Tylophorine (BioDeep_00000008211)
natural product
代谢物信息卡片
(+/-)-Tylophorine
化学式: C24H27NO4 (393.194)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C2C(=C1)C3=C(CN4CCCC4C3)C5=CC(=C(C=C52)OC)OC)OC
InChI: InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:9786
- KEGG: C10623
- PubChem: 92114
- PubChem: 5090648
- Metlin: METLIN68438
- ChEMBL: CHEMBL250426
- ChEMBL: CHEMBL493620
- KNApSAcK: C00002367
- CAS: 482-20-2
- CAS: 25908-92-3
- PMhub: MS000021788
- PubChem: 12806
- 3DMET: B04004
- NIKKAJI: J5.786J
- KNApSAcK: 9786
- LOTUS: LTS0165148
- LOTUS: LTS0018048
- wikidata: Q27254190
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
28 个相关的物种来源信息
- 4056 - Apocynaceae: LTS0165148
- 126747 - Cynanchum: LTS0165148
- 185069 - Cynanchum polyanthum: 10.1016/0031-9422(95)00034-5
- 2759 - Eukaryota: LTS0165148
- 3493 - Ficus: LTS0165148
- 100573 - Ficus septica:
- 100573 - Ficus septica: 10.1021/NP050095O
- 100573 - Ficus septica: 10.1021/NP900580F
- 100573 - Ficus septica: 10.3987/COM-02-9615
- 100573 - Ficus septica: LTS0165148
- 3398 - Magnoliopsida: LTS0165148
- 1655176 - Matelea carolinensis:
- 3487 - Moraceae: LTS0165148
- 35493 - Streptophyta: LTS0165148
- 58023 - Tracheophyta: LTS0165148
- 52863 - Tylophora: LTS0165148
- 1266040 - Tylophora asthmatica: 10.1055/S-0028-1097948
- 1266040 - Tylophora asthmatica: LTS0165148
- 63501 - Vincetoxicum: LTS0165148
- 228712 - Vincetoxicum floribundum: 10.1016/0031-9422(95)00034-5
- 167779 - Vincetoxicum hirsutum:
- 141524 - Vincetoxicum hirundinaria: LTS0165148
- 2591842 - Vincetoxicum hirundinaria subsp. hirundinaria: 10.1002/ARDP.19933260203
- 2591842 - Vincetoxicum hirundinaria subsp. hirundinaria: LTS0165148
- 63500 - Vincetoxicum indicum:
- 228704 - Vincetoxicum lindleyi: 10.1055/S-0030-1271199
- 228715 - Vincetoxicum tanakae:
- 33090 - Viridiplantae: LTS0165148
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Devika Nurhasanah, Nanang Fakhrudin, Bambang Retnoaji, Agung Endro Nugroho. Antiangiogenic Activity of n-hexane Insoluble Fraction and Its Tylophorine Component from Ficus septica Leaves in Chicken Chorioallantoic Membrane Induced by bFGF.
Asian Pacific journal of cancer prevention : APJCP.
2023 Jan; 24(1):75-80. doi:
10.31557/apjcp.2023.24.1.75. [PMID: 36708554] - Muhammad T Islam, Chandan Sarkar, Dina M El-Kersh, Sarmin Jamaddar, Shaikh J Uddin, Jamil A Shilpi, Mohammad S Mubarak. Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data.
Phytotherapy research : PTR.
2020 Oct; 34(10):2471-2492. doi:
10.1002/ptr.6700. [PMID: 32248575] - Zhiguo Mang, Shuai Zhang, Jing Bai, Meijuan Li, Hao Li. Design, Synthesis and in Vitro Evaluation of Tylophorine Derivatives as Possible Antitumor Agents.
Chemistry & biodiversity.
2020 Sep; 17(9):e2000066. doi:
10.1002/cbdv.202000066. [PMID: 32567792] - Helge Joa, Tina Blažević, Christoph Grojer, Iris Zeller, Elke H Heiss, Atanas G Atanasov, Ines Feldler, Päivi Gruzdaitis, Christa Czaloun, Peter Proksch, Barbara Messner, David Bernhard, Verena M Dirsch. Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Jul; 60(?):152938. doi:
10.1016/j.phymed.2019.152938. [PMID: 31078367] - Guifang Han, Linwei Chen, Qiang Wang, Meng Wu, Yuxiu Liu, Qingmin Wang. Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids.
Journal of agricultural and food chemistry.
2018 Jan; 66(4):780-788. doi:
10.1021/acs.jafc.7b03418. [PMID: 29355318] - Long V Pham, Huong T T Ngo, Yun-Sook Lim, Soon B Hwang. Hepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation.
Journal of hepatology.
2012 Nov; 57(5):960-6. doi:
10.1016/j.jhep.2012.07.006. [PMID: 22796893] - Ziwen Wang, Peng Wei, Lizhong Wang, Qingmin Wang. Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Journal of agricultural and food chemistry.
2012 Oct; 60(41):10212-9. doi:
10.1021/jf303550a. [PMID: 23035814] - Ziwen Wang, Lei Wang, Shuang Ma, Yuxiu Liu, Lizhong Wang, Qingmin Wang. Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Journal of agricultural and food chemistry.
2012 Jun; 60(23):5825-31. doi:
10.1021/jf3013376. [PMID: 22662864] - Wei Zhou, Zhijun Dai, Yuan Chen, Haiyan Wang, Zheming Yuan. High-Dimensional descriptor selection and computational QSAR modeling for antitumor activity of ARC-111 analogues Based on Support Vector Regression (SVR).
International journal of molecular sciences.
2012; 13(1):1161-1172. doi:
10.3390/ijms13011161. [PMID: 22312310] - Mohammad Ali, Nisha Chaudhary. Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties.
Pharmacognosy reviews.
2011 Jan; 5(9):96-102. doi:
10.4103/0973-7847.79104. [PMID: 22096323] - Kailiang Wang, Yanna Hu, Yuxiu Liu, Na Mi, Zhijin Fan, Yu Liu, Qingmin Wang. Design, synthesis, and antiviral evaluation of phenanthrene-based tylophorine derivatives as potential antiviral agents.
Journal of agricultural and food chemistry.
2010 Dec; 58(23):12337-42. doi:
10.1021/jf103440s. [PMID: 21058739] - Kuo-Hsiung Lee. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Journal of natural products.
2010 Mar; 73(3):500-16. doi:
10.1021/np900821e. [PMID: 20187635] - Kailiang Wang, Bo Su, Ziwen Wang, Meng Wu, Zheng Li, Yanna Hu, Zhijin Fan, Na Mi, Qingmin Wang. Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
Journal of agricultural and food chemistry.
2010 Mar; 58(5):2703-9. doi:
10.1021/jf902543r. [PMID: 20000413] - Jin-Young Choi, Wenli Gao, Jared Odegard, Her-Shyong Shiah, Michael Kashgarian, Jennifer M McNiff, David C Baker, Yung-Chi Cheng, Joseph Craft. Abrogation of skin disease in LUPUS-prone MRL/FASlpr mice by means of a novel tylophorine analog.
Arthritis and rheumatism.
2006 Oct; 54(10):3277-83. doi:
10.1002/art.22119. [PMID: 17009262] - Kuntal Narayan Chaudhuri, Biswajit Ghosh, David Tepfer, Sumita Jha. Spontaneous plant regeneration in transformed roots and calli from Tylophora indica: Changes in morphological phenotype and tylophorine accumulation associated with transformation by Agrobacterium rhizogenes.
Plant cell reports.
2006 Oct; 25(10):1059-66. doi:
10.1007/s00299-006-0164-z. [PMID: 16609889] - Kuntal Narayan Chaudhuri, Biswajit Ghosh, David Tepfer, Sumita Jha. Genetic transformation of Tylophora indica with Agrobacterium rhizogenes A4: growth and tylophorine productivity in different transformed root clones.
Plant cell reports.
2005 Apr; 24(1):25-35. doi:
10.1007/s00299-004-0904-x. [PMID: 15660269] - T Ganguly, K B Sainis. Inhibition of cellular immune responses by Tylophora indica in experimental models.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2001 Sep; 8(5):348-55. doi:
10.1078/0944-7113-00055. [PMID: 11695877] - Q Wang, L Xie, J Zhai. Tylophorine B benzene solvate.
Acta crystallographica. Section C, Crystal structure communications.
2000 Feb; 56 ( Pt 2)(?):197-8. doi:
10.1107/s0108270199013499. [PMID: 10777885]
