IsoRhy (BioDeep_00000000522)

   

PANOMIX_OTCML-2023


代谢物信息卡片


SPIRO(3H-INDOLE-3,1(5H)-INDOLIZINE)-7-ACETIC ACID, 6-ETHYL-1,2,2,3,6,7,8,8A-OCTAHYDRO-.ALPHA.-(METHOXYMETHYLENE)-2-OXO-, METHYL ESTER, (.ALPHA.E,1S,6R,7S,8AS)-

化学式: C22H28N2O4 (384.20489680000003)
中文名称: 异钩藤碱, 异钩藤碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 13.89%

分子结构信息

SMILES: CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
InChI: InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22-/m0/s1

描述信息

Isorhynchophylline is a member of indolizines. It has a role as a metabolite.
Isorhynchophylline is a natural product found in Uncaria tomentosa, Mitragyna inermis, and other organisms with data available.
See also: Cats Claw (part of).
A natural product found in Uncaria macrophylla.
Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia.
Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia.

同义名列表

25 个代谢物同义名

SPIRO(3H-INDOLE-3,1(5H)-INDOLIZINE)-7-ACETIC ACID, 6-ETHYL-1,2,2,3,6,7,8,8A-OCTAHYDRO-.ALPHA.-(METHOXYMETHYLENE)-2-OXO-, METHYL ESTER, (.ALPHA.E,1S,6R,7S,8AS)-; SPIRO(3H-INDOLE-3,1(5H)-INDOLIZINE)-7-ACETIC ACID, 6-ETHYL-1,2,2,3,6,7,8,8A-OCTAHYDRO-alpha-(METHOXYMETHYLENE)-2-OXO-, METHYL ESTER, (alphaE,1S,6R,7S,8AS)-; Spiro[3H-indole-3,1(5H)-indolizine]-7-acetic acid,6-ethyl-1,2,2,3,6,7,8,8a-octahydro-a-(methoxymethylene)-2-oxo-,methyl ester, (aE,1S,6R,7S,8aS)-; methyl (2E)-2-[(3S,6R,7S,8aS)-6-ethyl-2-oxo-1,2,3,5,6,7,8,8a-octahydro-2H-spiro[indole-3,1-indolizin]-7-yl]-3-methoxyprop-2-enoate; methyl (E)-2-[(3S,6R,7S,8aS)-6-ethyl-2-oxospiro[1H-indole-3,1-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7-yl]-3-methoxyprop-2-enoate; Rel-methyl (E)-2-((3S,6R,7S,8aS)-6-ethyl-2-oxo-2,3,6,7,8,8a-hexahydro-5H-spiro[indoline-3,1-indolizin]-7-yl)-3-methoxyacrylate; CORYNOXAN-16-CARBOXYLIC ACID, 16,17-DIDEHYDRO-17-METHOXY-2-OXO-, METHYL ESTER, (16E,20.ALPHA.)-; Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20-alpha)-; CORYNOXAN-16-CARBOXYLIC ACID, 16,17-DIDEHYDRO-17-METHOXY-2-OXO-, METHYL ESTER, (16E,20alpha)-; (16E,20-alpha)-16,17-Didehydro-17-methoxy-2-oxo-corynoxan-16-carboxylic acid; ISORHYNCHOPHYLLINE (CONSTITUENT OF CATS CLAW) [DSC]; ISORHYNCHOPHYLLINE (CONSTITUENT OF CATS CLAW); rhyncophylline, (16E,20alpha)-isomer; rhyncophylline, (16E)-isomer; (+/-)-isorhynchophylline; 7-Isorhyncophylline; isorhynchophylline; isorhyncophylline; Isorhychophylline; Rhynchophylline; UNII-7F4P99KHLJ; rhyncophylline; 7F4P99KHLJ; 1ST159053; IsoRhy



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lihua Wang, Haichao Li, Hao Zhang, Xiayinan Song, Haiqiang Jiang, Danyang Wang, Yu Wang. Serum-based metabolomics reveals the mechanism of action of isorhynchophylline in the intervention of atherosclerosis in ApoE-/- mice. Analytical methods : advancing methods and applications. 2024 Jan; ?(?):. doi: 10.1039/d3ay01803b. [PMID: 38284158]
  • Detian Mu, Yingying Shao, Jialong He, Lina Zhu, Deyou Qiu, Iain W Wilson, Yao Zhang, Limei Pan, Yu Zhou, Ying Lu, Qi Tang. Evaluation of Reference Genes for Normalizing RT-qPCR and Analysis of the Expression Patterns of WRKY1 Transcription Factor and Rhynchophylline Biosynthesis-Related Genes in Uncaria rhynchophylla. International journal of molecular sciences. 2023 Nov; 24(22):. doi: 10.3390/ijms242216330. [PMID: 38003520]
  • Xialin Zhu, Qingqing Hou, Ling Zhang, Danyang Wang, Zhenhua Tian, Yuecheng Liu, Yu Wang, Yunlun Li, Haiqiang Jiang. Isorhynchophylline improves lipid metabolism disorder by mediating a circadian rhythm gene Bmal1 in spontaneously hypertensive rat. Phytotherapy research : PTR. 2023 Sep; ?(?):. doi: 10.1002/ptr.8015. [PMID: 37752617]
  • Ming-Jin Jiang, Jing Li, Chao-Hua Luo, Chen Zhu, Zhi-Jie Chen, Wei Bai, Tian-Yu Hu, Chuan-Hua Feng, Chan Li, Zhi-Xian Mo. Rhynchophylline inhibits methamphetamine dependence via modulating the miR-181a-5p/GABRA1 axis. Journal of ethnopharmacology. 2023 May; 314(?):116635. doi: 10.1016/j.jep.2023.116635. [PMID: 37182675]
  • Kang Liu, Songsong Liu, Chou Wu, Yuwei Wang, Yurou Zhang, Jingsu Yu, Siqi Liu, Xiangling Li, Xinyu Qi, Songtao Su, Xinyi Qi, Lei Zhou, Yixing Li. Rhynchophylline relieves nonalcoholic fatty liver disease by activating lipase and increasing energy metabolism. International immunopharmacology. 2023 Apr; 117(?):109948. doi: 10.1016/j.intimp.2023.109948. [PMID: 37012893]
  • Li-Hua Wang, Zheng-Wei Gu, Jie Li, Wen-Qing Yang, Yun-Lun Li, Dong-Mei Qi, Dan-Yang Wang, Hai-Qiang Jiang. Isorhynchophylline inhibits inflammatory responses in endothelial cells and macrophages through the NF-κB/NLRP3 signaling pathway. BMC complementary medicine and therapies. 2023 Mar; 23(1):80. doi: 10.1186/s12906-023-03902-3. [PMID: 36906555]
  • Jieyun Jiang, Jin Li, Chenwei Xiong, Xindie Zhou, Ting Liu. Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes. Journal of orthopaedic surgery and research. 2023 Mar; 18(1):154. doi: 10.1186/s13018-023-03645-4. [PMID: 36864518]
  • Honglei Lin, Lukuan Xie, Lingrui Lv, Jianrong Chen, Feng Feng, Wenyuan Liu, Lingfei Han, Fulei Liu. Intranasally administered thermosensitive gel for brain-targeted delivery of rhynchophylline to treat Parkinson's disease. Colloids and surfaces. B, Biointerfaces. 2023 Feb; 222(?):113065. doi: 10.1016/j.colsurfb.2022.113065. [PMID: 36473372]
  • Danyang Wang, Mengjia Sun, Yuecheng Liu, Lihua Wang, Chao Li, Yunlun Li, Haiqiang Jiang. Isorhynchophylline regulates the circadian rhythm of the hypothalamus in spontaneously hypertensive rats to treat hypertension. Current pharmaceutical design. 2022 12; ?(?):. doi: 10.2174/1381612829666221222115134. [PMID: 36567301]
  • Mengquan Yang, Bowen Yao, Rongmei Lin. Profiles of Metabolic Genes in Uncaria rhynchophylla and Characterization of the Critical Enzyme Involved in the Biosynthesis of Bioactive Compounds-(iso)Rhynchophylline. Biomolecules. 2022 11; 12(12):. doi: 10.3390/biom12121790. [PMID: 36551218]
  • Zhenyu Li, Huasong Shi, Yanmei Li, Wang Wang, Zhexi Li, Biao Chen, Daibang Nie. Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway. European journal of pharmacology. 2022 Jun; 924(?):174971. doi: 10.1016/j.ejphar.2022.174971. [PMID: 35469836]
  • Xue Li, Xiao-Hong Wang, Wei Qiang, Hao-Jie Zheng, Li-Yang ShangGuan, Ming-Sheng Zhang. Transcriptome revealing the dual regulatory mechanism of ethylene on the rhynchophylline and isorhynchophylline in Uncaria rhynchophylla. Journal of plant research. 2022 May; 135(3):485-500. doi: 10.1007/s10265-022-01387-8. [PMID: 35380307]
  • Chuanfeng Lv, Hui Li, Hongxia Cui, Qianyu Bi, Meng Wang. Solid lipid nanoparticle delivery of rhynchophylline enhanced the efficiency of allergic asthma treatment via the upregulation of suppressor of cytokine signaling 1 by repressing the p38 signaling pathway. Bioengineered. 2021 12; 12(1):8635-8649. doi: 10.1080/21655979.2021.1988364. [PMID: 34629023]
  • Pan Jiang, Lei Chen, Jian Xu, Wenyuan Liu, Feng Feng, Wei Qu. Neuroprotective Effects of Rhynchophylline Against Aβ1-42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2-ARE Activation. Neurochemical research. 2021 Sep; 46(9):2439-2450. doi: 10.1007/s11064-021-03343-9. [PMID: 34170454]
  • Haikang Zhao, Xiaoqiang Li, Lei Yang, Liang Zhang, Xiaobing Jiang, Wenwen Gao, Peng Chen, Yingying Cheng, Fenglu Wang, Jianrong Liu. Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway. Neurochemical research. 2021 Aug; 46(8):1981-1994. doi: 10.1007/s11064-021-03320-2. [PMID: 33942214]
  • Qiang Zheng, Yuan Zhang, Zheng Zhao, Haitao Shen, Hongyu Zhao, Min Zhao. Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression. Toxicology and applied pharmacology. 2021 06; 420(?):115521. doi: 10.1016/j.taap.2021.115521. [PMID: 33838153]
  • Nan Qin, Xin Lu, Yijun Liu, Yuting Qiao, Wei Qu, Feng Feng, Haopeng Sun. Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry. European journal of medicinal chemistry. 2021 Jan; 210(?):112960. doi: 10.1016/j.ejmech.2020.112960. [PMID: 33148492]
  • Hui Li, Qianyu Bi, Hongxia Cui, Chuanfeng Lv, Meng Wang. Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma. BMC complementary medicine and therapies. 2021 Jan; 21(1):21. doi: 10.1186/s12906-020-03187-w. [PMID: 33413331]
  • Hua Geng, Xuqin Chen, Chengzhong Wang. Systematic elucidation of the pharmacological mechanisms of Rhynchophylline for treating epilepsy via network pharmacology. BMC complementary medicine and therapies. 2021 Jan; 21(1):9. doi: 10.1186/s12906-020-03178-x. [PMID: 33407404]
  • Xu Li, Tian-Jiao Xu, Li-Kun Liu, Miao-Xian Dong. [Antioxidant mechanism of gastrodin combined with isorhynchophylline in inhibiting MPP~+-induced apoptosis of PC12 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Jan; 46(2):420-425. doi: 10.19540/j.cnki.cjcmm.20201009.401. [PMID: 33645131]
  • Yuan Li, Ruixue Yu, Dan Zhang, Wenqing Yang, Qingqing Hou, Yunlun Li, Haiqiang Jiang. Deciphering the Mechanism of the Anti-Hypertensive Effect of Isorhynchophylline by Targeting Neurotransmitters Metabolism of Hypothalamus in Spontaneously Hypertensive Rats. ACS chemical neuroscience. 2020 06; 11(11):1563-1572. doi: 10.1021/acschemneuro.9b00699. [PMID: 32356970]
  • Jinyue Zhu, Weiqing Wang, Xia Wu. Isorhynchophylline exerts anti-asthma effects in mice by inhibiting the proliferation of airway smooth muscle cells: The involvement of miR-200a-mediated FOXC1/NF-κB pathway. Biochemical and biophysical research communications. 2020 01; 521(4):1055-1060. doi: 10.1016/j.bbrc.2019.10.178. [PMID: 31733831]
  • Yuting Zhou, Yingbo Lin, Zhijie Chen, Chen Zhu, Chan Li, Hancheng Li, Chuying Huo, Jinying Ou, Jing Li, Chaohua Luo, Zhixian Mo. Expression of miR-133a-5p and ROCK2 in Heart in Methamphetamine-Induced Rats and Intervention of Rhynchophylline. Pharmacology. 2020; 105(5-6):300-310. doi: 10.1159/000503756. [PMID: 31825931]
  • Ruiling Xu, Junying Wang, Juanjuan Xu, Xiangrong Song, Hai Huang, Yue Feng, Chunmei Fu. Rhynchophylline Loaded-mPEG-PLGA Nanoparticles Coated with Tween-80 for Preliminary Study in Alzheimer's Disease. International journal of nanomedicine. 2020; 15(?):1149-1160. doi: 10.2147/ijn.s236922. [PMID: 32110013]
  • Heng-Sheng Zhang, Mei-Fang Liu, Xiong-Ying Ji, Chang-Rong Jiang, Zi-Li Li, Bo OuYang. Gastrodin combined with rhynchophylline inhibits cerebral ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p. Life sciences. 2019 Dec; 239(?):116935. doi: 10.1016/j.lfs.2019.116935. [PMID: 31610203]
  • Jian-Jian Wang, La-la Ji, Xiao-Hong Deng, Li-Tang Lyu, Li-Fei Yu, Ping Guan. [Effects of light intensity on growth and content of active components of Uncaria rhynchophyll]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Dec; 44(23):5118-5123. doi: 10.19540/j.cnki.cjcmm.20191009.103. [PMID: 32237347]
  • Long Hongyan, Zhang Mengjiao, Wang Chunyan, Huang Yaruo. Rhynchophylline Attenuates Neurotoxicity in Tourette Syndrome Rats. Neurotoxicity research. 2019 Nov; 36(4):679-687. doi: 10.1007/s12640-019-00059-1. [PMID: 31115771]
  • Tianbao Lai, Liangyi Chen, Xingyu Chen, Jianquan He, Peiyu Lv, Hua Ge. Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling. Molecular and cellular biochemistry. 2019 Nov; 461(1-2):205-212. doi: 10.1007/s11010-019-03603-x. [PMID: 31420791]
  • Hongyan Long, Jie Ruan, Mengjiao Zhang, Chunyan Wang, Yaruo Huang. Rhynchophylline Attenuates Tourette Syndrome via BDNF/NF-κB Pathway In Vivo and In Vitro. Neurotoxicity research. 2019 Nov; 36(4):756-763. doi: 10.1007/s12640-019-00079-x. [PMID: 31243645]
  • Long Hongyan, Zhang Mengjiao, Wang Chunyan, Huang Yaruo. Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF-κB pathways. Environmental toxicology. 2019 Oct; 34(10):1114-1120. doi: 10.1002/tox.22813. [PMID: 31231976]
  • Chan Li, Genghong Tu, Chaohua Luo, Youli Guo, Miao Fang, Chen Zhu, Hancheng Li, Jinying Ou, Yuting Zhou, Wei Liu, Ken Kin Lam Yung, Zhixian Mo. Effects of rhynchophylline on the hippocampal miRNA expression profile in ketamine-addicted rats. Progress in neuro-psychopharmacology & biological psychiatry. 2018 08; 86(?):379-389. doi: 10.1016/j.pnpbp.2018.02.009. [PMID: 29476799]
  • Qiang Li, Chengu Niu, Xiaojie Zhang, Miaoxian Dong. Gastrodin and Isorhynchophylline Synergistically Inhibit MPP+-Induced Oxidative Stress in SH-SY5Y Cells by Targeting ERK1/2 and GSK-3β Pathways: Involvement of Nrf2 Nuclear Translocation. ACS chemical neuroscience. 2018 03; 9(3):482-493. doi: 10.1021/acschemneuro.7b00247. [PMID: 29115830]
  • Mei-Fang Song, Yan-Hong Guan, Hai-Tao Li, Shu-Gen Wei, Li-Xia Zhang, Zhong-Lian Zhang, Xiao-Jun Ma. The effects of genetic variation and environmental factors on rhynchophylline and isorhynchophylline in Uncaria macrophylla Wall. from different populations in China. PloS one. 2018; 13(6):e0199259. doi: 10.1371/journal.pone.0199259. [PMID: 29953548]
  • Lianguo Chen, Weiwei You, Dingwen Chen, Yuan Cai, Xianqin Wang, Congcong Wen, Bo Wu. Pharmacokinetic Interaction Study of Ketamine and Rhynchophylline in Rat Plasma by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry. BioMed research international. 2018; 2018(?):6562309. doi: 10.1155/2018/6562309. [PMID: 29951541]
  • Xin Wang, Mei Zheng, Jia Liu, Zhifeng Huang, Yidan Bai, Zhuoying Ren, Ziwen Wang, Yangli Tian, Zhou Qiao, Wenyuan Liu, Feng Feng. Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats. Journal of ethnopharmacology. 2017 Sep; 209(?):175-183. doi: 10.1016/j.jep.2017.07.039. [PMID: 28755970]
  • Li-Hong Wu, Jia Hou, Jue Wang, Man Luo, Li-Min Wang, Jian-Xin Wang, Yong-Ji Li, Jing Qin. [Effect of combination of gastrodia and uncaria on pharmacokinetics of gastrodin and rhynchophylline]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Jul; 42(13):2577-2582. doi: 10.19540/j.cnki.cjcmm.20170523.011. [PMID: 28840702]
  • Tim Förster, Sara López-Tosco, Slava Ziegler, Andrey P Antonchick, Herbert Waldmann. Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity. Chembiochem : a European journal of chemical biology. 2017 06; 18(12):1098-1108. doi: 10.1002/cbic.201700015. [PMID: 28421720]
  • Xin Wang, Mei Zheng, Jia Liu, Zhou Qiao, Wenyuan Liu, Feng Feng. Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography-tandem mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems. 2017 Jun; 47(6):479-487. doi: 10.1080/00498254.2016.1203043. [PMID: 27388920]
  • Hanwool Lee, Seung Ho Baek, Jong Hyun Lee, Chulwon Kim, Jeong-Hyeon Ko, Seok-Geun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. International journal of molecular sciences. 2017 May; 18(5):. doi: 10.3390/ijms18051095. [PMID: 28534824]
  • Chen Zhu, Wei Liu, Chaohua Luo, Yi Liu, Chan Li, Miao Fang, Yingbo Lin, Jinying Ou, Minting Chen, Daoqi Zhu, Ken Kin-Lam Yung, Zhixian Mo. Inhibiting effects of rhynchophylline on methamphetamine-dependent zebrafish are related with the expression of tyrosine hydroxylase (TH). Fitoterapia. 2017 Mar; 117(?):47-51. doi: 10.1016/j.fitote.2017.01.001. [PMID: 28063836]
  • Yi-Fei Chen, Ju Peng, Miao Fang, Yi Liu, Ling-Hui Nie, Zhi-Xian Mo, Ling-Ling Zhu. [Effect of rhynchophylline on behaviors of methamphetamine-dependent zebrafish and the mechanism]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2016 Nov; 36(11):1541-1545. doi: . [PMID: 27881347]
  • Jianwei Wang, Peng Qi, Jinjun Hou, Yao Shen, Bingpeng Yan, Qirui Bi, RuiHong Feng, Xiaojian Shi, Min Yang, Wanying Wu, De-An Guo. Profiling and identification of metabolites of isorhynchophylline in rats by ultra high performance liquid chromatography and linear ion trap Orbitrap mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Oct; 1033-1034(?):147-156. doi: 10.1016/j.jchromb.2016.08.013. [PMID: 27561181]
  • Mingjin Jiang, Yifei Chen, Chan Li, Qiuxian Peng, Miao Fang, Wei Liu, Qunzhao Kang, Yingbo Lin, Ken Kin Lam Yung, Zhixian Mo. Inhibiting effects of rhynchophylline on zebrafish methamphetamine dependence are associated with amelioration of neurotransmitters content and down-regulation of TH and NR2B expression. Progress in neuro-psychopharmacology & biological psychiatry. 2016 Jul; 68(?):31-43. doi: 10.1016/j.pnpbp.2016.03.004. [PMID: 27009763]
  • Yan Zhang, Juan Sun, Shijie Zhu, Ting Xu, Jianfei Lu, Hongbin Han, Changman Zhou, Junhao Yan. The role of rhynchophylline in alleviating early brain injury following subarachnoid hemorrhage in rats. Brain research. 2016 Jan; 1631(?):92-100. doi: 10.1016/j.brainres.2015.11.035. [PMID: 26631843]
  • Hui Shao, Ze Mi, Wei-gang Ji, Cheng-huan Zhang, Teng Zhang, Shuan-cheng Ren, Zhi-ru Zhu. Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats. Neurochemical research. 2015 Nov; 40(11):2365-73. doi: 10.1007/s11064-015-1730-y. [PMID: 26441223]
  • Chiaki Murayama, Shimpei Watanabe, Motokazu Nakamura, Hisayoshi Norimoto. Inhibitory Activity of Yokukansankachimpihange against Nerve Growth Factor-Induced Neurite Growth in Cultured Rat Dorsal Root Ganglion Neurons. Molecules (Basel, Switzerland). 2015 Aug; 20(8):14959-69. doi: 10.3390/molecules200814959. [PMID: 26287150]
  • Zhen-Feng Wu, Ya-Qi Wang, Na Wan, Gang Ke, Peng-Fei Yue, Hao Chen, Juan-Juan Zhan, Ming Yang. Structural Stabilities and Transformation Mechanism of Rhynchophylline and Isorhynchophylline by Ultra Performance Liquid Chromatography/Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS). Molecules (Basel, Switzerland). 2015 Aug; 20(8):14849-59. doi: 10.3390/molecules200814849. [PMID: 26287142]
  • Yanan Gai, Han Chen, Wenyuan Liu, Feng Feng, Ning Xie. The metabolism of YiGan San and subsequent pharmacokinetic evaluation of four metabolites in rat based on liquid chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Dec; 972(?):22-8. doi: 10.1016/j.jchromb.2014.09.033. [PMID: 25306115]
  • Yan He, Sheng-Ya Zeng, Shi-Wen Zhou, Gui-Sheng Qian, Kang Peng, Zhi-Xian Mo, Ji-Yin Zhou. Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons. Fitoterapia. 2014 Oct; 98(?):166-73. doi: 10.1016/j.fitote.2014.08.002. [PMID: 25110195]
  • Junkui Li, Wei Liu, Qiuxian Peng, Mingjin Jiang, Chaohua Luo, Youli Guo, Yi Liu, Miao Fang, Zhixian Mo. Effect of rhynchophylline on conditioned place preference on expression of NR2B in methamphetamine-dependent mice. Biochemical and biophysical research communications. 2014 Sep; 452(3):695-700. doi: 10.1016/j.bbrc.2014.08.127. [PMID: 25193707]
  • Fangfang Chen, Wen Qi, Jiahong Sun, James W Simpkins, Dan Yuan. Urinary metabolites of isorhynchophylline in rats and their neuroprotective activities in the HT22 cell assay. Fitoterapia. 2014 Sep; 97(?):156-63. doi: 10.1016/j.fitote.2014.05.022. [PMID: 24910000]
  • Qianqian Guo, Xiaojun Ma, Shugen Wei, Deyou Qiu, Iain W Wilson, Peng Wu, Qi Tang, Lijun Liu, Shoukun Dong, Wei Zu. De novo transcriptome sequencing and digital gene expression analysis predict biosynthetic pathway of rhynchophylline and isorhynchophylline from Uncaria rhynchophylla, a non-model plant with potent anti-alzheimer's properties. BMC genomics. 2014 Aug; 15(?):676. doi: 10.1186/1471-2164-15-676. [PMID: 25112168]
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