Caffeic acid ester (BioDeep_00000008115)

 

Secondary id: BioDeep_00000230921

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(E)-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 2-phenylethyl ester

化学式: C17H16O4 (284.1048536)
中文名称: 咖啡酸苯乙酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CCOC(=O)C=CC2=CC(=C(C=C2)O)O
InChI: InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+

描述信息

Caffeic acid ester, also known as caffeic acid phenethyl ester or cape, belongs to coumaric acids and derivatives class of compounds. Those are aromatic compounds containing Aromatic compounds containing a cinnamic acid moiety (or a derivative thereof) hydroxylated at the C2 (ortho-), C3 (meta-), or C4 (para-) carbon atom of the benzene ring. Caffeic acid ester is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Caffeic acid ester can be found in corn, flaxseed, oat, and peach, which makes caffeic acid ester a potential biomarker for the consumption of these food products.
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
Caffeic acid phenethyl ester is a NF-κB inhibitor.
Caffeic acid phenethyl ester is a NF-κB inhibitor.

同义名列表

20 个代谢物同义名

(E)-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 2-phenylethyl ester; 2-Phenylethyl (2e)-3-(3,4-Dihydroxyphenyl)prop-2-Enoate; 2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylic acid; 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate; Caffeic Acid 2-Phenylethyl Ester; Caffeic acid phenethyl ester; Caffeic acid-phenethyl ester; 2-Phenylethyl caffeic acid; caffeic acid phenyl ester; Caffeate phenethyl ester; Phenethyl caffeic acid; 2-phenylethyl caffeate; Phenethyl Caffeiate; phenethyl caffeate; Caffeic acid ester; phenyl caffeate; Caffeate ester; CAPE compound; Capeee; CAPE



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ying Lu, Luyan Gao, Wenwen Zhang, Ying Zeng, Ji Hu, Kai Song. Caffeic acid phenethyl ester restores mitochondrial homeostasis against peritoneal fibrosis induced by peritoneal dialysis through the AMPK/SIRT1 pathway. Renal failure. 2024 Dec; 46(1):2350235. doi: 10.1080/0886022x.2024.2350235. [PMID: 38721924]
  • Adam J Lewis, Amanda C Richards, Alejandra A Mendez, Bijaya K Dhakal, Tiffani A Jones, Jamie L Sundsbak, Danelle S Eto, Alexis A Rousek, Matthew A Mulvey. Plant phenolics inhibit focal adhesion kinase and suppress host cell invasion by uropathogenic Escherichia coli. Infection and immunity. 2024 May; 92(5):e0008024. doi: 10.1128/iai.00080-24. [PMID: 38534100]
  • Zhanding Cui, Jing Zhang, Jinlong Wang, Jinlong Liu, Pu Sun, Jiaoyang Li, Guoxiu Li, Ying Sun, Juanbin Ying, Kun Li, Zhixun Zhao, Hong Yuan, Xingwen Bai, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Dong Li, Qiang Zhang, Zaixin Liu, Yimei Cao, Zengjun Lu. Caffeic acid phenethyl ester: an effective antiviral agent against porcine reproductive and Respiratory Syndrome Virus. Antiviral research. 2024 May; 225(?):105868. doi: 10.1016/j.antiviral.2024.105868. [PMID: 38490343]
  • Showket Yahya, Mahaboob Khan Sulaiman, Ganapasam Sudhandiran. Caffeic acid phenethyl ester mediates apoptosis in serum-starved HT29 colon cancer cells through modulation of heat shock proteins and MAPK pathways. Cell biochemistry and function. 2024 Mar; 42(2):e3942. doi: 10.1002/cbf.3942. [PMID: 38379263]
  • Qian Wu, Junya Li, Shengyu Hao, Yuyang Guo, Zongze Li, Zhengxin Liu, Hongzhuan Xuan. Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115766. doi: 10.1016/j.biopha.2023.115766. [PMID: 37864895]
  • Edlene Ribeiro Prudêncio de Souza, Marcos Vinicius da Conceição Braz, Rosane Nora Castro, Marcos Dias Pereira, Cristiano Jorge Riger. Influence of microbial fermentation on the antioxidant activity of phenolic substances in Saccharomyces cerevisiae. Journal of applied microbiology. 2023 Jul; ?(?):. doi: 10.1093/jambio/lxad148. [PMID: 37451811]
  • Mathieu P A Hébert, Ayyoub Selka, Andréa A Lebel, Jérémie A Doiron, Audrey Isabel Chiasson, Vanessa L Gauvin, Alexis J Matthew, Martin J G Hébert, Marco S Doucet, Andrew P Joy, David A Barnett, Mohamed Touaibia, Marc E Surette, Luc H Boudreau. Caffeic acid phenethyl ester analogues as selective inhibitors of 12-lipoxygenase product biosynthesis in human platelets. International immunopharmacology. 2023 Jun; 121(?):110419. doi: 10.1016/j.intimp.2023.110419. [PMID: 37295028]
  • Lu-Chang Liang, Lei Zhao, Bo Yu, Han-Xiang Hu, Xu-Hua He, Yan-Min Zhang. Caffeic acid phenethyl ester reverses doxorubicin resistance in breast cancer cells via lipid metabolism regulation at least partly by suppressing the Akt/mTOR/SREBP1 pathway. The Kaohsiung journal of medical sciences. 2023 Mar; ?(?):. doi: 10.1002/kjm2.12675. [PMID: 36960852]
  • Xian-Chun Zhong, Ya-Meng Liu, Xiao-Xia Gao, Kristopher W Krausz, Bing Niu, Frank J Gonzalez, Cen Xie. Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity. Acta pharmacologica Sinica. 2023 Jan; 44(1):145-156. doi: 10.1038/s41401-022-00921-7. [PMID: 35655096]
  • Tianqiao Yong, Danling Liang, Shaodan Chen, Chun Xiao, Xiong Gao, Qingping Wu, Yizhen Xie, Longhua Huang, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai. Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154256. doi: 10.1016/j.phymed.2022.154256. [PMID: 35714456]
  • Qin Wan, Liwen Zhang, Qidi Zhou, Yanmin Han, Zhubo Li, Boheng Li. Protection of CAPE-pNO2 Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro. Inflammation. 2022 Jun; 45(3):1039-1058. doi: 10.1007/s10753-021-01600-1. [PMID: 34817763]
  • Yin-Hwa Shih, Shih-Min Hsia, Kuo-Chou Chiu, Tong-Hong Wang, Chi-Ying Chien, Po-Jung Li, Yueh-Hsiung Kuo, Tzong-Ming Shieh. In Vitro Antimicrobial Potential of CAPE and Caffeamide Derivatives against Oral Microbes. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084099. [PMID: 35456916]
  • Halil Sezgin Semis, Cihan Gur, Mustafa Ileriturk, Ozgur Kaynar, Fatih Mehmet Kandemir. Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan-induced paw edema in rats. Human & experimental toxicology. 2021 Dec; 40(12_suppl):S721-S738. doi: 10.1177/09603271211054436. [PMID: 34789018]
  • Zhanding Cui, Qian Wang, Dengliang Li, Shihui Zhao, Qian Zhang, Yuxin Tan, Qianwen Gong, Ting Liu, Jiang Shao, Shuang Zhang, Hailong Huang, Junzheng Wang, Zhihua Pei, Hao Dong, Kai Wang, Guixue Hu, Zhiyong Li. Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro. Archives of virology. 2021 Sep; 166(9):2443-2450. doi: 10.1007/s00705-021-05107-w. [PMID: 34173062]
  • Rajashri R Naik, Ashok K Shakya, Ghaleb A Oriquat, Shankar Katekhaye, Anant Paradkar, Hugo Fearnley, James Fearnley. Fatty Acid Analysis, Chemical Constituents, Biological Activity and Pesticide Residues Screening in Jordanian Propolis. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26165076. [PMID: 34443664]
  • Halil Ibrahim Guler, Gizem Tatar, Oktay Yildiz, Ali Osman Belduz, Sevgi Kolayli. Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study. Archives of microbiology. 2021 Aug; 203(6):3557-3564. doi: 10.1007/s00203-021-02351-1. [PMID: 33950349]
  • Umut Yiğit, Fatma Yeşim Kırzıoğlu, Özlem Özmen, Abdülhadi Cihangir Uğuz. Protective effects of caffeic acid phenethyl ester on the heart in experimental periodontitis against oxidative stress in rats. Dental and medical problems. 2021 Jul; 58(3):335-341. doi: 10.17219/dmp/132388. [PMID: 34597478]
  • Vipul Kumar, Jaspreet Kaur Dhanjal, Sunil C Kaul, Renu Wadhwa, Durai Sundar. Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity. Journal of biomolecular structure & dynamics. 2021 07; 39(11):3842-3854. doi: 10.1080/07391102.2020.1772108. [PMID: 32431217]
  • Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akın Yiğin, Abdulsamet Tanık, Mehmet Emrah Polat, Erhan Cahit Özcan. The effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper on the diabetic and nondiabetic gingival wound healing: an experimental study. Turkish journal of medical sciences. 2021 04; 51(2):848-856. doi: 10.3906/sag-2007-193. [PMID: 33244945]
  • Riichi Hashimoto, Hiyori Iai, Rie Fujita, Kengo Hanaya, Shuhei Higashibayashi, Hiroyoshi Inoue, Takeshi Sugai. Chemoenzymatic semisynthesis of caffeic acid β-phenethyl ester, an antioxidative component in propolis, from raw coffee bean extract. Bioscience, biotechnology, and biochemistry. 2021 Feb; 85(3):476-480. doi: 10.1093/bbb/zbaa077. [PMID: 33624772]
  • Xiaoyu Liu, Qianqian Du, Caiping Tian, Mei Tang, Yingjun Jiang, Yong Wang, Yang Cao, Zhe Wang, Zhenwei Wang, Jing Yang, Yan Li, Xiaozhen Jiao, Ping Xie. Discovery of CAPE derivatives as dual EGFR and CSK inhibitors with anticancer activity in a murine model of hepatocellular carcinoma. Bioorganic chemistry. 2021 02; 107(?):104536. doi: 10.1016/j.bioorg.2020.104536. [PMID: 33342565]
  • Milan Rančić, Lidija Ristić, Andrija Rančić, Dane Krtinić, Bojan Ilić, Milorad Pavlović, Miloš Milojković, Nikola Živković, Dušan Sokolović. Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin. Pharmacology. 2021; 106(7-8):400-408. doi: 10.1159/000515935. [PMID: 33975324]
  • Liza Ulčakar, Marko Novinec. Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives. Biomolecules. 2020 12; 11(1):. doi: 10.3390/biom11010031. [PMID: 33383850]
  • Tayfun Ceylan, Emin Kaymak, Fazile Cantürk Tan, Birkan Yakan. Research on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin. Turkish journal of medical sciences. 2020 12; 50(8):2032-2039. doi: 10.3906/sag-2002-58. [PMID: 32628437]
  • Marwa A Ali, Esther T Menze, Marianne G Tadros, Mai F Tolba. Caffeic acid phenethyl ester counteracts doxorubicin-induced chemobrain in Sprague-Dawley rats: Emphasis on the modulation of oxidative stress and neuroinflammation. Neuropharmacology. 2020 12; 181(?):108334. doi: 10.1016/j.neuropharm.2020.108334. [PMID: 33011199]
  • Da Hyun Kim, Joong-Hyuck Auh, Jeongyeon Oh, Seungpyo Hong, Sungbin Choi, Eun Ju Shin, Soon Ok Woo, Tae-Gyu Lim, Sanguine Byun. Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase. Nutrients. 2020 Dec; 12(12):. doi: 10.3390/nu12123790. [PMID: 33322005]
  • Alper Kızıldağ, Taner Arabacı, Mevlüt Albayrak, Havva Müge Balseven, Canan Aksu Kızıldağ, Ufuk Tasdemir. A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2020 Aug; 95(6):456-463. doi: 10.1080/10520295.2020.1718756. [PMID: 32013634]
  • Anna Kleczka, Robert Kubina, Radosław Dzik, Krzysztof Jasik, Jerzy Stojko, Krzysztof Cholewa, Agata Kabała-Dzik. Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes. Molecules (Basel, Switzerland). 2020 Jul; 25(15):. doi: 10.3390/molecules25153514. [PMID: 32752091]
  • M Akil. Effects of Caffeic Acid Phenethyl Ester and Oxidative Stress Caused by the Exhaustion Exercise on Endotelial Damage. Archives italiennes de biologie. 2020 Jun; 158(2):37-44. doi: 10.12871/00039829202021. [PMID: 33462797]
  • Tripti Khare, Sushesh Srivatsa Palakurthi, Brijesh M Shah, Srinath Palakurthi, Sharad Khare. Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease. International journal of molecular sciences. 2020 May; 21(11):. doi: 10.3390/ijms21113956. [PMID: 32486445]
  • Bo Shao, Meixia Wang, Anran Chen, Chunzhi Zhang, Li Lin, Zhaoqiang Zhang, Anlan Chen. Protective effect of caffeic acid phenethyl ester against imidacloprid-induced hepatotoxicity by attenuating oxidative stress, endoplasmic reticulum stress, inflammation and apoptosis. Pesticide biochemistry and physiology. 2020 Mar; 164(?):122-129. doi: 10.1016/j.pestbp.2020.01.001. [PMID: 32284117]
  • Mehmet Gül, Ahmet Günay, Abdulsamet Tanik. An evaluation of the effects of caffeic acid phenethyl ester and Ankaferd blood stopper on secondary wound healing of oral mucosal tissue. Turkish journal of medical sciences. 2020 02; 50(1):248-257. doi: 10.3906/sag-1908-114. [PMID: 31769639]
  • Ayyoub Selka, Jérémie A Doiron, Pierre Lyons, Sonia Dastous, Alison Chiasson, Marc Cormier, Sandra Turcotte, Marc E Surette, Mohamed Touaibia. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. European journal of medicinal chemistry. 2019 Oct; 179(?):347-357. doi: 10.1016/j.ejmech.2019.06.060. [PMID: 31260889]
  • Maroua Mbarik, Samuel J Poirier, Jérémie Doiron, Ayyoub Selka, David A Barnett, Marc Cormier, Mohamed Touaibia, Marc E Surette. Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells. Pharmacology research & perspectives. 2019 10; 7(5):e00524. doi: 10.1002/prp2.524. [PMID: 31523435]
  • Josephine M Gießel, Anne Loesche, René Csuk, Immo Serbian. Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase. European journal of medicinal chemistry. 2019 Sep; 177(?):259-268. doi: 10.1016/j.ejmech.2019.05.059. [PMID: 31158743]
  • N Bıçakçı, I Karaboğa, A H Dökmeci, S Güzel, Z Fidanol Erboğa. Cardioprotective effect of caffeic acid phenethyl ester on cardiac contusion following blunt chest trauma in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2019 Aug; 94(6):442-448. doi: 10.1080/10520295.2019.1586999. [PMID: 30929510]
  • William Collins, Noah Lowen, David J Blake. Caffeic Acid Esters Are Effective Bactericidal Compounds Against Paenibacilluslarvae by Altering Intracellular Oxidant and Antioxidant Levels. Biomolecules. 2019 07; 9(8):. doi: 10.3390/biom9080312. [PMID: 31357646]
  • Sai Li, Qin Huang, Liwen Zhang, Xufang Qiao, Yanyan Zhang, Fashu Tang, Zhubo Li. Effect of CAPE-pNO2 against type 2 diabetes mellitus via the AMPK/GLUT4/ GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice. European journal of pharmacology. 2019 Jun; 853(?):1-10. doi: 10.1016/j.ejphar.2019.03.027. [PMID: 30885574]
  • Toshiyuki Matsunaga, Saeka Tsuchimura, Nozomi Azuma, Satoshi Endo, Kenji Ichihara, Akira Ikari. Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin by decreasing proteasome function. Anti-cancer drugs. 2019 03; 30(3):251-259. doi: 10.1097/cad.0000000000000715. [PMID: 30489290]
  • Lu Fan, Qianhan Xiao, Liwen Zhang, Xiaoling Wang, Qin Huang, Sai Li, Xiaoyan Zhao, Zhubo Li. CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Dec; 108(?):1640-1650. doi: 10.1016/j.biopha.2018.10.026. [PMID: 30372866]
  • Bruna Romana-Souza, Jeanine Salles Dos Santos, Andréa Monte-Alto-Costa. Caffeic acid phenethyl ester promotes wound healing of mice pressure ulcers affecting NF-κB, NOS2 and NRF2 expression. Life sciences. 2018 Aug; 207(?):158-165. doi: 10.1016/j.lfs.2018.05.057. [PMID: 29864436]
  • Mohamed M Abdel-Daim, Suhair A Abdellatief. Attenuating effects of caffeic acid phenethyl ester and betaine on abamectin-induced hepatotoxicity and nephrotoxicity. Environmental science and pollution research international. 2018 Jun; 25(16):15909-15917. doi: 10.1007/s11356-018-1786-8. [PMID: 29589235]
  • Hany A Omar, Mai F Tolba. Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: Role of IGF-1R/protein kinase-B (Akt)/β-catenin signaling. IUBMB life. 2018 06; 70(6):519-528. doi: 10.1002/iub.1743. [PMID: 29603556]
  • Soon-Hee Kim, Hee-Sook Park, Moon Ju Hong, Haeng Jeon Hur, Dae Young Kwon, Myung-Sunny Kim. Caffeic Acid Phenethyl Ester Improves Metabolic Syndrome by Activating PPAR-γ and Inducing Adipose Tissue Remodeling in Diet-Induced Obese Mice. Molecular nutrition & food research. 2018 05; 62(10):e1700701. doi: 10.1002/mnfr.201700701. [PMID: 29508519]
  • Şule Ayla, Gülden Tunalı, Bülent E Bilgiç, Kenan Sofuoğlu, A Arman Özdemir, Gamze Tanrıverdi, Semra Özdemir, B Cem Soner, Bahar Öztürk, Serçin Karahüseyinoğlu, Esra Güler Aslan, Ismail Seçkin. Antioxidant activity of CAPE (caffeic acid phenethyl ester) in vitro can protect human sperm deoxyribonucleic acid from oxidative damage. Acta histochemica. 2018 Feb; 120(2):117-121. doi: 10.1016/j.acthis.2018.01.001. [PMID: 29325972]
  • Bekir Akgun, Sait Ozturk, Gokhan Artas, Fatih Serhat Erol. Effects of Intrathecal Caffeic Acid Phenethyl Ester (CAPE) on IL-6 and TNF-α Levels and Local Inflammatory Responses in Spinal Cord Injuries. Turkish neurosurgery. 2018; 28(4):625-629. doi: 10.5137/1019-5149.jtn.20011-17.1. [PMID: 30192364]
  • Haci Ahmet Deveci, Mahmut Karapehlivan. Chlorpyrifos-induced parkinsonian model in mice: Behavior, histopathology and biochemistry. Pesticide biochemistry and physiology. 2018 Jan; 144(?):36-41. doi: 10.1016/j.pestbp.2017.11.002. [PMID: 29463406]
  • Nanaware Sadhana, Sathiyanarayanan Lohidasan, Kakasaheb Ramoo Mahadik. Marker-based standardization and investigation of nutraceutical potential of Indian propolis. Journal of integrative medicine. 2017 Nov; 15(6):483-494. doi: 10.1016/s2095-4964(17)60360-1. [PMID: 29103419]
  • Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. Journal of natural products. 2017 10; 80(10):2602-2608. doi: 10.1021/acs.jnatprod.6b01052. [PMID: 29043803]
  • Jiarui Nie, Yaning Chang, Yujia Li, Yingjun Zhou, Jiawen Qin, Zhen Sun, Haibin Li. Caffeic Acid Phenethyl Ester (Propolis Extract) Ameliorates Insulin Resistance by Inhibiting JNK and NF-κB Inflammatory Pathways in Diabetic Mice and HepG2 Cell Models. Journal of agricultural and food chemistry. 2017 Oct; 65(41):9041-9053. doi: 10.1021/acs.jafc.7b02880. [PMID: 28799756]
  • Pin Gong, Xiangna Chang, Xuefeng Chen, Xiaohuan Bai, He Wen, Sihui Pi, Wenjuan Yang, Lan Wang, Fuxin Chen. Metabolomics study of cadmium-induced diabetic nephropathy and protective effect of caffeic acid phenethyl ester using UPLC-Q-TOF-MS combined with pattern recognition. Environmental toxicology and pharmacology. 2017 Sep; 54(?):80-92. doi: 10.1016/j.etap.2017.06.021. [PMID: 28704754]
  • Umut Yiğit, Fatma Yeşim Kırzıoğlu, Abdülhadi Cihangir Uğuz, Mustafa Nazıroğlu, Özlem Özmen. Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis?. Archives of oral biology. 2017 Sep; 81(?):61-68. doi: 10.1016/j.archoralbio.2017.04.017. [PMID: 28482239]
  • Hao Tang, Xiaofang Yao, Cong Yao, Xiaoyan Zhao, Hua Zuo, Zhubo Li. Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. Scientific reports. 2017 08; 7(1):7599. doi: 10.1038/s41598-017-07953-8. [PMID: 28790461]
  • Ramin Ekhteiari Salmas, Mehmet Fuat Gulhan, Serdar Durdagi, Engin Sahna, Huda I Abdullah, Zeliha Selamoglu. Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach. Cell biochemistry and function. 2017 Aug; 35(6):304-314. doi: 10.1002/cbf.3277. [PMID: 28833317]
  • Seung Ho Shin, Seoung Rak Lee, Eunjung Lee, Ki Hyun Kim, Sanguine Byun. Caffeic Acid Phenethyl Ester from the Twigs of Cinnamomum cassia Inhibits Malignant Cell Transformation by Inducing c-Fos Degradation. Journal of natural products. 2017 07; 80(7):2124-2130. doi: 10.1021/acs.jnatprod.7b00433. [PMID: 28682072]
  • Ayman M Mahmoud, Sanaa M Abd El-Twab. Caffeic acid phenethyl ester protects the brain against hexavalent chromium toxicity by enhancing endogenous antioxidants and modulating the JAK/STAT signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jul; 91(?):303-311. doi: 10.1016/j.biopha.2017.04.073. [PMID: 28463793]
  • Chonticha Seeka, Samran Prabpai, Palangpon Kongsaeree, Supinya Tewtrakul, Thitima Lhinhatrakool, Somyote Sutthivaiyakit. Anti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerrii. Journal of natural products. 2017 06; 80(6):1714-1724. doi: 10.1021/acs.jnatprod.6b00730. [PMID: 28561586]
  • Ü C Yazgan, B Elbey, S Kuş, B Baykal, I Keskin, A Yılmaz, A Şahin. Effect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication. Irish journal of medical science. 2017 May; 186(2):519-523. doi: 10.1007/s11845-016-1462-2. [PMID: 27139198]
  • Jérémie A Doiron, Luc M Leblanc, Martin J G Hébert, Natalie A Levesque, Aurélie F Paré, Jacques Jean-François, Marc Cormier, Marc E Surette, Mohamed Touaibia. Structure-activity relationship of caffeic acid phenethyl ester analogs as new 5-lipoxygenase inhibitors. Chemical biology & drug design. 2017 04; 89(4):514-528. doi: 10.1111/cbdd.12874. [PMID: 27717142]
  • Bonnie Williams, Eleni Tsangari, Romany Stansborough, Victor Marino, Melissa Cantley, Anak Dharmapatni, Rachel Gibson, Egon Perilli, Tania Crotti. Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis. Inflammopharmacology. 2017 Feb; 25(1):55-68. doi: 10.1007/s10787-016-0306-z. [PMID: 28044215]
  • Yan Xu, Sheng Sheng, Xi Liu, Chao Wang, Wei Xiao, Jun Wang, Fu-An Wu. Cooperative Reinforcement of Ionic Liquid and Reactive Solvent on Enzymatic Synthesis of Caffeic Acid Phenethyl Ester as an In Vitro Inhibitor of Plant Pathogenic Bacteria. Molecules (Basel, Switzerland). 2017 Jan; 22(1):. doi: 10.3390/molecules22010072. [PMID: 28045451]
  • Sonata Trumbeckaite, Neringa Pauziene, Darius Trumbeckas, Mindaugas Jievaltas, Rasa Baniene. Caffeic Acid Phenethyl Ester Reduces Ischemia-Induced Kidney Mitochondrial Injury in Rats. Oxidative medicine and cellular longevity. 2017; 2017(?):1697018. doi: 10.1155/2017/1697018. [PMID: 28883899]
  • Recep Dokuyucu, Ali Bilgili, Basak Hanedan, Hatice Dogan, Ahmet Dokuyucu, Muhammed Murat Celik. Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats. Medycyna pracy. 2016 Dec; 67(6):743-749. doi: 10.13075/mp.5893.00462. [PMID: 28005083]
  • Mahşuk Taylan, Halide Kaya, Melike Demir, Osman Evliyaoğlu, Hadice Selimoglu Sen, Ugur Fırat, Aysenur Keles, Sureyya Yilmaz, Cengizhan Sezgi. The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2016 Dec; 29(6):328-334. doi: 10.3109/08941939.2016.1149641. [PMID: 26980558]
  • Elif Demir, Seyithan Taysi, Behcet Al, Tuncer Demir, Seydi Okumus, Oguzhan Saygili, Edibe Saricicek, Ahmet Dirier, Muslum Akan, Mehmet Tarakcioglu, Cahit Bagci. The effects of Nigella sativa oil, thymoquinone, propolis, and caffeic acid phenethyl ester on radiation-induced cataract. Wiener klinische Wochenschrift. 2016 Dec; 128(Suppl 8):587-595. doi: 10.1007/s00508-015-0736-4. [PMID: 25860848]
  • Mujgan Cengiz, Nurnisa Oya Alansal, Matem Tuncdemir, Gamze Tanriverdi, Burcu Bayoglu. Evaluation of effects of melatonin and caffeic acid phenethyl ester on acute potassium dichromate toxicity and genotoxicity in rats. Indian journal of pharmacology. 2016 Jul; 48(4):407-411. doi: 10.4103/0253-7613.186213. [PMID: 27756952]
  • Mustafa Erboga, Mehmet Kanter, Cevat Aktas, Yeliz Bozdemir Donmez, Zeynep Fidanol Erboga, Emel Aktas, Ahmet Gurel. Anti-Apoptotic and Anti-Oxidant Effects of Caffeic Acid Phenethyl Ester on Cadmium-Induced Testicular Toxicity in Rats. Biological trace element research. 2016 May; 171(1):176-84. doi: 10.1007/s12011-015-0509-y. [PMID: 26424218]
  • Hongliang Li, Fan Wu, Jing Tan, Kai Wang, Cuiping Zhang, Huoqing Zheng, Fuliang Hu. Caffeic acid phenethyl ester exhibiting distinctive binding interaction with human serum albumin implies the pharmacokinetic basis of propolis bioactive components. Journal of pharmaceutical and biomedical analysis. 2016 Apr; 122(?):21-8. doi: 10.1016/j.jpba.2016.01.040. [PMID: 26829518]
  • Ahmet Koyu, Osman Gokalp, Nurhan Gumral, Faruk Oktem, Nermin Karahan, Nigar Yilmaz, Mustafa Saygin. Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats. Toxicology and industrial health. 2016 Feb; 32(2):306-12. doi: 10.1177/0748233713501708. [PMID: 24097368]
  • Zeynep Ginis, Gulfer Ozturk, Aynur Albayrak, Sefika Nur Kurt, Murat Albayrak, Ersin Fadillioglu. Protective effects of caffeic acid phenethyl ester on ifosfamide-induced central neurotoxicity in rats. Toxicology and industrial health. 2016 Feb; 32(2):337-43. doi: 10.1177/0748233713500817. [PMID: 24097369]
  • Ahmet Yılmaz, Bilal Elbey, Ümit Can Yazgan, Ahmet Dönder, Necmi Arslan, Serkan Arslan, Ulaş Alabalık, Hamza Aslanhan. Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study. BioMed research international. 2016; 2016(?):1247191. doi: 10.1155/2016/1247191. [PMID: 27144157]
  • Sedat Meydan, Ahmet Nacar, Hasan Oktay Oztürk, Ufuk Tas, Evren Köse, Ismail Zararsiz, Nigar Yılmaz, Ilter Kus. The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats. Toxicology and industrial health. 2016 Jan; 32(1):15-21. doi: 10.1177/0748233713485890. [PMID: 23858052]
  • Claudia Bosio, Giacomo Tomasoni, Rolando Martínez, Andrés F Olea, Héctor Carrasco, Joan Villena. Cytotoxic and apoptotic effects of leptocarpin, a plant-derived sesquiterpene lactone, on human cancer cell lines. Chemico-biological interactions. 2015 Dec; 242(?):415-21. doi: 10.1016/j.cbi.2015.11.006. [PMID: 26562779]
  • Yan Shi, Li Guo, Lu Shi, Jinyang Yu, Min Song, Yana Li. Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats. Medical science monitor : international medical journal of experimental and clinical research. 2015 Sep; 21(?):2774-80. doi: 10.12659/msm.895272. [PMID: 26378818]
  • Sumeyya Akyol, Bunyamin Isik, Aynur Altuntas, Gonul Erden, Ozlem Cakmak, S Fatih Kurşunlu, Bahattin Adam, Omer Akyol. Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review). Molecular medicine reports. 2015 Sep; 12(3):3231-3235. doi: 10.3892/mmr.2015.3785. [PMID: 25975288]
  • Liu-Gen Jin, Jian-Jun Chu, Qing-Feng Pang, Fu-Zheng Zhang, Gang Wu, Le-Yuan Zhou, Xiao-Jun Zhang, Chun-Gen Xing. Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats. Environmental toxicology and pharmacology. 2015 Jul; 40(1):156-63. doi: 10.1016/j.etap.2015.05.012. [PMID: 26122083]
  • Masahiko Imai, Takaya Kumaoka, Makiko Hosaka, Yui Sato, Chuan Li, Masashi Sudoh, Yoshiko Tamada, Hiromasa Yokoe, Setsu Saito, Masayoshi Tsubuki, Noriko Takahashi. Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation. Bioorganic & medicinal chemistry. 2015 Jul; 23(13):3788-95. doi: 10.1016/j.bmc.2015.03.086. [PMID: 25910587]
  • M S F Zawawi, E Perilli, R L Stansborough, V Marino, M D Cantley, J Xu, A A S S K Dharmapatni, D R Haynes, R J Gibson, T N Crotti. Caffeic acid phenethyl ester abrogates bone resorption in a murine calvarial model of polyethylene particle-induced osteolysis. Calcified tissue international. 2015 Jun; 96(6):565-74. doi: 10.1007/s00223-015-9982-8. [PMID: 25804981]
  • U Firat, S Senol, I Gelincik, M Kapan, O Tokgoz, R Tekin, O Evliyaoglu, A Onder, H Alp. The effects of caffeic acid phenethyl ester (CAPE) on bacterial translocation and inflammatory response in an experimental intestinal obstruction model in rats. European review for medical and pharmacological sciences. 2015 May; 19(10):1907-14. doi: NULL. [PMID: 26044239]
  • Mei Li, Xiu-Fang Wang, Juan-Juan Shi, Ya-Ping Li, Ning Yang, Song Zhai, Shuang-Suo Dang. Caffeic acid phenethyl ester inhibits liver fibrosis in rats. World journal of gastroenterology. 2015 Apr; 21(13):3893-903. doi: 10.3748/wjg.v21.i13.3893. [PMID: 25852274]
  • Kyung-Min Lim, SeungJin Bae, Jung Eun Koo, Eun-Sun Kim, Ok-Nam Bae, Joo Young Lee. Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester. Archives of dermatological research. 2015 Apr; 307(3):219-27. doi: 10.1007/s00403-014-1529-8. [PMID: 25501505]
  • Hakan Ak, İsmail Gülşen, Tamer Karaaslan, İlker Alaca, Aydın Candan, Havva Koçak, Tugay Atalay, Asuman Çelikbilek, İsmail Demir, Tevfik Yılmaz. The effects of caffeic acid phenethyl ester on inflammatory cytokines after acute spinal cord injury. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES. 2015 Mar; 21(2):96-101. doi: 10.5505/tjtes.2015.33848. [PMID: 25904269]
  • Murat Mehmet Rifaioglu, Fatih Sefil, Hasan Gokce, Ahmet Nacar, Bayram Ali Dorum, Mursel Davarci. Protective effects of caffeic acid phenethyl ester on the dose-dependent acute nephrotoxicity with paraquat in a rat model. Environmental toxicology. 2015 Mar; 30(3):375-81. doi: 10.1002/tox.21915. [PMID: 24265188]
  • JianJun Chu, Xiaojun Zhang, Liugen Jin, Junliang Chen, Bin Du, Qingfeng Pang. Protective effects of caffeic acid phenethyl ester against acute radiation-induced hepatic injury in rats. Environmental toxicology and pharmacology. 2015 Mar; 39(2):683-9. doi: 10.1016/j.etap.2015.01.020. [PMID: 25704035]
  • Oztekin Cikman, Seyithan Taysi, Murat Taner Gulsen, Elif Demir, Muslum Akan, Halit Diril, Hasan Ali Kiraz, Muammer Karaayvaz, Mehmet Tarakcioglu. The radio-protective effects of caffeic acid phenethyl ester and thymoquinone in rats exposed to total head irradiation. Wiener klinische Wochenschrift. 2015 Feb; 127(3-4):103-8. doi: 10.1007/s00508-014-0635-0. [PMID: 25409943]
  • Fırat Barış Barlas, Suat Erdoğan. Caffeic acid phenethyl ester protects lung alveolar epithelial cells from cigarette smoke-induced damage. Turkish journal of medical sciences. 2015; 45(3):534-41. doi: 10.3906/sag-1404-14. [PMID: 26281316]
  • Cuneyt Gocmez, Feyzi Celik, Kagan Kamasak, Metin Kaplan, Ertugrul Uzar, Adalet Arıkanoglu, Osman Evliyaoglu. Effects of intrathecal caffeic acid phenethyl ester and methylprednisolone on oxidant/antioxidant status in traumatic spinal cord injuries. Journal of neurological surgery. Part A, Central European neurosurgery. 2015 Jan; 76(1):20-4. doi: 10.1055/s-0034-1371513. [PMID: 24871822]
  • Ozlem Alici, Havva Sahin Kavakli, Cemile Koca, Neriman Defne Altintas, Murat Aydin, Suleyman Alici. Value of caffeic acid phenethyl ester pretreatment in experimental sepsis model in rats. Mediators of inflammation. 2015; 2015(?):810948. doi: 10.1155/2015/810948. [PMID: 25948886]
  • Takeshi Yokoyama, Yuto Kosaka, Mineyuki Mizuguchi. Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. Journal of medicinal chemistry. 2014 Nov; 57(21):8928-35. doi: 10.1021/jm500997m. [PMID: 25314129]
  • Selçuk İlhan, Nigar Yılmaz, Emel Nacar, Sedat Motor, Süleyman Oktar, Engin Şahna. The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology. 2014 Nov; 14(7):576-82. doi: 10.5152/akd.2014.4825. [PMID: 25036319]
  • Mustafa Kassim, Marzida Mansor, Tengku Ain Kamalden, Ina Ismiarti Shariffuddin, Mohd Shahnaz Hasan, Gracie Ong, Shamala Devi Sekaran, Anwar Suhaimi, Nazeh Al-Abd, Kamaruddin Mohd Yusoff. Caffeic acid phenethyl ester (CAPE): scavenger of peroxynitrite in vitro and in sepsis models. Shock (Augusta, Ga.). 2014 Aug; 42(2):154-60. doi: 10.1097/shk.0000000000000179. [PMID: 24667629]
  • Noura Ahmed Hassan, Hany M El-Bassossy, Mona Fouad Mahmoud, Ahmed Fahmy. Caffeic acid phenethyl ester, a 5-lipoxygenase enzyme inhibitor, alleviates diabetic atherosclerotic manifestations: effect on vascular reactivity and stiffness. Chemico-biological interactions. 2014 Apr; 213(?):28-36. doi: 10.1016/j.cbi.2014.01.019. [PMID: 24508943]
  • Murat Mehmet Rifaioglu, Mursel Davarci, Ahmet Nacar, Harun Alp, Murat Celik, Nebihat Kaplan Sefil, Mehmet Inci. Caffeic acid phenethyl ester (CAPE) protects against acute urogenital injury following pneumoperitoneum in the rat. Renal failure. 2014 Feb; 36(1):98-103. doi: 10.3109/0886022x.2013.832317. [PMID: 24028427]
  • John Yang, Phillip D Bowman, Sean M Kerwin, Salomon Stavchansky. Development and validation of an LCMS method to determine the pharmacokinetic profiles of caffeic acid phenethyl amide and caffeic acid phenethyl ester in male Sprague-Dawley rats. Biomedical chromatography : BMC. 2014 Feb; 28(2):241-6. doi: 10.1002/bmc.3011. [PMID: 23982887]
  • Hua Bai, Rui Liu, Hong-Li Chen, Wei Zhang, Xin Wang, Xiao-Di Zhang, Wen-Li Li, Chun-Xu Hai. Enhanced antioxidant effect of caffeic acid phenethyl ester and Trolox in combination against radiation induced-oxidative stress. Chemico-biological interactions. 2014 Jan; 207(?):7-15. doi: 10.1016/j.cbi.2013.10.022. [PMID: 24211618]
  • En-Pei Isabel Chiang, Shu-Yao Tsai, Yueh-Hsiung Kuo, Man-Hui Pai, Hsi-Lin Chiu, Raymond L Rodriguez, Feng-Yao Tang. Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. PloS one. 2014; 9(6):e99631. doi: 10.1371/journal.pone.0099631. [PMID: 24960186]
  • Sumeyya Akyol, Veli Ugurcu, Aynur Altuntas, Rukiye Hasgul, Ozlem Cakmak, Omer Akyol. Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: a detailed systematic review. TheScientificWorldJournal. 2014; 2014(?):561971. doi: 10.1155/2014/561971. [PMID: 25003138]
  • Atila Altuntaş, H Ramazan Yılmaz, Ayşegül Altuntaş, Efkan Uz, Murat Demir, Alparslan Gökçimen, Oğuzhan Aksu, Dilek Şenol Bayram, Mehmet Tuğrul Sezer. Caffeic acid phenethyl ester protects against amphotericin B induced nephrotoxicity in rat model. BioMed research international. 2014; 2014(?):702981. doi: 10.1155/2014/702981. [PMID: 25032223]
  • Esin Oğuzhanoğlu, Ahmet Cenk Andaç, Adnan Tüfek, Lütfi Yavuz, Hüseyin Vural, Osman Gökalp. Protective role of caffeic acid phenethyl ester on serum cholinesterase inhibition by acute exposure to diazinon in rats. Turkish journal of medical sciences. 2014; 44(1):115-20. doi: 10.3906/sag-1210-46. [PMID: 25558570]