Bellidifolin (BioDeep_00000000480)

 

Secondary id: BioDeep_00000866250, BioDeep_00001867509

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


9H-Xanthen-9-one, 1,5,8-trihydroxy-3-methoxy-

化学式: C14H10O6 (274.047736)
中文名称: 雏菊叶龙胆酮, 龙胆山酮酚, 龙胆酮酚, 雏菊叶龙胆酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.04%

分子结构信息

SMILES: c1(cc(c2c(c1)oc1c(c2=O)c(ccc1O)O)O)OC
InChI: InChI=1S/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5,15-17H,1H3

描述信息

Bellidifolin is a member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a hypoglycemic agent and a metabolite. It is a member of xanthones and a polyphenol. It is functionally related to a bellidin.
Bellidifolin is a natural product found in Gentiana orbicularis, Gentianella amarella, and other organisms with data available.
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities[1][2][3]. Bellidifolin also acts as a viral protein R (Vpr) inhibitor[4].
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities[1][2][3]. Bellidifolin also acts as a viral protein R (Vpr) inhibitor[4].

同义名列表

15 个代谢物同义名

9H-Xanthen-9-one, 1,5,8-trihydroxy-3-methoxy-; 1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one; Xanthen-9-one, 3-methoxy-1,5,8-trihydroxy-; Xanthen-9-one, 1,5,8-trihydroxy-3-methoxy-; 1,5,8-Trihydroxy-3-methoxy-xanthen-9-one; 3-Methoxy-1,5,8-trihydroxyxanthen-9-one; 1,5,8-trihydroxy-3-methoxyxanthen-9-one; 3-Methoxy-1,5,8-trihyroxyxanthen-9-one; 1,5,8-trihydroxyl-3-methoxy xanthone; 1,5,8-trihydroxy-3-methoxyxanthone; 3-Methoxy-1,5,8-trihydroxyxanthone; Xanthen-9-one, 1.1; Bellidifoline; Bellidifolium; Bellidifolin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Siqi Li, Congying Huang, Xing Li, Xiangxi Meng, Rong Wen, Xiaodong Zhang, Chunhong Zhang, Minhui Li. Bellidifolin from Gentianella acuta (Michx.) Hulten protects H9c2 cells from hydrogen peroxide-induced injury via the PI3K-Akt signal pathway. Toxicology reports. 2022; 9(?):1655-1665. doi: 10.1016/j.toxrep.2022.08.006. [PMID: 36518482]
  • Li Yan, Luo Yali, Li Chenghao, Feng Caiqin, Zhu Zhongbo, Ren Weiyu, Ma Yu, Zhou Xiaotian, Wang Biwen, Jin Xiaojie, Liu Yongqi. Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity. Journal of oncology. 2020; 2020(?):1723791. doi: 10.1155/2020/1723791. [PMID: 33299414]
  • So-Yeun Woo, Nwet Nwet Win, Wyine Myat Noe Oo, Hla Ngwe, Takuya Ito, Ikuro Abe, Hiroyuki Morita. Viral protein R inhibitors from Swertia chirata of Myanmar. Journal of bioscience and bioengineering. 2019 Oct; 128(4):445-449. doi: 10.1016/j.jbiosc.2019.04.006. [PMID: 31076338]
  • Tian-Yong Hu, Jian-Ming Ju, Li-Hua Mo, Li Ma, Wen-Hui Hu, Rong-Rong You, Xue-Qing Chen, Yan-Yan Chen, Zhi-Qiang Liu, Shu-Qi Qiu, Jun-Ting Fan, Bao-Hui Cheng. Anti-inflammation action of xanthones from Swertia chirayita by regulating COX-2/NF-κB/MAPKs/Akt signaling pathways in RAW 264.7 macrophage cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 55(?):214-221. doi: 10.1016/j.phymed.2018.08.001. [PMID: 30668431]
  • Kai Ren, He Su, Li-Juan Lv, Le-Tai Yi, Xue Gong, Lian-Sheng Dang, Rui-Fen Zhang, Min-Hui Li. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. BioMed research international. 2019; 2019(?):2692970. doi: 10.1155/2019/2692970. [PMID: 30800665]
  • Rong-Rong You, Xue-Qing Chen, Dan-Dan He, Chang-Gao Huang, Yang Jin, Shi-Hui Qian, Jian-Ming Ju, Jun-Ting Fan. [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Oct; 42(19):3764-3769. doi: 10.19540/j.cnki.cjcmm.20170807.003. [PMID: 29235293]
  • Xi-Yuan Zheng, Ying-Fan Yang, Wan Li, Xin Zhao, Yi Sun, Hua Sun, Yue-Hua Wang, Xiao-Ping Pu. Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo. Journal of ethnopharmacology. 2014 May; 153(3):854-63. doi: 10.1016/j.jep.2014.03.058. [PMID: 24690777]
  • Fuqiang Jiang, Xuemei Zhang, Yunbao Ma, Chang'an Geng, Zhiyong Jiang, Jijun Chen. [Chemical constituents of Swertia hispidicalyx]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Aug; 36(16):2215-8. doi: . [PMID: 22097333]
  • L-Y Tian, X Bai, X-H Chen, J-B Fang, S-H Liu, J-C Chen. Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Jun; 17(7):533-9. doi: 10.1016/j.phymed.2009.10.007. [PMID: 19962285]
  • Aleksandra Isakovic, Teodora Jankovic, Ljubica Harhaji, Sladjana Kostic-Rajacic, Zoran Nikolic, Vlatka Vajs, Vladimir Trajkovic. Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. Bioorganic & medicinal chemistry. 2008 May; 16(10):5683-94. doi: 10.1016/j.bmc.2008.03.069. [PMID: 18406151]
  • Virendra S Rana, Mohan S M Rawat. A new xanthone glycoside and antioxidant constituents from the rhizomes of Swertia speciosa. Chemistry & biodiversity. 2005 Oct; 2(10):1310-5. doi: 10.1002/cbdv.200590102. [PMID: 17191931]
  • Huiling Yang, Chenxu Ding, Yuanwen Duan, Jianquan Liu. Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed. Journal of ethnopharmacology. 2005 Apr; 98(1-2):31-5. doi: 10.1016/j.jep.2004.12.015. [PMID: 15763361]
  • Zhou Qing, Chen Jiachun, Liu Yanwen. [Study on chemical constituents from Swertia kauitchensis Franch]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2004 Dec; 27(12):908-10. doi: . [PMID: 15807240]
  • P Basnet, S Kadota, M Shimizu, T Namba. Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Planta medica. 1994 Dec; 60(6):507-11. doi: 10.1055/s-2006-959560. [PMID: 7809201]