010.12.007. [PMID: 21236583] - Boby Varkey Maramattom, Anu Jacob. N-methyl D-aspartate receptor encephalitis: A new addition to the spectrum of autoimmune encephalitis.
Annals of Indian Academy of Neurology.
2011 Jul; 14(3):153-7. doi:
10.4103/0972-2327.85872. [PMID: 22028524] - Raúl de la Fuente-Fernández, Michael Schulzer, Lisa Kuramoto, Jacquelyn Cragg, Nandhagopal Ramachandiran, Wing L Au, Edwin Mak, Jess McKenzie, Siobhan McCormick, Vesna Sossi, Thomas J Ruth, Chong S Lee, Donald B Calne, A Jon Stoessl. Age-specific progression of nigrostriatal dysfunction in Parkinson's disease.
Annals of neurology.
2011 May; 69(5):803-10. doi:
10.1002/ana.22284. [PMID: 21246604] - Xue Zhou, Jinping Qiao, Wei Yin, Lin Zhu, Hank F Kung. Study the effect of a pseudo-carrier on pharmacokinetics of 9-fluoropropyl-(+)-dihydrotetrabenazine in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Mar; 879(7-8):505-10. doi:
10.1016/j.jchromb.2011.01.011. [PMID: 21277842] - Y Simchon, A Weizman, M Rehavi. The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2010 Oct; 20(10):714-20. doi:
10.1016/j.euroneuro.2010.04.007. [PMID: 20493667] - Julie L Wang, Shunichi Oya, Ajit K Parhi, Brian P Lieberman, Karl Ploessl, Catherine Hou, Hank F Kung. In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease.
Nuclear medicine and biology.
2010 May; 37(4):479-86. doi:
10.1016/j.nucmedbio.2010.01.006. [PMID: 20447560] - André R Troiano, Michael Schulzer, Raul de la Fuente-Fernandez, Edwin Mak, Jess McKenzie, Vesna Sossi, Siobhan McCormick, Thomas J Ruth, A Jon Stoessl. Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function.
Synapse (New York, N.Y.).
2010 Feb; 64(2):146-51. doi:
10.1002/syn.20708. [PMID: 19852071] - Nobuyuki Okamura, Victor L Villemagne, John Drago, Svetlana Pejoska, Rajinder K Dhamija, Rachel S Mulligan, Julia R Ellis, Uwe Ackermann, Graeme O'Keefe, Gareth Jones, Hank F Kung, Michael J Pontecorvo, Daniel Skovronsky, Christopher C Rowe. In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2010 Feb; 51(2):223-8. doi:
10.2967/jnumed.109.070094. [PMID: 20080893] - Nicholas V Cozzi, Anupama Gopalakrishnan, Lyndsey L Anderson, Joel T Feih, Alexander T Shulgin, Paul F Daley, Arnold E Ruoho. Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.
Journal of neural transmission (Vienna, Austria : 1996).
2009 Dec; 116(12):1591-9. doi:
10.1007/s00702-009-0308-8. [PMID: 19756361] - Yu Shin Kim, Jung Hoon Shin, F Scott Hall, David J Linden. Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Jul; 29(26):8530-8. doi:
10.1523/jneurosci.0468-09.2009. [PMID: 19571144] - Trent J Volz, Sarah J Farnsworth, Glen R Hanson, Annette E Fleckenstein. Measurement of plasmalemmal dopamine transport, vesicular dopamine transport, and K(+)-stimulated dopamine release in frozen rat brain tissue.
Journal of neuroscience methods.
2009 Jun; 180(2):317-20. doi:
10.1016/j.jneumeth.2009.03.015. [PMID: 19464519] - R L Albin, R A Koeppe, K Wernette, W Zhuang, T Nichols, M R Kilbourn, K A Frey. Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome.
Neurology.
2009 Apr; 72(16):1390-6. doi:
10.1212/wnl.0b013e3181a187dd. [PMID: 19380698] - A R Troiano, R de la Fuente-Fernandez, V Sossi, M Schulzer, E Mak, T J Ruth, A J Stoessl. PET demonstrates reduced dopamine transporter expression in PD with dyskinesias.
Neurology.
2009 Apr; 72(14):1211-6. doi:
10.1212/01.wnl.0000338631.73211.56. [PMID: 19020294] - Robin Goland, Matthew Freeby, Ramin Parsey, Yoshifumi Saisho, Dileep Kumar, Norman Simpson, Joy Hirsch, Martin Prince, Antonella Maffei, J John Mann, Peter C Butler, Ronald Van Heertum, Rudolph L Leibel, Masanori Ichise, Paul E Harris. 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2009 Mar; 50(3):382-9. doi:
10.2967/jnumed.108.054866. [PMID: 19223416] - Tomás R Guilarte, Neal C Burton, Jennifer L McGlothan, Tatyana Verina, Yun Zhou, Mohab Alexander, Luu Pham, Michael Griswold, Dean F Wong, Tore Syversen, Jay S Schneider. Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism.
Journal of neurochemistry.
2008 Dec; 107(5):1236-47. doi:
10.1111/j.1471-4159.2008.05695.x. [PMID: 18808452] - Hank F Kung, Brian P Lieberman, Zhi-Ping Zhuang, Shunichi Oya, Mei-Ping Kung, Seok Rye Choi, Karl Poessl, Eric Blankemeyer, Catherine Hou, Daniel Skovronsky, Michael Kilbourn. In vivo imaging of vesicular monoamine transporter 2 in pancreas using an (18)F epoxide derivative of tetrabenazine.
Nuclear medicine and biology.
2008 Nov; 35(8):825-37. doi:
10.1016/j.nucmedbio.2008.08.004. [PMID: 19026944] - Anthony Raffo, Kolbe Hancock, Teresa Polito, Yuli Xie, Gordon Andan, Piotr Witkowski, Mark Hardy, Pasquale Barba, Caterina Ferrara, Antonella Maffei, Matthew Freeby, Robin Goland, Rudolph L Leibel, Ian R Sweet, Paul E Harris. Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.
The Journal of endocrinology.
2008 Jul; 198(1):41-9. doi:
10.1677/joe-07-0632. [PMID: 18577569] - Yoav Adam, Robert H Edwards, Shimon Schuldiner. Expression and function of the rat vesicular monoamine transporter 2.
American journal of physiology. Cell physiology.
2008 Apr; 294(4):C1004-11. doi:
10.1152/ajpcell.00348.2007. [PMID: 18287335] - Joanna S Fowler, Carsten Kroll, Richard Ferrieri, David Alexoff, Jean Logan, Stephen L Dewey, Wynne Schiffer, David Schlyer, Pauline Carter, Payton King, Colleen Shea, Youwen Xu, Lisa Muench, Helene Benveniste, Paul Vaska, Nora D Volkow. PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Oct; 48(10):1724-32. doi:
10.2967/jnumed.107.040279. [PMID: 17873134] - Jinghong Kou, Jeffrey R Bloomquist. Neurotoxicity in murine striatal dopaminergic pathways following long-term application of low doses of permethrin and MPTP.
Toxicology letters.
2007 Jul; 171(3):154-61. doi:
10.1016/j.toxlet.2007.05.005. [PMID: 17597311] - C C Sánchez-Mateo, C X Bonkanka, B Prado, R M Rabanal. Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice.
Journal of ethnopharmacology.
2007 May; 112(1):115-21. doi:
10.1016/j.jep.2007.02.019. [PMID: 17383128] - Agnès Maurel, Odile Spreux-Varoquaux, Francesco Amenta, Seyed Khosrow Tayebati, Daniele Tomassoni, Marie-Hélène Seguelas, Angelo Parini, Nathalie Pizzinat. Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1592-8. doi:
10.1152/ajprenal.00514.2006. [PMID: 17244889] - Carrie E John, Sara R Jones. Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice.
Neurochemistry international.
2006 Dec; 49(8):737-45. doi:
10.1016/j.neuint.2006.06.004. [PMID: 16901588] - John R Adams, Hinke van Netten, Michael Schulzer, Edwin Mak, Jessamyn Mckenzie, Audrey Strongosky, Vesna Sossi, Thomas J Ruth, Chong S Lee, Matthew Farrer, Thomas Gasser, Ryan J Uitti, Donald B Calne, Zbigniew K Wszolek, A Jon Stoessl. PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.
Brain : a journal of neurology.
2005 Dec; 128(Pt 12):2777-85. doi:
10.1093/brain/awh607. [PMID: 16081470] - C C Sánchez-Mateo, C X Bonkanka, B Prado, R M Rabanal. Antidepressant properties of some Hypericum canariense L. and Hypericum glandulosum Ait. extracts in the forced swimming test in mice.
Journal of ethnopharmacology.
2005 Mar; 97(3):541-7. doi:
10.1016/j.jep.2004.12.019. [PMID: 15740893] - Antonella Maffei, Zhuoru Liu, Piotr Witkowski, Federica Moschella, Giovanna Del Pozzo, Eric Liu, Kevan Herold, Robert J Winchester, Mark A Hardy, Paul E Harris. Identification of tissue-restricted transcripts in human islets.
Endocrinology.
2004 Oct; 145(10):4513-21. doi:
10.1210/en.2004-0691. [PMID: 15231694] - Dennis K Miller, Peter A Crooks, Guangrong Zheng, Vladimir P Grinevich, Seth D Norrholm, Linda P Dwoskin. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
The Journal of pharmacology and experimental therapeutics.
2004 Sep; 310(3):1035-45. doi:
10.1124/jpet.104.068098. [PMID: 15121762] - Michael R Kilbourn, Elyse S Kemmerer, Timothy J Desmond, Philip S Sherman, Kirk A Frey. Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain.
Experimental neurology.
2004 Aug; 188(2):387-90. doi:
10.1016/j.expneurol.2004.05.001. [PMID: 15246838] - Michael R Kilbourn. Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain.
Nuclear medicine and biology.
2004 Jul; 31(5):591-5. doi:
10.1016/j.nucmedbio.2004.02.003. [PMID: 15219277] - Janet Whitley, Jessica Parsons, Jeffrey Freeman, Yongjian Liu, Robert H Edwards, Joseph A Near. Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes.
Journal of neuroscience methods.
2004 Feb; 133(1-2):191-9. doi:
10.1016/j.jneumeth.2003.10.010. [PMID: 14757360] - D J Brooks, K A Frey, K L Marek, D Oakes, D Paty, R Prentice, C W Shults, A J Stoessl. Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease.
Experimental neurology.
2003 Nov; 184 Suppl 1(?):S68-79. doi:
10.1016/j.expneurol.2003.08.008. [PMID: 14597329] - Boris Mlinar, Renato Corradetti. Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons.
The European journal of neuroscience.
2003 Sep; 18(6):1559-71. doi:
10.1046/j.1460-9568.2003.02884.x. [PMID: 14511335] - R L Albin, R A Koeppe, N I Bohnen, T E Nichols, P Meyer, K Wernette, S Minoshima, M R Kilbourn, K A Frey. Increased ventral striatal monoaminergic innervation in Tourette syndrome.
Neurology.
2003 Aug; 61(3):310-5. doi:
10.1212/01.wnl.0000076181.39162.fc. [PMID: 12913189] - Begoña Prado, Rosa M Rabanal, Candelaria C Sánchez-Mateo. Evaluation of the central properties of several Hypericum species from the Canary Islands.
Phytotherapy research : PTR.
2002 Dec; 16(8):740-4. doi:
10.1002/ptr.1060. [PMID: 12458477] - A Ekue, J-F Boulanger, M Morissette, T Di Paolo. Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice.
Journal of neuroendocrinology.
2002 Sep; 14(9):731-6. doi:
10.1046/j.1365-2826.2002.00833.x. [PMID: 12213134] - Michael R Kilbourn, Phillip S Sherman, Kyle Kuszpit. In vivo measures of dopaminergic radioligands in the rat brain: equilibrium infusion studies.
Synapse (New York, N.Y.).
2002 Mar; 43(3):188-94. doi:
10.1002/syn.10039. [PMID: 11793424] - J Paul Hansen, Evan L Riddle, Verónica Sandoval, Jeffrey M Brown, James W Gibb, Glen R Hanson, Annette E Fleckenstein. Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity.
The Journal of pharmacology and experimental therapeutics.
2002 Mar; 300(3):1093-100. doi:
10.1124/jpet.300.3.1093. [PMID: 11861820] - C C Sánchez-Mateo, B Prado, R M Rabanal. Antidepressant effects of the methanol extract of several Hypericum species from the Canary Islands.
Journal of ethnopharmacology.
2002 Jan; 79(1):119-27. doi:
10.1016/s0378-8741(01)00393-2. [PMID: 11744305] - M Zucker, A Weizman, M Rehavi. Characterization of high-affinity [3H]TBZOH binding to the human platelet vesicular monoamine transporter.
Life sciences.
2001 Sep; 69(19):2311-7. doi:
10.1016/s0024-3205(01)01301-7. [PMID: 11669473] - M Suzuki, T J Desmond, R L Albin, K A Frey. Vesicular neurotransmitter transporters in Huntington's disease: initial observations and comparison with traditional synaptic markers.
Synapse (New York, N.Y.).
2001 Sep; 41(4):329-36. doi:
10.1002/syn.1089. [PMID: 11494403] - L Naudon, I Leroux-Nicollet, D Boulay, J Costentin. Decreased densities of dopamine and serotonin transporters and of vesicular monoamine transporter 2 in severely kainic acid lesioned subregions of the striatum.
Journal of neural transmission (Vienna, Austria : 1996).
2001; 108(4):431-44. doi:
10.1007/s007020170064. [PMID: 11475010] - J Hilton, F Yokoi, R F Dannals, H T Ravert, Z Szabo, D F Wong. Column-switching HPLC for the analysis of plasma in PET imaging studies.
Nuclear medicine and biology.
2000 Aug; 27(6):627-30. doi:
10.1016/s0969-8051(00)00125-6. [PMID: 11056380] - N I Bohnen, R A Koeppe, P Meyer, E Ficaro, K Wernette, M R Kilbourn, D E Kuhl, K A Frey, R L Albin. Decreased striatal monoaminergic terminals in Huntington disease.
Neurology.
2000 May; 54(9):1753-9. doi:
10.1212/wnl.54.9.1753. [PMID: 10802780] - C S Lee, A Samii, V Sossi, T J Ruth, M Schulzer, J E Holden, J Wudel, P K Pal, R de la Fuente-Fernandez, D B Calne, A J Stoessl. In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease.
Annals of neurology.
2000 Apr; 47(4):493-503. doi:
. [PMID: 10762161] - V Sossi, J E Holden, G Chan, M Krzywinski, A J Stoessl, T J Ruth. Analysis of four dopaminergic tracers kinetics using two different tissue input function methods.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2000 Apr; 20(4):653-60. doi:
10.1097/00004647-200004000-00002. [PMID: 10779009] - M R Kilbourn, K Kuszpit, P Sherman. Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice.
Synapse (New York, N.Y.).
2000 Mar; 35(4):250-5. doi:
10.1002/(sici)1098-2396(20000315)35:4<250::aid-syn2>3.0.co;2-s. [PMID: 10657034] - R A Koeppe, K A Frey, D E Kuhl, M R Kilbourn. Assessment of extrastriatal vesicular monoamine transporter binding site density using stereoisomers of [11C]dihydrotetrabenazine.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1999 Dec; 19(12):1376-84. doi:
10.1097/00004647-199912000-00011. [PMID: 10598942] - G L Chan, J E Holden, A J Stoessl, A Samii, D J Doudet, T Dobko, K S Morrison, M Adam, M Schulzer, D B Calne, T J Ruth. Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999 Feb; 40(2):283-9. doi:
NULL. [PMID: 10025836] - M Rehavi, M Goldin, N Roz, A Weizman. Regulation of rat brain vesicular monoamine transporter by chronic treatment with ovarian hormones.
Brain research. Molecular brain research.
1998 Jun; 57(1):31-7. doi:
10.1016/s0169-328x(98)00058-8. [PMID: 9630494] - S R Jones, R R Gainetdinov, R M Wightman, M G Caron. Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998 Mar; 18(6):1979-86. doi:
. [PMID: 9482784] - K Frey, M Kilbourn, T Robinson. Reduced striatal vesicular monoamine transporters after neurotoxic but not after behaviorally-sensitizing doses of methamphetamine.
European journal of pharmacology.
1997 Sep; 334(2-3):273-9. doi:
10.1016/s0014-2999(97)01152-7. [PMID: 9369358] - R A Koeppe, K A Frey, A Kume, R Albin, M R Kilbourn, D E Kuhl. Equilibrium versus compartmental analysis for assessment of the vesicular monoamine transporter using (+)-alpha-[11C]dihydrotetrabenazine (DTBZ) and positron emission tomography.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1997 Sep; 17(9):919-31. doi:
10.1097/00004647-199709000-00001. [PMID: 9307605] - S J Kish, M Guttman, Y Robitaille, M el-Awar, L J Chang, A I Levey. Striatal dopamine nerve terminal markers but not nigral cellularity are reduced in spinocerebellar ataxia type 1.
Neurology.
1997 Apr; 48(4):1109-11. doi:
10.1212/wnl.48.4.1109. [PMID: 9109912] - K A Frey, R A Koeppe, M R Kilbourn, T M Vander Borght, R L Albin, S Gilman, D E Kuhl. Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging.
Annals of neurology.
1996 Dec; 40(6):873-84. doi:
10.1002/ana.410400609. [PMID: 9007092] - J M Wilson, S J Kish. The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1996 May; 16(10):3507-10. doi:
10.1523/jneurosci.16-10-03507.1996. [PMID: 8627383] - C P Smith, A T Woods-Kettelberger, R Corbett, S M Chesson, G M Bores, W W Petko, J E Roehr, S Kongsamut. Serotonergic activity of HP 184: does spontaneous release have a role?.
Neurochemical research.
1996 May; 21(5):575-83. doi:
10.1007/bf02527756. [PMID: 8726966] - T Vander Borght, M Kilbourn, T Desmond, D Kuhl, K Frey. The vesicular monoamine transporter is not regulated by dopaminergic drug treatments.
European journal of pharmacology.
1995 Dec; 294(2-3):577-83. doi:
10.1016/0014-2999(95)00594-3. [PMID: 8750721] - T M Vander Borght, M R Kilbourn, R A Koeppe, J N DaSilva, J E Carey, D E Kuhl, K A Frey. In vivo imaging of the brain vesicular monoamine transporter.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1995 Dec; 36(12):2252-60. doi:
NULL. [PMID: 8523116] - A J Tanra, A Kagaya, Y Okamoto, M Muraoka, N Motohashi, S Yamawaki. TJS-010, a new prescription of oriental medicine, antagonizes tetrabenazine-induced suppression of spontaneous locomotor activity in rats.
Progress in neuro-psychopharmacology & biological psychiatry.
1995 Sep; 19(5):963-71. doi:
10.1016/0278-5846(95)00124-e. [PMID: 8539432] - I Leroux-Nicollet, J Costentin. Comparison of the subregional distributions of the monoamine vesicular transporter and dopamine uptake complex in the rat striatum and changes during aging.
Journal of neural transmission. General section.
1994; 97(2):93-106. doi:
10.1007/bf01277946. [PMID: 7873127] - A Subarnas, T Tadano, Y Oshima, K Kisara, Y Ohizumi. Pharmacological properties of beta-amyrin palmitate, a novel centrally acting compound, isolated from Lobelia inflata leaves.
The Journal of pharmacy and pharmacology.
1993 Jun; 45(6):545-50. doi:
10.1111/j.2042-7158.1993.tb05596.x. [PMID: 8103103] - A Subarnas, T Tadano, N Nakahata, Y Arai, H Kinemuchi, Y Oshima, K Kisara, Y Ohizumi. A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test.
Life sciences.
1993; 52(3):289-96. doi:
10.1016/0024-3205(93)90220-w. [PMID: 8423710] - C Desnos, M P Laran, D Scherman. Regulation of the chromaffin granule catecholamine transporter in cultured bovine adrenal medullary cells: stimulus-biosynthesis coupling.
Journal of neurochemistry.
1992 Dec; 59(6):2105-12. doi:
10.1111/j.1471-4159.1992.tb10101.x. [PMID: 1279122]