Nudifloramide (BioDeep_00000005979)

 

Secondary id: BioDeep_00001868157

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin


代谢物信息卡片


1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

化学式: C7H8N2O2 (152.0586)
中文名称: 1-甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺, 1-甲基-6-氧代吡啶-3-甲酰胺
谱图信息: 最多检出来源 Homo sapiens(feces) 25.82%

Reviewed

Last reviewed on 2024-09-26.

Cite this Page

Nudifloramide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/nudifloramide (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000005979). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1C=C(C=CC1=O)C(=O)N
InChI: InChI=1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)

描述信息

N-methyl-2-pyridone-5-carboxamide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Increased serum 2PY concentrations are observed in chronic renal failure (CRF) patients, which along with the deterioration of kidney function and its toxic properties (significant inhibition of PARP-1), suggests that 2PY is an uremic toxin. (PMID 12694300). 2PY has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
N-methyl-2-pyridone-5-carboxamide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Increased serum 2PY concentrations are observed in chronic renal failure (CRF) patients, which along with the deterioration of kidney function and its toxic properties (significant inhibition of PARP-1), suggests that 2PY is an uremic toxin. (PMID 12694300) [HMDB]
Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].

同义名列表

13 个代谢物同义名

N-Methyl-2-pyridone-5-carboxamide (Nudifloramide); 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide; N(1)-Methyl-2-pyridone-5-carboxamide; 1-methyl-6-oxopyridine-3-carboxamide; 1-Methyl-5-carboxylamide-2-pyridone; N1-Methyl-2-pyridone-5-carboxamide; N-methyl-2-pyridone-5-carboxamide; N-Methyl-2-pyridone-5-carboxamide; NMethyl-2-pyridone-5-carboxamide; Nudifloramide; 2PY; N1-Methyl-2-pyridone-5-carboxamide; 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ACMSD, AOX1, CASP3, ELAVL1, FGF23, HAAO, MARVELD1, PTGS2, SIRT1, SMAD3
Peripheral membrane protein 2 CYP1B1, PTGS2
Endoplasmic reticulum membrane 2 CYP1B1, PTGS2
Nucleus 7 CASP3, ELAVL1, LIG4, MARVELD1, PARP1, SIRT1, SMAD3
cytosol 9 ACMSD, AOX1, CASP3, ELAVL1, HAAO, LEP, PARP1, SIRT1, SMAD3
nuclear body 1 PARP1
nucleoplasm 6 CASP3, ELAVL1, LIG4, PARP1, SIRT1, SMAD3
Cell membrane 2 CLDN1, MARVELD1
Multi-pass membrane protein 2 CLDN1, MARVELD1
glutamatergic synapse 2 CASP3, ELAVL1
Golgi membrane 1 INS
neuronal cell body 1 CASP3
postsynapse 1 ELAVL1
Cytoplasm, cytosol 2 HAAO, PARP1
plasma membrane 4 CLDN1, KNG1, MARVELD1, SMAD3
Membrane 6 ACMSD, CLDN1, CYP1B1, ELAVL1, MARVELD1, PARP1
apical plasma membrane 1 CLDN1
basolateral plasma membrane 1 CLDN1
caveola 1 PTGS2
extracellular exosome 2 AOX1, KNG1
endoplasmic reticulum 2 ELAVL1, PTGS2
extracellular space 7 CRP, FGF23, GH1, INS, KNG1, LEP, PTH
Cell junction, tight junction 1 CLDN1
bicellular tight junction 1 CLDN1
mitochondrion 3 CYP1B1, PARP1, SIRT1
protein-containing complex 3 CLDN1, PARP1, PTGS2
intracellular membrane-bounded organelle 2 CYP1B1, LIG4
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Secreted 5 CRP, FGF23, GH1, INS, LEP
extracellular region 7 CRP, FGF23, GH1, INS, KNG1, LEP, PTH
transcription regulator complex 2 PARP1, SMAD3
cytoplasmic vesicle 1 ELAVL1
nucleolus 2 PARP1, SIRT1
sarcoplasm 1 ELAVL1
Cytoplasm, P-body 1 ELAVL1
P-body 1 ELAVL1
heterochromatin 1 SIRT1
Cytoplasm, cytoskeleton 1 MARVELD1
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
collagen-containing extracellular matrix 1 KNG1
lateral plasma membrane 1 CLDN1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 3 PTGS2, SIRT1, SMAD3
nuclear outer membrane 1 PTGS2
receptor complex 1 SMAD3
neuron projection 1 PTGS2
chromatin 3 PARP1, SIRT1, SMAD3
Chromosome 1 PARP1
cytoskeleton 1 MARVELD1
Secreted, extracellular space 1 KNG1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 LIG4, PARP1
blood microparticle 1 KNG1
Basolateral cell membrane 1 CLDN1
site of double-strand break 1 PARP1
fibrillar center 1 SIRT1
nuclear envelope 2 PARP1, SIRT1
endosome lumen 2 GH1, INS
Cytoplasm, Stress granule 1 ELAVL1
cytoplasmic stress granule 1 ELAVL1
euchromatin 1 SIRT1
secretory granule lumen 1 INS
Golgi lumen 2 FGF23, INS
endoplasmic reticulum lumen 4 FGF23, INS, KNG1, PTGS2
platelet alpha granule lumen 1 KNG1
transport vesicle 1 INS
tight junction 1 CLDN1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ribonucleoprotein complex 1 ELAVL1
heteromeric SMAD protein complex 1 SMAD3
SMAD protein complex 1 SMAD3
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
condensed chromosome 1 LIG4
site of DNA damage 1 PARP1
growth hormone receptor complex 1 GH1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
DNA-dependent protein kinase-DNA ligase 4 complex 1 LIG4
nonhomologous end joining complex 1 LIG4
DNA ligase IV complex 1 LIG4
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

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  • Elena Synesiou, Lynnette D Fairbanks, H Anne Simmonds, Ewa M Slominska, Ryszard T Smolenski, Elizabeth A Carrey. 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside triphosphate (4PyTP), a novel NAD metabolite accumulating in erythrocytes of uremic children: a biomarker for a toxic NAD analogue in other tissues?. Toxins. 2011 06; 3(6):520-37. doi: 10.3390/toxins3060520. [PMID: 22069723]
  • Jaswanth Kumar Inamadugu, Rajasekhar Damaramadugu, Ramesh Mullangi, Venkateswarlu Ponneri. Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Biomedical chromatography : BMC. 2010 Oct; 24(10):1059-74. doi: 10.1002/bmc.1406. [PMID: 20853461]
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