Asparagusic acid (BioDeep_00000000732)

   

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


5-19-07-00224 (Beilstein Handbook Reference)

化学式: C4H6O2S2 (149.9809)
中文名称: 1,2-二噻戊环-4-羧酸, 芦笋酸
谱图信息: 最多检出来源 Homo sapiens(otcml) 15.68%

分子结构信息

SMILES: C1C(CSS1)C(=O)O
InChI: InChI=1S/C4H6O2S2/c5-4(6)3-1-7-8-2-3/h3H,1-2H2,(H,5,6)

描述信息

Asparagusic acid is a sulfur-containing carboxylic acid, a dithiolanecarboxylic acid and a member of dithiolanes. It is a conjugate acid of an asparagusate. It derives from a hydride of a 1,2-dithiolane.
Asparagusic acid is a natural product found in Asparagus officinalis with data available.
Asparagusic acid is found in asparagus. Asparagusic acid is isolated from asparagus (Asparagus officinalis
Isolated from asparagus (Asparagus officinalis) [DFC]
Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor[1][2][3].

同义名列表

15 个代谢物同义名

5-19-07-00224 (Beilstein Handbook Reference); 1,2-DITHIACYCLOPENTANE-4-CARBOXYLIC ACID; ARACHIDONIC ACID TRIFLUOROMETHYLKETONE; 1,2-Dithiolan-4-carbonsA currencyure; [1,2]dithiolane-4-carboxylic acid; 1,2-dithiolane-4-carboxylic acid; 1,2-Dithiolane-4-carboxylate; dithiolane-4-carboxylic acid; ASPARAGUSIC ACID [MI]; Asparagusic acid; UNII-VAD3XV509R; Asparagusicacid; Asparagusate; VAD3XV509R; Asparagusate



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ACE, AIMP2, CTNNB1, FLNB, MTOR, PIK3R6, PTGS1, PTGS2, TXN, TYR
Peripheral membrane protein 5 HSD17B6, MTOR, PIK3R6, PTGS1, PTGS2
Endosome membrane 1 TFRC
Endoplasmic reticulum membrane 3 MTOR, PTGS1, PTGS2
Nucleus 4 AIMP2, CTNNB1, MTOR, TXN
cytosol 6 AIMP2, CTNNB1, FLNB, MTOR, PIK3R6, TXN
dendrite 1 MTOR
phagocytic vesicle 2 FLNB, MTOR
centrosome 1 CTNNB1
nucleoplasm 3 CTNNB1, MTOR, TXN
Cell membrane 4 ACE, CTNNB1, PIK3R6, TFRC
Cytoplasmic side 1 MTOR
lamellipodium 1 CTNNB1
Early endosome membrane 1 HSD17B6
Golgi apparatus membrane 1 MTOR
Synapse 1 CTNNB1
cell cortex 2 CTNNB1, FLNB
cell junction 1 CTNNB1
cell surface 1 TFRC
glutamatergic synapse 2 CTNNB1, TFRC
Golgi apparatus 1 PTGS1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 AIMP2
Lysosome 3 ACE, MTOR, TYR
endosome 2 ACE, TFRC
plasma membrane 5 ACE, CTNNB1, FLNB, PIK3R6, TFRC
Membrane 7 ACE, AIMP2, CTNNB1, FLNB, MTOR, PIK3R6, TFRC
basolateral plasma membrane 2 CTNNB1, TFRC
brush border 1 FLNB
caveola 1 PTGS2
extracellular exosome 6 ACE, CTNNB1, FLNB, PTGS1, TFRC, TXN
Lysosome membrane 1 MTOR
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, PTGS2
extracellular space 2 ACE, TFRC
perinuclear region of cytoplasm 3 CTNNB1, TFRC, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
protein-containing complex 2 CTNNB1, PTGS2
intracellular membrane-bounded organelle 4 HSD17B6, PTGS1, TFRC, TYR
Microsome membrane 4 HSD17B6, MTOR, PTGS1, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ACE, TYR
Secreted 2 ACE, TXN
extracellular region 3 ACE, TFRC, TXN
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
transcription regulator complex 1 CTNNB1
photoreceptor outer segment 1 PTGS1
external side of plasma membrane 2 ACE, TFRC
Extracellular vesicle 1 TFRC
actin cytoskeleton 1 FLNB
Z disc 2 CTNNB1, FLNB
beta-catenin destruction complex 1 CTNNB1
cytoplasmic vesicle 1 TFRC
Wnt signalosome 1 CTNNB1
Melanosome membrane 1 TYR
Early endosome 1 TFRC
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
clathrin-coated pit 1 TFRC
Golgi-associated vesicle 1 TYR
recycling endosome 1 TFRC
Single-pass type II membrane protein 1 TFRC
postsynaptic membrane 1 CTNNB1
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CTNNB1, FLNB
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
brush border membrane 1 ACE
spindle pole 1 CTNNB1
blood microparticle 1 TFRC
sperm midpiece 1 ACE
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Recycling endosome membrane 1 TFRC
Endomembrane system 3 CTNNB1, MTOR, PTGS1
Melanosome 2 TFRC, TYR
euchromatin 1 CTNNB1
stress fiber 1 FLNB
basal plasma membrane 1 ACE
HFE-transferrin receptor complex 1 TFRC
endoplasmic reticulum lumen 1 PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3R6
phosphatidylinositol 3-kinase complex, class IA 1 PIK3R6
beta-catenin-TCF complex 1 CTNNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 1 TFRC
protein-DNA complex 1 CTNNB1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
intracellular non-membrane-bounded organelle 1 FLNB
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
postsynaptic recycling endosome membrane 1 TFRC
[Transferrin receptor protein 1, serum form]: Secreted 1 TFRC
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3R6
organelle 1 FLNB


文献列表

  • Ryo Nakabayashi, Zhigang Yang, Tomoko Nishizawa, Tetsuya Mori, Kazuki Saito. Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis. Journal of natural products. 2015 May; 78(5):1179-83. doi: 10.1021/acs.jnatprod.5b00092. [PMID: 25922884]
  • Stephen C Mitchell, Rosemary H Waring. Asparagusic acid. Phytochemistry. 2014 Jan; 97(?):5-10. doi: 10.1016/j.phytochem.2013.09.014. [PMID: 24099657]
  • Alessandro Venditti, Manuela Mandrone, Anna Maria Serrilli, Armandodoriano Bianco, Carmelina Iannello, Ferruccio Poli, Fabiana Antognoni. Dihydroasparagusic acid: antioxidant and tyrosinase inhibitory activities and improved synthesis. Journal of agricultural and food chemistry. 2013 Jul; 61(28):6848-55. doi: 10.1021/jf401120h. [PMID: 23790134]
  • Stephen C Mitchell. Asparagus, urinary odor, and 1,2-dithiolane-4-carboxylic acid. Perspectives in biology and medicine. 2013; 56(3):341-51. doi: 10.1353/pbm.2013.0031. [PMID: 24375116]
  • Corinna Dawid, Thomas Hofmann. Identification of Sensory-Active Phytochemicals in Asparagus (Asparagus officinalis L.). Journal of agricultural and food chemistry. 2012 Dec; 60(48):11877-88. doi: 10.1021/jf3040868. [PMID: 23136992]
  • J S Negi, P Singh, G P Joshi, M S Rawat, V K Bisht. Chemical constituents of Asparagus. Pharmacognosy reviews. 2010 Jul; 4(8):215-20. doi: 10.4103/0973-7847.70921. [PMID: 22228964]