Dihydropteridine (BioDeep_00000005899)

 

Secondary id: BioDeep_00001869604

human metabolite Endogenous


代谢物信息卡片


6,7-dihydropteridine

化学式: C6H6N4 (134.0592)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 37.18%

分子结构信息

SMILES: C1CN=C2C(=N1)C=NC=N2
InChI: InChI=1S/C6H6N4/c1-2-9-6-5(8-1)3-7-4-10-6/h3-4H,1-2H2

描述信息

Dihydropteridine is a generic compound; the product of the reduction of 5,6,7,8-Tetrahydropteridine, which is catalyzed by 6,7-dihydropteridine reductase (EC 1.5.1.34). (KEGG) This compound is recognised as a cause of tetrahydrobiopterin (BH(4)) deficiency, leading to hyperphenylalaninemia (HPA) and impaired biogenic amine deficiency. (PMID: 14705166).
A generic compound; the product of the reduction of 5,6,7,8-Tetrahydropteridine, which is catalyzed by 6,7-dihydropteridine reductase (EC 1.5.1.34). (KEGG) This compound is recognised as a cause of tetrahydrobiopterin (BH(4)) deficiency, leading to hyperphenylalaninemia (HPA) and impaired biogenic amine deficiency. (PMID: 14705166) [HMDB]

同义名列表

2 个代谢物同义名

6,7-dihydropteridine; Dihydropteridine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 CTNNB1, DHFR, LRRK2, MYC, MYLK, PLK1, PRKX, QDPR, SNCA, SPR, VRK1, VRK2, WDR1
Peripheral membrane protein 2 HSD17B6, LRRK2
Endoplasmic reticulum membrane 2 LRRK2, VRK2
Mitochondrion membrane 1 VRK2
Nucleus 8 BRD4, CTNNB1, MYC, PLK1, PRKX, SNCA, VRK1, VRK2
cytosol 12 ACOX3, CTNNB1, DHFR, LRRK2, MYLK, PAH, PLK1, QDPR, SNCA, SPR, VRK1, WDR1
dendrite 2 LRRK2, SLC8A1
mitochondrial membrane 2 LRRK2, VRK2
phagocytic vesicle 1 LRRK2
trans-Golgi network 1 LRRK2
centrosome 2 CTNNB1, PLK1
nucleoplasm 8 BRD4, CTNNB1, MYC, PLK1, PRKX, SLC8A1, SPR, VRK1
Cell membrane 2 CTNNB1, SLC8A1
Cleavage furrow 1 MYLK
lamellipodium 2 CTNNB1, MYLK
Cell projection, axon 2 LRRK2, SNCA
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 2 SLC2A9, SLC8A1
Golgi apparatus membrane 1 LRRK2
Synapse 4 CTNNB1, MYLK, SLC8A1, SNCA
cell cortex 2 CTNNB1, SNCA
cell junction 3 CTNNB1, SLC8A1, WDR1
glutamatergic synapse 3 CTNNB1, LRRK2, WDR1
Golgi apparatus 1 LRRK2
Golgi membrane 1 LRRK2
growth cone 2 LRRK2, SNCA
mitochondrial inner membrane 1 LRRK2
neuronal cell body 3 LRRK2, SLC8A1, SNCA
postsynapse 3 LRRK2, SLC8A1, SNCA
presynaptic membrane 1 CTNNB1
sarcolemma 1 SLC8A1
Lysosome 2 LRRK2, SNCA
endosome 1 LRRK2
plasma membrane 7 CTNNB1, LRRK2, MYLK, SLC2A9, SLC8A1, SNCA, WDR1
synaptic vesicle membrane 2 LRRK2, SNCA
terminal bouton 1 LRRK2
Membrane 7 ACOX3, CTNNB1, MYC, SLC2A9, SLC8A1, SNCA, VRK1
apical plasma membrane 1 SLC2A9
axon 3 LRRK2, SLC8A1, SNCA
basolateral plasma membrane 2 CTNNB1, SLC2A9
extracellular exosome 5 CTNNB1, LRRK2, QDPR, SPR, WDR1
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 HSD17B6, LRRK2, VRK2
extracellular space 2 LRRK2, SNCA
perinuclear region of cytoplasm 2 CTNNB1, SNCA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 SLC8A1
mitochondrion 5 DHFR, LRRK2, QDPR, SNCA, SPR
protein-containing complex 4 CTNNB1, MYC, SNCA, VRK2
intracellular membrane-bounded organelle 2 HSD17B6, LRRK2
Microsome membrane 1 HSD17B6
postsynaptic density 1 SLC8A1
Secreted 1 SNCA
extracellular region 2 SNCA, WDR1
Mitochondrion outer membrane 1 LRRK2
mitochondrial outer membrane 1 LRRK2
mitochondrial matrix 1 LRRK2
transcription regulator complex 1 CTNNB1
centriolar satellite 1 PLK1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PLK1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 LRRK2
actin cytoskeleton 2 MYLK, SNCA
T-tubule 1 SLC8A1
perikaryon 1 LRRK2
Z disc 2 CTNNB1, SLC8A1
beta-catenin destruction complex 1 CTNNB1
cytoplasmic vesicle 1 LRRK2
microtubule cytoskeleton 1 PLK1
nucleolus 2 MYC, VRK1
Wnt signalosome 2 CTNNB1, LRRK2
midbody 1 PLK1
apical part of cell 1 CTNNB1
cell-cell junction 2 CTNNB1, WDR1
Golgi-associated vesicle 1 LRRK2
spindle midzone 1 PLK1
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 SLC2A9
Cell projection, lamellipodium 1 MYLK
Cytoplasm, cytoskeleton 3 CTNNB1, LRRK2, WDR1
Cytoplasm, cytoskeleton, spindle 1 PLK1
focal adhesion 1 CTNNB1
spindle 1 PLK1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 ACOX3
peroxisomal matrix 1 ACOX3
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
dendrite cytoplasm 1 LRRK2
neuron projection 1 LRRK2
chromatin 3 MYC, PLK1, VRK1
cell projection 1 WDR1
cell periphery 2 CTNNB1, SLC8A1
supramolecular fiber 1 SNCA
Chromosome 1 BRD4
cytoskeleton 1 LRRK2
Cell projection, podosome 1 WDR1
podosome 1 WDR1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
centriole 1 PLK1
Nucleus, nucleolus 1 MYC
spindle pole 2 CTNNB1, PLK1
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 SLC2A9
microvillus membrane 1 CTNNB1
[Isoform 2]: Cell membrane 1 SLC2A9
nuclear envelope 2 MYC, VRK2
Nucleus envelope 1 VRK2
Endomembrane system 1 CTNNB1
microvillus 1 LRRK2
Nucleus, nucleoplasm 1 MYC
Cell projection, dendrite 1 LRRK2
euchromatin 1 CTNNB1
stress fiber 1 MYLK
[Isoform 1]: Cytoplasm 1 VRK2
Golgi stack 1 VRK1
cortical actin cytoskeleton 1 WDR1
axon terminus 2 SLC8A1, SNCA
kinetochore 1 PLK1
mitotic spindle pole 1 PLK1
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 1 CTNNB1
endoplasmic reticulum exit site 1 LRRK2
Single-pass type IV membrane protein 1 VRK2
condensed nuclear chromosome 1 BRD4
outer kinetochore 1 PLK1
[Isoform 2]: Cytoplasm 1 VRK2
presynaptic active zone cytoplasmic component 1 CTNNB1
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
Cajal body 1 VRK1
ribonucleoprotein complex 1 LRRK2
protein-DNA complex 1 CTNNB1
synaptonemal complex 1 PLK1
[Isoform 1]: Cell membrane 1 SLC2A9
Rough endoplasmic reticulum 1 MYC
Cytoplasmic vesicle, phagosome 1 LRRK2
catenin complex 1 CTNNB1
Nucleus, Cajal body 1 VRK1
[Isoform B]: Chromosome 1 BRD4
presynaptic cytosol 1 LRRK2
Myc-Max complex 1 MYC
multivesicular body, internal vesicle 1 LRRK2
Autolysosome 1 LRRK2
inclusion body 1 SNCA
beta-catenin-TCF7L2 complex 1 CTNNB1
cytoplasmic side of mitochondrial outer membrane 1 LRRK2
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
amphisome 1 LRRK2
caveola neck 1 LRRK2
nucleoplasmic reticulum 1 MYC


文献列表

  • U Tröhler, J P Bonjour, H Fleisch. Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. The Journal of clinical investigation. 1976 Feb; 57(2):264-73. doi: 10.1172/jci108277. [PMID: 3518]