Acadesine (BioDeep_00000598494)
Main id: BioDeep_00000001288
代谢物信息卡片
5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
化学式: C9H14N4O5 (258.0964154)
中文名称: 阿卡地辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N
InChI: InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C - Cardiovascular system > C01 - Cardiac therapy
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:28498
- KEGG: C04663
- KEGGdrug: D02742
- PubChem: 17513
- Metlin: METLIN4162
- DrugBank: DB04944
- ChEMBL: CHEMBL1551724
- CAS: 2627-69-2
- ChEBI: CHEBI:177803
- PubChem: 7247
- NIKKAJI: J2.752.825B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kexin Su, Xuan Yao, Chenxu Guo, Chunmei Qian, Yiying Wang, Xiaoqi Ma, Xiaoyu Wang, Yifu Yang. Solasodine suppresses the metastasis of gastric cancer through claudin-2 via the AMPK/STAT3/NF-κB pathway.
Chemico-biological interactions.
2023 Apr; ?(?):110520. doi:
10.1016/j.cbi.2023.110520. [PMID: 37121296] - Xiandong Zhu, Feixiang Duan, Yan Zhang, Xiaowu Wang, Yongqiang Wang, Jiawei Chen, Lanyu Zhang, Minmin Wu, Zhuo Pan, Bicheng Chen. Acadesine alleviates acute pancreatitis-related lung injury by mediating the barrier protective function of pulmonary microvascular endothelial cells.
International immunopharmacology.
2022 Oct; 111(?):109165. doi:
10.1016/j.intimp.2022.109165. [PMID: 35987144] - Hyo-Moon Cho, Mi Zhang, Eun-Jin Park, Ba-Wool Lee, Yeon-Joo Park, Hyun-Woo Kim, Ha-Thanh-Tung Pham, Young-Won Chin, Won-Keun Oh. Flavonostilbenes Isolated from the Stems of Rhamnoneuron balansae as Potential SIRT1 Activators.
Journal of natural products.
2022 01; 85(1):70-82. doi:
10.1021/acs.jnatprod.1c00689. [PMID: 35040315] - Dan-Meng Zheng, Zhen-Ni An, Ming-Hao Ge, Dong-Zhuo Wei, Ding-Wen Jiang, Xue-Jiao Xing, Xiao-Lei Shen, Chang Liu. Medium & long-chain acylcarnitine's relation to lipid metabolism as potential predictors for diabetic cardiomyopathy: a metabolomic study.
Lipids in health and disease.
2021 Nov; 20(1):151. doi:
10.1186/s12944-021-01576-9. [PMID: 34727932] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Xiang Li, Xun Cui, Shuai Zhou, Da-Lin Xing, Hu-Ri Piao, Qing-Gao Zhang, Yu-Qing Zhao, Li-Ping Liu. The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria.
Chemico-biological interactions.
2021 Apr; 339(?):109430. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Mar; 149(?):112029. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Bioorganic & medicinal chemistry letters.
2018 06; 28(10):1931-1936. doi:
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European journal of medicinal chemistry.
2018 Mar; 147(?):90-101. doi:
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2017 11; 27(22):5076-5081. doi:
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Bioorganic & medicinal chemistry letters.
2017 01; 27(1):40-44. doi:
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Investigational new drugs.
2016 08; 34(4):522-9. doi:
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The American journal of pathology.
2015 Aug; 185(8):2168-80. doi:
10.1016/j.ajpath.2015.04.014. [PMID: 26071397] - Yong Rao, Hong Liu, Lin Gao, Hong Yu, Jia-Heng Tan, Tian-Miao Ou, Shi-Liang Huang, Lian-Quan Gu, Ji-Ming Ye, Zhi-Shu Huang. Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.
Bioorganic & medicinal chemistry.
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International immunopharmacology.
2015 Apr; 25(2):393-9. doi:
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European journal of medicinal chemistry.
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10.1016/j.ejmech.2014.09.094. [PMID: 25299682] - Charlotte Andersen, Dorota Kotowska, Christian G Tortzen, Karsten Kristiansen, John Nielsen, Rasmus Koefoed Petersen. 2-(2-Bromophenyl)-formononetin and 2-heptyl-formononetin are PPARγ partial agonists and reduce lipid accumulation in 3T3-L1 adipocytes.
Bioorganic & medicinal chemistry.
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The Journal of allergy and clinical immunology.
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Diabetes.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Feb; 915-916(?):64-70. doi:
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Journal of lipid research.
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Shock (Augusta, Ga.).
2012 Jan; 37(1):39-46. doi:
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Journal of lipid research.
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2011 Apr; 7(4):206-13. doi:
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Journal of dairy science.
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PloS one.
2010 Oct; 5(10):e13658. doi:
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American journal of physiology. Endocrinology and metabolism.
2009 Sep; 297(3):E759-66. doi:
10.1152/ajpendo.00141.2009. [PMID: 19602584] - Joseph E Baggott, Sarah L Morgan. Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2007 Jun; 31(2):95-101. doi:
10.1016/j.ejps.2007.02.006. [PMID: 17408934] - Myung-Ja Lee, Denis Feliers, Meenalakshmi M Mariappan, Kavithalakshmi Sataranatarajan, Lenin Mahimainathan, Nicolas Musi, Marc Foretz, Benoit Viollet, Joel M Weinberg, Goutam Ghosh Choudhury, Balakuntalam S Kasinath. A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
American journal of physiology. Renal physiology.
2007 Feb; 292(2):F617-27. doi:
10.1152/ajprenal.00278.2006. [PMID: 17018841] - Petr Hornik, Petra Vyskocilová, David Friedecký, Tomás Adam. Diagnosing AICA-ribosiduria by capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Oct; 843(1):15-9. doi:
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Molecular cancer therapeutics.
2006 Sep; 5(9):2211-7. doi:
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Diabetes.
2006 Jun; 55(6):1840-6. doi:
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Nucleosides, nucleotides & nucleic acids.
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The Journal of biological chemistry.
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Endocrinology.
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Diabetes.
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Diabetes.
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Critical care medicine.
1999 Mar; 27(3):565-75. doi:
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The Journal of biological chemistry.
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The American journal of physiology.
1997 12; 273(6):E1107-12. doi:
10.1152/ajpendo.1997.273.6.e1107. [PMID: 9435525] - D T Mangano. Effects of acadesine on myocardial infarction, stroke, and death following surgery. A meta-analysis of the 5 international randomized trials. The Multicenter Study of Perioperative Ischemia (McSPI) Research Group.
JAMA.
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Proteins.
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Surgery.
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The American journal of physiology.
1995 Nov; 269(5 Pt 2):H1752-9. doi:
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Anesthesiology.
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The Journal of clinical investigation.
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Journal of biochemical and biophysical methods.
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Anesthesia and analgesia.
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Journal of clinical pharmacology.
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Circulatory shock.
1993 May; 40(1):29-36. doi:
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Journal of clinical pharmacology.
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Journal of cellular physiology.
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