Costunolide (BioDeep_00000000469)

 

Secondary id: BioDeep_00000359835, BioDeep_00000897278, BioDeep_00001103458

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-

化学式: C15H20O2 (232.14632200000003)
中文名称: 木烃香内酯, 木香烃内酯, 木香烃内酯
谱图信息: 最多检出来源 Viridiplantae(plant) 0.38%

分子结构信息

SMILES: C/C/1=C\CC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C
InChI: InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5-,11-9-

描述信息

Costunolide is a germacranolide with anthelminthic, antiparasitic and antiviral activities. It has a role as an anthelminthic drug, an antiinfective agent, an antineoplastic agent, an antiparasitic agent, an antiviral drug and a metabolite. It is a germacranolide and a heterobicyclic compound.
(+)-Costunolide is a natural product found in Magnolia garrettii, Critonia morifolia, and other organisms with data available.
Constituent of costus root (Saussurea lappa). Costunolide is found in tarragon, sweet bay, and herbs and spices.
Costunolide is found in herbs and spices. Costunolide is a constituent of costus root (Saussurea lappa)
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
INTERNAL_ID 2266; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2266
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].

同义名列表

22 个代谢物同义名

Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-; (3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3abeta,4,5,8,9,11aalpha-octahydrocyclodeca[b]furan-2-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one; (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3,3a,4,5,8,9-hexahydrocyclodeca[b]furan-2(11aH)-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one; 6,10-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,8H,9H,11aH-cyclodeca[b]furan-2-one; (E,E)-germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-gamma-lactone; (10S,1R)-3,7-dimethyl-11-methylene-13-oxabicyclo[8.3.0]trideca-2,6-dien-12-one; (E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone; 6,10-dimethyl-3-methylidene-3aH,4H,5H,8H,9H,11aH-cyclodeca[b]furan-2-one; Costunolide, >=97\\% (HPLC); Costunolide,(S); (+)-costunolide; isocostunolide; Costus lactone; Costunolide; melampolide; Costunlide; Costunolid



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

117 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(115)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

121 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • María Ángeles Ávila-Gálvez, Daniela Marques, Inês Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Cláudia Nunes Dos Santos. Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Sep; 167(?):115413. doi: 10.1016/j.biopha.2023.115413. [PMID: 37683593]
  • Anil Bhushan, Dixhya Rani, Misbah Tabassum, Saajan Kumar, Prem N Gupta, Sumeet Gairola, Ajai P Gupta, Prasoon Gupta. HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124815. [PMID: 37375368]
  • Ravneet Kaur, Shivalika Pathania, Monika Kajal, Vasundhara Thakur, Jagdeep Kaur, Kashmir Singh. Integrated analysis of smRNAome, transcriptome, and degradome data to decipher microRNAs regulating costunolide biosynthesis in Saussurea lappa. Plant science : an international journal of experimental plant biology. 2023 Jun; 331(?):111689. doi: 10.1016/j.plantsci.2023.111689. [PMID: 36965630]
  • Zhiyuan Mao, Yang Liu, Xiaojing Lv, Yu Jiang, Qun Zhang, Li Yang, Hezhong Jiang, Renxiang Tan, Rui Tan. Inter-synergized neuroprotection of costunolide engineered bone marrow mesenchymal stem cells targeting system. International journal of pharmaceutics. 2023 May; 639(?):122823. doi: 10.1016/j.ijpharm.2023.122823. [PMID: 36921741]
  • Mehmet Enes Arslan, Hasan Türkez, Yasemin Sevim, Harun Selvitopi, Abdurrahim Kadi, Sena Öner, Adil Mardinoğlu. Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model. Cells. 2023 03; 12(7):. doi: 10.3390/cells12070992. [PMID: 37048065]
  • Zi-Ying Zhan, Zhi-Hong Zhang, Hong-Xu Yang, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis. Food & function. 2023 Feb; ?(?):. doi: 10.1039/d2fo02545k. [PMID: 36786020]
  • Arman Beyraghdar Kashkooli, Aalt D J van Dijk, Harro Bouwmeester, Alexander van der Krol. Individual lipid transfer proteins from Tanacetum parthenium show different specificity for extracellular accumulation of sesquiterpenes. Plant molecular biology. 2023 Jan; 111(1-2):153-166. doi: 10.1007/s11103-022-01316-2. [PMID: 36255594]
  • Wenlong Wu, Hongjuan Huang, Jietian Su, Xiaopeng Yun, Yixiao Zhang, Shouhui Wei, Zhaofeng Huang, Chaoxian Zhang, Quanjiang Bai. Dynamics of germination stimulants dehydrocostus lactone and costunolide in the root exudates and extracts of sunflower. Plant signaling & behavior. 2022 12; 17(1):2025669. doi: 10.1080/15592324.2022.2025669. [PMID: 35060434]
  • Wen Xing, Chaoling Wen, Deguo Wang, Hui Shao, Chunhong Liu, Chunling He, Opeyemi Joshua Olatunji. Cardiorenal Protective Effect of Costunolide against Doxorubicin-Induced Toxicity in Rats by Modulating Oxidative Stress, Inflammation and Apoptosis. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072122. [PMID: 35408518]
  • Jingxin Mao, Honghong Zhan, Fancheng Meng, Guowei Wang, Dan Huang, Zhihua Liao, Min Chen. Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro. Phytotherapy research : PTR. 2022 Mar; 36(3):1268-1283. doi: 10.1002/ptr.7383. [PMID: 35084790]
  • FanCheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, GuoWei Wang, ZhiHua Liao, Min Chen. Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 87(?):153588. doi: 10.1016/j.phymed.2021.153588. [PMID: 34091148]
  • InWha Park, Hee Sun Byun, Gang Min Hur, MinKyun Na. Tulipiferamide A, an Alkamide from Liriodendron tulipifera, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation. Journal of natural products. 2021 05; 84(5):1598-1606. doi: 10.1021/acs.jnatprod.1c00146. [PMID: 33939429]
  • Zi-Wei Yu, Yu Xie, Ze-Cheng Huang, Ke Yang, Zhan-Guo Wang, Hui-Ling Hu. Study of the therapeutic effect of raw and processed Vladimiriae Radix on ulcerative colitis based on intestinal flora, metabolomics and tissue distribution analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 May; 85(?):153538. doi: 10.1016/j.phymed.2021.153538. [PMID: 33765553]
  • Vasundhara Thakur, Savita Bains, Ravneet Kaur, Kashmir Singh. Identification and characterization of SlbHLH, SlDof and SlWRKY transcription factors interacting with SlDPD gene involved in costunolide biosynthesis in Saussurea lappa. International journal of biological macromolecules. 2021 Mar; 173(?):146-159. doi: 10.1016/j.ijbiomac.2021.01.114. [PMID: 33482203]
  • Sawalee Saosathan, Jalernsri Khounvong, Methee Rungrojsakul, Trinnakorn Katekunlaphan, Singkome Tima, Sawitree Chiampanichayakul, Cory Berkland, Songyot Anuchapreeda. Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines. Natural product research. 2021 Mar; 35(6):988-992. doi: 10.1080/14786419.2019.1610752. [PMID: 31135208]
  • Shinya Okubo, Tomoe Ohta, Hideaki Fujita, Yukihiro Shoyama, Takuhiro Uto. Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells. Journal of natural medicines. 2021 Jan; 75(1):240-245. doi: 10.1007/s11418-020-01462-1. [PMID: 33159250]
  • Maximilian Frey, Iris Klaiber, Jürgen Conrad, Otmar Spring. CYP71BL9, the missing link in costunolide synthesis of sunflower. Phytochemistry. 2020 Sep; 177(?):112430. doi: 10.1016/j.phytochem.2020.112430. [PMID: 32516579]
  • Fan Xie, Hai Zhang, Chuan Zheng, Xiao-Fei Shen. Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways. International immunopharmacology. 2020 Jul; 84(?):106567. doi: 10.1016/j.intimp.2020.106567. [PMID: 32413737]
  • Otmar Spring, Katharina Schmauder, Nathalie D Lackus, Jasmin Schreiner, Carolin Meier, Jan Wellhausen, Lisa V Smith, Maximilian Frey. Spatial and developmental synthesis of endogenous sesquiterpene lactones supports function in growth regulation of sunflower. Planta. 2020 Jun; 252(1):2. doi: 10.1007/s00425-020-03409-y. [PMID: 32504343]
  • Qijuan Li, Zhanguo Wang, Yu Xie, Huiling Hu. Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):109955. doi: 10.1016/j.biopha.2020.109955. [PMID: 32014691]
  • Vasundhara Thakur, Savita Bains, Shivalika Pathania, Shailesh Sharma, Ravneet Kaur, Kashmir Singh. Comparative transcriptomics reveals candidate transcription factors involved in costunolide biosynthesis in medicinal plant-Saussurea lappa. International journal of biological macromolecules. 2020 May; 150(?):52-67. doi: 10.1016/j.ijbiomac.2020.01.312. [PMID: 32035965]
  • Trinh-Don Nguyen, Moonhyuk Kwon, Soo-Un Kim, Conrad Fischer, Dae-Kyun Ro. Catalytic Plasticity of Germacrene A Oxidase Underlies Sesquiterpene Lactone Diversification. Plant physiology. 2019 11; 181(3):945-960. doi: 10.1104/pp.19.00629. [PMID: 31534022]
  • Maximilian Frey, Iris Klaiber, Jürgen Conrad, Aylin Bersch, Irini Pateraki, Dae-Kyun Ro, Otmar Spring. Characterization of CYP71AX36 from Sunflower (Helianthus annuus L., Asteraceae). Scientific reports. 2019 10; 9(1):14295. doi: 10.1038/s41598-019-50520-6. [PMID: 31586110]
  • Zhanpeng Yan, Tingting Xu, Zhentao An, Ying Hu, Wanzhen Chen, Jinxia Ma, Changle Shao, Fangshi Zhu. Costunolide induces mitochondria-mediated apoptosis in human gastric adenocarcinoma BGC-823 cells. BMC complementary and alternative medicine. 2019 Jun; 19(1):151. doi: 10.1186/s12906-019-2569-6. [PMID: 31242894]
  • Yichen Fang, Jie Li, Yinan Wu, Jing Gui, Yang Shen. Costunolide Inhibits the Growth of OAW42-A Multidrug-Resistant Human Ovarian Cancer Cells by Activating Apoptotic and Autophagic Pathways, Production of Reactive Oxygen Species (ROS), Cleaved Caspase-3 and Cleaved Caspase-9. Medical science monitor : international medical journal of experimental and clinical research. 2019 05; 25(?):3231-3237. doi: 10.12659/msm.914029. [PMID: 31043579]
  • Eti Mehrotra, Jyotsna Vishwakarma, Avinash C Tripathi, Pankaj K Sonar, Shailendra K Saraf. Schizonticidal antimalarial sesquiterpene lactones from Magnolia champaca (L.) Baill. ex Pierre: microwave-assisted extraction, HPTLC fingerprinting and computational studies. Natural product research. 2019 Feb; 33(4):568-572. doi: 10.1080/14786419.2017.1396595. [PMID: 29086620]
  • Qing Liu, Arman Beyraghdar Kashkooli, David Manzano, Irini Pateraki, Lea Richard, Pim Kolkman, Maria Fátima Lucas, Victor Guallar, Ric C H de Vos, Maurice C R Franssen, Alexander van der Krol, Harro Bouwmeester. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity. Nature communications. 2018 11; 9(1):4657. doi: 10.1038/s41467-018-06565-8. [PMID: 30405138]
  • Shu Dong, Li-Yan Ma, Yue-Tao Liu, Meng Yu, Hong-Mei Jia, Hong-Wu Zhang, Chang-Yuan Yu, Zhong-Mei Zou. Pharmacokinetics of costunolide and dehydrocostuslactone after oral administration of Radix aucklandiae extract in normal and gastric ulcer rats. Journal of Asian natural products research. 2018 Nov; 20(11):1055-1063. doi: 10.1080/10286020.2018.1489379. [PMID: 30130142]
  • Jingkun Liu, Min Xie, Xiuzhuang Li, Hui Jin, Xiaoyan Yang, Zhiqiang Yan, Anxiang Su, Bo Qin. Main Allelochemicals from the Rhizosphere Soil of Saussurea lappa (Decne.) Sch. Bip. and Their Effects on Plants' Antioxidase Systems. Molecules (Basel, Switzerland). 2018 Sep; 23(10):. doi: 10.3390/molecules23102506. [PMID: 30274332]
  • Bo-Kyung Lee, Soo-Jin Park, So-Yeon Nam, Saeromi Kang, Jin Hwang, Seung-Jin Lee, Dong-Soon Im. Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments. Journal of ethnopharmacology. 2018 Mar; 213(?):256-261. doi: 10.1016/j.jep.2017.11.018. [PMID: 29158156]
  • Siwattra Choodej, Khanitha Pudhom, Tohru Mitsunaga. Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues. Planta medica. 2018 Mar; 84(5):329-335. doi: 10.1055/s-0043-120115. [PMID: 28962049]
  • Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt. Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata. Journal of natural products. 2018 01; 81(1):124-130. doi: 10.1021/acs.jnatprod.7b00747. [PMID: 29244495]
  • Yanan Wang, Xu Zhang, Lilei Zhao, Mingyu Shi, Zhengkai Wei, Zhengtao Yang, Changming Guo, Yunhe Fu. Costunolide protects lipopolysaccharide/d-galactosamine-induced acute liver injury in mice by inhibiting NF-κB signaling pathway. The Journal of surgical research. 2017 12; 220(?):40-45. doi: 10.1016/j.jss.2017.06.083. [PMID: 29180209]
  • Antonio Cala, José M G Molinillo, Mónica Fernández-Aparicio, Jesús Ayuso, José A Álvarez, Diego Rubiales, Francisco A Macías. Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds. Organic & biomolecular chemistry. 2017 Aug; 15(31):6500-6510. doi: 10.1039/c7ob01394a. [PMID: 28745382]
  • Zhi Dai, Shi-Rong Li, Pei-Feng Zhu, Lu Liu, Bei Wang, Ya-Ping Liu, Xiao-Dong Luo, Xu-Dong Zhao. Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis. Bioorganic & medicinal chemistry letters. 2017 07; 27(13):2863-2867. doi: 10.1016/j.bmcl.2017.04.075. [PMID: 28487072]
  • Ch Pavan Kumar, A Devi, P Ashok Yadav, R Rao Vadaparthi, G Shankaraiah, P Sowjanya, Nishant Jain, K Suresh Babu. 'Click' reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity. Journal of Asian natural products research. 2016 Nov; 18(11):1063-78. doi: 10.1080/10286020.2016.1193012. [PMID: 27329166]
  • Eunchong Park, Ju Han Song, Myun Soo Kim, Su-Ho Park, Tae Sung Kim. Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4+ T cells through the modulation of mitogen-activated protein kinases. International immunopharmacology. 2016 Nov; 40(?):508-516. doi: 10.1016/j.intimp.2016.10.006. [PMID: 27756053]
  • Kun Cao, Wei Qian, Yi Xu, Zhen Zhou, Qing Zhang, Xiaofeng Zhang. A new sesquiterpenoid from Saussurea lappa roots. Natural product research. 2016 Oct; 30(19):2160-3. doi: 10.1080/14786419.2016.1149708. [PMID: 26956664]
  • Hong Zheng, Yuling Chen, Jingze Zhang, Lei Wang, Zhaoxiang Jin, Hanhan Huang, Shuli Man, Wenyuan Gao. Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation. Chemico-biological interactions. 2016 Apr; 250(?):68-77. doi: 10.1016/j.cbi.2016.03.003. [PMID: 26970604]
  • Zhong-Jin Yang, Wei-Zhi Ge, Qiu-Ying Li, Yaxin Lu, Jian-Miao Gong, Bei-Jia Kuang, Xiaonan Xi, Haiting Wu, Quan Zhang, Yue Chen. Syntheses and Biological Evaluation of Costunolide, Parthenolide, and Their Fluorinated Analogues. Journal of medicinal chemistry. 2015 Sep; 58(17):7007-20. doi: 10.1021/acs.jmedchem.5b00915. [PMID: 26226279]
  • Hye-Sun Lim, Sung-Eun Jin, Ohn-Soon Kim, Hyeun-Kyoo Shin, Soo-Jin Jeong. Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells. Phytotherapy research : PTR. 2015 Jul; 29(7):1088-96. doi: 10.1002/ptr.5354. [PMID: 25881570]
  • Hua Yin, Yi-Bin Zhuang, E-E Li, Hui-Ping Bi, Wei Zhou, Tao Liu. Heterologous biosynthesis of costunolide in Escherichia coli and yield improvement. Biotechnology letters. 2015 Jun; 37(6):1249-55. doi: 10.1007/s10529-015-1784-6. [PMID: 25700819]
  • Guang-Zhi Dong, Ah-Ram Shim, Jin Seong Hyeon, Hwa Jin Lee, Jae-Ha Ryu. Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. Phytotherapy research : PTR. 2015 May; 29(5):680-6. doi: 10.1002/ptr.5299. [PMID: 25625870]
  • Jing-ze Zhang, Lei Wang, Zhao-xiang Jin, Zhuo Qu, Yu-ling Chen, Wen-yuan Gao. [Pharmacokinetics study on costunolide and dehydrocostuslactone after administration of traditional Chinese medicine Weichang'an pills]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Mar; 40(6):1173-8. doi: . [PMID: 26226766]
  • Roula Tahtouh, Anne-Sophie Azzi, Nada Alaaeddine, Soulaima Chamat, Hasnaa Bouharoun-Tayoun, Layal Wardi, Issam Raad, Riad Sarkis, Najibe Abou Antoun, George Hilal. Telomerase inhibition decreases alpha-fetoprotein expression and secretion by hepatocellular carcinoma cell lines: in vitro and in vivo study. PloS one. 2015; 10(3):e0119512. doi: 10.1371/journal.pone.0119512. [PMID: 25822740]
  • Daisy Pitchai, Anita Roy, Sakhila Banu. In vitro and in silico evaluation of NF-κB targeted costunolide action on estrogen receptor-negative breast cancer cells--a comparison with normal breast cells. Phytotherapy research : PTR. 2014 Oct; 28(10):1499-505. doi: 10.1002/ptr.5155. [PMID: 24733523]
  • Zhangxiao Peng, Yan Wang, Xue Gu, Xiaojie Guo, Chao Yan. Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC-UV and UPLC-Q-TOF/MS. Biomedical chromatography : BMC. 2014 Oct; 28(10):1325-34. doi: 10.1002/bmc.3167. [PMID: 24889523]
  • Huimin Guo, Jingze Zhang, Wenyuan Gao, Zhuo Qu, Changxiao Liu. Gastrointestinal effect of methanol extract of Radix Aucklandiae and selected active substances on the transit activity of rat isolated intestinal strips. Pharmaceutical biology. 2014 Sep; 52(9):1141-9. doi: 10.3109/13880209.2013.879601. [PMID: 24649908]
  • Kaouthar Eljounaidi, Katarina Cankar, Cinzia Comino, Andrea Moglia, Alain Hehn, Frédéric Bourgaud, Harro Bouwmeester, Barbara Menin, Sergio Lanteri, Jules Beekwilder. Cytochrome P450s from Cynara cardunculus L. CYP71AV9 and CYP71BL5, catalyze distinct hydroxylations in the sesquiterpene lactone biosynthetic pathway. Plant science : an international journal of experimental plant biology. 2014 Jun; 223(?):59-68. doi: 10.1016/j.plantsci.2014.03.007. [PMID: 24767116]
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