Cassaine (BioDeep_00000006913)
natural product
代谢物信息卡片
化学式: C24H39NO4 (405.2879)
中文名称:
谱图信息:
最多检出来源 Escherichia coli(endogenous) 50%
分子结构信息
SMILES: CC1/C(=C/C(=O)OCCN(C)C)CCC2C1C(=O)CC1C(C)(C)C(O)CCC21C
InChI: InChI=1S/C24H39NO4/c1-15-16(13-21(28)29-12-11-25(5)6)7-8-17-22(15)18(26)14-19-23(2,3)20(27)9-10-24(17,19)4/h13,15,17,19-20,22,27H,7-12,14H2,1-6H3/b16-13+/t15-,17-,19-,20-,22-,24+/m0/s1
描述信息
A tricyclic diterpenoid isolated from several plant species of the genus Erythrophleum.
同义名列表
3 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:3454
- KEGG: C08670
- PubChem: 5281267
- PubChem: 118078
- Metlin: METLIN67105
- ChEMBL: CHEMBL2010022
- CAS: 468-76-8
- PMhub: MS000020098
- MetaboLights: MTBLC3454
- PubChem: 10863
- KNApSAcK: C00001626
- 3DMET: B02318
- NIKKAJI: J10.137K
- RefMet: Cassaine
- LOTUS: LTS0016682
- KNApSAcK: 3454
- LOTUS: LTS0133462
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
19 个相关的物种来源信息
- 53876 - Erythrophleum: 10.1002/HLCA.193902201187
- 53876 - Erythrophleum: LTS0016682
- 53876 - Erythrophleum: LTS0133462
- 3086805 - Erythrophleum couminga: LTS0016682
- 1206079 - Erythrophleum guineense: 10.1002/HLCA.193902201187
- 53877 - Erythrophleum ivorense: 10.1002/HLCA.193902201187
- 162772 - Erythrophleum suaveolens: 10.1002/HLCA.193902201187
- 2759 - Eukaryota: LTS0016682
- 2759 - Eukaryota: LTS0133462
- 3803 - Fabaceae: LTS0016682
- 3803 - Fabaceae: LTS0133462
- 3398 - Magnoliopsida: LTS0016682
- 3398 - Magnoliopsida: LTS0133462
- 35493 - Streptophyta: LTS0016682
- 35493 - Streptophyta: LTS0133462
- 58023 - Tracheophyta: LTS0016682
- 58023 - Tracheophyta: LTS0133462
- 33090 - Viridiplantae: LTS0016682
- 33090 - Viridiplantae: LTS0133462
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zeping Chen, Ying Mou, Hao Zhong, Jiekun Xu, Xiaoqi Zhang, Guoqiang Li, Jun He, Weiku Zhang, Weihuan Huang, Haiyan Tian. Cassaine diterpenoids from the seeds of Erythrophleum fordii Oliv. and their antiangiogenic activity.
Phytochemistry.
2022 Nov; 203(?):113399. doi:
10.1016/j.phytochem.2022.113399. [PMID: 36027967] - Hao Zhong, Li Wang, Si Xiong, Zhen Wang, Zeping Chen, Weihuan Huang, Manmei Li, Haiyan Tian. Cassaine diterpenoid glycosides from the seeds of Erythrophleum fordii Oliv. and their antiviral and anti-inflammatory activities.
Fitoterapia.
2022 Nov; 163(?):105348. doi:
10.1016/j.fitote.2022.105348. [PMID: 36368611] - Tu Thanh Thi Nguyen, Dao Cuong To, Phuong Hien Thi Vo, Thanh Hoa Tran, Phi Hung Nguyen, Hien Minh Nguyen, Manh Hung Tran. Cassaine Diterpenoid Amide from Stem Bark of Erythrophleum fordii Suppresses Cytotoxic and Induces Apoptosis of Human Leukemia Cells.
Molecules (Basel, Switzerland).
2020 Jul; 25(14):. doi:
10.3390/molecules25143304. [PMID: 32708204] - Xiuyong Huang, Zeping Chen, Shiwen Zhou, Pengyun Huang, Zhenjian Zhuo, Sudan Zeng, Lei Wang, Yong Wang, Chuanshan Xu, Haiyan Tian. Cassaine diterpenoids from the seeds of Erythrophleum fordii and their cytotoxic activities.
Fitoterapia.
2018 Jun; 127(?):245-251. doi:
10.1016/j.fitote.2018.02.028. [PMID: 29496564] - Manh Tuan Ha, Manh Hung Tran, Thien Thuong Phuong, Jeong Ah Kim, Mi Hee Woo, Jae Sue Choi, Suhyun Lee, Jeong Hyung Lee, Hyeong Kyu Lee, Byung Sun Min. Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of Erythrophleum fordii.
Bioorganic & medicinal chemistry letters.
2017 07; 27(13):2946-2952. doi:
10.1016/j.bmcl.2017.05.006. [PMID: 28506750] - Tran Manh Hung, To Dao Cuong, Jeong Ah Kim, Nara Tae, Jeong Hyung Lee, Byung Sun Min. Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect.
Bioorganic & medicinal chemistry letters.
2014 Jan; 24(1):168-72. doi:
10.1016/j.bmcl.2013.11.048. [PMID: 24332631] - Dan Du, Lei Fang, Jing Qu, Shishan Yu, Shuanggang Ma, Haining Lv, Jing Liu, Yuanyan Liu, Jiaming Wang, Xiaojing Wang. Oleanane-type triterpene saponins and cassaine-type diterpenoids from Erythrophleum fordii.
Planta medica.
2011 Sep; 77(14):1631-8. doi:
10.1055/s-0030-1270992. [PMID: 21484673] - Dan Du, Jing Qu, Jia-Ming Wang, Shi-Shan Yu, Xiao-Guang Chen, Song Xu, Shuang-Gang Ma, Yong Li, Guang-Zhi Ding, Lei Fang. Cytotoxic cassaine diterpenoid-diterpenoid amide dimers and diterpenoid amides from the leaves of Erythrophleum fordii.
Phytochemistry.
2010 Oct; 71(14-15):1749-55. doi:
10.1016/j.phytochem.2010.07.004. [PMID: 20678783] - Jing Qu, You-Cai Hu, Shi-Shan Yu, Xiao-Guang Chen, Yan Li. New cassaine diterpenoid amides with cytotoxic activities from the bark of Erythrophleum fordii.
Planta medica.
2006 Apr; 72(5):442-9. doi:
10.1055/s-2005-916264. [PMID: 16557459] - S De Munari, P Barassi, A Cerri, G Fedrizzi, M Gobbini, M Mabilia, P Melloni. A new approach to the design of novel inhibitors of Na+,K+-ATPase: 17alpha-substituted seco-D 5beta-androstane as cassaine analogues.
Journal of medicinal chemistry.
1998 Jul; 41(16):3033-40. doi:
10.1021/jm980108d. [PMID: 9685243] - T Akera, Y C Ng, I S Shieh, E Bero, T M Brody, W E Braselton. Effects of K+ on the interaction between cardiac glycosides and Na,K-ATPase.
European journal of pharmacology.
1985 May; 111(2):147-57. doi:
10.1016/0014-2999(85)90751-4. [PMID: 2990948] - J Derka, G Carbonell, E Petrovský. [Induction of components of the natural precipitation system (GANS) and another antibody after alloimmunization with serum or egg yolk in fowl].
Veterinarni medicina.
1978 Mar; 23(3):141-5. doi:
NULL. [PMID: 96563]
