MELARSOPROL (BioDeep_00000006645)

   


代谢物信息卡片


MELARSOPROL

化学式: C12H15AsN6OS2 (397.9965)
中文名称: 美拉胂醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(S[As](S1)C2=CC=C(C=C2)NC3=NC(=NC(=N3)N)N)CO
InChI: InChI=1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)

描述信息

P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01C - Agents against leishmaniasis and trypanosomiasis > P01CD - Arsenic compounds
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent

同义名列表

2 个代谢物同义名

MELARSOPROL; Melarsoprol



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ANXA5, APOBEC3G, AQP3, BCL2, MSMP, ODC1, PML, POMC, RARA
Golgi apparatus, trans-Golgi network membrane 1 AQP2
Peripheral membrane protein 2 ANXA5, PML
Endosome membrane 2 HLA-A, HLA-B
Endoplasmic reticulum membrane 4 BCL2, HLA-A, HLA-B, PML
Nucleus 4 APOBEC3G, BCL2, PML, RARA
cytosol 6 ANXA5, APOBEC3G, BCL2, ODC1, PML, RARA
dendrite 2 RARA, TACR1
trans-Golgi network 1 FUT4
nucleoplasm 3 AQP3, PML, RARA
RNA polymerase II transcription regulator complex 1 RARA
Cell membrane 6 AQP2, AQP3, HLA-A, HLA-B, TACR1, TNF
Cytoplasmic side 1 PML
Early endosome membrane 3 HLA-A, HLA-B, PML
Multi-pass membrane protein 3 AQP2, AQP3, TACR1
Synapse 1 TAC1
cell surface 6 CD38, FUT4, HLA-A, HLA-B, TACR1, TNF
Golgi apparatus 4 AQP2, FUT4, HLA-A, HLA-B
Golgi membrane 3 FUT4, HLA-A, HLA-B
lysosomal membrane 2 HLA-A, HLA-B
neuronal cell body 2 TAC1, TNF
sarcolemma 1 ANXA5
plasma membrane 8 AQP2, AQP3, CD38, HLA-A, HLA-B, RARA, TACR1, TNF
Membrane 8 ANXA5, AQP2, AQP3, BCL2, CD38, FUT4, HLA-A, HLA-B
apical plasma membrane 1 AQP2
axon 1 TAC1
basolateral plasma membrane 3 AQP2, AQP3, CD38
extracellular exosome 5 ANXA5, AQP2, CD38, HLA-A, HLA-B
Lysosome membrane 2 HLA-A, HLA-B
endoplasmic reticulum 3 BCL2, HLA-A, HLA-B
extracellular space 9 HLA-A, HLA-B, IFNA1, IL10, IL6, MSMP, POMC, TAC1, TNF
perinuclear region of cytoplasm 2 AQP2, RARA
mitochondrion 1 BCL2
protein-containing complex 2 BCL2, RARA
Single-pass type I membrane protein 2 HLA-A, HLA-B
Secreted 5 IFNA1, IL10, IL6, MSMP, POMC
extracellular region 6 ANXA5, IL10, IL6, POMC, TAC1, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 3 BCL2, HLA-A, HLA-B
mitochondrial outer membrane 1 BCL2
transcription regulator complex 1 RARA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CD38, PML
external side of plasma membrane 4 ANXA5, HLA-A, HLA-B, TNF
actin cytoskeleton 1 RARA
nucleolus 2 PML, RARA
Cytoplasm, P-body 1 APOBEC3G
P-body 1 APOBEC3G
cell-cell junction 1 AQP3
recycling endosome 2 AQP2, TNF
Single-pass type II membrane protein 2 CD38, TNF
postsynaptic membrane 1 TACR1
Apical cell membrane 1 AQP2
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
Nucleus, PML body 1 PML
PML body 1 PML
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 POMC
lateral plasma membrane 1 AQP2
Zymogen granule membrane 1 ANXA5
apolipoprotein B mRNA editing enzyme complex 1 APOBEC3G
chromatin 1 RARA
phagocytic cup 1 TNF
phagocytic vesicle membrane 2 HLA-A, HLA-B
cell periphery 1 FUT4
chromosome, telomeric region 1 PML
sperm midpiece 1 TACR1
Basolateral cell membrane 2 AQP2, AQP3
sperm flagellum 1 TACR1
Recycling endosome membrane 2 HLA-A, HLA-B
Cytoplasmic vesicle membrane 1 AQP2
Golgi cisterna membrane 1 FUT4
cell body 1 TACR1
myelin sheath 1 BCL2
secretory granule lumen 1 POMC
secretory granule membrane 1 HLA-B
endoplasmic reticulum lumen 1 IL6
nuclear matrix 1 PML
endoplasmic reticulum exit site 1 HLA-A
ER to Golgi transport vesicle membrane 2 HLA-A, HLA-B
vesicle membrane 1 ANXA5
ribonucleoprotein complex 1 APOBEC3G
lumenal side of endoplasmic reticulum membrane 2 HLA-A, HLA-B
MHC class I peptide loading complex 1 HLA-A
Golgi medial cisterna 1 HLA-A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
MHC class I protein complex 2 HLA-A, HLA-B
MHC class II protein complex 2 HLA-A, HLA-B
transport vesicle membrane 1 AQP2
sperm head 1 TACR1
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
lumenal side of membrane 1 AQP2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Janet Khatenje Wendo, James Mucunu Mbaria, James Nyabuga Nyariki, Alfred Orina Isaac. Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol. PLoS neglected tropical diseases. 2024 Apr; 18(4):e0012103. doi: 10.1371/journal.pntd.0012103. [PMID: 38620045]
  • Jun Li, Nasir Tajuddeen, Doris Feineis, Virima Mudogo, Marcel Kaiser, Ean-Jeong Seo, Thomas Efferth, Gerhard Bringmann. Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities. Bioorganic & medicinal chemistry letters. 2023 Apr; 86(?):129258. doi: 10.1016/j.bmcl.2023.129258. [PMID: 36972793]
  • Blaise Kimbadi Lombe, Doris Feineis, Virima Mudogo, Marcel Kaiser, Gerhard Bringmann. Spirombandakamine A3 and Cyclombandakamines A8 and A9, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Ancistrocladus Plant. Journal of natural products. 2021 04; 84(4):1335-1344. doi: 10.1021/acs.jnatprod.1c00063. [PMID: 33843232]
  • Shaimaa Fayez, Jun Li, Doris Feineis, Laurent Aké Assi, Marcel Kaiser, Reto Brun, Mohamed A Anany, Harald Wajant, Gerhard Bringmann. A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus. Journal of natural products. 2019 11; 82(11):3033-3046. doi: 10.1021/acs.jnatprod.9b00589. [PMID: 31642313]
  • Dieudonné Tshitenge Tshitenge, Torsten Bruhn, Doris Feineis, David Schmidt, Virima Mudogo, Marcel Kaiser, Reto Brun, Frank Würthner, Suresh Awale, Gerhard Bringmann. Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells. Journal of natural products. 2019 11; 82(11):3150-3164. doi: 10.1021/acs.jnatprod.9b00755. [PMID: 31630523]
  • Jerald J Nair, Johannes van Staden. Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. Bioorganic & medicinal chemistry letters. 2019 10; 29(20):126642. doi: 10.1016/j.bmcl.2019.126642. [PMID: 31515186]
  • Mahdi M Farimani, Bahareh Khodaei, Hanzaleh Moradi, Abbas Aliabadi, Samad N Ebrahimi, Maria De Mieri, Marcel Kaiser, Matthias Hamburger. Phytochemical Study of Salvia leriifolia Roots: Rearranged Abietane Diterpenoids with Antiprotozoal Activity. Journal of natural products. 2018 06; 81(6):1384-1390. doi: 10.1021/acs.jnatprod.7b01019. [PMID: 29896963]
  • Dieudonné Tshitenge Tshitenge, Doris Feineis, Virima Mudogo, Marcel Kaiser, Reto Brun, Ean-Jeong Seo, Thomas Efferth, Gerhard Bringmann. Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities. Journal of natural products. 2018 04; 81(4):918-933. doi: 10.1021/acs.jnatprod.7b01041. [PMID: 29560715]
  • Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt. Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata. Journal of natural products. 2018 01; 81(1):124-130. doi: 10.1021/acs.jnatprod.7b00747. [PMID: 29244495]
  • Jun Li, Raina Seupel, Torsten Bruhn, Doris Feineis, Marcel Kaiser, Reto Brun, Virima Mudogo, Suresh Awale, Gerhard Bringmann. Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products. 2017 10; 80(10):2807-2817. doi: 10.1021/acs.jnatprod.7b00650. [PMID: 29043798]
  • Jun Li, Raina Seupel, Doris Feineis, Virima Mudogo, Marcel Kaiser, Reto Brun, Daniela Brünnert, Manik Chatterjee, Ean-Jeong Seo, Thomas Efferth, Gerhard Bringmann. Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines. Journal of natural products. 2017 02; 80(2):443-458. doi: 10.1021/acs.jnatprod.6b00967. [PMID: 28121440]
  • Sylvian Cretton, Lise Breant, Lucie Pourrez, Chiara Ambuehl, Laurence Marcourt, Samad Nejad Ebrahimi, Matthias Hamburger, Remo Perozzo, Soumana Karimou, Marcel Kaiser, Muriel Cuendet, Philippe Christen. Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica. Journal of natural products. 2014 Oct; 77(10):2304-11. doi: 10.1021/np5006554. [PMID: 25314007]
  • Georg Raber, Thomas Raber, Reingard Raml, Manuela Murko, Christoph Magnes, Kevin A Francesconi. Determination of the trypanocidal drug melarsoprol and its conversion products in biological fluids with HPLC-ICPMS/ESMS. Talanta. 2013 Nov; 116(?):876-81. doi: 10.1016/j.talanta.2013.07.066. [PMID: 24148488]
  • Anne Baumann, Thorben Pfeifer, Daniel Melles, Uwe Karst. Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis. Analytical and bioanalytical chemistry. 2013 Jun; 405(15):5249-58. doi: 10.1007/s00216-013-6929-7. [PMID: 23552974]
  • Nicola Baker, Lucy Glover, Jane C Munday, David Aguinaga Andrés, Michael P Barrett, Harry P de Koning, David Horn. Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul; 109(27):10996-1001. doi: 10.1073/pnas.1202885109. [PMID: 22711816]
  • Sam Alsford, Sabine Eckert, Nicola Baker, Lucy Glover, Alejandro Sanchez-Flores, Ka Fai Leung, Daniel J Turner, Mark C Field, Matthew Berriman, David Horn. High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature. 2012 Jan; 482(7384):232-6. doi: 10.1038/nature10771. [PMID: 22278056]
  • Andreas Link, Philipp Heidler, Marcel Kaiser, Reto Brun. Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites. European journal of medicinal chemistry. 2009 Sep; 44(9):3665-71. doi: 10.1016/j.ejmech.2009.02.010. [PMID: 19285758]
  • Maria Forlenza, Joern P Scharsack, Neli M Kachamakova, Anja J Taverne-Thiele, Jan H W M Rombout, Geert F Wiegertjes. Differential contribution of neutrophilic granulocytes and macrophages to nitrosative stress in a host-parasite animal model. Molecular immunology. 2008 Jun; 45(11):3178-89. doi: 10.1016/j.molimm.2008.02.025. [PMID: 18406465]
  • Martin Senn, Sigmund Gunzenhauser, Reto Brun, Urs Séquin. Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii. Journal of natural products. 2007 Oct; 70(10):1565-9. doi: 10.1021/np0702133. [PMID: 17922552]
  • Anne-Emmanuelle Hay, Jean-Robert Ioset, Kouassi Maximin Ahua, Drissa Diallo, Reto Brun, Kurt Hostettmann. Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. Journal of natural products. 2007 Jan; 70(1):9-13. doi: 10.1021/np0680230. [PMID: 17253841]
  • Mhairi L Stewart, Sanjeev Krishna, Richard J S Burchmore, Reto Brun, Harry P de Koning, David W Boykin, Richard R Tidwell, J Ed Hall, Michael P Barrett. Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (London, England). 2005 Aug; 366(9484):486-7. doi: 10.1016/s0140-6736(05)66793-1. [PMID: 16084257]
  • Sabine Van Miert, Steven Hostyn, Bert U W Maes, Kanyanga Cimanga, Reto Brun, Marcel Kaiser, Péter Mátyus, Roger Dommisse, Guy Lemière, Arnold Vlietinck, Luc Pieters. Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound. Journal of natural products. 2005 May; 68(5):674-7. doi: 10.1021/np0496284. [PMID: 15921407]
  • Gerhard Bringmann, Michael Dreyer, Hélène Kopff, Heiko Rischer, Michael Wohlfarth, Hamid A Hadi, Reto Brun, Harald Meimberg, Günther Heubl. ent-Dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the 'new'plant species Ancistrocladus benomensis. Journal of natural products. 2005 May; 68(5):686-90. doi: 10.1021/np049626j. [PMID: 15921410]
  • Gerhard Bringmann, Michael Dreyer, Heiko Rischer, Kristina Wolf, Hamid A Hadi, Reto Brun, Harald Meimberg, Günther Heubl. Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the 'new' plant species ancistrocladusbenomensis. Journal of natural products. 2004 Dec; 67(12):2058-62. doi: 10.1021/np0497651. [PMID: 15620251]
  • Gerhard Bringmann, Michael Dreyer, Johan H Faber, Petur Weihe Dalsgaard, Dan Staerk, Jerzy W Jaroszewski, Henry Ndangalasi, Frank Mbago, Reto Brun, Søren Brøgger Christensen. Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis. Journal of natural products. 2004 May; 67(5):743-8. doi: 10.1021/np0340549. [PMID: 15165131]
  • Philippe Rousselot, Jérôme Larghero, Sylvaine Labaume, Joël Poupon, Martine Chopin, Christine Dosquet, Jean-Pierre Marolleau, Anne Janin, Jean-Claude Brouet, Jean-Paul Fermand. Arsenic trioxide is effective in the treatment of multiple myeloma in SCID mice. European journal of haematology. 2004 Mar; 72(3):166-71. doi: 10.1046/j.0902-4441.2003.00194.x. [PMID: 14962234]
  • Pierre Kamnaing, Apollinaire Tsopmo, Eric A Tanifum, Marguerite H K Tchuendem, Pierre Tane, Johnson F Ayafor, Olov Sterner, Donna Rattendi, Maurice M Iwu, Brian Schuster, Cyrus Bacchi. Trypanocidal diarylheptanoids from Aframomum letestuianum. Journal of natural products. 2003 Mar; 66(3):364-7. doi: 10.1021/np020362f. [PMID: 12662093]
  • Gerhard Bringmann, Kim Messer, Reto Brun, Virima Mudogo. Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis. Journal of natural products. 2002 Aug; 65(8):1096-101. doi: 10.1021/np010622d. [PMID: 12193010]
  • V Lejon, J Lardon, G Kenis, L Pinoges, D Legros, S Bisser, X N'Siesi, E Bosmans, P Büscher. Interleukin (IL)-6, IL-8 and IL-10 in serum and CSF of Trypanosoma brucei gambiense sleeping sickness patients before and after treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2002 May; 96(3):329-33. doi: 10.1016/s0035-9203(02)90115-x. [PMID: 12174791]
  • José Antonio Ruiz, Pere P Simarro, Teofilo Josenando. Control of human African trypanosomiasis in the Quiçama focus, Angola. Bulletin of the World Health Organization. 2002; 80(9):738-45. doi: NULL. [PMID: 12378293]
  • R Brun, R Schumacher, C Schmid, C Kunz, C Burri. The phenomenon of treatment failures in Human African Trypanosomiasis. Tropical medicine & international health : TM & IH. 2001 Nov; 6(11):906-14. doi: 10.1046/j.1365-3156.2001.00775.x. [PMID: 11703845]
  • C Burri, J Keiser. Pharmacokinetic investigations in patients from northern Angola refractory to melarsoprol treatment. Tropical medicine & international health : TM & IH. 2001 May; 6(5):412-20. doi: 10.1046/j.1365-3156.2001.00725.x. [PMID: 11348536]
  • E Matovu, J C Enyaru, D Legros, C Schmid, T Seebeck, R Kaminsky. Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda. Tropical medicine & international health : TM & IH. 2001 May; 6(5):407-11. doi: 10.1046/j.1365-3156.2001.00712.x. [PMID: 11348535]
  • J Keiser, O Ericsson, C Burri. Investigations of the metabolites of the trypanocidal drug melarsoprol. Clinical pharmacology and therapeutics. 2000 May; 67(5):478-88. doi: 10.1067/mcp.2000.105990. [PMID: 10824626]
  • J D Onyango, C Burri, R Brun. An automated biological assay to determine levels of the trypanocidal drug melarsoprol in biological fluids. Acta tropica. 2000 Jan; 74(1):95-100. doi: 10.1016/s0001-706x(99)00080-7. [PMID: 10643913]
  • A Buguet. Is sleeping sickness a circadian disorder? The serotonergic hypothesis. Chronobiology international. 1999 Jul; 16(4):477-89. doi: 10.3109/07420529908998722. [PMID: 10442241]
  • P Rousselot, S Labaume, J P Marolleau, J Larghero, M H Noguera, J C Brouet, J P Fermand. Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. Cancer research. 1999 Mar; 59(5):1041-8. doi: . [PMID: 10070961]
  • S L Soignet, W P Tong, S Hirschfeld, R P Warrell. Clinical study of an organic arsenical, melarsoprol, in patients with advanced leukemia. Cancer chemotherapy and pharmacology. 1999; 44(5):417-21. doi: 10.1007/s002800050998. [PMID: 10501916]
  • U Bronner, R Brun, F Doua, O Ericsson, C Burri, J Keiser, T W Miézan, Y F Boa, L Rombo, L L Gustafsson. Discrepancy in plasma melarsoprol concentrations between HPLC and bioassay methods in patients with T. gambiense sleeping sickness indicates that melarsoprol is metabolized. Tropical medicine & international health : TM & IH. 1998 Nov; 3(11):913-7. doi: 10.1046/j.1365-3156.1998.00327.x. [PMID: 9855405]
  • A G Scott, A Tait, C M Turner. Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites. Experimental parasitology. 1997 Jul; 86(3):181-90. doi: 10.1006/expr.1997.4167. [PMID: 9225768]
  • S M Harrison, R W Harris, J D Bales. Attempt to correlate urine arsenic excretion with clinical course during melarsoprol therapy of patients with Rhodesian trypanosomiasis. The American journal of tropical medicine and hygiene. 1997 Jun; 56(6):632-6. doi: 10.4269/ajtmh.1997.56.632. [PMID: 9230794]
  • S G Rhind, B H Sabiston, P N Shek, A Buguet, G Muanga, A Stanghellini, M Dumas, M W Radomski. Effect of melarsoprol treatment on circulating IL-10 and TNF-alpha levels in human African trypanosomiasis. Clinical immunology and immunopathology. 1997 May; 83(2):185-9. doi: 10.1006/clin.1997.4350. [PMID: 9143380]
  • O Ericsson, E K Schweda, U Bronner, L Rombo, M Fridén, L L Gustafsson. Determination of melarsoprol in biological fluids by high-performance liquid chromatography and characterisation of two stereoisomers by nuclear magnetic resonance spectroscopy. Journal of chromatography. B, Biomedical sciences and applications. 1997 Mar; 690(1-2):243-51. doi: 10.1016/s0378-4347(96)00418-5. [PMID: 9106049]
  • B B Youan, S Coulibaly, T B Miezan, F Doua, M Bamba. In vivo evaluation of sixteen plant extracts on mice inoculated with Trypanosoma brucei gambiense. Bulletin of the World Health Organization. 1997; 75(4):343-8. doi: . [PMID: 9342893]
  • U Bronner, L L Gustafsson, F Doua, O Ericsson, T Miézan, M Rais, L Rombo. Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness. British journal of clinical pharmacology. 1995 Mar; 39(3):289-95. doi: 10.1111/j.1365-2125.1995.tb04451.x. [PMID: 7619671]
  • C Burri, J D Onyango, J E Auma, E M Burudi, R Brun. Pharmacokinetics of melarsoprol in uninfected vervet monkeys. Acta tropica. 1994 Oct; 58(1):35-49. doi: 10.1016/0001-706x(94)90120-1. [PMID: 7863853]
  • C W Gichuki, V M Nantulya, P D Sayer. Trypanosoma brucei rhodesiense: use of an antigen detection enzyme immunoassay for evaluation of response to chemotherapy in infected vervet monkeys (Cercopithecus aethiops). Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1994 Sep; 45(3):237-42. doi: NULL. [PMID: 7899795]
  • D M Kimata, D W Makawiti, K M Tengekyon, S Dadzie, E N Waindi. Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis. Acta tropica. 1994 Jun; 57(1):69-74. doi: 10.1016/0001-706x(94)90094-9. [PMID: 7942356]
  • C Burri, T Baltz, C Giroud, F Doua, H A Welker, R Brun. Pharmacokinetic properties of the trypanocidal drug melarsoprol. Chemotherapy. 1993 Jul; 39(4):225-34. doi: 10.1159/000239130. [PMID: 8391966]
  • C Burri, R Brun. An in vitro bioassay for quantification of melarsoprol in serum and cerebrospinal fluid. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 1992 Dec; 43(4):223-5. doi: NULL. [PMID: 1293724]
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