Cyclopamine (BioDeep_00000008324)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Spiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-octadecahydro-3,6,10,11b-tetramethyl-, (2R,3S,3R,3aS,6S,6aS,6bS,7aR,11aS,11bR)- (9CI)

化学式: C27H41NO2 (411.3137)
中文名称: 环杷明, 环巴胺, 11-去氧芥芬胺
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 23.27%

分子结构信息

SMILES: CC1=C2CC3C(CC=C4CC(O)CCC43C)C2CCC12OC1CC(C)CNC1C2C
InChI: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3

描述信息

Cyclopamine is a member of piperidines. It has a role as a glioma-associated oncogene inhibitor.
Cyclopamine is a natural product found in Veratrum grandiflorum, Veratrum dahuricum, and Veratrum californicum with data available.
Cyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents > D014704 - Veratrum Alkaloids
CONFIDENCE standard compound; INTERNAL_ID 654; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7995; ORIGINAL_PRECURSOR_SCAN_NO 7993
CONFIDENCE standard compound; INTERNAL_ID 654; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8002; ORIGINAL_PRECURSOR_SCAN_NO 8001
CONFIDENCE standard compound; INTERNAL_ID 654; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8041; ORIGINAL_PRECURSOR_SCAN_NO 8038
CONFIDENCE standard compound; INTERNAL_ID 654; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8047; ORIGINAL_PRECURSOR_SCAN_NO 8046
CONFIDENCE standard compound; INTERNAL_ID 654; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8048; ORIGINAL_PRECURSOR_SCAN_NO 8045
CONFIDENCE standard compound; INTERNAL_ID 654; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7958; ORIGINAL_PRECURSOR_SCAN_NO 7956
Data obtained from a cyclopamine standard purchased from Logan Natural Products, Logan, Utah USA.
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

同义名列表

34 个代谢物同义名

Spiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-octadecahydro-3,6,10,11b-tetramethyl-, (2R,3S,3R,3aS,6S,6aS,6bS,7aR,11aS,11bR)- (9CI); Spiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-octadecahydro-3,6,10,11b-tetramethyl-, (3S,3R,3aS,6S,6aS,6bS,7aR,9R,11aS,11bR)-; (2R,3S,3R,3aS,6S,6aS,6bS,7aR,11aS,11bR)-1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-Octadecahydro-3,6,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-3-ol; (2R,3S,3R,3aS,6aS,6bS,6S,7aR,11aS,11bR)-3,6,10,11b-tetramethyl-1,2,3,3a,4,4,5,6,6a,6b,6,7,7,7a,8,11,11a,11b-octadecahydro-3H-spiro[benzo[a]fluorene-9,2-furo[3,2-b]pyridin]-3-ol; Spiro(9H-benzo(a)fluorene-9,2-b)pyridin)-3-o l, 1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-octa deca hydro-3,6,10,11b-tetramethyl-, (2R,3S,3R,3aS,6S,6aS,6bS,7aR,11aS,11bR)-; (3alpha,8alpha,14beta,22S,23R)-17,23-epoxyveratraman-3-ol; Veratraman-3-ol, 17,23-epoxy-, (3-beta,23-beta)-; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; Veratraman-3-ol,23-epoxy-, (3-beta,23-beta)-; (3beta,22S,23R)-17,23-epoxyveratraman-3-ol; (3beta23R)-17,23-Epoxyveratraman-3-ol; QASFUMOKHFSJGL-LAFRSMQTSA-N; Cyclopamine Tartrate; CYCLOPAMINE [HSDB]; Jervine, 11-deoxo-; [3H]-Cyclopamine; CYCLOPAMINE [MI]; 11-Deoxojervine; 11-Deoxyjervine; Tox21_300632; Cyclopamine; C27H41NO2; CY8; Spiro(9H-benzo(a)fluorene-9,2(3H)-furo(3,2-b)pyridin)-3-o l, 1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-octa deca hydro-3,6,10,11b-tetramethyl-, (2R,3S,3R,3aS,6S,6aS,6bS,7aR,11aS,11bR)-; (3S,3R,3aS,6S,6aS,6bS,7aR,9R,11aS,11bR)-3,6,10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[i]fluorene-9,2-3a,4,5,6,7,7a-hexahydro-3H-furo[4,5-b]pyridine]-3-ol; (3S,3R,3aS,6S,6aS,6bS,7aR,9R,11aS,11bR)-3,6,10,11b-tetramethyl-3-spiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[i]fluorene-9,2-3a,4,5,6,7,7a-hexahydro-3H-furo[4,5-b]pyridine]ol; nchembio753-comp1; BSPBio_001032; C4116_SIGMA; NSC734950; 4449-51-8; C10798; 3,6,10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol; Cyclopamine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANXA5, BCL2, CASP3, CCND1, CDH1, EGFR, GLI1, GLI2, GLI3, SMO, VEGFA
Peripheral membrane protein 1 ANXA5
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 BCL2, DHH, EGFR
Nucleus 10 BCL2, CASP3, CCND1, CDH1, EGFR, GLI1, GLI2, GLI3, SMO, VEGFA
cytosol 10 ANXA5, BCL2, CASP3, CCND1, CD44, CDH1, GLI1, GLI2, GLI3, SMO
dendrite 1 SMO
trans-Golgi network 1 CDH1
centrosome 1 CCND1
nucleoplasm 7 CASP3, CCND1, CDH1, GLI1, GLI2, GLI3, SMO
Cell membrane 7 CD44, CDH1, DHH, EGFR, PTCH1, SMO, TNF
Lipid-anchor 1 DHH
lamellipodium 1 CDH1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 PROM1, PTCH1, SMO
Golgi apparatus membrane 1 DHH
cell junction 2 CDH1, EGFR
cell surface 5 CD44, EGFR, PROM1, TNF, VEGFA
glutamatergic synapse 3 CASP3, CDH1, EGFR
Golgi apparatus 4 CD44, CDH1, SMO, VEGFA
Golgi membrane 3 DHH, EGFR, INS
lysosomal membrane 1 EGF
neuronal cell body 2 CASP3, TNF
postsynapse 1 CDH1
sarcolemma 1 ANXA5
endosome 2 CDH1, EGFR
plasma membrane 9 CD44, CDH1, DHH, EGF, EGFR, PROM1, PTCH1, SMO, TNF
Membrane 9 ANXA5, BCL2, CD44, CDH1, EGF, EGFR, GLI2, PTCH1, VEGFA
apical plasma membrane 3 CD44, EGFR, PROM1
basolateral plasma membrane 2 CD44, EGFR
caveola 1 PTCH1
extracellular exosome 7 ANXA5, BMP3, CD44, CDH1, EGF, PROM1, SMO
endoplasmic reticulum 4 BCL2, PROM1, SMO, VEGFA
extracellular space 9 BMP3, BMP4, DHH, EGF, EGFR, INS, PROM1, TNF, VEGFA
perinuclear region of cytoplasm 3 CDH1, EGFR, PTCH1
adherens junction 2 CDH1, VEGFA
bicellular tight junction 1 CCND1
mitochondrion 1 BCL2
protein-containing complex 2 BCL2, EGFR
intracellular membrane-bounded organelle 3 GLI3, PTCH1, SMO
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD44, CDH1, EGFR
Secreted 6 BMP3, BMP4, CD44, DHH, INS, VEGFA
extracellular region 9 ANXA5, BMP3, BMP4, CD44, CDH1, EGF, INS, TNF, VEGFA
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CD44
mitochondrial outer membrane 1 BCL2
Cell projection, cilium 2 GLI2, SMO
ciliary membrane 2 PTCH1, SMO
motile cilium 1 GLI2
photoreceptor outer segment 1 PROM1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 5 BCL2, CCND1, CDH1, EGFR, SMO
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 CDH1
nucleolus 2 GLI2, GLI3
midbody 1 PTCH1
apical part of cell 1 PTCH1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 PROM1
postsynaptic membrane 1 PTCH1
Apical cell membrane 1 PROM1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
focal adhesion 3 ANXA5, CD44, EGFR
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
lateral plasma membrane 1 CDH1
axoneme 3 GLI1, GLI2, GLI3
ciliary tip 4 GLI1, GLI2, GLI3, SMO
nuclear speck 2 GLI2, GLI3
Late endosome 1 SMO
receptor complex 1 EGFR
Zymogen granule membrane 1 ANXA5
ciliary base 3 GLI1, GLI2, GLI3
cilium 4 GLI2, GLI3, PROM1, SMO
axonal growth cone 1 PTCH1
cell projection 1 CD44
phagocytic cup 1 TNF
centriole 1 SMO
Cell projection, cilium, photoreceptor outer segment 1 PROM1
Golgi apparatus, trans-Golgi network 1 CDH1
Cell projection, microvillus membrane 1 PROM1
microvillus membrane 1 PROM1
endosome lumen 1 INS
microvillus 2 CD44, PROM1
Cell projection, microvillus 1 CD44
[Sonic hedgehog protein]: Endoplasmic reticulum membrane 1 DHH
[Protein hedgehog N-product]: Cell membrane 1 DHH
dendritic growth cone 1 PTCH1
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
secretory granule membrane 1 CD44
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BMP4, INS
transcription repressor complex 2 CCND1, GLI3
platelet alpha granule lumen 2 EGF, VEGFA
endocytic vesicle membrane 2 PTCH1, SMO
transport vesicle 1 INS
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 GLI1
9+0 non-motile cilium 1 SMO
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
endoplasmic reticulum-Golgi intermediate compartment 2 PROM1, SMO
[Isoform 2]: Nucleus 2 CDH1, GLI2
[Isoform 1]: Nucleus 1 GLI2
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
[Desert hedgehog protein N-product]: Cell membrane 1 DHH
[Desert hedgehog protein]: Endoplasmic reticulum membrane 1 DHH
photoreceptor outer segment membrane 1 PROM1
prominosome 1 PROM1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
lamellipodium membrane 1 CD44
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
macrophage migration inhibitory factor receptor complex 1 CD44
GLI-SUFU complex 3 GLI1, GLI2, GLI3
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yibin Pan, Jiena Zhou, Weidan Zhang, Lili Yan, Meifei Lu, Yongdong Dai, Hanjing Zhou, Songying Zhang, Jianhua Yang. The Sonic Hedgehog signaling pathway regulates autophagy and migration in ovarian cancer. Cancer medicine. 2021 07; 10(13):4510-4521. doi: 10.1002/cam4.4018. [PMID: 34076346]
  • Chaonan Deng, Lin Xu, Ying Zhang, Lina Zhao, Yan Linghu, Yanni Yu. The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury. Journal of orthopaedic surgery and research. 2021 Feb; 16(1):160. doi: 10.1186/s13018-021-02287-8. [PMID: 33637095]
  • Luise Spormann, Christiane Rennert, Erik Kolbe, Fritzi Ott, Carolin Lossius, Robert Lehmann, Rolf Gebhardt, Thomas Berg, Madlen Matz-Soja. Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver. Cells. 2020 07; 9(8):. doi: 10.3390/cells9081817. [PMID: 32751882]
  • Lana M Pollock, Brian Perkins, Bela Anand-Apte. Primary cilia are present on endothelial cells of the hyaloid vasculature but are not required for the development of the blood-retinal barrier. PloS one. 2020; 15(7):e0225351. doi: 10.1371/journal.pone.0225351. [PMID: 32735563]
  • Matthew W Turner, Meagan Rossi, Vannessa Campfield, John French, Ellie Hunt, Emily Wade, Owen M McDougal. Steroidal alkaloid variation in Veratrum californicum as determined by modern methods of analytical analysis. Fitoterapia. 2019 Sep; 137(?):104281. doi: 10.1016/j.fitote.2019.104281. [PMID: 31381957]
  • Shen Liu, Liping Chang, Cong Wei. The sonic hedgehog pathway mediates Tongxinluo capsule-induced protection against blood-brain barrier disruption after ischaemic stroke in mice. Basic & clinical pharmacology & toxicology. 2019 Jun; 124(6):660-669. doi: 10.1111/bcpt.13186. [PMID: 30548093]
  • Jyoti B Kaushal, Pooja Popli, Pushplata Sankhwar, Vinay Shukla, Anila Dwivedi. Sonic hedgehog protects endometrial hyperplasial cells against oxidative stress via suppressing mitochondrial fission protein dynamin-like GTPase (Drp1). Free radical biology & medicine. 2018 12; 129(?):582-599. doi: 10.1016/j.freeradbiomed.2018.10.427. [PMID: 30347228]
  • Yasunori Sato, Minako Yamamura, Motoko Sasaki, Kenichi Harada. Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat. The American journal of pathology. 2018 10; 188(10):2251-2263. doi: 10.1016/j.ajpath.2018.06.014. [PMID: 30036521]
  • Yuan Du, Zu-Guo Zheng, Yue Yu, Zi-Tian Wu, Dan Liang, Ping Li, Yan Jiang, Hui-Jun Li. Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS. Journal of pharmaceutical and biomedical analysis. 2017 Aug; 142(?):201-209. doi: 10.1016/j.jpba.2017.04.049. [PMID: 28521273]
  • Gang Liu, Ding Xue, Jun Yang, Juan Wang, Xiaohua Liu, Wenjing Huang, Jie Li, Ya-Qiu Long, Wenfu Tan, Ao Zhang. Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists. Journal of medicinal chemistry. 2016 12; 59(24):11050-11068. doi: 10.1021/acs.jmedchem.6b01247. [PMID: 27736063]
  • Vivian Y L Chua, Irma Larma, Jennet Harvey, Marc A Thomas, Jacqueline M Bentel. Activity of ABCG2 Is Regulated by Its Expression and Localization in DHT and Cyclopamine-Treated Breast Cancer Cells. Journal of cellular biochemistry. 2016 10; 117(10):2249-59. doi: 10.1002/jcb.25523. [PMID: 26917208]
  • James K Chen. I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs. Natural product reports. 2016 05; 33(5):595-601. doi: 10.1039/c5np00153f. [PMID: 26787175]
  • Papavee Samatiwat, Kazuhisa Takeda, Soisungwan Satarug, Koji Ohba, Veerapol Kukongviriyapan, Shigeki Shibahara. Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular carcinoma cells by cyclopamine, an inhibitor of the Hedgehog signaling. Biochemical and biophysical research communications. 2016 Jan; 470(1):144-149. doi: 10.1016/j.bbrc.2016.01.010. [PMID: 26773496]
  • Alysha A Rauhauser, Chongyu Ren, Dongmei Lu, Binghua Li, Jili Zhu, Kayla McEnery, Komal Vadnagara, Diana Zepeda-Orozco, Xin J Zhou, Fangming Lin, Anton M Jetten, Massimo Attanasio. Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury. American journal of physiology. Renal physiology. 2015 Nov; 309(9):F770-8. doi: 10.1152/ajprenal.00232.2015. [PMID: 26290370]
  • Rong Li, Li Cai, Jing Ding, Cheng-Mu Hu, Ting-Ni Wu, Xiang-Yang Hu. Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis. The Journal of pharmacy and pharmacology. 2015 Jul; 67(7):963-71. doi: 10.1111/jphp.12379. [PMID: 25645065]
  • Megan M Augustin, Dan R Ruzicka, Ashutosh K Shukla, Jörg M Augustin, Courtney M Starks, Mark O'Neil-Johnson, Michael R McKain, Bradley S Evans, Matt D Barrett, Ann Smithson, Gane Ka-Shu Wong, Michael K Deyholos, Patrick P Edger, J Chris Pires, James H Leebens-Mack, David A Mann, Toni M Kutchan. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. The Plant journal : for cell and molecular biology. 2015 Jun; 82(6):991-1003. doi: 10.1111/tpj.12871. [PMID: 25939370]
  • Jian You, Jun Zhao, Xiaoxia Wen, Chunhui Wu, Qian Huang, Fada Guan, Richard Wu, Dong Liang, Chun Li. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal of controlled release : official journal of the Controlled Release Society. 2015 Mar; 202(?):40-8. doi: 10.1016/j.jconrel.2015.01.031. [PMID: 25637565]
  • Wen G Jiang, Lin Ye, Fiona Ruge, Ping-Hui Sun, Andrew J Sanders, Ki Ji, Jane Lane, Lijian Zhang, Lucy Satherley, Hoi P Weeks, Xiuyi Zhi, Yong Gao, Cong Wei, Yiling Wu, Malcolm D Mason. Expression of Sonic Hedgehog (SHH) in human lung cancer and the impact of YangZheng XiaoJi on SHH-mediated biological function of lung cancer cells and tumor growth. Anticancer research. 2015 Mar; 35(3):1321-31. doi: ". [PMID: 25750281]
  • Hiromi Mizuochi, Katsunori Fujii, Tadashi Shiohama, Hideki Uchikawa, Naoki Shimojo. Hedgehog signaling is synergistically enhanced by nutritional deprivation and ligand stimulation in human fibroblasts of Gorlin syndrome. Biochemical and biophysical research communications. 2015 Feb; 457(3):318-23. doi: 10.1016/j.bbrc.2014.12.108. [PMID: 25576868]
  • Shantanu S Chandratre, Alekha K Dash. Multifunctional nanoparticles for prostate cancer therapy. AAPS PharmSciTech. 2015 Feb; 16(1):98-107. doi: 10.1208/s12249-014-0202-z. [PMID: 25190362]
  • Fukashi Yamamichi, Katsumi Shigemura, Hosny M Behnsawy, Fatma Y Meligy, Wen-Chin Huang, Xiangyan Li, Kunito Yamanaka, Keisuke Hanioka, Hideaki Miyake, Kazushi Tanaka, Masato Kawabata, Toshiro Shirakawa, Masato Fujisawa. Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial-mesenchymal transition in prostate cancer. Scandinavian journal of urology. 2014 Dec; 48(6):523-32. doi: 10.3109/21681805.2014.898336. [PMID: 25356787]
  • Lina Zhao, Yanni Yu, Chaonan Deng. [Expression of sonic hedgehog signaling pathw ay and its inhibition by cyclopamine in rat liver with chronic fluorosis]. Zhonghua bing li xue za zhi = Chinese journal of pathology. 2014 Dec; 43(12):814-9. doi: NULL. [PMID: 25623978]
  • Bat-Erdene Batsaikhan, Kozo Yoshikawa, Nobuhiro Kurita, Takashi Iwata, Chie Takasu, Hideya Kashihara, Mitsuo Shimada. Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells. Anticancer research. 2014 Nov; 34(11):6339-44. doi: NULL. [PMID: 25368233]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • Stephen T Lee, Kevin D Welch, Kip E Panter, Dale R Gardner, Massoud Garrossian, Cheng-Wei Tom Chang. Cyclopamine: from cyclops lambs to cancer treatment. Journal of agricultural and food chemistry. 2014 Jul; 62(30):7355-62. doi: 10.1021/jf5005622. [PMID: 24754790]
  • Kosuke Kanke, Hideki Masaki, Taku Saito, Yuske Komiyama, Hironori Hojo, Hiromitsu Nakauchi, Alexander C Lichtler, Tsuyoshi Takato, Ung-Il Chung, Shinsuke Ohba. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem cell reports. 2014 Jun; 2(6):751-60. doi: 10.1016/j.stemcr.2014.04.016. [PMID: 24936463]
  • Lina Zhao, Yanni Yu, Chaonan Deng. Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis. Toxicology letters. 2014 Mar; 225(2):318-24. doi: 10.1016/j.toxlet.2013.12.022. [PMID: 24388991]
  • Shiang-Suo Huang, Henrich Cheng, Ching-Min Tang, Mao-Wei Nien, Yuahn-Sieh Huang, I-Huei Lee, Jiu-Haw Yin, Terry B J Kuo, Cheryl C H Yang, Shen-Kou Tsai, Ding-I Yang. Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental neurology. 2013 Sep; 247(?):680-8. doi: 10.1016/j.expneurol.2013.03.004. [PMID: 23499832]
  • Ye Yang, Jumei Shi, Giulia Tolomelli, Hongwei Xu, Jiliang Xia, He Wang, Wen Zhou, Yi Zhou, Satyabrata Das, Zhimin Gu, Dana Levasseur, Fenghuang Zhan, Guido Tricot. RARα2 expression confers myeloma stem cell features. Blood. 2013 Aug; 122(8):1437-47. doi: 10.1182/blood-2013-02-482919. [PMID: 23847194]
  • Kohei Kazuma, Katsuhiro Konno. [Poisoning by accidental ingestion of poisonous plants]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2013 Jun; 26(2):97-101. doi: ". [PMID: 23855239]
  • Lamia Ghezali, David Yannick Leger, Youness Limami, Jeanne Cook-Moreau, Jean-Louis Beneytout, Bertrand Liagre. Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect. Experimental cell research. 2013 Apr; 319(7):1043-53. doi: 10.1016/j.yexcr.2013.01.014. [PMID: 23357584]
  • Sandrine Eimer, Frédéric Dugay, Kelly Airiau, Tony Avril, Véronique Quillien, Marc-Antoine Belaud-Rotureau, Francis Belloc. Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures. Neuro-oncology. 2012 Dec; 14(12):1441-51. doi: 10.1093/neuonc/nos266. [PMID: 23104476]
  • Shu-Yan Zheng, Hong-Sheng Tan, Jian-Sheng Tao, Zheng-Wu Shen. A convenient and efficient one-pot conversion of peimisine into cyclopamine. Fitoterapia. 2012 Oct; 83(7):1238-41. doi: 10.1016/j.fitote.2012.06.010. [PMID: 22735603]
  • Yandong Shi, Ubiratan Moura, Isabelle Opitz, Alex Soltermann, Hubert Rehrauer, Svenja Thies, Walter Weder, Rolf A Stahel, Emanuela Felley-Bosco. Role of hedgehog signaling in malignant pleural mesothelioma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 Sep; 18(17):4646-56. doi: 10.1158/1078-0432.ccr-12-0599. [PMID: 22733539]
  • Pietro Ferruzzi, Federica Mennillo, Antonella De Rosa, Cinzia Giordano, Marco Rossi, Giovanni Benedetti, Roberta Magrini, Gal la Pericot Mohr, Vincenzo Miragliotta, Letizia Magnoni, Elisa Mori, Russell Thomas, Patrizia Tunici, Annette Bakker. In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines. International journal of cancer. 2012 Jul; 131(2):E33-44. doi: 10.1002/ijc.27349. [PMID: 22072503]
  • Stephen T Lee, Kip E Panter, Dale R Gardner, Benedict T Green, Kevin D Welch, Jianjun Zhang, Cheng-Wei Tom Chang. Development of a monoclonal antibody-based ELISA for the hedgehog inhibitors cyclopamine and KAAD-cyclopamine. Journal of pharmaceutical and biomedical analysis. 2012 Jul; 66(?):282-6. doi: 10.1016/j.jpba.2012.03.043. [PMID: 22516681]
  • Hong Ding, Dong Zhou, Sha Hao, Lili Zhou, Weichun He, Jing Nie, Fan Fan Hou, Youhua Liu. Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis. Journal of the American Society of Nephrology : JASN. 2012 May; 23(5):801-13. doi: 10.1681/asn.2011060614. [PMID: 22302193]
  • Bobby Bhatia, Chad R Potts, Cemile Guldal, SunPhil Choi, Andrey Korshunov, Stefan Pfister, Anna M Kenney, Zaher A Nahlé. Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma. Acta neuropathologica. 2012 Apr; 123(4):587-600. doi: 10.1007/s00401-012-0968-6. [PMID: 22407012]
  • Jin-bin Han, Yong-qiang Hua, Lian-yu Chen, Lu-ming Liu. Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2012 Mar; 10(3):256-63. doi: 10.3736/jcim20120303. [PMID: 22409914]
  • Peng Du, Lin Ye, Han Li, Yong Yang, Wen G Jiang. The tumour suppressive role of metastasis suppressor-1, MTSS1, in human kidney cancer, a possible connection with the SHH pathway. Journal of experimental therapeutics & oncology. 2012; 10(2):91-9. doi: NULL. [PMID: 23350348]
  • Christian D Fingas, Steven F Bronk, Nathan W Werneburg, Justin L Mott, Maria E Guicciardi, Sophie C Cazanave, Joachim C Mertens, Alphonse E Sirica, Gregory J Gores. Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells. Hepatology (Baltimore, Md.). 2011 Dec; 54(6):2076-88. doi: 10.1002/hep.24588. [PMID: 22038837]
  • Jana Balbuena, Gisela Pachon, Guillermo Lopez-Torrents, Josep M Aran, Javier S Castresana, Jordi Petriz. ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2011 Sep; 79(9):672-83. doi: 10.1002/cyto.a.21103. [PMID: 21774076]
  • Sungmin Baek, Young-Suk Lee, Hye-Eun Shim, Sik Yoon, Sun-Yong Baek, Bong-Seon Kim, Sae-Ock Oh. Vitamin D3 regulates cell viability in gastric cancer and cholangiocarcinoma. Anatomy & cell biology. 2011 Sep; 44(3):204-9. doi: 10.5115/acb.2011.44.3.204. [PMID: 22025972]
  • Qipeng Fan, Dongsheng Gu, Miao He, Hailan Liu, Tao Sheng, Guorui Xie, Ching-Xin Li, Xiaoli Zhang, Brandon Wainwright, Arash Garrossian, Massoud Garrossian, Dale Gardner, Jingwu Xie. Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling. Chinese journal of cancer. 2011 Jul; 30(7):472-81. doi: 10.5732/cjc.011.10157. [PMID: 21718593]
  • Akshay Pratap, Ravikiran Panakanti, Ningning Yang, Ramasubramanian Lakshmi, Kian A Modanlou, James D Eason, Ram I Mahato. Cyclopamine attenuates acute warm ischemia reperfusion injury in cholestatic rat liver: hope for marginal livers. Molecular pharmaceutics. 2011 Jun; 8(3):958-68. doi: 10.1021/mp200115v. [PMID: 21491930]
  • Tsutomu Takahashi, Koshi Kawakami, Seiji Mishima, Miho Akimoto, Keizo Takenaga, Junji Suzumiya, Yoshio Honma. Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells. Leukemia research. 2011 May; 35(5):638-45. doi: 10.1016/j.leukres.2010.09.022. [PMID: 20971508]
  • Hermine Roudaut, Elisabeth Traiffort, Tatiana Gorojankina, Ludwig Vincent, Helene Faure, Angele Schoenfelder, Andre Mann, Fabrizio Manetti, Antonio Solinas, Maurizio Taddei, Martial Ruat. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Molecular pharmacology. 2011 Mar; 79(3):453-60. doi: 10.1124/mol.110.069708. [PMID: 21177415]
  • Michel Bidet, Olivier Joubert, Benoit Lacombe, Marine Ciantar, Rony Nehmé, Patrick Mollat, Lionel Brétillon, Hélène Faure, Robert Bittman, Martial Ruat, Isabelle Mus-Veteau. The hedgehog receptor patched is involved in cholesterol transport. PloS one. 2011; 6(9):e23834. doi: 10.1371/journal.pone.0023834. [PMID: 21931618]
  • Steven Ray Wilson, Martin Frank Strand, Andreas Krapp, Frode Rise, Gunnar Herstad, Karl Egil Malterud, Stefan Krauss. Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album. Journal of pharmaceutical and biomedical analysis. 2010 Nov; 53(3):497-502. doi: 10.1016/j.jpba.2010.05.024. [PMID: 20646889]
  • Akshay Pratap, Ravikiran Panakanti, Ningning Yang, James D Eason, Ram I Mahato. Inhibition of endogenous hedgehog signaling protects against acute liver injury after ischemia reperfusion. Pharmaceutical research. 2010 Nov; 27(11):2492-504. doi: 10.1007/s11095-010-0246-z. [PMID: 20737284]
  • Tarek Benameur, Raffaella Soleti, Chiara Porro, Ramaroson Andriantsitohaina, Maria Carmen Martínez. Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice. PloS one. 2010 Sep; 5(9):e12688. doi: 10.1371/journal.pone.0012688. [PMID: 20856928]
  • Josué Kunjom Mfopou, Bing Chen, Lina Sui, Karen Sermon, Luc Bouwens. Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells. Diabetes. 2010 Sep; 59(9):2094-101. doi: 10.2337/db10-0439. [PMID: 20805383]
  • Yan Xu, Minlu Zhang, Yanhua Wang, Pooja Kadambi, Vrushank Dave, Long J Lu, Jeffrey A Whitsett. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC genomics. 2010 Jul; 11(?):451. doi: 10.1186/1471-2164-11-451. [PMID: 20659319]
  • Jian Tang, Hui-Liang Li, Yun-Heng Shen, Hui-Zi Jin, Shi-Kai Yan, Xiao-Hua Liu, Hua-Wu Zeng, Run-Hui Liu, Ye-Xiong Tan, Wei-Dong Zhang. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytotherapy research : PTR. 2010 Jun; 24(6):821-6. doi: 10.1002/ptr.3022. [PMID: 20013819]
  • Rony Nehmé, Olivier Joubert, Michel Bidet, Benoît Lacombe, Ange Polidori, Bernard Pucci, Isabelle Mus-Veteau. Stability study of the human G-protein coupled receptor, Smoothened. Biochimica et biophysica acta. 2010 Jun; 1798(6):1100-10. doi: 10.1016/j.bbamem.2010.02.015. [PMID: 20188061]
  • Yusnita Rifai, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi. Terpenoids and a flavonoid glycoside from Acacia pennata leaves as hedgehog/GLI-mediated transcriptional inhibitors. Journal of natural products. 2010 May; 73(5):995-7. doi: 10.1021/np1000818. [PMID: 20450170]
  • Ville Härmä, Johannes Virtanen, Rami Mäkelä, Antti Happonen, John-Patrick Mpindi, Matias Knuuttila, Pekka Kohonen, Jyrki Lötjönen, Olli Kallioniemi, Matthias Nees. A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PloS one. 2010 May; 5(5):e10431. doi: 10.1371/journal.pone.0010431. [PMID: 20454659]
  • Anna Slusarz, Nader S Shenouda, Mary S Sakla, Sara K Drenkhahn, Acharan S Narula, Ruth S MacDonald, Cynthia L Besch-Williford, Dennis B Lubahn. Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. Cancer research. 2010 Apr; 70(8):3382-90. doi: 10.1158/0008-5472.can-09-3012. [PMID: 20395211]
  • James Kim, Jean Y Tang, Ruoyu Gong, Jynho Kim, John J Lee, Karl V Clemons, Curtis R Chong, Kris S Chang, Mark Fereshteh, Dale Gardner, Tannishtha Reya, Jun O Liu, Ervin H Epstein, David A Stevens, Philip A Beachy. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer cell. 2010 Apr; 17(4):388-99. doi: 10.1016/j.ccr.2010.02.027. [PMID: 20385363]
  • Shun-Kai Chan, Paul R Riley, Karen L Price, Fiona McElduff, Paul J Winyard, Simon J M Welham, Adrian S Woolf, David A Long. Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog. American journal of physiology. Renal physiology. 2010 Feb; 298(2):F346-56. doi: 10.1152/ajprenal.00574.2009. [PMID: 20007344]
  • Valérian Dormoy, Sabrina Danilin, Véronique Lindner, Lionel Thomas, Sylvie Rothhut, Catherine Coquard, Jean-Jacques Helwig, Didier Jacqmin, Hervé Lang, Thierry Massfelder. The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth. Molecular cancer. 2009 Dec; 8(?):123. doi: 10.1186/1476-4598-8-123. [PMID: 20015350]
  • Tyler Schwend, Sara C Ahlgren. Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development. BMC developmental biology. 2009 Nov; 9(?):59. doi: 10.1186/1471-213x-9-59. [PMID: 19948063]
  • Jason E Cain, Epshita Islam, Fiona Haxho, Lin Chen, Darren Bridgewater, Erica Nieuwenhuis, Chi-Chung Hui, Norman D Rosenblum. GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PloS one. 2009 Oct; 4(10):e7313. doi: 10.1371/journal.pone.0007313. [PMID: 19809516]
  • Amalya Hovhannisyan, Madlen Matz, Rolf Gebhardt. From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age. Planta medica. 2009 Oct; 75(13):1371-80. doi: 10.1055/s-0029-1185979. [PMID: 19639534]
  • Martin R Tremblay, André Lescarbeau, Michael J Grogan, Eddy Tan, Grace Lin, Brian C Austad, Lin-Chen Yu, Mark L Behnke, Somarajan J Nair, Margit Hagel, Kerry White, James Conley, Joseph D Manna, Teresa M Alvarez-Diez, Jennifer Hoyt, Caroline N Woodward, Jens R Sydor, Melissa Pink, John MacDougall, Matthew J Campbell, Jill Cushing, Jeanne Ferguson, Michael S Curtis, Karen McGovern, Margaret A Read, Vito J Palombella, Julian Adams, Alfredo C Castro. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). Journal of medicinal chemistry. 2009 Jul; 52(14):4400-18. doi: 10.1021/jm900305z. [PMID: 19522463]
  • Anita Büttner, Katrin Seifert, Thomas Cottin, Vasiliki Sarli, Lito Tzagkaroulaki, Stefan Scholz, Athanassios Giannis. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorganic & medicinal chemistry. 2009 Jul; 17(14):4943-54. doi: 10.1016/j.bmc.2009.06.008. [PMID: 19541490]
  • K D Welch, K E Panter, S T Lee, D R Gardner, B L Stegelmeier, D Cook. Cyclopamine-induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation. Journal of applied toxicology : JAT. 2009 Jul; 29(5):414-21. doi: 10.1002/jat.1427. [PMID: 19301244]
  • Mikhail V Blagosklonny. Inhibition of S6K by resveratrol: in search of the purpose. Aging. 2009 Jun; 1(6):511-4. doi: 10.18632/aging.100059. [PMID: 20157534]
  • Cynthia M Rominger, Wei-Lin Tiger Bee, Robert A Copeland, Elizabeth A Davenport, Aidan Gilmartin, Richard Gontarek, Keith R Hornberger, Lorena A Kallal, Zhihong Lai, Kenneth Lawrie, Quinn Lu, Lynette McMillan, Maggie Truong, Peter J Tummino, Brandon Turunen, Matthew Will, William J Zuercher, David H Rominger. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. The Journal of pharmacology and experimental therapeutics. 2009 Jun; 329(3):995-1005. doi: 10.1124/jpet.109.152090. [PMID: 19304771]
  • Raffaella Soleti, Tarek Benameur, Chiara Porro, Maria Antonietta Panaro, Ramaroson Andriantsitohaina, Maria Carmen Martínez. Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors. Carcinogenesis. 2009 Apr; 30(4):580-8. doi: 10.1093/carcin/bgp030. [PMID: 19168578]
  • Zhicheng Mo, Nada Zecevic. Human fetal radial glia cells generate oligodendrocytes in vitro. Glia. 2009 Apr; 57(5):490-8. doi: 10.1002/glia.20775. [PMID: 18814269]
  • Rafal P Witek, Liu Yang, Renshui Liu, Youngmi Jung, Alessia Omenetti, Wing-Kin Syn, Steve S Choi, Yeiwon Cheong, Caitlin M Fearing, Kolade M Agboola, Wei Chen, Anna Mae Diehl. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2009 Jan; 136(1):320-330.e2. doi: 10.1053/j.gastro.2008.09.066. [PMID: 19013163]
  • Jian Tang, Hui-Liang Li, Yun-Heng Shen, Hui-Zi Jin, Shi-Kai Yan, Run-Hui Liu, Wei-Dong Zhang. Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum. Phytotherapy research : PTR. 2008 Aug; 22(8):1093-6. doi: 10.1002/ptr.2463. [PMID: 18570211]
  • Sonia J Wakelin, John L R Forsythe, O James Garden, Sarah E M Howie. Commercially available recombinant sonic hedgehog up-regulates Ptc and modulates the cytokine and chemokine expression of human macrophages: an effect mediated by endotoxin contamination?. Immunobiology. 2008; 213(1):25-38. doi: 10.1016/j.imbio.2007.06.006. [PMID: 18207025]
  • Murielle Mimeault, Parmender P Mehta, Ralph Hauke, Jean-Pierre Henichart, Patrick Depreux, Ming-Fong Lin, Surinder K Batra. Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades. Growth factors (Chur, Switzerland). 2007 Dec; 25(6):400-16. doi: 10.1080/08977190801930935. [PMID: 18365871]
  • Abdelali Agouni, H Ahmed Mostefai, Chiarra Porro, Nunzia Carusio, Julie Favre, Vincent Richard, Daniel Henrion, M Carmen Martínez, Ramaroson Andriantsitohaina. Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007 Sep; 21(11):2735-41. doi: 10.1096/fj.07-8079com. [PMID: 17428963]
  • Christine Dierks, Jovana Grbic, Katja Zirlik, Ronak Beigi, Nathan P Englund, Gui-Rong Guo, Hendrik Veelken, Monika Engelhardt, Roland Mertelsmann, Joseph F Kelleher, Peter Schultz, Markus Warmuth. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature medicine. 2007 Aug; 13(8):944-51. doi: 10.1038/nm1614. [PMID: 17632527]
  • Craig D Peacock, Qiuju Wang, Gregory S Gesell, Ian M Corcoran-Schwartz, Evan Jones, Jynho Kim, Wendy L Devereux, Jonathan T Rhodes, Carol A Huff, Philip A Beachy, D Neil Watkins, William Matsui. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar; 104(10):4048-53. doi: 10.1073/pnas.0611682104. [PMID: 17360475]
  • Aubie Shaw, Wade Bushman. Hedgehog signaling in the prostate. The Journal of urology. 2007 Mar; 177(3):832-8. doi: 10.1016/j.juro.2006.10.061. [PMID: 17296352]
  • Rui Ma, Anneli Ritala, Kirsi-Marja Oksman-Caldentey, Heiko Rischer. Development of in vitro techniques for the important medicinal plant Veratrum californicum. Planta medica. 2006 Oct; 72(12):1142-8. doi: 10.1055/s-2006-946697. [PMID: 17024590]
  • Matthieu De Rivoyre, Laurent Ruel, Markku Varjosalo, Agnès Loubat, Michel Bidet, Pascal Thérond, Isabelle Mus-Veteau. Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells. The Journal of biological chemistry. 2006 Sep; 281(39):28584-95. doi: 10.1074/jbc.m512986200. [PMID: 16867986]
  • Alex S Kiselyov. Targeting the hedgehog signaling pathway with small molecules. Anti-cancer agents in medicinal chemistry. 2006 Sep; 6(5):445-9. doi: 10.2174/187152006778226495. [PMID: 17017853]
  • Jason Doles, Crist Cook, Xudong Shi, Janine Valosky, Robert Lipinski, Wade Bushman. Functional compensation in Hedgehog signaling during mouse prostate development. Developmental biology. 2006 Jul; 295(1):13-25. doi: 10.1016/j.ydbio.2005.12.002. [PMID: 16707121]
  • Vincent C Daniel, Craig D Peacock, D Neil Watkins. Developmental signalling pathways in lung cancer. Respirology (Carlton, Vic.). 2006 May; 11(3):234-40. doi: 10.1111/j.1440-1843.2006.00838.x. [PMID: 16635080]
  • Marcus A McFerren. Useful plants of dermatology. VIII. The false hellebore (Veratrum californicum). Journal of the American Academy of Dermatology. 2006 Apr; 54(4):718-20. doi: 10.1016/j.jaad.2005.11.1075. [PMID: 16546599]
  • Mohamed Ali-Seyed, Noelani Laycock, Suresh Karanam, Wenming Xiao, Eric T Blair, Carlos S Moreno. Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells. BMC cancer. 2006 Mar; 6(?):54. doi: 10.1186/1471-2407-6-54. [PMID: 16522205]
  • Murielle Mimeault, Erik Moore, Nicolas Moniaux, Jean-Pierre Hénichart, Patrick Depreux, Ming-Fong Lin, Surinder K Batra. Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells. International journal of cancer. 2006 Feb; 118(4):1022-31. doi: 10.1002/ijc.21440. [PMID: 16108016]
  • Ming Chang Hu, Rong Mo, Sita Bhella, Christopher W Wilson, Pao-Tien Chuang, Chi-Chung Hui, Norman D Rosenblum. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development (Cambridge, England). 2006 Feb; 133(3):569-78. doi: 10.1242/dev.02220. [PMID: 16396903]
  • Mikhail V Blagosklonny. Teratogens as anti-cancer drugs. Cell cycle (Georgetown, Tex.). 2005 Nov; 4(11):1518-21. doi: 10.4161/cc.4.11.2208. [PMID: 16258270]
  • Rebecca J Dawber, Stephen Hebbes, Bram Herpers, France Docquier, Marcel van den Heuvel. Differential range and activity of various forms of the Hedgehog protein. BMC developmental biology. 2005 Sep; 5(?):21. doi: 10.1186/1471-213x-5-21. [PMID: 16197551]
  • M Koleva, R Kappler, M Vogler, A Herwig, S Fulda, H Hahn. Pleiotropic effects of sonic hedgehog on muscle satellite cells. Cellular and molecular life sciences : CMLS. 2005 Aug; 62(16):1863-70. doi: 10.1007/s00018-005-5072-9. [PMID: 16003493]
  • Ingo Thievessen, Marietta Wolter, Andrea Prior, Hans-Helge Seifert, Wolfgang A Schulz. Hedgehog signaling in normal urothelial cells and in urothelial carcinoma cell lines. Journal of cellular physiology. 2005 May; 203(2):372-7. doi: 10.1002/jcp.20248. [PMID: 15521068]
  • D N Watkins, C D Peacock. Hedgehog signalling in foregut malignancy. Biochemical pharmacology. 2004 Sep; 68(6):1055-60. doi: 10.1016/j.bcp.2004.04.025. [PMID: 15313401]
  • Lynn F James, Kip E Panter, William Gaffield, Russell J Molyneux. Biomedical applications of poisonous plant research. Journal of agricultural and food chemistry. 2004 Jun; 52(11):3211-30. doi: 10.1021/jf0308206. [PMID: 15161174]
  • Stephen T Lee, Kip E Panter, William Gaffield, Bryan L Stegelmeier. Development of an enzyme-linked immunosorbent assay for the veratrum plant teratogens: cyclopamine and jervine. Journal of agricultural and food chemistry. 2003 Jan; 51(3):582-6. doi: 10.1021/jf020961s. [PMID: 12537426]
  • Y Lavie, T Harel-Orbital, W Gaffield, M Liscovitch. Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells. Anticancer research. 2001 Mar; 21(2A):1189-94. doi: . [PMID: 11396162]
  • R K Mann, P A Beachy. Cholesterol modification of proteins. Biochimica et biophysica acta. 2000 Dec; 1529(1-3):188-202. doi: 10.1016/s1388-1981(00)00148-7. [PMID: 11111088]
  • J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 2000 Aug; 406(6799):1005-9. doi: 10.1038/35023008. [PMID: 10984056]
  • W Gaffield, J P Incardona, R P Kapur, H Roelink. A looking glass perspective: thalidomide and cyclopamine. Cellular and molecular biology (Noisy-le-Grand, France). 1999 Jul; 45(5):579-88. doi: ". [PMID: 10512190]