Mechlorethamine (BioDeep_00000006426)
Secondary id: BioDeep_00001867865
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
Merck frosst brand OF mechlorethamine hydrochloride
化学式: C5H11Cl2N (155.0269)
中文名称: 氮芥
谱图信息:
最多检出来源 Danio rerio(blood) 27.9%
分子结构信息
SMILES: CN(CCCl)CCCl
InChI: InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3
描述信息
Mechlorethamine is only found in individuals that have used or taken this drug. It is a vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkins disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. [PubChem]Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Mechlorethamine is cell cycle phase-nonspecific.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AA - Nitrogen mustard analogues
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D011042 - Poisons > D002619 - Chemical Warfare Agents
D009676 - Noxae > D000477 - Alkylating Agents
D009676 - Noxae > D007509 - Irritants
同义名列表
52 个代谢物同义名
Merck frosst brand OF mechlorethamine hydrochloride; Merck brand OF mechlorethamine hydrochloride; beta,Beta-dichlorodiethyl-N-methylamine; Hydrochloride N-oxide, mechlorethamine; N-Oxide, mechlorethamine hydrochloride; Mechlorethamine hydrochloride N oxide; Mechlorethamine hydrochloride N-oxide; b,Beta-dichlorodiethyl-N-methylamine; Β,beta-dichlorodiethyl-N-methylamine; N-Methyl-bis(beta-chloroethyl)amine; 2,2-Dichloro-N-methyldiethylamine; N-Methyl-bis(b-chloroethyl)amine; Methylbis(beta-chloroethyl)amine; N-Methyl-bis(2-chloroethyl)amine; Bis(beta-chloroethyl)methylamine; N-Methyl-bis(β-chloroethyl)amine; bis(2-chloroethyl)(methyl)amine; Hydrochloride, mechlorethamine; Methylbis(b-chloroethyl)amine; Bis(2-chloroethyl)methylamine; Methylbis(β-chloroethyl)amine; Mechlorethamine hydrochloride; Bis(β-chloroethyl)methylamine; Bis(b-chloroethyl)methylamine; Methylbis(2-chloroethyl)amine; N-Oxide, nitrogen mustard; Nitrogen mustard N-oxide; Nitrogen mustard N oxide; Mechlorethamine N-oxide; Mechlorethamine N oxide; Mechlorethamine oxide; Methylchlorethamine; Mechloroethamine; Nitrogen mustard; Nitrogranulogen; mechlorethamine; Chlorethazine; Mecloretamina; Chlormethine; Caryolysine; Mustargen; Nitromin; Cloramin; Embichin; NSC-762; Mustine; Mitomen; NSC 762; HN2; MBA; Nitrogen mustard; Mechlorethamine
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:28925
- KEGG: C07115
- KEGGdrug: D07671
- PubChem: 4033
- HMDB: HMDB0015025
- Metlin: METLIN43236
- DrugBank: DB00888
- ChEMBL: CHEMBL427
- Wikipedia: Mechlorethamine
- MeSH: Mechlorethamine
- chemspider: 3893
- CAS: 51-75-2
- PMhub: MS000019463
- PubChem: 9326
- NIKKAJI: J2.305A
- RefMet: Mechlorethamine
- KNApSAcK: 28925
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haichang Li, Zhongguang Li, Xiuchun Li, Chuanxi Cai, Serena Li Zhao, Robert E Merritt, Xinyu Zhou, Tao Tan, Valerie Bergdall, Jianjie Ma. MG53 Mitigates Nitrogen Mustard-Induced Skin Injury.
Cells.
2023 07; 12(14):. doi:
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The Journal of pharmacology and experimental therapeutics.
2023 May; ?(?):. doi:
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Toxicology and applied pharmacology.
2022 11; 454(?):116208. doi:
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Analytical chemistry.
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Toxicological sciences : an official journal of the Society of Toxicology.
2021 10; 184(1):127-141. doi:
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