benzoate (BioDeep_00000614848)

Main id: BioDeep_00000001650

Secondary id: BioDeep_00000416056, BioDeep_00000866237

PANOMIX_OTCML-2023


代谢物信息卡片


3,5-Dihydroxybenzoic acid (acd/name 4.0)

化学式: C7H6O4 (154.0266)
中文名称: 3,5-二羟基苯甲酸, 2,6-二羟基苯甲酸
谱图信息: 最多检出来源 Homo sapiens(plant) 17.63%

分子结构信息

SMILES: C1=C(C=C(C=C1O)O)C(=O)O
InChI: InChI=1S/C7H6O4/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,8-9H,(H,10,11)

描述信息

2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism.
2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism.
3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses.
3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses.

同义名列表

18 个代谢物同义名

3,5-Dihydroxybenzoic acid (acd/name 4.0); 3,5-Dihydroxy-benzoic acid; 3,5-DIHYDROXYBENZOIC ACID; 3,5-Dihydroxybenzoate; alpha-Resorcylic acid; 5-Carboxyresorcinol; a-Resorcylic acid; Benzoic Acid; benzoate; 2,6-Dihydroxybenzoic acid (acd/name 4.0); 2,6-Dihydroxy-benzoic acid; 2,6-DIHYDROXYBENZOIC ACID; 6-Hydroxysalicylic acid; gamma-Resorcylic acid; 2,6-Dihydroxybenzoate; 2,6-Resorcylic acid; 2-Carboxyresorcinol; 2,6-Dihydroxybenzoic acid



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 CDK1, CDK2, CDK4, CDK6, EP300, HDAC9, HELB, MTOR, PRKAA2, PTGS2, SYK, TYR
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 3 CDK1, MTOR, PTGS2
Nucleus 11 CDK1, CDK2, CDK4, CDK6, EP300, HDAC9, HELB, MTOR, NSL1, PRKAA2, SYK
cytosol 10 CDK1, CDK2, CDK4, CDK6, EP300, HELB, MTOR, NSL1, PRKAA2, SYK
dendrite 2 MTOR, PRKAA2
nuclear body 1 HELB
phagocytic vesicle 1 MTOR
centrosome 3 CDK1, CDK2, CDK6
nucleoplasm 10 CDK1, CDK2, CDK4, CDK6, EP300, HDAC9, HELB, MTOR, NSL1, PRKAA2
Cell membrane 3 ITGAM, PTPRC, SYK
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 1 UCP1
Golgi apparatus membrane 1 MTOR
Synapse 1 PTPRC
cell surface 3 ITGAM, ITGAX, PTPRC
Golgi apparatus 1 PRKAA2
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 2 ATP5ME, UCP1
neuronal cell body 1 PRKAA2
Cytoplasm, cytosol 1 SYK
Lysosome 2 MTOR, TYR
endosome 1 CDK2
plasma membrane 4 ITGAM, ITGAX, PTPRC, SYK
Membrane 6 CDK1, ITGAM, ITGAX, MTOR, PRKAA2, PTPRC
axon 1 PRKAA2
caveola 1 PTGS2
extracellular exosome 3 CDK1, ITGAM, PTPRC
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 PTGS2
extracellular space 3 CRP, IL17A, ITGAM
perinuclear region of cytoplasm 1 TYR
bicellular tight junction 1 CDK4
mitochondrion 5 ATP5ME, CDK1, HELB, NSL1, UCP1
protein-containing complex 2 PTGS2, SYK
intracellular membrane-bounded organelle 1 TYR
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 4 ITGAM, ITGAX, PTPRC, TYR
Secreted 2 CRP, IL17A
extracellular region 2 CRP, IL17A
cytoplasmic side of plasma membrane 1 PTPRC
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 CDK1
transcription regulator complex 4 CDK2, CDK4, EP300, HDAC9
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 CDK1, CDK2, CDK6
Nucleus membrane 1 CDK4
nuclear membrane 1 CDK4
external side of plasma membrane 4 IL17A, ITGAM, ITGAX, PTPRC
nucleolus 1 CDK4
Melanosome membrane 1 TYR
midbody 1 CDK1
Golgi-associated vesicle 1 TYR
Mitochondrion inner membrane 1 UCP1
Membrane raft 2 ITGAM, PTPRC
focal adhesion 1 PTPRC
Nucleus, PML body 1 MTOR
PML body 1 MTOR
nuclear speck 2 NSL1, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
ruffle 1 CDK6
neuron projection 1 PTGS2
chromatin 2 CDK4, EP300
mitotic spindle 1 CDK1
Chromosome 2 EP300, HELB
spindle pole 1 NSL1
chromosome, telomeric region 2 CDK1, CDK2
site of double-strand break 1 HELB
nuclear envelope 2 CDK2, MTOR
Endomembrane system 1 MTOR
Chromosome, centromere, kinetochore 1 NSL1
NSL complex 1 NSL1
specific granule membrane 1 ITGAM
tertiary granule membrane 2 ITGAM, ITGAX
Melanosome 1 TYR
cytoplasmic stress granule 1 PRKAA2
plasma membrane raft 1 ITGAM
secretory granule membrane 2 ITGAX, PTPRC
endoplasmic reticulum lumen 1 PTGS2
histone methyltransferase complex 1 HDAC9
MLL1 complex 1 NSL1
male germ cell nucleus 1 CDK2
kinetochore 1 NSL1
histone deacetylase complex 1 HDAC9
outer kinetochore 1 NSL1
Cajal body 1 CDK2
histone acetyltransferase complex 2 EP300, NSL1
protein-DNA complex 1 EP300
ficolin-1-rich granule membrane 1 ITGAX
spindle microtubule 1 CDK1
early phagosome 1 SYK
nucleotide-activated protein kinase complex 1 PRKAA2
condensed chromosome 1 CDK2
Cytoplasmic vesicle, phagosome 1 MTOR
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
integrin complex 2 ITGAM, ITGAX
proton-transporting ATP synthase complex 1 ATP5ME
membrane microdomain 1 PTPRC
cyclin-dependent protein kinase holoenzyme complex 4 CDK1, CDK2, CDK4, CDK6
bleb 1 PTPRC
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
T cell receptor complex 1 SYK
integrin alphaM-beta2 complex 1 ITGAM
integrin alphaX-beta2 complex 1 ITGAX
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
cyclin D1-CDK4 complex 1 CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
B cell receptor complex 1 SYK
cyclin A2-CDK2 complex 1 CDK2
cyclin D1-CDK6 complex 1 CDK6
cyclin A1-CDK2 complex 1 CDK2
cyclin D3-CDK6 complex 1 CDK6
cyclin D2-CDK6 complex 1 CDK6
MIS12/MIND type complex 1 NSL1


文献列表

  • Zhiqiang Li, Ludan Zhao, Qiaomei Sun, Na Gan, Qiyi Zhang, Ji Yang, Bin Yi, Xiaoxiang Liao, Donglai Zhu, Hui Li. Study on the interaction between 2,6-dihydroxybenzoic acid nicotine salt and human serum albumin by multi-spectroscopy and molecular dynamics simulation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Apr; 270(?):120868. doi: 10.1016/j.saa.2022.120868. [PMID: 35032760]
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  • Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Janusz Szemraj, Tomasz Skorski, Adam J Białas, Tomasz Sakowicz, Tomasz Kowalczyk, Maciej Radek, Halina Wysokińska, Tomasz Śliwiński. Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells. Pathology oncology research : POR. 2017 Jul; 23(3):679-687. doi: 10.1007/s12253-016-0170-6. [PMID: 28032310]
  • Roksana Wierzbicka, Galia Zamaratskaia, Afaf Kamal-Eldin, Rikard Landberg. Novel urinary alkylresorcinol metabolites as biomarkers of whole grain intake in free-living Swedish adults. Molecular nutrition & food research. 2017 07; 61(7):. doi: 10.1002/mnfr.201700015. [PMID: 28444884]
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  • Nicola M McKeown, Matti Marklund, Jiantao Ma, Alastair B Ross, Alice H Lichtenstein, Kara A Livingston, Paul F Jacques, Helen M Rasmussen, Jeffrey B Blumberg, C-Y Oliver Chen. Comparison of plasma alkylresorcinols (AR) and urinary AR metabolites as biomarkers of compliance in a short-term, whole-grain intervention study. European journal of nutrition. 2016 Apr; 55(3):1235-44. doi: 10.1007/s00394-015-0936-8. [PMID: 26043861]
  • Laila Meija, Indriķis Krams, Vinita Cauce, Adile Samaletdin, Paivi Söderholm, Raimonds Meija, Līga Lārmane, Aivars Lejnieks, Vilnis Lietuvietis, Herman Adlercreutz. Alkylresorcinol metabolites in urine and plasma as potential biomarkers of rye and wheat fiber consumption in prostate cancer patients and controls. Nutrition and cancer. 2015; 67(2):258-65. doi: 10.1080/01635581.2015.989371. [PMID: 25608053]
  • Matti Marklund, Eric A Strömberg, Helle N Lærke, Knud E Bach Knudsen, Afaf Kamal-Eldin, Andrew C Hooker, Rikard Landberg. Simultaneous pharmacokinetic modeling of alkylresorcinols and their main metabolites indicates dual absorption mechanisms and enterohepatic elimination in humans. The Journal of nutrition. 2014 Nov; 144(11):1674-80. doi: 10.3945/jn.114.196220. [PMID: 25332465]
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