Hypolaetin (BioDeep_00000007862)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5,7,8-trihydroxy-4H-chromen-4-one

化学式: C15H10O7 (302.0427)
中文名称:
谱图信息: 最多检出来源 Astragalus membranaceus(plant) 75%

分子结构信息

SMILES: C1(O)=C(O)C2OC(C3C=CC(O)=C(O)C=3)=CC(=O)C=2C(O)=C1
InChI: InChI=1S/C15H10O7/c16-7-2-1-6(3-8(7)17)12-5-10(19)13-9(18)4-11(20)14(21)15(13)22-12/h1-5,16-18,20-21H



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALOX5, BCL2, CALM2, GPX1, HSPA5, HYAL1, PLA2G12A, POMC, PTGS2, TYR, YKT6
Peripheral membrane protein 3 ACHE, ALOX5, PTGS2
Endoplasmic reticulum membrane 3 BCL2, HSPA5, PTGS2
Nucleus 5 ACHE, BCL2, CALM2, CEBPA, HSPA5
cytosol 7 ALOX5, BCL2, GPX1, HSPA5, LEP, SLC2A4, YKT6
trans-Golgi network 1 SLC2A4
centrosome 1 CALM2
nucleoplasm 2 ALOX5, CEBPA
RNA polymerase II transcription regulator complex 1 CEBPA
Cell membrane 3 ACHE, SLC2A4, TNF
Lipid-anchor 1 YKT6
Cytoplasmic side 1 YKT6
Multi-pass membrane protein 1 SLC2A4
Golgi apparatus membrane 1 YKT6
Synapse 1 ACHE
cell surface 4 ACHE, ADIPOQ, HSPA5, TNF
Golgi apparatus 2 ACHE, YKT6
Golgi membrane 2 INS, YKT6
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 2 TNF, YKT6
sarcolemma 1 SLC2A4
Cytoplasm, cytosol 1 ALOX5
Lysosome 3 GAA, HYAL1, TYR
Presynapse 1 SLC2A4
endosome 1 YKT6
plasma membrane 8 ACHE, BCHE, CALM2, GAA, HSPA5, SLC2A4, TNF, YKT6
Membrane 7 ACHE, BCL2, CALM2, GAA, HSPA5, SLC2A4, YKT6
caveola 1 PTGS2
extracellular exosome 4 GAA, HSPA5, HYAL1, SLC2A4
Lysosome membrane 1 GAA
endoplasmic reticulum 5 ADIPOQ, BCL2, HSPA5, PTGS2, YKT6
extracellular space 9 ACHE, ADIPOQ, ALOX5, BCHE, HYAL1, INS, LEP, POMC, TNF
lysosomal lumen 2 GAA, HYAL1
perinuclear region of cytoplasm 4 ACHE, ALOX5, SLC2A4, TYR
mitochondrion 4 BCL2, GPX1, HSPA5, YKT6
protein-containing complex 4 BCL2, CALM2, HSPA5, PTGS2
intracellular membrane-bounded organelle 4 CEBPA, GAA, HSPA5, TYR
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 TYR
Secreted 9 ACHE, ADIPOQ, BCHE, GAA, HYAL1, INS, LEP, PLA2G12A, POMC
extracellular region 11 ACHE, ADIPOQ, ALOX5, BCHE, GAA, HYAL1, INS, LEP, PLA2G12A, POMC, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 GPX1
Extracellular side 1 ACHE
transcription regulator complex 1 CEBPA
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CALM2
Nucleus membrane 2 ALOX5, BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 ALOX5, BCL2
external side of plasma membrane 2 SLC2A4, TNF
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
cytoplasmic vesicle 1 HYAL1
nucleolus 1 CEBPA
Melanosome membrane 1 TYR
midbody 1 HSPA5
clathrin-coated pit 1 SLC2A4
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 CALM2
Cytoplasm, perinuclear region 2 ALOX5, SLC2A4
Membrane raft 2 SLC2A4, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton, spindle 1 CALM2
focal adhesion 1 HSPA5
basement membrane 1 ACHE
collagen trimer 1 ADIPOQ
sarcoplasmic reticulum 1 SLC2A4
collagen-containing extracellular matrix 1 ADIPOQ
secretory granule 1 POMC
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
sarcomere 1 CALM2
neuron projection 1 PTGS2
chromatin 1 CEBPA
phagocytic cup 1 TNF
spindle pole 1 CALM2
blood microparticle 1 BCHE
sperm midpiece 1 CALM2
Lipid-anchor, GPI-anchor 1 ACHE
Cytoplasm, cytoskeleton, spindle pole 1 CALM2
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 2 SLC2A4, YKT6
endosome lumen 1 INS
Cytoplasmic vesicle membrane 2 SLC2A4, YKT6
tertiary granule membrane 1 GAA
Melanosome 2 HSPA5, TYR
side of membrane 1 ACHE
myelin sheath 2 BCL2, CALM2
SNARE complex 1 YKT6
clathrin-coated vesicle 1 SLC2A4
voltage-gated potassium channel complex 1 CALM2
trans-Golgi network transport vesicle 1 SLC2A4
hyaluranon cable 1 HYAL1
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 3 ALOX5, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BCHE, HSPA5, INS, PTGS2
nuclear matrix 1 ALOX5
transport vesicle 2 INS, YKT6
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 INS, YKT6
Nucleus matrix 1 ALOX5
nuclear envelope lumen 2 ALOX5, BCHE
calyx of Held 1 CALM2
vesicle membrane 1 SLC2A4
calcium channel complex 1 CALM2
endoplasmic reticulum-Golgi intermediate compartment 1 HSPA5
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
spindle microtubule 1 CALM2
apical dendrite 1 YKT6
basal dendrite 1 YKT6
presynaptic cytosol 1 CALM2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalytic complex 1 CALM2
endoplasmic reticulum chaperone complex 1 HSPA5
Nucleus intermembrane space 1 ALOX5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
insulin-responsive compartment 1 SLC2A4
C/EBP complex 1 CEBPA
CHOP-C/EBP complex 1 CEBPA
[Isoform H]: Cell membrane 1 ACHE
[Isoform 4]: Nucleus, nucleolus 1 CEBPA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Nan Qin, Chun-Bao Li, Mei-Na Jin, Li-Huan Shi, Hong-Quan Duan, Wen-Yan Niu. Synthesis and biological activity of novel tiliroside derivants. European journal of medicinal chemistry. 2011 Oct; 46(10):5189-95. doi: 10.1016/j.ejmech.2011.07.059. [PMID: 21856048]
  • Wafa Marouane, Ahlem Soussi, Jean-Claude Murat, Sofiane Bezzine, Abdelfattah El Feki. The protective effect of Malva sylvestris on rat kidney damaged by vanadium. Lipids in health and disease. 2011 Apr; 10(?):65. doi: 10.1186/1476-511x-10-65. [PMID: 21513564]
  • Jie Feng, Xiu-Wei Yang, Ru-Feng Wang. Bio-assay guided isolation and identification of α-glucosidase inhibitors from the leaves of Aquilaria sinensis. Phytochemistry. 2011 Feb; 72(2-3):242-7. doi: 10.1016/j.phytochem.2010.11.025. [PMID: 21215978]
  • Elizabeth A Mazzio, Fran Close, Karam F A Soliman. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences. 2011 Jan; 12(1):506-69. doi: 10.3390/ijms12010506. [PMID: 21340000]
  • Jasmina Petreska, Gjose Stefkov, Svetlana Kulevanova, Kalina Alipieva, Vassya Bankova, Marina Stefova. Phenolic compounds of mountain tea from the Balkans: LC/DAD/ESI/MSn profile and content. Natural product communications. 2011 Jan; 6(1):21-30. doi: . [PMID: 21366039]
  • Peng-Fei Xia, Zi-Ming Feng, Ya-Nan Yang, Pei-Cheng Zhang. Two flavonoid glycosides and a phenylpropanoid glucose ester from the leaves of Sterculia foetida. Journal of Asian natural products research. 2009 Aug; 11(8):766-71. doi: 10.1080/10286020903055103. [PMID: 20183322]
  • Bisera Janeska, Marina Stefova, Kalina Alipieva. Assay of flavonoid aglycones from the species of genus Sideritis (Lamiaceae) from Macedonia with HPLC-UV DAD. Acta pharmaceutica (Zagreb, Croatia). 2007 Sep; 57(3):371-7. doi: 10.2478/v10007-007-0030-8. [PMID: 17878116]
  • Marita Hillenbrand, Josef Zapp, Hans Becker. Depsides from the petals of Papaver rhoeas. Planta medica. 2004 Apr; 70(4):380-2. doi: 10.1055/s-2004-818956. [PMID: 15095160]
  • E A Aboutabl, M I Nassar, F M Elsakhawy, Y A Maklad, A F Osman, E A M El-Khrisy. Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild. Journal of ethnopharmacology. 2002 Oct; 82(2-3):177-84. doi: 10.1016/s0378-8741(02)00172-1. [PMID: 12241993]