Vernodalin (BioDeep_00000007471)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Vernodalin

化学式: C19H20O7 (360.1209)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: C=CC12CC(C3C(C1C(=C)C(=O)OC2)OC(=O)C3=C)OC(=O)C(=C)CO
InChI: InChI=1S/C19H20O7/c1-5-19-6-12(25-16(21)9(2)7-20)13-10(3)18(23)26-15(13)14(19)11(4)17(22)24-8-19/h5,12-15,20H,1-4,6-8H2/t12-,13+,14+,15-,19+/m0/s1

描述信息

同义名列表

3 个代谢物同义名

Vernodalin; NSC124459; Vernodalin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AIMP2, ANXA5, BCL2, BCL2L1, CASP3, CASP9, CCND1, CDKN1B, JAK2, MAPK3, MAPK8, MTOR, PIK3CA, SGCB, STAT3
Peripheral membrane protein 3 ANXA5, JAK2, MTOR
Endoplasmic reticulum membrane 2 BCL2, MTOR
Mitochondrion membrane 1 BCL2L1
Nucleus 13 AIMP2, BCL2, CASP3, CASP9, CCND1, CDKN1B, JAK2, MAPK3, MAPK8, MTOR, PARP1, PCNA, STAT3
cytosol 15 AIMP2, ANXA5, BCL2, BCL2L1, CASP3, CASP9, CCND1, CDKN1B, JAK2, MAPK3, MAPK8, MTOR, PARP1, PIK3CA, STAT3
dendrite 1 MTOR
nuclear body 2 PARP1, PCNA
phagocytic vesicle 1 MTOR
centrosome 3 BCL2L1, CCND1, PCNA
nucleoplasm 10 CASP3, CCND1, CDKN1B, JAK2, MAPK3, MAPK8, MTOR, PARP1, PCNA, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cytoplasmic side 2 BCL2L1, MTOR
lamellipodium 1 PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
glutamatergic synapse 3 CASP3, JAK2, MAPK3
Golgi apparatus 1 MAPK3
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 1 CASP3
postsynapse 1 JAK2
sarcolemma 2 ANXA5, SGCB
Cytoplasm, cytosol 3 AIMP2, BCL2L1, PARP1
Lysosome 1 MTOR
endosome 1 CDKN1B
plasma membrane 5 JAK2, MAPK3, PIK3CA, SGCB, STAT3
synaptic vesicle membrane 1 BCL2L1
Membrane 6 AIMP2, ANXA5, BCL2, JAK2, MTOR, PARP1
axon 1 MAPK8
caveola 2 JAK2, MAPK3
extracellular exosome 2 ANXA5, PCNA
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, BCL2L1, PRAP1
perinuclear region of cytoplasm 1 PIK3CA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, BCL2L1, CASP9, MAPK3, PARP1
protein-containing complex 4 BCL2, CASP9, CDKN1B, PARP1
intracellular membrane-bounded organelle 1 CDKN1B
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 1 PRAP1
extracellular region 2 ANXA5, PRAP1
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 3 BCL2, BCL2L1, MTOR
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 3 BCL2, BCL2L1, MTOR
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
transcription regulator complex 2 PARP1, STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CCND1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, CCND1
external side of plasma membrane 1 ANXA5
nucleolus 1 PARP1
Early endosome 1 MAPK3
Single-pass type II membrane protein 1 SGCB
Cell membrane, sarcolemma 1 SGCB
Membrane raft 1 JAK2
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK3
Cytoplasm, cytoskeleton 1 SGCB
focal adhesion 3 ANXA5, JAK2, MAPK3
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
Late endosome 1 MAPK3
Zymogen granule membrane 1 ANXA5
chromatin 3 PARP1, PCNA, STAT3
Chromosome 1 PARP1
cytoskeleton 3 JAK2, MAPK3, SGCB
Nucleus, nucleolus 1 PARP1
nuclear replication fork 2 PARP1, PCNA
chromosome, telomeric region 2 PARP1, PCNA
site of double-strand break 1 PARP1
nuclear envelope 3 MAPK3, MTOR, PARP1
Endomembrane system 2 JAK2, MTOR
endosome lumen 1 JAK2
Membrane, caveola 1 MAPK3
euchromatin 1 JAK2
replication fork 1 PCNA
myelin sheath 1 BCL2
pseudopodium 1 MAPK3
endoplasmic reticulum lumen 1 MAPK3
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
nuclear lamina 1 PCNA
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
protein-DNA complex 1 PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
dystrophin-associated glycoprotein complex 1 SGCB
sarcoglycan complex 1 SGCB
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
Cul4A-RING E3 ubiquitin ligase complex 1 CDKN1B
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Sanit Thongnest, Pornsuda Chawengrum, Siriporn Keeratichamroen, Kriengsak Lirdprapamongkol, Chatchakorn Eurtivong, Jutatip Boonsombat, Prasat Kittakoop, Jisnuson Svasti, Somsak Ruchirawat. Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells. Bioorganic chemistry. 2019 11; 92(?):103197. doi: 10.1016/j.bioorg.2019.103197. [PMID: 31445193]
  • Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt. Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity. Molecules (Basel, Switzerland). 2018 Jan; 23(2):. doi: 10.3390/molecules23020248. [PMID: 29382040]
  • Suresh Kumar Ananda Sadagopan, Nooshin Mohebali, Chung Yeng Looi, Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Aditya Arya, Hamed Karimian, Mohd Rais Mustafa. Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. Journal of experimental & clinical cancer research : CR. 2015 Dec; 34(?):147. doi: 10.1186/s13046-015-0266-y. [PMID: 26643256]
  • Chung Yeng Looi, Aditya Arya, Foo Kit Cheah, Bushra Muharram, Kok Hoong Leong, Khalit Mohamad, Won Fen Wong, Nitika Rai, Mohd Rais Mustafa. Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PloS one. 2013; 8(2):e56643. doi: 10.1371/journal.pone.0056643. [PMID: 23437193]
  • Lateef Saka Kasim, Valerie Ferro, Oluwakemi A Odukoya, Grace Eigbibhalu Ukpo, Veronique Seidel, Alexander I Gray, Roger Waigh. Cytotoxicity of isolated compounds from the extracts of Struchium sparganophora (Linn) Ktze asteraceae. Pakistan journal of pharmaceutical sciences. 2011 Oct; 24(4):475-8. doi: . [PMID: 21959807]
  • T Rabe, D Mullholland, J van Staden. Isolation and identification of antibacterial compounds from Vernonia colorata leaves. Journal of ethnopharmacology. 2002 Apr; 80(1):91-4. doi: 10.1016/s0378-8741(02)00010-7. [PMID: 11891091]