p-Anisic acid (BioDeep_00000000837)

Secondary id: BioDeep_00000405415, BioDeep_00000863719

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs

代谢物信息卡片

4-Methoxy-benzoic Acid; 4-Anisic acid; Anisic acid pound>>p-Anisic acid pound>>p-Methoxybenzoic acid

化学式: C8H8O3 (152.0473418)
中文名称: 对甲氧基苯甲酸
谱图信息: 最多检出来源 Viridiplantae(plant) 0.49%

分子结构信息

SMILES: c1c(ccc(c1)C(=O)O)OC
InChI: InChI=1S/C8H8O3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10)

描述信息

p-Anisic acid, also known as 4-anisate or draconic acid, belongs to the class of organic compounds known as p-methoxybenzoic acids and derivatives. These are benzoic acids in which the hydrogen atom at position 4 of the benzene ring is replaced by a methoxy group. p-Anisic acid is a drug. p-Anisic acid exists in all eukaryotes, ranging from yeast to humans. p-Anisic acid is a faint, sweet, and cadaverous tasting compound. Outside of the human body, p-anisic acid has been detected, but not quantified in several different foods, such as anises, cocoa beans, fennels, and german camomiles. This could make p-anisic acid a potential biomarker for the consumption of these foods. It is a white crystalline solid which is insoluble in water, highly soluble in alcohols and soluble in ether, and ethyl acetate. p-Anisic acid has antiseptic properties. It is also used as an intermediate in the preparation of more complex organic compounds. It is generally obtained by the oxidation of anethole or p-methoxyacetophenone. The term "anisic acid" often refers to this form specifically. p-Anisic acid is found naturally in anise.
4-methoxybenzoic acid is a methoxybenzoic acid substituted with a methoxy group at position C-4. It has a role as a plant metabolite. It is functionally related to a benzoic acid. It is a conjugate acid of a 4-methoxybenzoate.
4-Methoxybenzoic acid is a natural product found in Chaenomeles speciosa, Annona purpurea, and other organisms with data available.
Anisic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
See also: Stevia rebaudiuna Leaf (part of).
Flavouring agent. Food additive listed in the EAFUS Food Additive Database (Jan. 2001)
A methoxybenzoic acid substituted with a methoxy group at position C-4.
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
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SARS
KEIO_ID A154
p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[1].
p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[1].

同义名列表

52 个代谢物同义名

4-Methoxy-benzoic Acid; 4-Anisic acid; Anisic acid pound>>p-Anisic acid pound>>p-Methoxybenzoic acid; 4-Methoxybenzoic acid, certified reference material, TraceCERT(R); InChI=1/C8H8O3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10; p-Anisic acid, Vetec(TM) reagent grade, 98\\%; 4-10-00-00346 (Beilstein Handbook Reference); 4-Methoxybenzoic acid, ReagentPlus(R), 99\\%; 4-Methoxybenzoic acid;Draconic acid; Kyselina 4-methoxybenzoova [Czech]; p-Anisic acid, analytical standard; p-Anisic acid, natural, 99\\%, FG; 4-Anisic acid, copper (+2) salt; 4-Anisic acid, potassium salt; 4-METHOXYBENZOIC ACID [FHFI]; Kyselina 4-methoxybenzoova; 4-Anisic acid, 14C-carboxy; 4-Anisic acid, sodium salt; 4-(methyloxy)benzoic acid; p-Anisic acid, >=99\\%, FG; Benzoic acid, 4-methoxy-; paramethoxy benzoic acid; 4-(methoxy)benzoic acid; 4-methoxy-benzoic acid; 4-Methoxy benzoic acid; 4-methoxylbenzoic acid; Benzoic acid, methoxy-; P-Methoxy Benzoic Acid; 4-methoxybenzoic acid; p-Methoxybenzoic acid; Anisic acid, p-isomer; P-ANISIC ACID [INCI]; Methoxybenzoic acid; P-ANISIC ACID [MI]; p-methoxybenzoate; 4-Methoxybenzoate; ANISIC ACID, PARA; para-anisic acid; UNII-4SB6Y7DMM3; NCIOpen2_004706; P-ANISIC ACID,; 4-Anisic acid; Draconic acid; p-Anisic acid; anisoic acid; ANISIC ACID; 4SB6Y7DMM3; p-anisate; 4-Anisate; Draconate; AI3-00893; Anisate; 1sv3; ANN

数据库引用编号

30 个数据库交叉引用编号

ChEBI: CHEBI:40813
KEGG: C02519
PubChem: 7478
HMDB: HMDB0001101
Metlin: METLIN58021
DrugBank: DB02795
ChEMBL: CHEMBL21932
Wikipedia: P-Anisic_acid
MeSH: 4-methoxybenzoic acid
ChemIDplus: 0000100094
MetaCyc: CPD-1076
KNApSAcK: C00029536
foodb: FDB010587
chemspider: 10181338
CAS: 73424-02-9
CAS: 1335-08-6
CAS: 100-09-4
MoNA: KO000257
MoNA: KO000254
MoNA: KO000256
MoNA: KO000253
MoNA: KO000255
medchemexpress: HY-N1394
PMhub: MS000006850
MetaboLights: MTBLC40813
ChEBI: CHEBI:16639
PubChem: 5529
PDB-CCD: ANN
NIKKAJI: J3.229H
RefMet: Methoxybenzoic acid

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

63 个相关的物种来源信息

219065 - Aconitum forrestii: 10.4268/CJCMM20120916
68527 - Aegle marmelos: 10.1080/14786410310001608037
1209451 - Anaphalis busua: 10.1016/0031-9422(82)80062-9
663965 - Anastatica hierochuntica:
165353 - Angelica sinensis (Oliv.)Diels: -
1123437 - Annona purpurea:
65558 - Capparis spinosa: 10.1016/S0378-8741(98)00229-3
36622 - Chaenomeles Sinensis (Thouin) Koehne: -
106546 - Chaenomeles speciosa: 10.1080/10412905.1994.9698331
1208297 - Colchicum bornmuelleri: 10.1016/0031-9422(90)87143-I
13445 - Colchicum speciosum: 10.1016/0031-9422(90)87143-I
589831 - Cota palaestina: 10.1021/NP9004129
1851000 - Cotoneaster orbicularis: 10.1016/S0031-9422(99)00598-1
456977 - Cyathobasis fruticulosa: 10.1021/NP0580006
2783874 - Daphne mucronata: 10.1016/S0367-326X(99)00010-6
1333886 - Euphorbia aleppica: 10.1016/0031-9422(95)00889-6
1514050 - Ferula sinaica: 10.1016/S0031-9422(98)00489-0
309328 - Ficus mucuso: 10.1021/NP100896W
429701 - Handroanthus impetiginosus:
9606 - Homo sapiens: -
124778 - Illicium verum:
124778 - Illicium verum Hook.f.: -
161756 - Isatis tinctoria: 10.1055/S-2006-958019
2338863 - Kalanchoe deficiens: 10.1016/J.TET.2008.01.090
2116407 - Kali collina: 10.1007/S10600-011-9896-2
2116407 - Kali collinum: 10.1007/S10600-011-9896-2
1310066 - Lagotis yunnanensis:
640809 - Lysionotus denticulosus: 10.1007/978-3-7091-1084-3_4
145754 - Malva sylvestris: 10.1016/J.PHYTOCHEM.2005.11.023
3673 - Momordica charantia:
5098 - Monascus purpureus: 10.1016/J.PHYTOL.2011.08.003
4432 - Nelumbo nucifera: 10.1248/CPB.59.947
2803928 - Neolitsea acuminatissima: 10.1021/NP010236W
1609885 - Neolitsea hiiranensis: 10.1016/J.PHYTOCHEM.2011.01.006
1616377 - Nymphaea nouchali var. caerulea: 10.1016/J.PHYTOCHEM.2008.04.009
72228 - Ophiocordyceps sinensis: 10.1021/NP100902F
183063 - Parthenium hysterophorus:
451078 - Pentagramma triangularis: 10.1016/S0031-9422(96)00597-3
2045269 - Peperomia heyneana: 10.1021/NP070089N
271192 - Pimpinella anisum: 10.1007/BF00629778
130377 - Piper aduncum: 10.1016/J.PHYTOCHEM.2009.03.010
405316 - Piper aequale: 10.1016/J.PHYTOCHEM.2007.05.003
33090 - Plants: -
582575 - Polycarpa aurata: 10.1021/NP000570C
3696 - Populus deltoides: 10.1016/0021-9673(95)00585-B
55489 - Posidonia oceanica:
211592 - Pulicaria paludosa: 10.1021/NP50060A017
880079 - Rhododendron dauricum: 10.1016/J.JCHROMB.2004.06.048
49622 - Rhododendron ferrugineum: 10.1021/NP100778K
694325 - Rostrinucula dependens: 10.1016/J.FITOTE.2005.06.010
525237 - Salsola collina: 10.1007/S10600-011-9896-2
268885 - Salvia yangii: 10.1016/S0367-326X(01)00290-8
202097 - Scapholeberis mucronata: 10.1016/S0367-326X(99)00010-6
996406 - Soroseris hookeriana: 10.1055/S-2000-8607
85282 - Stemona japonica: 10.1002/HLCA.200790036
1603837 - Strobilanthes dimorphotricha: 10.1055/S-2005-873125
170733 - Taraxacum formosanum: 10.1248/CPB.53.853
90037 - Taraxacum mongolicum: 10.1248/CPB.53.853
3548 - Trianthema portulacastrum: 10.1016/S0031-9422(00)00270-3
13750 - Vaccinium macrocarpon: 10.1016/S0021-9673(00)01030-X
51239 - Vanilla planifolia: 10.1021/JF9606971
117957 - Vanilla pompona: 10.1080/10412905.1997.9700743
237933 - Viburnum dilatatum: 10.1016/0031-9422(95)00790-3

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Young H Seo, Shin-Young Kang, Ji-Sun Shin, Seung M Ryu, A Y Lee, Goya Choi, Byeong C Moon, Dae-Sik Jang, Sang H Shim, Dongho Lee, Kyung-Tae Lee, Jun Lee. Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages. Journal of natural products. 2019 12; 82(12):3379-3385. doi: 10.1021/acs.jnatprod.9b00697. [PMID: 31747281]
Manoj K Shivhare, P K Singour, P K Chaurasiya, Rajesh S Pawar. Trianthema portulacastrum Linn. (Bishkhapra). Pharmacognosy reviews. 2012 Jul; 6(12):132-40. doi: 10.4103/0973-7847.99947. [PMID: 23055639]
Shaheen Faizi, Shahina Fayyaz, Samina Bano, Erum Yawar Iqbal, Lubna, Humaira Siddiqi, Aneela Naz. Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. Journal of agricultural and food chemistry. 2011 Sep; 59(17):9080-93. doi: 10.1021/jf201611b. [PMID: 21780738]
Atsuko Itoh, Tomomi Saitoh, Kaori Tani, Misaki Uchigaki, Yumi Sugimoto, Jun Yamada, Hiroshi Nakajima, Hideo Ohshiro, Schujian Sun, Takao Tanahashi. Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera. Chemical & pharmaceutical bulletin. 2011; 59(8):947-51. doi: 10.1248/cpb.59.947. [PMID: 21804237]
Christy E Manyi-Loh, Roland N Ndip, Anna M Clarke. Volatile compounds in honey: a review on their involvement in aroma, botanical origin determination and potential biomedical activities. International journal of molecular sciences. 2011; 12(12):9514-32. doi: 10.3390/ijms12129514. [PMID: 22272147]
Souichi Nakashima, Hisashi Matsuda, Yoshimi Oda, Seikou Nakamura, Fengming Xu, Masayuki Yoshikawa. Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic & medicinal chemistry. 2010 Mar; 18(6):2337-2345. doi: 10.1016/j.bmc.2010.01.046. [PMID: 20189399]
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Mahalingam Gayathri, Krishnan Kannabiran. 2-hydroxy 4-methoxy benzoic acid isolated from roots of Hemidesmus indicus ameliorates liver, kidney and pancreas injury due to streptozotocin-induced diabetes in rats. Indian journal of experimental biology. 2010 Feb; 48(2):159-64. doi: NULL. [PMID: 20455325]
Soumaya Kilani-Jaziri, Aicha Neffati, Ilef Limem, Jihed Boubaker, Ines Skandrani, Mohamed Ben Sghair, Ines Bouhlel, Wissem Bhouri, Anne Marie Mariotte, Kamel Ghedira, Marie-Genviève Dijoux Franca, Leila Chekir-Ghedira. Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells. Chemico-biological interactions. 2009 Sep; 181(1):85-94. doi: 10.1016/j.cbi.2009.04.014. [PMID: 19446539]
Li-Juan Yang, Yi-Ping Luo, Wen Chen, Jing-Feng Zhao, Xiao-Dong Yang, Liang Li. A novel norditerpenoid alkaloid from Aconitum macrorhynchum. Journal of Asian natural products research. 2009 Aug; 11(8):728-31. doi: 10.1080/10286020903029223. [PMID: 20183315]
Dae Sik Jang, Nam Hee Yoo, Yun Mi Lee, Jeong Lim Yoo, Young Sook Kim, Jin Sook Kim. Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase. Archives of pharmacal research. 2008 Jul; 31(7):900-4. doi: 10.1007/s12272-001-1244-z. [PMID: 18704333]
Virginia Claudia da Silva, Mário Geraldo de Carvalho, Aline Nogueira Alves. Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). Journal of natural medicines. 2008 Jul; 62(3):356-7. doi: 10.1007/s11418-008-0227-2. [PMID: 18404310]
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Nagendra Singh, Talat Jabeen, Aritra Pal, Sujata Sharma, Markus Perbandt, Christian Betzel, Tej P Singh. Crystal structures of the complexes of a group IIA phospholipase A2 with two natural anti-inflammatory agents, anisic acid, and atropine reveal a similar mode of binding. Proteins. 2006 Jul; 64(1):89-100. doi: 10.1002/prot.20970. [PMID: 16596639]
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