1,3,5,8-Tetrahydroxyxanthone (BioDeep_00000007774)

Main id: BioDeep_00000229849

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


1,3,5,8-Tetrahydroxy-9H-xanthen-9-one

化学式: C13H8O6 (260.0321)
中文名称: 去甲基雏叶龙胆酮, 1,3,5,8-四羟基x吨酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(cc(c2c(c1)oc1c(c2=O)c(ccc1O)O)O)O
InChI: InChI=1S/C13H8O6/c14-5-3-8(17)10-9(4-5)19-13-7(16)2-1-6(15)11(13)12(10)18/h1-4,14-17H

描述信息

同义名列表

10 个代谢物同义名

1,3,5,8-Tetrahydroxy-9H-xanthen-9-one; 1,3,5,8-Tetrahydroxyxanthen-9-one; 1,3,5,8-Tetrahydroxyxanthone; 1,3,5,8-Tetrahdroxyyxanthone; Desmethylbellidifolin; Demethylbellidifolin; Bellidin; DMB; Demethylbellidifolin; 1,3,5,8-Tetrahydroxyxanthone



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(2)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(5)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

105 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ADIG, AIMP2, AKR1B1, CAT, CES2, FDPS, GLI1, MARVELD1, MTOR, PGR, PIK3CA, PPARG, PTGS2, TJP1
Peripheral membrane protein 3 MTOR, PTGS2, TJP1
Endoplasmic reticulum membrane 2 MTOR, PTGS2
Nucleus 10 ADIG, AIMP2, CEBPA, GLI1, MARVELD1, MPO, MTOR, PGR, PPARG, TJP1
cytosol 11 AIMP2, AKR1B1, CAT, CES2, FDPS, GLI1, MTOR, PGR, PIK3CA, PPARG, TJP1
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 8 AKR1B1, CEBPA, FDPS, GLI1, MPO, MTOR, PGR, PPARG
RNA polymerase II transcription regulator complex 2 CEBPA, PPARG
Cell membrane 2 MARVELD1, TJP1
Cytoplasmic side 2 MTOR, TJP1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 MARVELD1
Golgi apparatus membrane 1 MTOR
cell junction 1 TJP1
Golgi apparatus 1 CCN2
Golgi membrane 1 MTOR
lysosomal membrane 2 GAA, MTOR
Cytoplasm, cytosol 1 AIMP2
Lysosome 3 GAA, MPO, MTOR
plasma membrane 6 CCN2, GAA, MARVELD1, PGR, PIK3CA, TJP1
Membrane 7 ADIG, AIMP2, CAT, FDPS, GAA, MARVELD1, MTOR
apical plasma membrane 1 TJP1
basolateral plasma membrane 1 TJP1
caveola 1 PTGS2
extracellular exosome 6 AKR1B1, ALDH2, CAT, CES2, GAA, MPO
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 2 CES2, PTGS2
extracellular space 4 AKR1B1, CCN2, IL6, MPO
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 PIK3CA, PPARG
Cell junction, tight junction 1 TJP1
adherens junction 1 TJP1
apicolateral plasma membrane 1 TJP1
bicellular tight junction 1 TJP1
gap junction 1 TJP1
intercalated disc 2 PIK3CA, TJP1
intercellular canaliculus 1 TJP1
mitochondrion 4 AKR1B1, ALDH2, CAT, TJP1
protein-containing complex 3 CAT, PTGS2, TJP1
intracellular membrane-bounded organelle 7 CAT, CCN2, CEBPA, CES2, GAA, MPO, PPARG
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 4 ADIG, CCN2, GAA, IL6
extracellular region 6 ADIG, CAT, CCN2, GAA, IL6, MPO
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 ADIG
mitochondrial outer membrane 2 MTOR, PGR
Mitochondrion matrix 1 ALDH2
mitochondrial matrix 3 ALDH2, CAT, FDPS
transcription regulator complex 1 CEBPA
Secreted, extracellular space, extracellular matrix 1 CCN2
nucleolus 1 CEBPA
apical part of cell 1 TJP1
Cytoplasm, cytoskeleton 1 MARVELD1
focal adhesion 1 CAT
extracellular matrix 1 CCN2
Peroxisome 2 CAT, FDPS
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 1 MPO
axoneme 1 GLI1
ciliary tip 1 GLI1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
ciliary base 1 GLI1
chromatin 3 CEBPA, PGR, PPARG
cell projection 1 TJP1
cytoskeleton 1 MARVELD1
Cell projection, podosome 1 TJP1
podosome 1 TJP1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Lipid droplet 2 ADIG, CES2
tertiary granule membrane 1 GAA
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 3 CES2, IL6, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 GAA
tight junction 1 TJP1
azurophil granule lumen 1 MPO
[Isoform 2]: Cytoplasm 1 GLI1
phagocytic vesicle lumen 1 MPO
ficolin-1-rich granule membrane 1 GAA
apical junction complex 1 TJP1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, phagosome 1 MTOR
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[Isoform 4]: Mitochondrion outer membrane 1 PGR
GLI-SUFU complex 1 GLI1
autolysosome lumen 1 GAA
C/EBP complex 1 CEBPA
CHOP-C/EBP complex 1 CEBPA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform 4]: Nucleus, nucleolus 1 CEBPA


文献列表

  • Kai Ren, He Su, Li-Juan Lv, Le-Tai Yi, Xue Gong, Lian-Sheng Dang, Rui-Fen Zhang, Min-Hui Li. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. BioMed research international. 2019; 2019(?):2692970. doi: 10.1155/2019/2692970. [PMID: 30800665]
  • Hong-Bo Xiao, Zhi-Liang Sun, Nan Zhou. 1,3,5,8-tetrahydroxyxanthone regulates ANGPTL3-LPL pathway to lessen the ketosis in mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2012 May; 46(1-2):26-31. doi: 10.1016/j.ejps.2012.02.001. [PMID: 22342712]
  • Fuqiang Jiang, Xuemei Zhang, Yunbao Ma, Chang'an Geng, Zhiyong Jiang, Jijun Chen. [Chemical constituents of Swertia hispidicalyx]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Aug; 36(16):2215-8. doi: . [PMID: 22097333]
  • Zong-Ping Zheng, Qin Zhu, Chun-Lin Fan, Hui-Yuan Tan, Mingfu Wang. Phenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis. Food & function. 2011 May; 2(5):259-64. doi: 10.1039/c1fo10033e. [PMID: 21779564]
  • Aleksandra Isakovic, Teodora Jankovic, Ljubica Harhaji, Sladjana Kostic-Rajacic, Zoran Nikolic, Vlatka Vajs, Vladimir Trajkovic. Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. Bioorganic & medicinal chemistry. 2008 May; 16(10):5683-94. doi: 10.1016/j.bmc.2008.03.069. [PMID: 18406151]
  • . . . . doi: . [PMID: 12846828]