neamine (BioDeep_00000004690)

   

natural product


代谢物信息卡片


5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol

化学式: C12H26N4O6 (322.1852)
中文名称: 新霉胺
谱图信息: 最多检出来源 Homo sapiens(blood) 26.24%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)O)O)N
InChI: InChI=1S/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1

描述信息

C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

4 个代谢物同义名

neamine; 5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol; Neamine (Neomycin A); Neamine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ANG, CXCR4, MSMP, OPA1, PIK3C3, RIGI, RPS12, RPS17, TLR4, VEGFA
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 1 CD4
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 6 ANG, MKI67, PCNA, RNASEH2B, RNASEH2C, VEGFA
autophagosome 1 PIK3C3
cytosol 7 ANG, GOLPH3, OPA1, PIK3C3, RIGI, RPS12, RPS17
dendrite 1 OPA1
mitochondrial membrane 1 OPA1
nuclear body 2 MKI67, PCNA
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
trans-Golgi network 1 GOLPH3
centrosome 1 PCNA
nucleoplasm 6 MKI67, OPA1, PCNA, RNASEH2B, RPS12, RPS17
Cell membrane 5 CD4, CXCR4, GOLPH3, PECAM1, TLR4
ruffle membrane 1 RIGI
Multi-pass membrane protein 1 CXCR4
Synapse 1 RPS17
cell junction 2 CXCR4, PECAM1
cell surface 3 CXCR4, TLR4, VEGFA
glutamatergic synapse 1 PIK3C3
Golgi apparatus 3 GOLPH3, RPS12, VEGFA
Golgi membrane 1 GOLPH3
growth cone 1 ANG
mitochondrial inner membrane 1 OPA1
neuronal cell body 1 ANG
Lysosome 1 CXCR4
endosome 2 GOLPH3, PIK3C3
plasma membrane 6 ANGPT1, CD4, CXCR4, GOLPH3, PECAM1, TLR4
Membrane 9 CXCR4, GOLPH3, MKI67, OPA1, PIK3C3, RPS12, RPS17, TLR4, VEGFA
extracellular exosome 5 ANGPT1, CXCL12, CXCR4, PCNA, PECAM1
endoplasmic reticulum 1 VEGFA
extracellular space 6 ANG, ANGPT1, ANGPT2, MSMP, PECAM1, VEGFA
perinuclear region of cytoplasm 1 TLR4
adherens junction 1 VEGFA
bicellular tight junction 1 RIGI
mitochondrion 2 GOLPH3, OPA1
protein-containing complex 2 CXCR4, PECAM1
intracellular membrane-bounded organelle 2 GOLPH3, RPS12
Single-pass type I membrane protein 3 CD4, PECAM1, TLR4
Secreted 5 ANG, ANGPT1, ANGPT2, MSMP, VEGFA
extracellular region 5 ANG, ANGPT1, ANGPT2, CXCL12, VEGFA
Single-pass membrane protein 1 OPA1
mitochondrial outer membrane 1 OPA1
anchoring junction 1 CXCR4
external side of plasma membrane 5 CD4, CXCL12, CXCR4, PECAM1, TLR4
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 2 ANG, RIGI
cytoplasmic vesicle 1 CXCR4
nucleolus 4 ANG, MKI67, RPS12, RPS17
axon cytoplasm 1 OPA1
midbody 1 PIK3C3
Early endosome 3 CD4, CXCR4, TLR4
cell-cell junction 1 PECAM1
Mitochondrion inner membrane 1 OPA1
Membrane raft 3 ANGPT1, CD4, PECAM1
focal adhesion 1 RPS17
microtubule 1 OPA1
GABA-ergic synapse 1 PIK3C3
extracellular matrix 1 VEGFA
Peroxisome 1 PIK3C3
basement membrane 1 ANG
Mitochondrion intermembrane space 1 OPA1
mitochondrial intermembrane space 2 GOLPH3, OPA1
collagen-containing extracellular matrix 3 ANGPT1, ANGPT2, CXCL12
secretory granule 1 VEGFA
axoneme 1 PIK3C3
Cell projection, ruffle 1 TLR4
Late endosome 2 CXCR4, PIK3C3
ruffle 1 TLR4
receptor complex 1 TLR4
chromatin 1 PCNA
cell leading edge 1 CXCR4
cell projection 1 ANGPT2
phagocytic cup 1 TLR4
phagocytic vesicle membrane 1 PIK3C3
Chromosome 2 ANG, MKI67
mitochondrial crista 1 OPA1
Nucleus, nucleolus 4 ANG, MKI67, RPS12, RPS17
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
microvillus 1 ANGPT1
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Golgi cisterna membrane 1 GOLPH3
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
replication fork 1 PCNA
lipopolysaccharide receptor complex 1 TLR4
secretory granule membrane 1 PECAM1
endoplasmic reticulum lumen 1 CD4
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
small-subunit processome 2 RPS12, RPS17
presynaptic endosome 1 PIK3C3
Golgi cisterna 1 GOLPH3
nuclear lamina 1 PCNA
clathrin-coated endocytic vesicle membrane 1 CD4
ribonucleoprotein complex 2 RIGI, RPS17
[Dynamin-like GTPase OPA1, long form]: Mitochondrion inner membrane 1 OPA1
[Dynamin-like GTPase OPA1, short form]: Mitochondrion intermembrane space 1 OPA1
[Isoform Long]: Cell membrane 1 PECAM1
cytosolic ribosome 2 RPS12, RPS17
platelet alpha granule membrane 1 PECAM1
ribonuclease H2 complex 2 RNASEH2B, RNASEH2C
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
postsynaptic endosome 1 PIK3C3
ribosome 1 RPS17
T cell receptor complex 1 CD4
Autolysosome 1 PIK3C3
angiogenin-PRI complex 1 ANG
cytosolic small ribosomal subunit 2 RPS12, RPS17
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform Delta15]: Cell junction 1 PECAM1


文献列表

  • Yanli Wu, Yongdong Feng, Yanling Li, Yiping Xu, Nian Shi, Guo-Fu Hu, Yunxia Wu. Sub-chronic 90-day toxicity of neamine in SD rats and its anti-liver cancer activity in vitro and in vivo. Toxicology and applied pharmacology. 2017 Jan; 315(?):50-59. doi: 10.1016/j.taap.2016.12.006. [PMID: 27940282]
  • Guillaume Sautrey, Micheline El Khoury, Andreia Giro Dos Santos, Louis Zimmermann, Magali Deleu, Laurence Lins, Jean-Luc Décout, Marie-Paule Mingeot-Leclercq. Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY. The Journal of biological chemistry. 2016 Jun; 291(26):13864-74. doi: 10.1074/jbc.m115.665364. [PMID: 27189936]
  • Yaping Liu, Xiaoyan Zhang, Songlin An, Yanli Wu, Guofu Hu, Yunxia Wu. Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. Cancer chemotherapy and pharmacology. 2015 Mar; 75(3):465-74. doi: 10.1007/s00280-014-2658-7. [PMID: 25552400]
  • Benedikt Huttner, Thomas Haustein, Ilker Uçkay, Gesuele Renzi, Andrew Stewardson, Danièle Schaerrer, Americo Agostinho, Antoine Andremont, Jacques Schrenzel, Didier Pittet, Stephan Harbarth. Decolonization of intestinal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae with oral colistin and neomycin: a randomized, double-blind, placebo-controlled trial. The Journal of antimicrobial chemotherapy. 2013 Oct; 68(10):2375-82. doi: 10.1093/jac/dkt174. [PMID: 23719234]
  • Bernhard Westermann, Simon Dörner, Sebastian Brauch, Angela Schaks, Ramona Heinke, Sebastian Stark, Floris L van Delft, Sander S van Berkel. CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides. Carbohydrate research. 2013 Apr; 371(?):61-7. doi: 10.1016/j.carres.2013.02.003. [PMID: 23507494]
  • Myriam Ouberai, Farid El Garch, Antoine Bussiere, Mickael Riou, David Alsteens, Laurence Lins, Isabelle Baussanne, Yves F Dufrêne, Robert Brasseur, Jean-Luc Decout, Marie-Paule Mingeot-Leclercq. The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative?. Biochimica et biophysica acta. 2011 Jun; 1808(6):1716-27. doi: 10.1016/j.bbamem.2011.01.014. [PMID: 21291859]