Curine (BioDeep_00000007834)

 

Secondary id: BioDeep_00001869845

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3,2:14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinoline-9,19-diol, 2,3,13a,14,15,16,25,25a-octahydro-18,29-dimethoxy-1,14-dimethyl-, (13aR,25aR)-

化学式: C36H38N2O6 (594.273)
中文名称: 左旋箭毒碱, 綠心樹鹼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)N(CCC6=CC(=C5O)OC)C)OC
InChI: InChI=1S/C36H38N2O6/c1-37-13-11-23-18-31(41-3)32-20-26(23)27(37)15-21-5-8-25(9-6-21)43-36-34-24(19-33(42-4)35(36)40)12-14-38(2)28(34)16-22-7-10-29(39)30(17-22)44-32/h5-10,17-20,27-28,39-40H,11-16H2,1-4H3/t27-,28-/m0/s1

描述信息

Curine is an aromatic ether.
Curine is a natural product found in Cissampelos pareira, Cyclea barbata, and other organisms with data available.

同义名列表

23 个代谢物同义名

13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3,2:14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinoline-9,19-diol, 2,3,13a,14,15,16,25,25a-octahydro-18,29-dimethoxy-1,14-dimethyl-, (13aR,25aR)-; (1R,16R)-10,25-dimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene-9,21-diol; (13AR,25AR)-2,3,13A,14,15,16,25,25A-OCTAHYDRO-18,29-DIMETHOXY-1,14-DIMETHYL-13H-4,6:21,24-DIETHENO-8,12-METHENO-1H-PYRIDO(3,2:14,15)(1,11)DIOXACYCLO-EICOSINO(2,3,4-IJ)ISOQUINOLINE-9,19-DIOL; (11R,51R)-16,56-dimethoxy-12,52-dimethyl-11,12,13,14,51,52,53,54-octahydro-2,6-dioxa-1(7,1),5(1,8)-diisoquinolina-3(1,3),7(1,4)-dibenzenacyclooctaphane-36,57-diol; Tubocuran-7,12-diol, 6,6-dimethoxy-2,2-dimethyl-, (1beta)-(+-)-; Tubocuraran-7,12-diol, 6,6-dimethoxy-2,2-dimethyl-, (1.beta.)-; Tubocuraran-7,12-diol, 6,6-dimethoxy-2,2-dimethyl-, (1beta)-; (1beta)-(+-)-6,6-Dimethoxy-2,2-dimethyltubocuran-7,12-diol; Tubocuraran-7, 6,6-dimethoxy-2,2-dimethyl-, (1.beta.)-; Aristolochine (C36 alkaloid); (-)-Bebeerine, ~95\\% (TLC); CHONODOENDRINE (L); (-)-Bebeerine; (-)-Bebeerin; CURINE [MI]; 1-Bebeerine; L-Bebeerine; (-)-Curine; 1-Curine; l-Curine; Curine; Bebeerine; (+)-Bebeerine



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

41 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ANXA5, IL13, MTOR, PPARG, PRKX, PTEN, PTGS2
Peripheral membrane protein 4 ACHE, ANXA5, MTOR, PTGS2
Endoplasmic reticulum membrane 2 MTOR, PTGS2
Nucleus 5 ACHE, MTOR, PPARG, PRKX, PTEN
cytosol 6 ANXA5, HCCS, MTOR, PPARG, PRKCQ, PTEN
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 4 MTOR, PPARG, PRKX, PTEN
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 3 ABCB1, ACHE, TNF
Lipid-anchor 1 HCCS
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 2 ABCB1, CACNA1I
Golgi apparatus membrane 1 MTOR
Synapse 1 ACHE
cell surface 3 ABCB1, ACHE, TNF
Golgi apparatus 1 ACHE
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 HCCS
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
sarcolemma 1 ANXA5
Lysosome 1 MTOR
plasma membrane 7 ABCB1, ACHE, CACNA1I, IGHE, PRKCQ, PTEN, TNF
Membrane 6 ABCB1, ACHE, ANXA5, CACNA1I, HCCS, MTOR
apical plasma membrane 2 ABCB1, PTEN
caveola 1 PTGS2
extracellular exosome 2 ABCB1, ANXA5
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 PTGS2
extracellular space 5 ACHE, CCL11, IGHE, IL13, TNF
perinuclear region of cytoplasm 2 ACHE, PPARG
mitochondrion 1 HCCS
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 PTEN
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 IGHE
Secreted 3 ACHE, CCL11, IL13
extracellular region 7 ACHE, ANXA5, CCL11, IGHE, IL13, PTEN, TNF
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Extracellular side 1 ACHE
centriolar satellite 1 PRKCQ
external side of plasma membrane 3 ANXA5, IL13, TNF
dendritic spine 1 PTEN
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 1 HCCS
Membrane raft 1 TNF
focal adhesion 1 ANXA5
basement membrane 1 ACHE
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 2 MTOR, PTEN
PML body 2 MTOR, PTEN
collagen-containing extracellular matrix 1 ANXA5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
Cell projection, neuron projection 1 PTEN
Zymogen granule membrane 1 ANXA5
neuron projection 2 PTEN, PTGS2
chromatin 1 PPARG
IgE immunoglobulin complex 1 IGHE
cell projection 1 PTEN
phagocytic cup 1 TNF
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
side of membrane 1 ACHE
endoplasmic reticulum lumen 1 PTGS2
voltage-gated calcium channel complex 1 CACNA1I
Schmidt-Lanterman incisure 1 PTEN
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
vesicle membrane 1 ANXA5
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, phagosome 1 MTOR
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
myelin sheath adaxonal region 1 PTEN
endothelial microparticle 1 ANXA5
[Isoform alpha]: Secreted 1 PTEN
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Thitima Rukachaisirikul, Sittisak Kumjun, Parichat Suebsakwong, Nuttapon Apiratikul, Apichart Suksamrarn. A new pyrrole alkaloid from the roots of Cissampelos pareira. Natural product research. 2021 Jan; 35(1):80-87. doi: 10.1080/14786419.2019.1614576. [PMID: 31135214]
  • Saqib Ali, Muhammad Alamzeb, Mamoon Ur Rashid, William N Setzer. Effect of Temperature on 1H NMR Spectra, Antitrypanosomal Activity, Conformational Analysis, and Molecular Docking of Curine Derivatives from Berberis brevissima. Journal of natural products. 2020 05; 83(5):1383-1393. doi: 10.1021/acs.jnatprod.9b00397. [PMID: 32364734]
  • Manju Bala, Shiv Kumar, Kunal Pratap, Praveen Kumar Verma, Yogendra Padwad, Bikram Singh. Bioactive isoquinoline alkaloids from Cissampelos pareira †. Natural product research. 2019 Mar; 33(5):622-627. doi: 10.1080/14786419.2017.1402319. [PMID: 29126362]
  • Bruna Braga Dantas, Gláucia Veríssimo Faheina-Martins, Tangbadioa Hervé Coulidiati, Caio César Barbosa Bomfim, Celidarque da Silva Dias, José Maria Barbosa-Filho, Demetrius Antônio Machado Araújo. Effects of curine in HL-60 leukemic cells: cell cycle arrest and apoptosis induction. Journal of natural medicines. 2015 Apr; 69(2):218-23. doi: 10.1007/s11418-014-0881-5. [PMID: 25616501]
  • Jaime Ribeiro-Filho, Márcia Regina Piuvezam, Patrícia T Bozza. Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid. Molecules (Basel, Switzerland). 2015 Mar; 20(3):4695-707. doi: 10.3390/molecules20034695. [PMID: 25781071]
  • Jaime Ribeiro-Filho, Fagner Carvalho Leite, Hermann Ferreira Costa, Andrea Surrage Calheiros, Rafael Carvalho Torres, Carolina Trindade de Azevedo, Marco Aurélio Martins, Celidarque da Silva Dias, Patrícia T Bozza, Márcia Regina Piuvezam. Curine inhibits mast cell-dependent responses in mice. Journal of ethnopharmacology. 2014 Sep; 155(2):1118-24. doi: 10.1016/j.jep.2014.06.041. [PMID: 24969825]
  • Fagner Carvalho Leite, Jaime Ribeiro-Filho, Hermann Ferreira Costa, Paula Regina Rodrigues Salgado, Andrea Surrage Calheiros, Alan Brito Carneiro, Reinaldo Nobrega de Almeida, Celidarque da Silva Dias, Patricia T Bozza, Marcia Regina Piuvezam. Curine, an alkaloid isolated from Chondrodendron platyphyllum inhibits prostaglandin E2 in experimental models of inflammation and pain. Planta medica. 2014 Aug; 80(13):1072-8. doi: 10.1055/s-0034-1382997. [PMID: 25197953]
  • Jaime Ribeiro-Filho, Andrea Surrage Calheiros, Adriana Vieira-de-Abreu, Katharinne Ingrid Moraes de Carvalho, Diego da Silva Mendes, Christianne Bandeira Melo, Marco Aurélio Martins, Celidarque da Silva Dias, Márcia Regina Piuvezam, Patrícia T Bozza. Curine inhibits eosinophil activation and airway hyper-responsiveness in a mouse model of allergic asthma. Toxicology and applied pharmacology. 2013 Nov; 273(1):19-26. doi: 10.1016/j.taap.2013.08.015. [PMID: 23994558]
  • Jian-Zhong Wang, Xiao-Yu Liu, Feng-Peng Wang. Two new curine-type bisbenzylisoquinoline alkaloids from the roots of Cyclea wattii with cytotoxic activities. Chemical & pharmaceutical bulletin. 2010 Jul; 58(7):986-8. doi: 10.1248/cpb.58.986. [PMID: 20606353]
  • Gemini Alam, Subagus Wahyuono, Ibnu G Ganjar, Lukman Hakim, H Timmerman, Rob Verpoorte. Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia. Planta medica. 2002 Nov; 68(11):1047-9. doi: 10.1055/s-2002-35650. [PMID: 12451502]