Folic acid (BioDeep_00000000725)

 

Secondary id: BioDeep_00000400036, BioDeep_00000415839

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


FOLVITE(Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 1422)

化学式: C19H19N7O6 (441.1397)
中文名称: 维生素 B9, 维生素 M, 叶酸, DL-叶酸, 维生素B9
谱图信息: 最多检出来源 Homo sapiens(feces) 30.78%

分子结构信息

SMILES: C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
InChI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)

描述信息

Folic acid appears as odorless orange-yellow needles or platelets. Darkens and chars from approximately 482 °F.
Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. It has a role as a human metabolite, a nutrient and a mouse metabolite. It is a member of folic acids and a N-acyl-amino acid. It is functionally related to a pteroic acid. It is a conjugate acid of a folate(2-).
Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits. In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as [DB00563] as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, [DB00563] impedes the bodys ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. [DB00650] (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF. There are also several antiepileptic drugs (AEDs) that are associated with reduced serum and red blood cell folate, including [DB00564] (CBZ), [DB00252] (PHT), or barbiturates. Folic acid is therefore often provided as supplementation to individuals using these medications, particularly to women of child-bearing age. Inadequate folate levels can result in a number of health concerns including cardiovascular disease, megaloblastic anemias, cognitive deficiencies, and neural tube defects (NTDs). Folic acid is typically supplemented during pregnancy to prevent the development of NTDs and in individuals with alcoholism to prevent the development of neurological disorders, for example.
Folic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
CID 6037 is a natural product found in Beta vulgaris, Angelica sinensis, and other organisms with data available.
Folic Acid is a collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. (NCI05)
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treat...
Folic acid or folate, is a vitamin that belongs to the class of compounds known as pterins. Chemically, folate consists of three distinct chemical moieties linked together. A pterin (2-amino-4-hydroxy-pteridine) linked by a methylene bridge to a p-aminobenzoyl group that in turn is linked through an amide linkage to glutamic acid. It is a member of the vitamin B family and is primarily known as vitamin B9. Folate is required for the body to make DNA and RNA and metabolize amino acids necessary for cell division for the hematopoietic system. As humans cannot make folate, it is required in the diet, making it an essential nutrient (i.e. a vitamin). Folate occurs naturally in many foods including mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid, being biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by the enzyme known as dihydrofolate reductase. Tetrahydrofolate and methyltetrahydrofolate are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids and generate formic acid. Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in babies. Low levels in early pregnancy are believed to be the cause of more than half of babies born with NTDs (PMID: 28097362). Folic acid is also a microbial metabolite produced by Bifidobacterium and Lactobacillus (PMID: 22254078).
An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
B - Blood and blood forming organs > B03 - Antianemic preparations > B03B - Vitamin b12 and folic acid > B03BB - Folic acid and derivatives
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D006397 - Hematinics
D018977 - Micronutrients > D014815 - Vitamins
V - Various > V04 - Diagnostic agents
Dietary supplement
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Formula(Parent): C19H19N7O6; Bottle Name:Folic acid ,approx; PRIME Parent Name:Folic acid; PRIME in-house No.:V0080; SubCategory_DNP: Pteridines and analogues, Pteridine alkaloids
Acquisition and generation of the data is financially supported in part by CREST/JST.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.543
CONFIDENCE standard compound; INTERNAL_ID 134
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].

同义名列表

206 个代谢物同义名

FOLVITE(Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 1422); Folic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=97\\%; (2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid; (2S)-2-[(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid; Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L; N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid; (2S)-2-[(4-{[(2-AMINO-4-HYDROXYPTERIDIN-6-YL)METHYL]AMINO}PHENYL)FORMAMIDO]PENTANEDIOIC ACID; (2S)-2-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid; (S)-2-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid; N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamate; (S)-2-(4-((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methylamino)benzamido)pentanedioic acid; L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-; (2S)-2-[[4-[(2-amino-4-hydroxypteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid; (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid; .beta.-D-ribo-2-Heptulopyranose, 2,7-anhydro-1,4-dideoxy-3-O-methyl-5-O-(phenylmethyl)-; L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid; L-Glutamic acid, N-(4-(((2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; L-glutamic acid, N-[4-[[(2-amino-4,8-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; L-Glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; N-(4-(((2-AMINO-4-OXO-1,4-DIHYDROPTERIDIN-6-YL)METHYL)AMINO)BENZOYL)-L-GLUTAMIC ACID; N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid; N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid; N-[4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzoyl]-l-glutamic acid; N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, l-; 2-(4-((2-amino-4-oxo-1H-pteridin-6-yl)methylamino)benzoyl)aminopentanedioic acid; N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; 4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-; Folic acid, Pharmaceutical Secondary Standard; Certified Reference Material; 2-AMINO-6-((P-((1,3-DICARBOXYPROPYL)CARBAMOYL)ANILINO)METHYL)-4-PTERIDINOL; N-{p-[(2-amino-4-hydroxypteridin-6-yl)methylamino]benzoyl}glutamic acid; .beta.-D-Allopyranose, 1,6-anhydro-2,3-di-O-methyl-4-O-(phenylmethyl)-; Folic acid, United States Pharmacopeia (USP) Reference Standard; Folic acid, European Pharmacopoeia (EP) Reference Standard; Folic acid, British Pharmacopoeia (BP) Reference Standard; Folic acid, meets USP testing specifications; Folic acid, Vetec(TM) reagent grade, >=97\\%; CALCIUM FOLINATE IMPURITY C [EP IMPURITY]; PteGlu;Vitamin M;Pteroyl-L-glutamic acid; Folic acid, tested according to Ph.Eur.; Liver Lactobacillus casei factor; FOLIC ACID COMPONENT OF FOLVRON; Folic acid, analytical standard; Folic Acid, Monopotassium Salt; Folic Acid, Calcium Salt (1:1); ACIDUM FOLICUM [WHO-IP LATIN]; Folic acid (USP:INN:BAN:JAN); FOLVRON COMPONENT FOLIC ACID; Folic acid [USP:INN:BAN:JAN]; Glutamic acid, pteroyl-, l-; Pteroyl-L-monoglutamic acid; Folic Acid, Monosodium Salt; Acido folico [INN-Spanish]; Acide folique [INN-French]; Acidum folicum [INN-Latin]; FOLIC ACID (USP MONOGRAPH); FOLIC ACID [USP MONOGRAPH]; Acidum folicum (INN-Latin); Acide folique (INN-French); Folic Acid, Potassium Salt; Acido folico (INN-Spanish); Folic acid (JP17/USP/INN); N-pteroyl-L-glutamic acid; Kyselina listova [Czech]; Folic acid [BAN:INN:JAN]; FOLIC ACID (EP IMPURITY); FOLIC ACID [EP IMPURITY]; FOLIC ACID [ORANGE BOOK]; Pteroylmonoglutamic acid; Pteroyl-L-monoglutamate; Pteroyl-L-glutamic acid; FOLIC ACID [GREEN BOOK]; Folic acid, crystalline; Folic Acid, Sodium Salt; Folic Acid, (DL)-Isomer; Folaemin (Netherlands); Folic Acid, (D)-Isomer; Folaemin [Netherlands]; Folic acid, USP grade; N-Pteroyl-L-glutamate; Pteroylglutamic acid; T-dol JIANG SUAN BAO; Novofolacid [Canada]; Novofolacid (Canada); Pteroylmonoglutamate; FOLIC ACID [WHO-DD]; Folasic (Australia); FOLIC ACID [WHO-IP]; FOLIC ACID [USP-RS]; Pteroyglutamic acid; FOLIC ACID (USP-RS); Pteroyl-L-glutamate; FOLIC ACID [VANDF]; FOLIC ACID [MART.]; FOLIC ACID (MART.); Folic acid, >=97\\%; Nifolin (Denmark); Nifolin [Denmark]; Antianemia factor; Prestwick3_000627; FOLIC ACID [HSDB]; FOLIC ACID [INCI]; Dosfolat B activ; Foldine [France]; Spectrum2_001459; Spectrum3_000749; Pteroylglutamate; Spectrum4_001751; Kyselina listova; Spectrum5_000602; FOLIC ACID [FCC]; Mission prenatal; Foldine (France); FOLIC ACID [JAN]; FOLIC ACID [INN]; FOLIC ACID [DSC]; FOLIC ACID [MI]; [3H]-folic acid; [3H]folic acid; Folina (Italy); Folic Acid,(S); Tox21_111559_1; Folico (Italy); Folcidin (VAN); Acidum folicum; Acfol (Spain); Acide folique; DivK1c_000494; BPBio1_000654; Tox21_111559; Folicet (TN); KBio2_001861; KBio2_006997; Tox21_300127; KBio3_001558; KBio2_004429; Acido folico; KBio1_000494; Folcysteine; CAS-59-30-3; Vitamin B11; SMP2_000137; IDI1_000494; Bio Science; Novofolacid; Preconceive; B9, Vitamin; Usaf cb-13; folic-acid; Folic acid; Vitamin Bc; Natur Flow; Vitamin Be; Vitamin B9; AI3-26387; Folsaeure; Incafolic; Vitamin M; PGA (VAN); Folcidin; Folaemin; Folettes; Folicare; Folic D3; Foliamin; Folsaure; Millafol; Neocepri; Factor U; Mittafol; Acifolic; Cytofol; B03BB01; Folvite; Foluite; Megafol; Foldine; Folicet; Folacid; Nifolin; Folipac; V04CX02; Folacin; Folico; Lexpec; PteGlu; Folate; Folsan; folite; Folsav; Folbal; Folina; Folan; Acfol; Facid; Folic; 2d0k; PGA; FOL; Folic acid ,approx; Vitamin B9; Folate; Folic acid



数据库引用编号

56 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

77 个相关的代谢反应过程信息。

Reactome(56)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(16)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, AKT1, FBP1, MTHFD1, SHMT1, SLC46A1, TYMS
Endosome membrane 2 SLC46A1, TFRC
Endoplasmic reticulum membrane 2 CD4, TKT
Mitochondrion membrane 1 ABCG2
Nucleus 7 AKT1, DNMT1, DNMT3B, FBP1, RFC1, SHMT1, TYMS
cytosol 10 AKT1, COMT, FBP1, GSR, MTHFD1, MTHFR, NAT1, SHMT1, TKT, TYMS
dendrite 1 COMT
mitochondrial membrane 1 ABCG2
nuclear body 1 TKT
nucleoplasm 7 ABCG2, AKT1, DNMT1, DNMT3B, RFC1, SHMT1, TKT
Cell membrane 10 ABCG2, ACE, AKT1, CD4, COMT, NAT1, RFC1, SLC46A1, TFRC, TKT
lamellipodium 1 AKT1
Multi-pass membrane protein 4 ABCG2, NAT1, RFC1, SLC46A1
Synapse 2 COMT, NAT1
cell cortex 1 AKT1
cell surface 3 NAT1, SLC46A1, TFRC
glutamatergic synapse 2 AKT1, TFRC
mitochondrial inner membrane 1 TYMS
postsynapse 1 AKT1
presynaptic membrane 1 NAT1
Lysosome 1 ACE
endosome 3 ACE, SLC46A1, TFRC
plasma membrane 11 ABCG2, ACE, AKT1, CD4, COMT, NAT1, RFC1, SLC46A1, TCN2, TFRC, TKT
synaptic vesicle membrane 1 NAT1
Membrane 8 ABCG2, ACE, AKT1, COMT, MTHFD1, NAT1, SLC46A1, TFRC
apical plasma membrane 5 ABCG2, NAT1, RFC1, SLC46A1, TKT
axon 2 COMT, NAT1
basolateral plasma membrane 4 NAT1, RFC1, SLC46A1, TFRC
extracellular exosome 9 ACE, COMT, FBP1, GSR, MTHFD1, RFC1, SHMT1, TFRC, TKT
extracellular space 4 ACE, PTH, TCN2, TFRC
lysosomal lumen 1 TCN2
perinuclear region of cytoplasm 1 TFRC
mitochondrion 5 DNMT1, GSR, MTHFD1, SHMT1, TYMS
protein-containing complex 1 AKT1
intracellular membrane-bounded organelle 2 COMT, TFRC
pericentric heterochromatin 1 DNMT1
Single-pass type I membrane protein 3 ACE, CD4, TKT
Secreted 2 ACE, TCN2
extracellular region 4 ACE, PTH, TCN2, TFRC
neuronal cell body membrane 1 NAT1
Mitochondrion matrix 1 TYMS
mitochondrial matrix 2 GSR, TYMS
Extracellular side 1 COMT
external side of plasma membrane 5 ACE, CD4, GSR, TCN2, TFRC
Extracellular vesicle 1 TFRC
actin cytoskeleton 1 TKT
cytoplasmic vesicle 1 TFRC
microtubule cytoskeleton 1 AKT1
Early endosome 2 CD4, TFRC
cell-cell junction 1 AKT1
clathrin-coated pit 1 TFRC
recycling endosome 1 TFRC
Single-pass type II membrane protein 2 COMT, TFRC
vesicle 2 AKT1, TKT
Apical cell membrane 3 ABCG2, RFC1, SLC46A1
Mitochondrion inner membrane 1 TYMS
Membrane raft 2 ABCG2, CD4
focal adhesion 1 TKT
spindle 1 AKT1
Peroxisome 1 TKT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
receptor complex 1 TKT
ciliary basal body 1 AKT1
brush border membrane 4 ABCG2, ACE, RFC1, SLC46A1
blood microparticle 1 TFRC
sperm midpiece 1 ACE
Basolateral cell membrane 3 NAT1, RFC1, SLC46A1
Recycling endosome membrane 1 TFRC
female germ cell nucleus 1 DNMT1
Melanosome 1 TFRC
replication fork 1 DNMT1
basal plasma membrane 1 ACE
HFE-transferrin receptor complex 1 TFRC
endoplasmic reticulum lumen 1 CD4
clathrin-coated endocytic vesicle membrane 2 CD4, TFRC
external side of apical plasma membrane 1 ABCG2
postsynaptic recycling endosome membrane 1 TFRC
T cell receptor complex 1 CD4
[Transferrin receptor protein 1, serum form]: Secreted 1 TFRC
catalytic complex 1 DNMT3B
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
DNA replication factor C complex 1 RFC1
Elg1 RFC-like complex 1 RFC1


文献列表

  • Yifei Lu, Chenqi Xu, Kewei Xie, Bingru Zhao, Minzhou Wang, Cheng Qian, Xuemei Chen, Leyi Gu, Wangshu Wu, Renhua Lu. The relationship between thiamin, folic acid and cognitive function in a rat model of uremia. Renal failure. 2024 Dec; 46(1):2329257. doi: 10.1080/0886022x.2024.2329257. [PMID: 38482596]
  • Yunsong Jiang, Mengzhen Xing, Jinyuan Sun, Xin-An Zeng, Charles Brennan, Jayani Chandrapala, Mahsa Majzoobi, Baoguo Sun. Construction of resveratrol and quercetin nanoparticles based on folic acid targeted Maillard products between Jiuzao glutelin isolate and carboxymethyl chitosan: Improved stability and function. Food chemistry. 2024 Aug; 450(?):139296. doi: 10.1016/j.foodchem.2024.139296. [PMID: 38636381]
  • Li He, Lisheng Peng, Lianan Wang, Xiaoyan Jiang, Xinfeng Sun, Haiwen Li, Tong Lin, Zhulin Wu, Sen Lin. Investigation of folate-modified EGCG-loaded thermosensitive nanospheres inducing immunogenic cell death and damage-associated molecular patterns in hepatocellular carcinoma. Biochemical and biophysical research communications. 2024 Jun; 714(?):149976. doi: 10.1016/j.bbrc.2024.149976. [PMID: 38677007]
  • Shijing Yang, Yaoxing Li, Xiaoman Zheng, Xirui Zheng, Yongshi Lin, Shining Guo, Cui Liu. Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155415. doi: 10.1016/j.phymed.2024.155415. [PMID: 38503151]
  • Federica Fogacci, Carmine Pizzi, Luca Bergamaschi, Valentina Di Micoli, Arrigo F G Cicero. Folic acid and plasma lipids: Interactions and effect of folate supplementation. Current problems in cardiology. 2024 Jun; 49(6):102539. doi: 10.1016/j.cpcardiol.2024.102539. [PMID: 38521293]
  • Chi-Yen Hung, Hsin-Ju Lee, Zhao-Ting Tsai, Shu-Jung Huang, Hsin-Yi Huang, Hui-Ju Tsai, Tsung-Chieh Yao. Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity. Obesity (Silver Spring, Md.). 2024 Jun; 32(6):1179-1186. doi: 10.1002/oby.24012. [PMID: 38572577]
  • Min Hong, Juan Wang, Haobin Chen, Jiayu Qi, Qinghong Ji, Xiaoyan Liu, Qiaoli Yue, Lei Li, Shuang Cheng. Synthesis and biological evaluation of folic acid-rotenol conjugate as a potent targeted anticancer prodrug. European journal of pharmacology. 2024 May; 970(?):176482. doi: 10.1016/j.ejphar.2024.176482. [PMID: 38452835]
  • Changhao Fang, Karen Kanemaru, Wildemar S P Carvalho, Krista R Fruehauf, Sunshine Zhang, Prem P Das, Caishuang Xu, Yuping Lu, Nandhakishore Rajagopalan, Marianna Kulka, Darren A Makeiff, Michael J Serpe. Self-assembled poloxamer-legumin/vicilin nanoparticles for the nanoencapsulation and controlled release of folic acid. International journal of biological macromolecules. 2024 May; 268(Pt 2):131646. doi: 10.1016/j.ijbiomac.2024.131646. [PMID: 38636765]
  • Yaqi Zhao, Junyan Shi, Bihong Feng, Shuzhi Yuan, Xiaozhen Yue, Wenlin Shi, Zhicheng Yan, Dongying Xu, Jinhua Zuo, Qing Wang. Multi-omic analysis of the extension of broccoli quality during storage by folic acid. Journal of advanced research. 2024 May; 59(?):65-78. doi: 10.1016/j.jare.2023.07.001. [PMID: 37406731]
  • Xiaowan Hou, Zhiwei Lu, Taifei Yu, Yuanyuan Zhang, Quansheng Yao, Chunyi Zhang, Yiding Niu, Qiuju Liang. Two maize homologs of mammalian proton-coupled folate transporter, ZmMFS_1-62 and ZmMFS_1-73, are essential to salt and drought tolerance. Plant physiology and biochemistry : PPB. 2024 May; 210(?):108623. doi: 10.1016/j.plaphy.2024.108623. [PMID: 38626656]
  • Luiza Avezum, Yann E Madode, Christian Mestres, Nawel Achir, Charlotte Delpech, Morgane Chapron, Olivier Gibert, Loïc Rajjou, Eric Rondet. New insights into the rapid germination process of lentil and cowpea seeds: High thiamine and folate, and low α-galactoside content. Food chemistry. 2024 May; 439(?):138027. doi: 10.1016/j.foodchem.2023.138027. [PMID: 38029561]
  • Yaxi Zhang, Jieqiong Wei, Xiangling Feng, Qian Lin, Jing Deng, Yuehan Yuan, Min Li, Bingfang Zhai, Jihua Chen. Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways. Food & function. 2024 Apr; 15(8):4193-4206. doi: 10.1039/d4fo00404c. [PMID: 38506303]
  • Ilham Naeem Abd Ali Al-Fatlawi, Vahid Pouresmaeil, Fatemeh Davoodi-Dehaghani, Aida Pouresmaeil, Ali Akhtari, Masoud Homayouni Tabrizi. Effects of solid lipid nanocarrier containing methyl urolithin A by coating folate-bound chitosan and evaluation of its anti-cancer activity. BMC biotechnology. 2024 Apr; 24(1):18. doi: 10.1186/s12896-024-00845-6. [PMID: 38600497]
  • Yitong Ling, Shiqi Yuan, Xiaxuan Huang, Shanyuan Tan, Hongtao Cheng, Anding Xu, Jun Lyu. Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024 Apr; 79(4):. doi: 10.1093/gerona/glad266. [PMID: 38029284]
  • Ursula M Leonard, Clarissa L Leydon, Elena Arranz, Mairead E Kiely. Impact of consuming an environmentally protective diet on micronutrients: a systematic literature review. The American journal of clinical nutrition. 2024 Apr; 119(4):927-948. doi: 10.1016/j.ajcnut.2024.01.014. [PMID: 38569787]
  • Jinyun Li, Lu Fang, Miaocui Xi, Anyu Ni, Qiuhui Qian, Zejun Wang, Huili Wang, Jin Yan. Toxic effects of triclosan on hepatic and intestinal lipid accumulation in zebrafish via regulation of m6A-RNA methylation. Aquatic toxicology (Amsterdam, Netherlands). 2024 Apr; 269(?):106884. doi: 10.1016/j.aquatox.2024.106884. [PMID: 38458066]
  • Zhengquan Yan, Yulian Tang, Zhaoran Zhang, Jing Feng, Junkai Hao, Shuo Sun, Meng Li, Yuguang Song, Wei Dong, Lei Hu. Biocompatible Folic-Acid-Strengthened Ag-Ir Quantum Dot Nanozyme for Cell and Plant Root Imaging of Cysteine/Stress and Multichannel Monitoring of Hg2+ and Dopamine. Analytical chemistry. 2024 Mar; 96(10):4299-4307. doi: 10.1021/acs.analchem.4c00081. [PMID: 38414258]
  • Jinfang Song, Wenqiang Yu, Shuangquan Chen, Jiamin Huang, Chujun Zhou, Hua Liang. Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury. European journal of pharmacology. 2024 Mar; 966(?):176342. doi: 10.1016/j.ejphar.2024.176342. [PMID: 38290569]
  • Manru Xu, Yue Zhu, Jinxin Chen, Jie Li, Jingbo Qin, Yiran Fan, Pan Ren, Huixue Hu, Wenbin Wu. Effects of folic acid supplementation on cognitive impairment: A meta-analysis of randomized controlled trials. Journal of evidence-based medicine. 2024 Mar; 17(1):134-144. doi: 10.1111/jebm.12588. [PMID: 38465839]
  • Daniel Leclerc, Karen E Christensen, Alaina M Reagan, Vafa Keser, Yan Luan, Olga V Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A Caudill, Gareth R Howell, Rima Rozen. Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner. Molecular nutrition & food research. 2024 Mar; 68(5):e2300355. doi: 10.1002/mnfr.202300355. [PMID: 38327171]
  • Naveen Rajana, Padakanti Sandeep Chary, Valamla Bhavana, Rajeshwari Deshmukh, Komalatha Dukka, Anamika Sharma, Neelesh Kumar Mehra. Targeted delivery and apoptosis induction of CDK-4/6 inhibitor loaded folic acid decorated lipid-polymer hybrid nanoparticles in breast cancer cells. International journal of pharmaceutics. 2024 Feb; 651(?):123787. doi: 10.1016/j.ijpharm.2024.123787. [PMID: 38184023]
  • Helena J Bentil, Seth Adu-Afarwuah, Elizabeth L Prado, Charles D Arnold, Paul D Hastings, Amanda E Guyer, Mavis O Mensah, Adom Manu, Xiuping Tan, Ebenezer Adjetey, Benjamin Amponsah, Maku E Demuyakor, Kathryn G Dewey, Brietta M Oaks. Sustained effects of small-quantity lipid-based nutrient supplements provided during the first 1000 days on child growth at 9-11 y in a randomized controlled trial in Ghana. The American journal of clinical nutrition. 2024 Feb; 119(2):425-432. doi: 10.1016/j.ajcnut.2023.10.033. [PMID: 38309829]
  • Rolland Mutumba, Hannah Pesu, Joseph Mbabazi, Eva Greibe, Ebba Nexo, Mette F Olsen, André Briend, Christian Mølgaard, Kim F Michaelsen, Christian Ritz, Suzanne Filteau, Ezekiel Mupere, Henrik Friis, Benedikte Grenov. Effect of lipid-based nutrient supplements on micronutrient status and hemoglobin among children with stunting: secondary analysis of a randomized, controlled trial in Uganda. The American journal of clinical nutrition. 2024 Jan; ?(?):. doi: 10.1016/j.ajcnut.2024.01.018. [PMID: 38278366]
  • Denglu Zhang, Shuai Liu, Huihui Jiang, Shuangde Liu, Feng Kong. DIA proteomics analysis reveals the mechanism of folic acid-induced acute kidney injury and the effects of icariin. Chemico-biological interactions. 2024 Jan; 390(?):110878. doi: 10.1016/j.cbi.2024.110878. [PMID: 38272249]
  • Stephen G Andrews, Anthony M Koehle, Devendra Paudel, Thomas Neuberger, A Catharine Ross, Vishal Singh, Teodoro Bottiglieri, Rita Castro. Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice. Nutrients. 2024 Jan; 16(3):. doi: 10.3390/nu16030330. [PMID: 38337615]
  • Tanja Sobot, Zorislava Bajic, Ranko Skrbic, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Djordje Djukanovic, Milica Gajic Bojic, Sanja Jovicic, Maja Barudzija, Milos P Stojiljkovic, Dragan M Djuric. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiology international. 2024 Jan; ?(?):. doi: 10.1556/2060.2023.00291. [PMID: 38261080]
  • Chutikun Kanjanaruch, Kerri A Bochantin, Bethania J Dávila Ruiz, Jessica Syring, Yssi Entzie, Layla King, Pawel P Borowicz, Matthew S Crouse, Joel S Caton, Carl R Dahlen, Alison K Ward, Lawrence P Reynolds. One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy. Journal of animal science. 2024 Jan; 102(?):. doi: 10.1093/jas/skae044. [PMID: 38407272]
  • Meryem Al Fatly, Monique T Mulder, Jeanine Roeters van Lennep, Henk J Blom, Kirsten A C Berk. The effect of diet-induced weight loss on circulating homocysteine levels in people with obesity and type 2 diabetes. Nutrition journal. 2024 Jan; 23(1):2. doi: 10.1186/s12937-023-00908-y. [PMID: 38167024]
  • Zhaoyun Liu, Xi Wang, Chen Zhang, Kui Lin, Jian Yang, Yi Zhang, Jia Hao, Fei Tian. Folic acid-coupled bovine serum albumin-modified magnetic nanocomposites from quantum-sized Fe3O4 and layered double hydroxide for actively targeted delivery of 5-fluorouracil. International journal of biological macromolecules. 2024 Jan; 256(Pt 1):128385. doi: 10.1016/j.ijbiomac.2023.128385. [PMID: 38000576]
  • Chun Lei, Gangjie Wu, Yan Cui, Hui Xia, Jianbing Chen, Xiaoyao Zhan, Yanlan Lv, Meng Li, Ronghua Zhang, Xiaofeng Zhu. Development and validation of a cognitive dysfunction risk prediction model for the abdominal obesity population. Frontiers in endocrinology. 2024; 15(?):1290286. doi: 10.3389/fendo.2024.1290286. [PMID: 38481441]
  • Jeremy Marshall, Ana Vargas, Kirstin Bett. B vitamin quantification in lentil seed tissues using ultra-performance liquid chromatography-selected reaction monitoring mass spectrometry. Food chemistry. 2024 Jan; 430(?):136922. doi: 10.1016/j.foodchem.2023.136922. [PMID: 37517945]
  • Mozhdeh Aghabagherzadeh, Ehsan Karimi, Mohsen Zareian. Folic Acid-Conjugated Chitosan-Coated Solid Lipid Nanoparticles: Precision Targeting of Artemisia vulgaris Essential Oils for Anticancer Therapy. Chemistry & biodiversity. 2024 Jan; 21(1):e202300187. doi: 10.1002/cbdv.202300187. [PMID: 38164058]
  • Yuanyuan Wang, Ruibo Guo, Ming Zou, Lingling Jiang, Liang Kong, Sen Zhao, Xuan Zhang, Wei Wang, Baoli Xu. Combined ROS Sensitive Folate Receptor Targeted Micellar Formulations of Curcumin Effective Against Rheumatoid Arthritis in Rat Model. International journal of nanomedicine. 2024; 19(?):4217-4234. doi: 10.2147/ijn.s458957. [PMID: 38766660]
  • Guangyi Gao, Wenhang Zhou, Xuan Jiang, Jun Ma. Bovine serum albumin and folic acid-modified aurum nanoparticles loaded with paclitaxel and curcumin enhance radiotherapy sensitization for esophageal cancer. International journal of radiation biology. 2024; 100(3):411-419. doi: 10.1080/09553002.2023.2281524. [PMID: 37934908]
  • Yoshihiro Kawada, Eriko Hayashi, Yuya Katsuragi, Aya Imamura-Jinda, Takatsugu Hirokawa, Tamio Mizukami, Makoto Hayashi. Identification of Chemicals That Abrogate Folate-Dependent Inhibition of Starch Accumulation in Non-Photosynthetic Plastids of Arabidopsis. Plant & cell physiology. 2023 Dec; 64(12):1551-1562. doi: 10.1093/pcp/pcad116. [PMID: 37801291]
  • Jae-Ik Lee, Sang-Soon Kim, Dong-Hyun Kang. Characteristics of Staphylococcus aureus biofilm matured in tryptic soy broth, low-fat milk, or whole milk samples along with inactivation by 405 nm light combined with folic acid. Food microbiology. 2023 Dec; 116(?):104350. doi: 10.1016/j.fm.2023.104350. [PMID: 37689424]
  • Inés Domínguez-López, Rosa Casas, Gemma Chiva-Blanch, Miguel Ángel Martínez-González, Montserrat Fitó, Emilio Ros, Rosa M Lamuela-Raventós, Ramon Estruch. Serum vitamin B12 concentration is associated with improved memory in older individuals with higher adherence to the Mediterranean diet. Clinical nutrition (Edinburgh, Scotland). 2023 12; 42(12):2562-2568. doi: 10.1016/j.clnu.2023.10.025. [PMID: 37948836]
  • Jibiao He, Ruihuan Ding, Yuping Tao, Zhenyu Zhao, Ranran Yuan, Houqian Zhang, Aiping Wang, Kaoxiang Sun, Youxin Li, Yanan Shi. Folic acid-modified reverse micelle-lipid nanocapsules overcome intestinal barriers and improve the oral delivery of peptides. Drug delivery. 2023 Dec; 30(1):2181744. doi: 10.1080/10717544.2023.2181744. [PMID: 36855953]
  • Ming Wu, Hongrui Ping, Kun Wang, Hui Ding, Meng Zhang, Ziqiong Yang, Qian Du. Oral delivery of pectin-chitosan hydrogels entrapping macrophage-targeted curcumin-loaded liposomes for the treatment of ulcerative colitis. International journal of pharmaceutics. 2023 Nov; 647(?):123510. doi: 10.1016/j.ijpharm.2023.123510. [PMID: 37839497]
  • Abiodun Maiyegun Afisulahi, Bappah Aminu, Yahkub Mutalub Babatunde, Nasiru Yakubu Nusaiba, Ibrahim Garba Halima. HERBAL MEDICINE USE DURING PREGNANCY IN A FEDERAL TEACHING HOSPITAL IN NORTHERN NIGERIA- A CROSS-SECTIONAL STUDY. West African journal of medicine. 2023 Nov; 40(11 Suppl 1):S29. doi: ". [PMID: 37978929]
  • Huaqi Zhang, Yutong Wang, Xinyu Zhang, Li Zhang, Xuenuo Zhao, Yan Xu, Peng Wang, Xi Liang, Meilan Xue, Hui Liang. Maternal Folic Acid Supplementation during Pregnancy Prevents Hepatic Steatosis in Male Offspring of Rat Dams Fed High-Fat Diet, Which Is Associated with the Regulation of Gut Microbiota. Nutrients. 2023 Nov; 15(22):. doi: 10.3390/nu15224726. [PMID: 38004120]
  • Nicola A Gillies, Amber M Milan, David Cameron-Smith, Karen D Mumme, Cathryn A Conlon, Pamela R von Hurst, Crystal F Haskell-Ramsay, Beatrix Jones, Nicole C Roy, Jane Coad, Clare R Wall, Kathryn L Beck. Vitamin B and One-Carbon Metabolite Profiles Show Divergent Associations with Cardiometabolic Risk Markers but not Cognitive Function in Older New Zealand Adults: A Secondary Analysis of the REACH Study. The Journal of nutrition. 2023 Oct; ?(?):. doi: 10.1016/j.tjnut.2023.10.012. [PMID: 37863266]
  • Inge Schwedt, Kerstin Schöne, Maike Eckert, Manon Pizzinato, Laura Winkler, Barbora Knotkova, Björn Richts, Jann-Louis Hau, Julia Steuber, Raul Mireles, Lianet Noda-Garcia, Günter Fritz, Carolin Mittelstädt, Robert Hertel, Fabian M Commichau. The low mutational flexibility of the EPSP synthase in Bacillus subtilis is due to a higher demand for shikimate pathway intermediates. Environmental microbiology. 2023 Oct; ?(?):. doi: 10.1111/1462-2920.16518. [PMID: 37822042]
  • David A Korasick, Luckio F Owuocha, Pramod K Kandoth, John J Tanner, Melissa G Mitchum, Lesa J Beamer. Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance. The FEBS journal. 2023 Oct; ?(?):. doi: 10.1111/febs.16971. [PMID: 37811683]
  • L M He, Y X Yan, C J Zhao, X L Zhu, B F Liang, G T Lin, J C Chen, F Zhang. [Evaluation of the effect of internet-based dietary self-management on blood pressure in high-risk population of hypertension in Haikou City community]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2023 Oct; 57(10):1581-1589. doi: 10.3760/cma.j.cn112150-20230106-00017. [PMID: 37859374]
  • Xue Yang, Shihui Dong, Yun Fan, Yuanyuan Xia, Fan Yang, Zhaohong Chen, Dacheng Chen, Mingchao Zhang, Dandan Liang, Caihong Zeng. Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914530. [PMID: 37833977]
  • Fangqian Sui, Zengjun Fang, Lingjun Li, Xinhuan Wan, Yongqing Zhang, Xiaoqing Cai. pH-triggered 'PEG' sheddable and folic acid-targeted nanoparticles for docetaxel delivery in breast cancer treatment. International journal of pharmaceutics. 2023 Sep; 644(?):123293. doi: 10.1016/j.ijpharm.2023.123293. [PMID: 37541534]
  • Da-Tong Ju, Rwei-Fen S Huang, Bruce Chi-Kang Tsai, Yi-Chen Su, Ping-Ling Chiu, Yung-Ming Chang, V Vijaya Padma, Tsung-Jung Ho, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang. Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways. Neurotoxicity research. 2023 Sep; ?(?):. doi: 10.1007/s12640-023-00666-z. [PMID: 37707697]
  • Ying Feng, Shannon K Chang, Daniel A Portnoy. The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine. mBio. 2023 Sep; ?(?):e0107423. doi: 10.1128/mbio.01074-23. [PMID: 37695058]
  • Leandro Teixeira Cacau, Giles T Hanley-Cook, Inge Huybrechts, Stefaan De Henauw, Mathilde Kersting, Marcela Gonzalez-Gross, Frederic Gottrand, Marika Ferrari, Esther Nova, Manuel J Castillo, Dénes Molnár, Kurt Widhalm, Odysseas Androutsos, Yannis Manios, Peter Stehle, Carl Lachat, Dirce Maria Marchioni, Luis A Moreno. Relative validity of the Planetary Health Diet Index by comparison with usual nutrient intakes, plasma food consumption biomarkers, and adherence to the Mediterranean diet among European adolescents: the HELENA study. European journal of nutrition. 2023 Sep; 62(6):2527-2539. doi: 10.1007/s00394-023-03171-3. [PMID: 37171585]
  • Eman A El-Khateeb, Mohamed S Youssef, Mohammed M Mira, Abir U Igamberdiev, Robert D Hill, Claudio Stasolla. Interplay between the Brassica napus phytoglobin (BnPgb1), folic acid, and antioxidant responses enhances plant tolerance to waterlogging. Plant science : an international journal of experimental plant biology. 2023 Sep; 334(?):111775. doi: 10.1016/j.plantsci.2023.111775. [PMID: 37329959]
  • Chun-Wai Chan, Bi-Fong Lin. Folate Deficiency Enhanced Inflammation and Exacerbated Renal Fibrosis in High-Fat High-Fructose Diet-Fed Mice. Nutrients. 2023 Aug; 15(16):. doi: 10.3390/nu15163616. [PMID: 37630806]
  • Kirti Kirti, Shri Kant Singh. Obesogenic diet and metabolic syndrome among adolescents in India: data-driven cluster analysis. BMC cardiovascular disorders. 2023 08; 23(1):393. doi: 10.1186/s12872-023-03429-y. [PMID: 37559027]
  • Dwaipayan Bhattacharya, Kalyani Sakhare, Chhavi Dhiman, Aasia Ansari, Tapas Kumar Kundu, Kumar Pranav Narayan, Rajkumar Banerjee. Delivery of chemotherapeutic drug targeting folate receptor to oral cancer cells using functionalized carbon nanospheres. Biomedical materials (Bristol, England). 2023 08; 18(5):. doi: 10.1088/1748-605x/ace8de. [PMID: 37467764]
  • Sedighe Esmaeilzadeh, Reza Ghadimi, Sepideh Mashayekh-Amiri, Mouloud A Delavar, Zahra Basirat. The effect of myo-inositol supplementation on the prevention of gestational diabetes in overweight pregnant women: a randomized, double-blind, controlled trial. Minerva obstetrics and gynecology. 2023 Aug; 75(4):357-364. doi: 10.23736/s2724-606x.22.05036-9. [PMID: 35686634]
  • Asghar Narmani, Saeid Ganji, Maryam Amirishoar, Roghayyeh Jahedi, Mohammad Saeed Kharazmi, Seid Mahdi Jafari. Smart chitosan-PLGA nanocarriers functionalized with surface folic acid ligands against lung cancer cells. International journal of biological macromolecules. 2023 Aug; 245(?):125554. doi: 10.1016/j.ijbiomac.2023.125554. [PMID: 37356696]
  • Di Wu, Mengjie Si, Hui Yi Xue, Ngoc T Tran, Kamel Khalili, Rafal Kaminski, Ho Lun Wong. Lipid nanocarrier targeting activated macrophages for antiretroviral therapy of HIV reservoir. Nanomedicine (London, England). 2023 08; 18(20):1343-1360. doi: 10.2217/nnm-2023-0120. [PMID: 37815117]
  • Hua Huang, Jiangyan He, Dongyang Deng, Rong Chen, Yiyuan Zhou. Correlation between single nucleotide polymorphisms of folate metabolism genes and ethnic distribution in pregnant women. Medicine. 2023 Jul; 102(30):e34472. doi: 10.1097/md.0000000000034472. [PMID: 37505156]
  • Faris J Alyasiri, Maryam Ghobeh, Masoud Homayouni Tabrizi. Preparation and Characterization of Allicin-Loaded Solid Lipid Nanoparticles Surface-Functionalized with Folic Acid-Bonded Chitosan: In Vitro Anticancer and Antioxidant Activities. Frontiers in bioscience (Landmark edition). 2023 07; 28(7):135. doi: 10.31083/j.fbl2807135. [PMID: 37525919]
  • Tattari Shalini, Raghu Pullakhandam, Santu Ghosh, Bharati Kulkarni, Hemalatha Rajkumar, Harshpal S Sachdev, Anura V Kurpad, Geereddy Bhanuprakash Reddy. Prevalence of Vitamin B12 and Folate Deficiencies in Indian Children and Adolescents. Nutrients. 2023 Jul; 15(13):. doi: 10.3390/nu15133026. [PMID: 37447351]
  • Seth Adu-Afarwuah, Charles D Arnold, Anna Lartey, Harriet Okronipa, Kenneth Maleta, Per Ashorn, Ulla Ashorn, Kathryn G Dewey. Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials. Maternal & child nutrition. 2023 07; 19(3):e13501. doi: 10.1111/mcn.13501. [PMID: 37021807]
  • Yaqiong Li, Yongqing Chen, Ruiqing Liu, Shaobo Duan, Lijuan Chen, Jun Sun, Lianzhong Zhang. Study on Contrast-Enhanced Ultrasound Imaging and Anti-Tumor Effects of Drug-Loaded Nanodroplets with Tumor Targeting and Ultrasound Sensitivity. Frontiers in bioscience (Landmark edition). 2023 06; 28(6):115. doi: 10.31083/j.fbl2806115. [PMID: 37395016]
  • Lukas Babylon, Julia Meißner, Gunter P Eckert. Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210029. [PMID: 37373177]
  • Ying-Xia Xiong, Nan Li, Miao-Miao Han, Fan Ye, Tian Liu, Han-Yi Ye, Ting-Ting Zheng, Jin-Jia Wu, Ying Li, Shaowa Lv, Ying-Hua Zhang, Yun Zhang, Zheng-Qi Dong. Rhodiola rosea polysaccharides-based nanoparticles loaded with DOX boosts chemo-immunotherapy for triple-negative breast cancer by re-educating Tumor-associated macrophages. International journal of biological macromolecules. 2023 Jun; 239(?):124110. doi: 10.1016/j.ijbiomac.2023.124110. [PMID: 36958441]
  • Kai Zhang, Bingjin Li, Zhaoxuan Gu, Zhengyan Hou, Tianzhou Liu, Jiayu Zhao, Mengyu Ruan, Tianqi Zhang, Qin Yu, Xiaoqi Yu, Qianyu Lv. Association between dietary folate intake and cognitive impairment in older US adults: National Health and Nutrition Examination Survey. Archives of gerontology and geriatrics. 2023 06; 109(?):104946. doi: 10.1016/j.archger.2023.104946. [PMID: 36764201]
  • Jun Zhu, Jiaxi Jin, Qing Qi, Qi Zhou, Jing Zhou, Ling Wang. Drug substitution and adjuvant therapy in patients with genetics related infertility: A review. Drug discoveries & therapeutics. 2023 May; 17(2):73-86. doi: 10.5582/ddt.2022.01096. [PMID: 36990765]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Raghu Solanki, Ashok Kumar Jangid, Mahima Jadav, Hitesh Kulhari, Sunita Patel. Folate Functionalized and Evodiamine-Loaded Pluronic Nanomicelles for Augmented Cervical Cancer Cell Killing. Macromolecular bioscience. 2023 May; ?(?):e2300077. doi: 10.1002/mabi.202300077. [PMID: 37163974]
  • Fu Li, Fangfang Yang, Chenxi Guan, Pengcheng Wei, Dongqiong He, Qingwen Li, Lisheng Wang, Mingqing Yuan. Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles. Pharmaceutical development and technology. 2023 May; ?(?):1-8. doi: 10.1080/10837450.2023.2206487. [PMID: 37104639]
  • C L Girard, M Duplessis. Review - State of knowledge on the importance of folates and cobalamin for dairy cow metabolism. Animal : an international journal of animal bioscience. 2023 Apr; ?(?):100834. doi: 10.1016/j.animal.2023.100834. [PMID: 37210233]
  • Rebecca Simonian, Emanuela Pannia, Rola Hammoud, Ramil R Noche, Xiucheng Cui, Eva Kranenburg, Ruslan Kubant, Paula Ashcraft, Brandi Wasek, Teodoro Bottiglieri, James J Dowling, G Harvey Anderson. Methylenetetrahydrofolate reductase deficiency and high-dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish. Human molecular genetics. 2023 04; 32(9):1575-1588. doi: 10.1093/hmg/ddac308. [PMID: 36637428]
  • Arpita Das, Chyi-Huey Bai, Jung-Su Chang, Ya-Li Huang, Fan-Fen Wang, Yi-Chun Chen, Jane C-J Chao. Associations of Dietary Patterns and Vitamin D Levels with Iron Status in Pregnant Women: A Cross-Sectional Study in Taiwan. Nutrients. 2023 Apr; 15(8):. doi: 10.3390/nu15081805. [PMID: 37111023]
  • Alanna C Green, Petra Marttila, Nicole Kiweler, Christina Chalkiadaki, Elisée Wiita, Victoria Cookson, Antoine Lesur, Kim Eiden, François Bernardin, Karl S A Vallin, Sanjay Borhade, Maeve Long, Elahe Kamali Ghahe, Julio J Jiménez-Alonso, Ann-Sofie Jemth, Olga Loseva, Oliver Mortusewicz, Marianne Meyers, Elodie Viry, Annika I Johansson, Ondřej Hodek, Evert Homan, Nadilly Bonagas, Louise Ramos, Lars Sandberg, Morten Frödin, Etienne Moussay, Ana Slipicevic, Elisabeth Letellier, Jérôme Paggetti, Claus Storgaard Sørensen, Thomas Helleday, Martin Henriksson, Johannes Meiser. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature metabolism. 2023 Apr; ?(?):. doi: 10.1038/s42255-023-00771-5. [PMID: 37012496]
  • Soroush Sadeghi, Masoud Homayouni Tabrizi, Amin Farhadi. Folic acid-chitosan coated stylosin nanostructured lipid carriers: fabrication, in vitro-in vivo assessment in breast malignant cells. Journal of biomaterials science. Polymer edition. 2023 04; 34(6):791-809. doi: 10.1080/09205063.2022.2145868. [PMID: 36345914]
  • Luke Cui, Rong Gong. Effect of nutritional supplementation on mortality in peritoneal dialysis patients: A meta-analysis. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2023 Apr; 27(2):296-303. doi: 10.1111/1744-9987.13918. [PMID: 36071661]
  • Naijing Ye, Peng Zhao, Shibu Ayue, Shanshan Qi, Yan Ye, Haoqi He, Linxin Dai, Ruifeng Luo, Degui Chang, Fei Gao. Folic acid-modified lactoferrin nanoparticles coated with a laminarin layer loaded curcumin with dual-targeting for ulcerative colitis treatment. International journal of biological macromolecules. 2023 Mar; 232(?):123229. doi: 10.1016/j.ijbiomac.2023.123229. [PMID: 36642354]
  • Johan Peter Woelber, Katharina Reichenbächer, Tara Groß, Kirstin Vach, Petra Ratka-Krüger, Valentin Bartha. Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review. Nutrients. 2023 Mar; 15(6):. doi: 10.3390/nu15061538. [PMID: 36986267]
  • Yunfu Feng, Xiaohua Chen, Ying Pan, Yanting Yang. The associations of dietary folate and serum folate with lipid profiles: findings from the national health and nutrition examination survey 2011-2016. Lipids in health and disease. 2023 Mar; 22(1):30. doi: 10.1186/s12944-023-01793-4. [PMID: 36859278]
  • Azadeh Kordzadeh, Mahdi Zarif, Sepideh Amjad-Iranagh. Molecular dynamics insight of interaction between the functionalized-carbon nanotube and cancerous cell membrane in doxorubicin delivery. Computer methods and programs in biomedicine. 2023 Mar; 230(?):107332. doi: 10.1016/j.cmpb.2022.107332. [PMID: 36603233]
  • Seyedeh Fatemeh Hoseinlar, Masoud Nikanfar, Delara Laghousi, Masoud Darabi, Behrouz Shademan, Alireza Nourazarian. Diagnostic Value of ATG5, Apo-Lipoprotein B-48, Thyroid Hormones, and Homocysteine in Patients with Alzheimer's Disease. Clinical laboratory. 2023 Mar; 69(3):. doi: 10.7754/clin.lab.2022.220614. [PMID: 36912305]
  • Kunal Sarkar, Kaushik Dutta, Arindam Chatterjee, Jit Sarkar, Dipankar Das, Arbind Prasad, Dipankar Chattopadhyay, Krishnendu Acharya, Madhusudan Das, Suresh K Verma, Sriparna De. Nanotherapeutic potential of antibacterial folic acid-functionalized nanoceria for wound-healing applications. Nanomedicine (London, England). 2023 Feb; ?(?):. doi: 10.2217/nnm-2022-0233. [PMID: 36853798]
  • Ya-Lin Yao, Xin-Yu Ma, Tian-Yu Wang, Jin-Yang Yan, Nai-Fei Chen, Ji-Sheng Hong, Bing-Qi Liu, Zi-Qi Xu, Nuo Zhang, Chao Lv, Xiang Sun, Jun-Bo Luan. A bacteriocyte symbiont determines whitefly sex ratio by regulating mitochondrial function. Cell reports. 2023 02; 42(2):112102. doi: 10.1016/j.celrep.2023.112102. [PMID: 36774548]
  • Zhi-Qiang Du, Yan-Qin Pang, Yu Zhang, Li Wang, Rong Zhang, Hui Li, Cai-Xia Yang. Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes. Poultry science. 2023 Feb; 102(2):102363. doi: 10.1016/j.psj.2022.102363. [PMID: 36525749]
  • Amin Farhadi, Masoud Homayouni Tabrizi, Soroush Sadeghi, Danial Vala, Tina Khosravi. Targeted delivery and anticancer effects of Chrysin-loaded chitosan-folic acid coated solid lipid nanoparticles in pancreatic malignant cells. Journal of biomaterials science. Polymer edition. 2023 Feb; 34(3):315-333. doi: 10.1080/09205063.2022.2121589. [PMID: 36063019]
  • Yali Zhang, Changmao Long, Guiping Hu, Shiyi Hong, Zekang Su, Qiaojian Zhang, Pai Zheng, Tiancheng Wang, Shanfa Yu, Guang Jia. Two-week repair alleviates hexavalent chromium-induced hepatotoxicity, hepatic metabolic and gut microbial changes: A dynamic inhalation exposure model in male mice. The Science of the total environment. 2023 Jan; 857(Pt 1):159429. doi: 10.1016/j.scitotenv.2022.159429. [PMID: 36243064]
  • Xun Pei, Junjie Yao, Simiao Ran, Haifei Lu, Shuo Yang, Yini Zhang, Miyuan Wang, Heyuan Shi, Aihua Tan. Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006. Frontiers in endocrinology. 2023; 14(?):1167317. doi: 10.3389/fendo.2023.1167317. [PMID: 37251666]
  • C Laurent, H Caillat, C L Girard, A Ferlay, S Laverroux, J Jost, B Graulet. Impacts of production conditions on goat milk vitamin, carotenoid contents and colour indices. Animal : an international journal of animal bioscience. 2023 Jan; 17(1):100683. doi: 10.1016/j.animal.2022.100683. [PMID: 36610084]
  • Mehdi Afrouz, Amin Amani, Ali Eftekhari, Christophe Coudret, Sabry G Elias, Zainab Ahmadian, Mohammad Taghi Alebrahim. Design and synthesis of multi-targeted nanoparticles for gene delivery to breast cancer tissues. Naunyn-Schmiedeberg's archives of pharmacology. 2023 01; 396(1):121-137. doi: 10.1007/s00210-022-02303-6. [PMID: 36255459]
  • C Y T Kwok, Y K P Poon, P Chook, D S Guo, C Q Lin, Y H Yin, D S Celermajer, K S Woo. A Potential Strategy for Atherosclerosis Prevention in Modernizing China - Hyperhomocysteinemia, MTHFR C677T Polymorphism and Air Pollution (PM2.5) on Atherogenesis in Chinese Adults. The journal of nutrition, health & aging. 2023; 27(2):134-141. doi: 10.1007/s12603-023-1889-x. [PMID: 36806868]
  • Erika Castaño-Moreno, Ana María Ronco, Paola Casanello. Metabolic Interaction Between Folate, Vitamin B12, and Polyunsaturated Fatty Acids in Pregnancy. Advances in experimental medicine and biology. 2023; 1428(?):83-98. doi: 10.1007/978-3-031-32554-0_4. [PMID: 37466770]
  • Qi Liu, Lijun Luo, Xiaofeng Gao, Di Zhang, Xinqian Feng, Peng Yang, Hui Li, Shengjun Mao. Co-Delivery of Daunorubicin and Homoharringtonine in Folic Acid Modified-Liposomes for Enhancing Therapeutic Effect on Acute Myeloid Leukemia. Journal of pharmaceutical sciences. 2023 01; 112(1):123-131. doi: 10.1016/j.xphs.2022.04.014. [PMID: 35469834]
  • Qingyun Yang, Chuncao Zhao, Jian Yang, Jingyi Zhao, Yi Feng, Minchen Liu, Jiquan Zhang. Physical Characterization and Safety Evaluation of Folic Acid-conjugated Mesoporous Silica Nanoparticles Loaded with Rhodojaponin III. Current drug delivery. 2023; 20(10):1559-1568. doi: 10.2174/1567201820666221108121347. [PMID: 36366851]
  • Enju Liu, Dongqing Wang, Anne M Darling, Nandita Perumal, Molin Wang, Tahmeed Ahmed, Parul Christian, Kathryn G Dewey, Gilberto Kac, Stephen Kennedy, Vishak Subramoney, Brittany Briggs, Wafaie W Fawzi. Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: a meta-analysis of individual participant data. The American journal of clinical nutrition. 2022 12; 116(6):1864-1876. doi: 10.1093/ajcn/nqac259. [PMID: 36130877]
  • Hua-Tsen Hsiao, Mi-Chia Ma, Hsin-I Chang, Ching-Heng Lin, Shih-Wei Hsu, Shu-Hua Huang, Chen-Chang Lee, Chi-Wei Huang, Chiung-Chih Chang. Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer's Disease Using Surface-Based Morphometry. Nutrients. 2022 Dec; 14(24):. doi: 10.3390/nu14245300. [PMID: 36558459]
  • Wei He, Hao Yang, Qikun Pu, Yu Li. Novel control strategies for the endocrine-disrupting effect of PAEs to pregnant women in traffic system. The Science of the total environment. 2022 Dec; 851(Pt 2):158269. doi: 10.1016/j.scitotenv.2022.158269. [PMID: 36029816]
  • Safiullah Khan, Asadullah Madni, Hassan Shah, Nasrullah Jan, Afifa Shafiq, Abdul Basit, Nadia Rai, Ahsan Ali, Muhammad Muzamil Khan. Folate decorated lipid chitosan hybrid nanoparticles of 5-fluorouracil for enhanced anticancer efficacy against colon cancer. International journal of biological macromolecules. 2022 Dec; 222(Pt A):497-508. doi: 10.1016/j.ijbiomac.2022.09.196. [PMID: 36174854]
  • Qian-Nan Guo, Ling Wang, Zheng-Yan Liu, Hong-Dan Wang, Li Wang, Jian-Gang Long, Shi-Xiu Liao. Different effects of maternal homocysteine concentration, MTHFR and MTRR genetic polymorphisms on the occurrence of fetal aneuploidy. Reproductive biomedicine online. 2022 12; 45(6):1207-1215. doi: 10.1016/j.rbmo.2022.06.024. [PMID: 36210274]
  • Yu-Meng Chen, Jin-Lai Wei, Rui-Si Qin, Jin-Ping Hou, Guang-Chao Zang, Guang-Yuan Zhang, Ting-Ting Chen. Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein. Pharmaceutical biology. 2022 Dec; 60(1):862-878. doi: 10.1080/13880209.2022.2063341. [PMID: 35594385]
  • Bo Li, Tingfei Tan, Weiwei Chu, Ying Zhang, Yuanzi Ye, Shanshan Wang, Yan Qin, Jihui Tang, Xi Cao. Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy. Drug delivery. 2022 Dec; 29(1):75-88. doi: 10.1080/10717544.2021.2018523. [PMID: 34964421]