Trachelogenin (BioDeep_00000008387)
Secondary id: BioDeep_00000228503
PANOMIX_OTCML-2023 natural product
代谢物信息卡片
化学式: C21H24O7 (388.1522)
中文名称: 络石苷元
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 79.59%
分子结构信息
SMILES: COC1=C(C=C(C=C1)CC2COC(=O)C2(CC3=CC(=C(C=C3)O)OC)O)OC
InChI: InChI=1S/C21H24O7/c1-25-17-7-5-13(9-19(17)27-3)8-15-12-28-20(23)21(15,24)11-14-4-6-16(22)18(10-14)26-2/h4-7,9-10,15,22,24H,8,11-12H2,1-3H3/t15-,21-/m0/s1
描述信息
Trachelogenin is a lignan.
Trachelogenin is a natural product found in Volutaria tubuliflora, Ipomoea cairica, and other organisms with data available.
同义名列表
13 个代谢物同义名
2(3H)-FURANONE, 4-((3,4-DIMETHOXYPHENYL)METHYL)DIHYDRO-3-HYDROXY-3-((4-HYDROXY-3-METHOXYPHENYL)METHYL)-, (3S-CIS)-; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-hydroxy-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3S,4S)-; 2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-hydroxy-3-[(4-hydroxy-3-methoxyphenyl)methyl]-, (3S,4S)-; (3S,4S)-4-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-3-[(4-hydroxy-3-methoxy-phenyl)methyl]tetrahydrofuran-2-one; (3S,4S)-4-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one; 2(3H)-Furanone, dihydro-3-hydroxy-3-vanillyl-4-veratryl-; TRACHELOGENIN, (-)-; (-)-Trachelogenin; Trachelogenin; MEGxp0_001798; ACon1_002414; NSC659371; Trachelogenin
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:9647
- KEGG: C10891
- PubChem: 452855
- Metlin: METLIN68661
- ChEMBL: CHEMBL491178
- MeSH: trachelogenin
- ChemIDplus: 0034209693
- KNApSAcK: C00000600
- CAS: 34209-69-3
- medchemexpress: HY-N7934
- PMhub: MS000022003
- PubChem: 13074
- 3DMET: B04195
- NIKKAJI: J512.147G
- KNApSAcK: 9647
- LOTUS: LTS0192696
- wikidata: Q105347840
- LOTUS: LTS0098422
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
48 个相关的物种来源信息
- 4056 - Apocynaceae: LTS0098422
- 4210 - Asteraceae: LTS0098422
- 4118 - Convolvulaceae: LTS0098422
- 2759 - Eukaryota: LTS0098422
- 3977 - Euphorbiaceae: LTS0098422
- 316688 - Glycydendron: LTS0098422
- 316689 - Glycydendron amazonicum: 10.1021/NP50087A022
- 316689 - Glycydendron amazonicum: LTS0098422
- 4119 - Ipomoea: LTS0098422
- 129201 - Ipomoea cairica:
- 129201 -
Ipomoea cairica:
10.1002/(SICI)1099-1573(1998)12:1+
- 129201 - Ipomoea cairica: 10.1016/S0031-9422(99)00304-0
- 129201 - Ipomoea cairica: 10.1590/S0103-50531997000300009
- 129201 - Ipomoea cairica: LTS0098422
- 3398 - Magnoliopsida: LTS0098422
- 145818 - Mantisalca: LTS0098422
- 145819 - Mantisalca salmantica: 10.1016/0031-9422(93)85349-V
- 145819 - Mantisalca salmantica: LTS0098422
- 6381 - Oligochaeta: LTS0098422
- 75642 - Oligochaeta divaricata: 10.15228/2012.V02.I01.P04
- 75642 - Oligochaeta divaricata: LTS0098422
- 58019 - Pinopsida: LTS0098422
- 362626 - Rhaponticum: LTS0098422
- 362630 - Rhaponticum carthamoides: 10.1135/CCCC20070334
- 41629 - Saussurea: LTS0098422
- 446849 - Saussurea salicifolia: 10.1016/0031-9422(88)80612-5
- 446849 - Saussurea salicifolia: LTS0098422
- 35493 - Streptophyta: LTS0098422
- 25623 - Taxaceae: LTS0098422
- 50188 - Torreya: 10.1016/S0021-9673(99)00050-3
- 50188 - Torreya: LTS0098422
- 147277 - Torreya jackii: 10.1016/S0021-9673(99)00050-3
- 69388 - Trachelospermum: LTS0098422
- 276781 - Trachelospermum asiaticum: 10.1248/CPB.20.2075
- 276781 - Trachelospermum asiaticum: LTS0098422
- 429296 - Trachelospermum axillare: 10.1016/0031-9422(93)85183-R
- 429296 - Trachelospermum axillare: LTS0098422
- 69389 - Trachelospermum jasminoides: 10.1055/S-2005-837761
- 69389 - Trachelospermum jasminoides: LTS0098422
- 58023 - Tracheophyta: LTS0098422
- 33090 - Viridiplantae: LTS0098422
- 3602 - Vitaceae: LTS0098422
- 3603 - Vitis: LTS0098422
- 29760 - Vitis vinifera: 10.1016/S0308-8146(03)00222-X
- 29760 - Vitis vinifera: LTS0098422
- 41662 - Volutaria: LTS0098422
- 1284450 - Volutaria tubuliflora: 10.1016/0031-9422(90)85370-U
- 1284450 - Volutaria tubuliflora: LTS0098422
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Peter Kiplangʼat Koech, Gergely Jócsák, Imre Boldizsár, Kinga Moldován, Sándor Borbély, Ildikó Világi, Arpád Dobolyi, Petra Varró. Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin - An ex vivo Study on Rat Brain Slices.
Planta medica.
2023 Feb; ?(?):. doi:
10.1055/a-2005-5497. [PMID: 36592636] - A F Moura, K S B Lima, T S Sousa, J D B Marinho-Filho, C Pessoa, E R Silveira, O D L Pessoa, L V Costa-Lotufo, M O Moraes, A J Araújo. In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2018 Mar; 47(?):129-136. doi:
10.1016/j.tiv.2017.11.014. [PMID: 29174024] - Xi-Jing Qian, Yong-Sheng Jin, Hai-Sheng Chen, Qing-Qiang Xu, Hao Ren, Shi-Ying Zhu, Hai-Lin Tang, Yan Wang, Ping Zhao, Zhong-Tian Qi, Yong-Zhe Zhu. Trachelogenin, a novel inhibitor of hepatitis C virus entry through CD81.
The Journal of general virology.
2016 05; 97(5):1134-1144. doi:
10.1099/jgv.0.000432. [PMID: 26879209] - Zsolt Mervai, Anna Sólyomváry, Gergő Tóth, Béla Noszál, Ibolya Molnár-Perl, Kornélia Baghy, Ilona Kovalszky, Imre Boldizsár. Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line.
Fitoterapia.
2015 Jan; 100(?):19-26. doi:
10.1016/j.fitote.2014.10.017. [PMID: 25447161] - Hee Soon Shin, Min-Jung Bae, Sun Young Jung, Hye-Jeong See, Yun Tai Kim, Jeong-Ryong Do, Su Yeon Back, Sang-Won Choi, Dong-Hwa Shon. Enhancing Effect of Trachelogenin from Trachelospermi caulis Extract on Intestinal Barrier Function.
Biological & pharmaceutical bulletin.
2015; 38(11):1707-13. doi:
10.1248/bpb.b15-00332. [PMID: 26268064] - Xiao-Ting Liu, Zhe-Xing Wang, Yu Yang, Lin Wang, Ruo-Feng Sun, Yi-Min Zhao, Neng-Jiang Yu. Active components with inhibitory activities on IFN-γ/STAT1 and IL-6/STAT3 signaling pathways from Caulis Trachelospermi.
Molecules (Basel, Switzerland).
2014 Aug; 19(8):11560-71. doi:
10.3390/molecules190811560. [PMID: 25100250] - Anna Sólyomváry, Zsolt Mervai, Ibolya Molnár-Perl, Imre Boldizsár. Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC.
Natural product research.
2014; 28(10):732-9. doi:
10.1080/14786419.2013.879473. [PMID: 24483775] - Susanne Kuehnl, Sebastian Schroecksnadel, Veronika Temml, Johanna M Gostner, Harald Schennach, Daniela Schuster, Stefan Schwaiger, Judith M Rollinger, Dietmar Fuchs, Hermann Stuppner. Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Oct; 20(13):1190-5. doi:
10.1016/j.phymed.2013.06.006. [PMID: 23867649] - Li Li, Fanhua Meng, Jifen Guo, Lu Sun, Nengjiang Yu, Yimin Zhao. Simultaneous quantification of tracheloside and trachelogenin in rat plasma using liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 May; 879(15-16):1033-7. doi:
10.1016/j.jchromb.2011.02.021. [PMID: 21482203]
