Trigonelline (N'-methylnicotinate) (BioDeep_00000000769)

   

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Pyridinium, 3-carboxy-1-methyl-, hydroxide, inner salt

化学式: C7H7NO2 (137.0477)
中文名称: 葫芦巴碱, 三叶草碱
谱图信息: 最多检出来源 Homo sapiens(plant) 15.65%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Trigonelline (N'-methylnicotinate). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/trigonelline_(n_-methylnicotinate) (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000769). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C[n+1](c1)cc(cc1)C([O-1])=O
InChI: InChI=1/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3

描述信息

Trigonelline, also known as caffearin or gynesine, belongs to the class of organic compounds known as alkaloids and derivatives. These are naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and more rarely other elements such as chlorine, bromine, and phosphorus. It is also found in coffee, where it may help to prevent dental caries by preventing the bacteria Streptococcus mutans from adhering to teeth. Trigonelline is an alkaloid with chemical formula C7H7NO2 and CAS number 535-83-1. Trigonelline is a product of the metabolism of niacin (vitamin B3) which is excreted in the urine. High amounts of trigonelline have been found in arabica coffee, fenugreeks, and common peas. Another foods such as yellow bell peppers, orange bellpeppers and muskmelons also contain trigonelline but in lower concentrations. Trigonelline has also been detected but not quantified in several different foods, such as rices, triticales, alfalfa, cereals and cereal products, and ryes. Trigonelline in the urine is a biomarker for the consumption of coffee, legumes and soy products.
Alkaloid from fenugreek (Trigonella foenum-graecum) (Leguminosae), and very many other subspecies; also present in coffee beans and many animals. Trigonelline is an alkaloid with chemical formula C7H7NO2 and CAS number 535-83-1. It is found in coffee, where it may help to prevent dental caries by preventing the bacteria Streptococcus mutans from adhering to teeth.; Trigonelline is an alkaloid with chemical formula C7H7NO2. It is an inner salt formed by the addition of a methyl group to the nitrogen atom of niacin. Trigonelline is a product of the metabolism of niacin (vitamin B3) which is excreted in the urine. Trigonelline in the urine is a biomarker for the consumption of coffee, legumes and soy products.
N-methylnicotinate is an iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group. It has a role as a plant metabolite, a food component and a human urinary metabolite. It is an iminium betaine and an alkaloid. It is functionally related to a nicotinate. It is a conjugate base of a N-methylnicotinic acid.
Trigonelline is a natural product found in Hypoestes phyllostachya, Schumanniophyton magnificum, and other organisms with data available.
See also: Fenugreek seed (part of).
Acquisition and generation of the data is financially supported in part by CREST/JST.
CONFIDENCE standard compound; ML_ID 52
KEIO_ID T060
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

同义名列表

57 个代谢物同义名

Pyridinium, 3-carboxy-1-methyl-, hydroxide, inner salt; 3-Carboxy-1-methylpyridinium, Hydroxide, Inner salt; 3-Carboxy-1-methylpyridinium hydroxide, inner salt; TRIGONELLINE (CONSTITUENT OF FENUGREEK SEED) [DSC]; 3-carboxy-1-methyl-Pyridinium hydroxide inner salt; 3-Carboxy-1-methylpyridinium hydroxide inner salt; 5-22-02-00143 (Beilstein Handbook Reference); TRIGONELLINE (CONSTITUENT OF FENUGREEK SEED); 1-Methyl-Nicotinic Acid Anion(Trigonelline); Pyridinium, 3-carboxy-1-methyl-, inner salt; 3-Carboxy-1-methylpyridin-1-ium hydroxide; 1-methylpyridin-1-ium-3-carboxylic acid; 3-Carboxy-1-methylpyridinium inner salt; 1-Methyl-3-pyridiniumcarboxylic acid; 1-Methylpyridinio-3-carboxylic acid; 1-methylpyridin-1-ium-3-carboxylate; 1-methylpyridinium-3-carboxylate; 1-Methyl-3-pyridiniumcarboxylate; 1-Methylpyridinio-3-carboxylate; Nicotinic acid N-methylbetaine; N-Methylnicotinic acid betaine; WWNNZCOKKKDOPX-UHFFFAOYSA-N; Nicotinate N-methylbetaine; N-Methyl-nicotinic acid; Betaine nicotinic acid; N-Methylnicotinic acid; 1-Methylnicotinic acid; trigonelline tosylate; TRIGONELLINE [USP-RS]; Betain nicotinic acid; trigonelline chloride; TRIGONELLINE (USP-RS); trigonelline iodide; N-methyl-nicotinate; TRIGONELLINE [HSDB]; 1-methylnicotinate; N-Methylnicotinate; Betaine nicotinate; TRIGONELLINE [MI]; Betain nicotinate; Trigonelline,(S); trigonelline ion; UNII-3NQ9N60I00; Trigenelline; Trigenolline; Trigonelline; Trigonellin; Coffearine; Caffearine; 3NQ9N60I00; Coffearin; Caffearin; Gynesine; Trigonelline hydrochloride; Trigonelline; N-Methylnicotinate; Trigonelline



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

105 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, BCL2, CASP3, CAT, CCND1, NFE2L2, NQO1, PIK3CA, PPARG, PRKAA2, SRARP
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 2 BCL2, HMOX1
Nucleus 11 ACHE, ALB, BCL2, CASP3, CCND1, HMOX1, NFE2L2, NQO1, PPARG, PRKAA2, SRARP
cytosol 12 ALB, BCL2, CASP3, CAT, CCND1, HMOX1, LEP, NFE2L2, NQO1, PIK3CA, PPARG, PRKAA2
dendrite 2 NQO1, PRKAA2
centrosome 3 ALB, CCND1, NFE2L2
nucleoplasm 6 CASP3, CCND1, HMOX1, NFE2L2, PPARG, PRKAA2
RNA polymerase II transcription regulator complex 2 NFE2L2, PPARG
Cell membrane 2 ACHE, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 1 PIK3CA
Synapse 2 ACHE, NQO1
cell surface 3 ACHE, ADIPOQ, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 4 ACHE, ALB, NFE2L2, PRKAA2
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 4 CASP3, NQO1, PRKAA2, TNF
Cytoplasm, cytosol 2 NFE2L2, NQO1
Lysosome 1 GAA
plasma membrane 6 ACHE, GAA, GCG, NFE2L2, PIK3CA, TNF
Membrane 7 ACHE, BCL2, CAT, GAA, HMOX1, NQO1, PRKAA2
axon 1 PRKAA2
extracellular exosome 3 ALB, CAT, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 4 ADIPOQ, ALB, BCL2, HMOX1
extracellular space 9 ACHE, ADIPOQ, ALB, GCG, HMOX1, IL6, INS, LEP, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 ACHE, HMOX1, PIK3CA, PPARG
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, CAT
protein-containing complex 3 ALB, BCL2, CAT
intracellular membrane-bounded organelle 3 CAT, GAA, PPARG
postsynaptic density 1 CASP3
Secreted 8 ACHE, ADIPOQ, ALB, GAA, GCG, IL6, INS, LEP
extracellular region 10 ACHE, ADIPOQ, ALB, CAT, GAA, GCG, IL6, INS, LEP, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
collagen trimer 1 ADIPOQ
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ADIPOQ
nuclear speck 1 PRKAA2
receptor complex 1 PPARG
ciliary basal body 1 ALB
chromatin 2 NFE2L2, PPARG
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
tertiary granule membrane 1 GAA
cytoplasmic stress granule 1 PRKAA2
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, GCG, IL6, INS
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 ALB
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Menna S Zeyada, Salma M Eraky, Mamdouh M El-Shishtawy. Trigonelline mitigates bleomycin-induced pulmonary inflammation and fibrosis: Insight into NLRP3 inflammasome and SPHK1/S1P/Hippo signaling modulation. Life sciences. 2024 Jan; 336(?):122272. doi: 10.1016/j.lfs.2023.122272. [PMID: 37981228]
  • Minmin Gong, Yujin Guo, Hui Dong, Wenbin Wu, Fan Wu, Fuer Lu. Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115747. doi: 10.1016/j.biopha.2023.115747. [PMID: 37864898]
  • Sharmin Aktar, Farhana Ferdousi, Shinji Kondo, Tamami Kagawa, Hiroko Isoda. Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release. GeroScience. 2023 Sep; ?(?):. doi: 10.1007/s11357-023-00919-x. [PMID: 37721682]
  • Nick Konstantinidis, Heike Franke, Steffen Schwarz, Dirk W Lachenmeier. Risk Assessment of Trigonelline in Coffee and Coffee By-Products. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083460. [PMID: 37110693]
  • Youdan Liang, Xiaolin Dai, Yi Cao, Xian Wang, Jing Lu, Long Xie, Kai Liu, Xiaofang Li. The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms. Biochimie. 2023 Mar; 206(?):93-104. doi: 10.1016/j.biochi.2022.10.009. [PMID: 36257493]
  • M A Hamzawy, A M Abo-Youssef, M N Malak, M M Khalaf. Multiple targets of Nrf 2 inhibitor; trigonelline in combating urethane-induced lung cancer by caspase-executioner apoptosis, cGMP and limitation of cyclin D1 and Bcl2. European review for medical and pharmacological sciences. 2022 12; 26(24):9393-9408. doi: 10.26355/eurrev_202212_30690. [PMID: 36591848]
  • Moein Masjedi, Aida Solhjoo. Does trigonelline help skin tone? Molecular docking studies of trigonelline on the human tyrosinase, formulation, optimization, and characterization of an emulgel-containing Trigonella foenum-graecum L. fenugreek standardized hydroalcoholic extract. Journal of cosmetic dermatology. 2022 Dec; 21(12):7178-7193. doi: 10.1111/jocd.15453. [PMID: 36217567]
  • Paleerath Peerapen, Wanida Boonmark, Visith Thongboonkerd. Trigonelline prevents kidney stone formation processes by inhibiting calcium oxalate crystallization, growth and crystal-cell adhesion, and downregulating crystal receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112876. doi: 10.1016/j.biopha.2022.112876. [PMID: 35367760]
  • Geetika Wadhwa, Kowthavarapu Venkata Krishna, Rajeev Taliyan, Neeraj Tandon, Satyapal Singh Yadav, Dipankar Banerjee, Avinash Narwaria, Chandrakant Katiyar, Sunil Kumar Dubey. A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats. Biomedical chromatography : BMC. 2022 Feb; 36(2):e5275. doi: 10.1002/bmc.5275. [PMID: 34738247]
  • Weijie Zou, Shuang Yang, Li Chen, Su Hu, Guangyu Hao, Chunhong Hu. Iodixanol activation of mast cells: Implications in the pathogenesis of iodixanol-induced delayed cutaneous adverse reactions. Toxicology. 2022 01; 465(?):153034. doi: 10.1016/j.tox.2021.153034. [PMID: 34774977]
  • Gustavo Galo Marcheafave, Cláudia Domiciano Tormena, Amelia Elena Terrile, Carlos Alberto Rossi Salamanca-Neto, Elen Romão Sartori, Miroslava Rakocevic, Roy Edward Bruns, Ieda Spacino Scarminio, Elis Daiane Pauli. Ecometabolic mixture design-fingerprints from exploratory multi-block data analysis in Coffea arabica beans from climate changes: Elevated carbon dioxide and reduced soil water availability. Food chemistry. 2021 Nov; 362(?):129716. doi: 10.1016/j.foodchem.2021.129716. [PMID: 34006394]
  • Nuntouchaporn Hutachok, Pimpisid Koonyosying, Tanachai Pankasemsuk, Pongsak Angkasith, Chaiwat Chumpun, Suthat Fucharoen, Somdet Srichairatanakool. Chemical Analysis, Toxicity Study, and Free-Radical Scavenging and Iron-Binding Assays Involving Coffee (Coffea arabica) Extracts. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144169. [PMID: 34299444]
  • Lone A Nazir, Malik A Tanveer, Sheikh A Umar, Sharma Love, Gupta Divya, Sheikh A Tasduq. Inhibition of Ultraviolet-B Radiation Induced Photodamage by Trigonelline Through Modulation of Mitogen Activating Protein Kinases and Nuclear Factor-κB Signaling Axis in Skin. Photochemistry and photobiology. 2021 07; 97(4):785-794. doi: 10.1111/php.13369. [PMID: 33345344]
  • Neda Mohamadi, Fariba Sharififar, Mehdi Ansari, Mostafa Pournamdari, Mahdieh Rezaei, Navid Hassanabadi. Pharmacokinetic profile of diosgenin and trigonelline following intravenous and oral administration of fenugreek seed extract and pure compound in rabbit. Journal of Asian natural products research. 2021 May; 23(5):466-477. doi: 10.1080/10286020.2020.1769609. [PMID: 32447972]
  • Maria Alessia Schouten, Silvia Tappi, Simone Angeloni, Manuela Cortese, Giovanni Caprioli, Sauro Vittori, Santina Romani. Acrylamide formation and antioxidant activity in coffee during roasting - A systematic study. Food chemistry. 2021 May; 343(?):128514. doi: 10.1016/j.foodchem.2020.128514. [PMID: 33187741]
  • Minji Choi, Sulagna Mukherjee, Jong Won Yun. Trigonelline induces browning in 3T3-L1 white adipocytes. Phytotherapy research : PTR. 2021 Feb; 35(2):1113-1124. doi: 10.1002/ptr.6892. [PMID: 33015893]
  • Neda Mohamadi, Fariba Sharififar, Mostafa Pournamdari, Mehdi Ansari. Determination of trigonelline in human plasma by magnetic solid-phase extraction: a pharmacokinetic study. Nanomedicine (London, England). 2021 02; 16(4):323-333. doi: 10.2217/nnm-2020-0365. [PMID: 33501838]
  • Flávia de Abreu Pinheiro, Luzia Ferreira Elias, Milton de Jesus Filho, Mariana Uliana Modolo, Juliana de Cássia Gomes Rocha, Mayara Fumiere Lemos, Rodrigo Scherer, Wilton Soares Cardoso. Arabica and Conilon coffee flowers: Bioactive compounds and antioxidant capacity under different processes. Food chemistry. 2021 Jan; 336(?):127701. doi: 10.1016/j.foodchem.2020.127701. [PMID: 32781354]
  • Wen-Yu Zeng, Lin Tan, Cong Han, Zhuo-Ya Zheng, Gui-Sheng Wu, Huai-Rong Luo, Su-Lian Li. Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1. Oxidative medicine and cellular longevity. 2021; 2021(?):7656834. doi: 10.1155/2021/7656834. [PMID: 34616504]
  • Grace F Crotty, Romeo Maciuca, Eric A Macklin, Junhua Wang, Manuel Montalban, Sonnet S Davis, Jamal I Alkabsh, Rachit Bakshi, Xiqun Chen, Alberto Ascherio, Giuseppe Astarita, Sarah Huntwork-Rodriguez, Michael A Schwarzschild. Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers: A metabolomic study. Neurology. 2020 12; 95(24):e3428-e3437. doi: 10.1212/wnl.0000000000010863. [PMID: 32999056]
  • Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Jothi Jayalakshmi, Margabandhu Gopi, Azeez Shajahan, Kaliyan Barathikannan, Pudupalayam Thangavelu Kalaichelvan, Myeong-Hyeon Wang. Trigonelline-loaded chitosan nanoparticles prompted antitumor activity on glioma cells and biocompatibility with pheochromocytoma cells. International journal of biological macromolecules. 2020 Nov; 163(?):36-43. doi: 10.1016/j.ijbiomac.2020.06.165. [PMID: 32585274]
  • Taehoon Lee, Hyesung Park, Pradeep Puligundla, Gwi-Hee Koh, Jungro Yoon, Chulkyoon Mok. Degradation of benzopyrene and acrylamide in roasted coffee beans by corona discharge plasma jet (CDPJ) and its effects on biochemical and sensory properties. Food chemistry. 2020 Oct; 328(?):127117. doi: 10.1016/j.foodchem.2020.127117. [PMID: 32474240]
  • Mai M Farid, Ximeng Yang, Tomoharu Kuboyama, Chihiro Tohda. Trigonelline recovers memory function in Alzheimer's disease model mice: evidence of brain penetration and target molecule. Scientific reports. 2020 10; 10(1):16424. doi: 10.1038/s41598-020-73514-1. [PMID: 33009465]
  • Juliana dePaula, Sara C Cunha, Ildi Revi, Alessandro M Batista, Soraia V M D Sá, Veronica Calado, José O Fernandes, Adriano Cruz, Adriana Farah. Contents of key bioactive and detrimental compounds in health performance coffees compared to conventional types of coffees sold in the United States market. Food & function. 2020 Sep; 11(9):7561-7575. doi: 10.1039/d0fo01674h. [PMID: 32820768]
  • Letizia Bresciani, Michele Tassotti, Alice Rosi, Daniela Martini, Monica Antonini, Alessandra Dei Cas, Riccardo Bonadonna, Furio Brighenti, Daniele Del Rio, Pedro Mena. Absorption, Pharmacokinetics, and Urinary Excretion of Pyridines After Consumption of Coffee and Cocoa-Based Products Containing Coffee in a Repeated Dose, Crossover Human Intervention Study. Molecular nutrition & food research. 2020 09; 64(18):e2000489. doi: 10.1002/mnfr.202000489. [PMID: 32776430]
  • Mar Garcia-Aloy, Marynka Ulaszewska, Pietro Franceschi, Sheila Estruel-Amades, Christoph H Weinert, Alba Tor-Roca, Mireia Urpi-Sarda, Fulvio Mattivi, Cristina Andres-Lacueva. Discovery of Intake Biomarkers of Lentils, Chickpeas, and White Beans by Untargeted LC-MS Metabolomics in Serum and Urine. Molecular nutrition & food research. 2020 07; 64(13):e1901137. doi: 10.1002/mnfr.201901137. [PMID: 32420683]
  • Maho Sasaki, Yuri Nonoshita, Takashi Kajiya, Nobuhiko Atsuchi, Megumi Kido, Djong-Chi Chu, Lekh Raj Juneja, Yuji Minami, Katsuko Kajiya. Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans. Nutrients. 2020 Jun; 12(6):. doi: 10.3390/nu12061872. [PMID: 32585930]
  • Wenjing Liu, Mengqin Xia, Li Yang, Zhengtao Wang, Rui Wang, Yanhong Shi. Development and optimization of a method for determining betaine and trigonelline in the fruits of Lycium species by using solid-phase extraction combined with high-performance liquid chromatography-diode array detector. Journal of separation science. 2020 Jun; 43(11):2073-2078. doi: 10.1002/jssc.201901124. [PMID: 32129569]
  • Guilin Hu, Xingrong Peng, Xia Wang, Xian Li, Xing Li, Minghua Qiu. Excavation of coffee maturity markers and further research on their changes in coffee cherries of different maturity. Food research international (Ottawa, Ont.). 2020 06; 132(?):109121. doi: 10.1016/j.foodres.2020.109121. [PMID: 32331680]
  • Akshoo Rathi, Mohd Ishaq, Abul Kalam Najmi, Mohd Akhtar. Trigonelline Demonstrated Ameliorative Effects in Dexamethasone Induced Osteoporotic Rats. Drug research. 2020 Jun; 70(6):257-264. doi: 10.1055/a-1147-5724. [PMID: 32289834]
  • Mayara Fumiere Lemos, Consuelo Perez, Pedro Henrique Pereira da Cunha, Paulo Roberto Filgueiras, Lucas Louzada Pereira, Aymbiré Francisco Almeida da Fonseca, Demian R Ifa, Rodrigo Scherer. Chemical and sensory profile of new genotypes of Brazilian Coffea canephora. Food chemistry. 2020 Apr; 310(?):125850. doi: 10.1016/j.foodchem.2019.125850. [PMID: 31771915]
  • Erikka Loftfield, Joseph A Rothwell, Rashmi Sinha, Pekka Keski-Rahkonen, Nivonirina Robinot, Demetrius Albanes, Stephanie J Weinstein, Andriy Derkach, Joshua Sampson, Augustin Scalbert, Neal D Freedman. Prospective Investigation of Serum Metabolites, Coffee Drinking, Liver Cancer Incidence, and Liver Disease Mortality. Journal of the National Cancer Institute. 2020 03; 112(3):286-294. doi: 10.1093/jnci/djz122. [PMID: 31168595]
  • Yin-Pan Chau, Philip C M Au, Gloria H Y Li, Chor-Wing Sing, Vincent K F Cheng, Kathryn C B Tan, Annie W C Kung, Ching-Lung Cheung. Serum Metabolome of Coffee Consumption and its Association With Bone Mineral Density: The Hong Kong Osteoporosis Study. The Journal of clinical endocrinology and metabolism. 2020 03; 105(3):. doi: 10.1210/clinem/dgz210. [PMID: 31750515]
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