N-Methylserotonin (BioDeep_00000006093)

 

Secondary id: BioDeep_00000268166

human metabolite Endogenous natural product


代谢物信息卡片


3-[2-(Methylamino)ethyl]-1H-indol-5-ol

化学式: C11H14N2O (190.1106074)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 14.7%

分子结构信息

SMILES: CNCCC1=CNC2=C1C=C(C=C2)O
InChI: InChI=1S/C11H14N2O/c1-12-5-4-8-7-13-11-3-2-9(14)6-10(8)11/h2-3,6-7,12-14H,4-5H2,1H3

描述信息

N-methylserotonin is a product of the serotonin-degradative pathway, found in urine specimens of patients with psychiatric disorders (PubMed ID 8747157 ).

同义名列表

6 个代谢物同义名

3-[2-(Methylamino)ethyl]-1H-indol-5-ol; 3-(2-(Methylamino)ethyl)-1H-indol-5-ol; N-Methylserotonin oxalate salt; N-Methylserotonin; Lopac-m-1514; N-Methylserotonin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

8 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenhui Duan, Lingxi Zhou, Yilin Ren, Fei Liu, Yuzheng Xue, Fang-Zhou Wang, Ran Lu, Xiao-Juan Zhang, Jin-Song Shi, Zheng-Hong Xu, Yan Geng. Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice. Food & function. 2024 Feb; 15(3):1612-1626. doi: 10.1039/d3fo03324d. [PMID: 38240339]
  • Nathan D Han, Jiye Cheng, Omar Delannoy-Bruno, Daniel Webber, Nicolas Terrapon, Bernard Henrissat, Dmitry A Rodionov, Aleksandr A Arzamasov, Andrei L Osterman, David K Hayashi, Alexandra Meynier, Sophie Vinoy, Chandani Desai, Stacey Marion, Michael J Barratt, Andrew C Heath, Jeffrey I Gordon. Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans. Cell. 2022 07; 185(14):2495-2509.e11. doi: 10.1016/j.cell.2022.06.004. [PMID: 35764090]
  • Yu Zhang, Bo Yuan, Norio Takagi, Hongjie Wang, Yanyan Zhou, Nan Si, Jian Yang, Xiaolu Wei, Haiyu Zhao, Baolin Bian. Comparative Analysis of Hydrophilic Ingredients in Toad Skin and Toad Venom Using the UHPLC-HR-MS/MS and UPLC-QqQ-MS/MS Methods Together with the Anti-Inflammatory Evaluation of Indolealkylamines. Molecules (Basel, Switzerland). 2018 Dec; 24(1):. doi: 10.3390/molecules24010086. [PMID: 30591646]
  • Ayano Imai, David C Lankin, Dejan Nikolić, Soyoun Ahn, Richard B van Breemen, Norman R Farnsworth, James B McAlpine, Shao-Nong Chen, Guido F Pauli. Cycloartane Triterpenes from the Aerial Parts of Actaea racemosa. Journal of natural products. 2016 Mar; 79(3):541-54. doi: 10.1021/acs.jnatprod.5b00927. [PMID: 26760374]
  • Dejan Nikolić, Jinghu Li, Richard B van Breemen. Metabolism of Nω -methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes. Biomedical chromatography : BMC. 2014 Dec; 28(12):1647-51. doi: 10.1002/bmc.3197. [PMID: 24817649]
  • D Alberghina, A M Amorini, G Lazzarino. Modulation of peripheral markers of the serotoninergic system in healthy horses. Research in veterinary science. 2011 Jun; 90(3):392-5. doi: 10.1016/j.rvsc.2010.06.023. [PMID: 20633913]
  • Daniela Alberghina, Claudia Giannetto, Giuseppe Piccione. Peripheral serotoninergic response to physical exercise in athletic horses. Journal of veterinary science. 2010 Dec; 11(4):285-9. doi: 10.4142/jvs.2010.11.4.285. [PMID: 21113096]
  • Ashwin A Patkar, Steve Rozen, Paolo Mannelli, Wayne Matson, Chi-Un Pae, K Ranga Krishnan, Rima Kaddurah-Daouk. Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study. Psychopharmacology. 2009 Oct; 206(3):479-89. doi: 10.1007/s00213-009-1625-1. [PMID: 19649617]
  • Tanja Gödecke, Dejan Nikolic, David C Lankin, Shao-Nong Chen, Sharla L Powell, Birgit Dietz, Judy L Bolton, Richard B van Breemen, Norman R Farnsworth, Guido F Pauli. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts. Phytochemical analysis : PCA. 2009 Mar; 20(2):120-33. doi: 10.1002/pca.1106. [PMID: 19140115]
  • Sharla L Powell, Tanja Gödecke, Dejan Nikolic, Shao-Nong Chen, Soyoun Ahn, Birgit Dietz, Norman R Farnsworth, Richard B van Breemen, David C Lankin, Guido F Pauli, Judy L Bolton. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. Journal of agricultural and food chemistry. 2008 Dec; 56(24):11718-26. doi: 10.1021/jf803298z. [PMID: 19049296]
  • Kornélia Tekes. HPLC determination of serotonin and its metabolites from human platelet-rich plasma; shift to 5-hydroxytryptophol formation following alcohol consumption. Journal of chromatographic science. 2008 Feb; 46(2):169-73. doi: 10.1093/chromsci/46.2.169. [PMID: 18366879]
  • N Takeda, R Ikeda, K Ohba, M Kondo. Bufotenine reconsidered as a diagnostic indicator of psychiatric disorders. Neuroreport. 1995 Nov; 6(17):2378-80. doi: 10.1097/00001756-199511270-00024. [PMID: 8747157]
  • K Shibata, M Onodera, T Kawada, K Iwai. Simultaneous micro-determination of serotonin and 5-hydroxyindole-3-acetic acid with 5-hydroxy-N omega-methyltryptamine, as an internal standard, in biological materials by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1988 Sep; 430(2):381-7. doi: 10.1016/s0378-4347(00)83174-6. [PMID: 2466858]