neamine (BioDeep_00000004690)

   


代谢物信息卡片


5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol

化学式: C12H26N4O6 (322.18522559999997)
中文名称: 新霉胺
谱图信息: 最多检出来源 Homo sapiens(blood) 0.11%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)O)O)N
InChI: InChI=1S/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1

描述信息

C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

3 个代谢物同义名

neamine; 5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol; Neamine (Neomycin A)



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yanli Wu, Yongdong Feng, Yanling Li, Yiping Xu, Nian Shi, Guo-Fu Hu, Yunxia Wu. Sub-chronic 90-day toxicity of neamine in SD rats and its anti-liver cancer activity in vitro and in vivo. Toxicology and applied pharmacology. 2017 Jan; 315(?):50-59. doi: 10.1016/j.taap.2016.12.006. [PMID: 27940282]
  • Guillaume Sautrey, Micheline El Khoury, Andreia Giro Dos Santos, Louis Zimmermann, Magali Deleu, Laurence Lins, Jean-Luc Décout, Marie-Paule Mingeot-Leclercq. Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY. The Journal of biological chemistry. 2016 Jun; 291(26):13864-74. doi: 10.1074/jbc.m115.665364. [PMID: 27189936]
  • Yaping Liu, Xiaoyan Zhang, Songlin An, Yanli Wu, Guofu Hu, Yunxia Wu. Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. Cancer chemotherapy and pharmacology. 2015 Mar; 75(3):465-74. doi: 10.1007/s00280-014-2658-7. [PMID: 25552400]
  • Benedikt Huttner, Thomas Haustein, Ilker Uçkay, Gesuele Renzi, Andrew Stewardson, Danièle Schaerrer, Americo Agostinho, Antoine Andremont, Jacques Schrenzel, Didier Pittet, Stephan Harbarth. Decolonization of intestinal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae with oral colistin and neomycin: a randomized, double-blind, placebo-controlled trial. The Journal of antimicrobial chemotherapy. 2013 Oct; 68(10):2375-82. doi: 10.1093/jac/dkt174. [PMID: 23719234]
  • Bernhard Westermann, Simon Dörner, Sebastian Brauch, Angela Schaks, Ramona Heinke, Sebastian Stark, Floris L van Delft, Sander S van Berkel. CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides. Carbohydrate research. 2013 Apr; 371(?):61-7. doi: 10.1016/j.carres.2013.02.003. [PMID: 23507494]
  • Myriam Ouberai, Farid El Garch, Antoine Bussiere, Mickael Riou, David Alsteens, Laurence Lins, Isabelle Baussanne, Yves F Dufrêne, Robert Brasseur, Jean-Luc Decout, Marie-Paule Mingeot-Leclercq. The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative?. Biochimica et biophysica acta. 2011 Jun; 1808(6):1716-27. doi: 10.1016/j.bbamem.2011.01.014. [PMID: 21291859]