Lactaldehyde (BioDeep_00000004424)

 

Secondary id: BioDeep_00000015564, BioDeep_00001869238, BioDeep_00001890475

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


alpha-Hydroxypropionaldehyde

化学式: C3H6O2 (74.0368)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 5.63%

分子结构信息

SMILES: CC(C=O)O
InChI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1

描述信息

L-lactaldehyde is an intermediate metabolite in the pyruvate metabolism pathway. L-lactaldehyde is irreversibly produced from pyruvaldehyde via the enzyme aldehyde reductase (EC:1.1.1.21) which is then irreversibly converted to propylene glycol via aldehyde reductase (EC:1.1.1.21). [HMDB]
L-lactaldehyde is an intermediate metabolite in the pyruvate metabolism pathway. L-lactaldehyde is irreversibly produced from pyruvaldehyde via the enzyme aldehyde reductase (EC:1.1.1.21) which is then irreversibly converted to propylene glycol via aldehyde reductase (EC:1.1.1.21).

同义名列表

12 个代谢物同义名

alpha-Hydroxypropionaldehyde; L-2-Hydroxypropionaldehyde; 2-Hydroxypropionaldehyde; (+-)-2-Hydroxypropanal; (2S)-2-Hydroxypropanal; Hydroxypropionaldehyde; 2-Hydroxypropanal; (S)-Lactaldehyde; L-Lactaldehyde; lactaldehyde; Lactaldehyde; (S)-Lactaldehyde



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(7)

PlantCyc(1)

代谢反应

211 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(82)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(102)

COVID-19 Disease Map(0)

PathBank(27)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 CDK1, CDK2, ERBB2, GAPDH, GLO1, HDAC1, HDAC2, HDAC3, HPGDS, PML, RYR1
Peripheral membrane protein 2 HSD17B6, PML
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 2 CDK1, PML
Nucleus 12 CDK1, CDK2, ERBB2, ERBB4, GAPDH, HDAC1, HDAC2, HDAC3, KDR, MPO, PML, SIN3A
cytosol 12 AKR1A1, CDK1, CDK2, ERBB2, ERBB4, FCSK, GAPDH, GLO1, HDAC1, HDAC3, HPGDS, PML
centrosome 2 CDK1, CDK2
nucleoplasm 12 CDK1, CDK2, ERBB2, ERBB4, GLO1, HDAC1, HDAC2, HDAC3, HPGDS, MPO, PML, SIN3A
Cell membrane 3 ERBB2, ERBB4, KDR
Cytoplasmic side 1 PML
ruffle membrane 1 ERBB2
Early endosome membrane 2 HSD17B6, PML
Multi-pass membrane protein 1 RYR1
Synapse 1 AKR1A1
cell cortex 1 RYR1
cell junction 2 AGER, KDR
cell surface 1 AGER
glutamatergic synapse 1 ERBB4
Golgi apparatus 2 HDAC3, KDR
neuromuscular junction 2 ERBB2, ERBB4
neuronal cell body 2 HDAC1, SERPINI1
postsynapse 1 AGER
presynaptic membrane 2 ERBB2, ERBB4
sarcolemma 1 RYR1
smooth endoplasmic reticulum 1 RYR1
Cytoplasm, cytosol 3 AKR1A1, GAPDH, HDAC3
Lysosome 1 MPO
endosome 2 CDK2, KDR
plasma membrane 8 AGER, ERBB2, ERBB4, GAPDH, GLO1, HDAC3, KDR, RYR1
Membrane 7 AGER, CDK1, ERBB2, ERBB4, GAPDH, HDAC2, RYR1
apical plasma membrane 3 AGER, AKR1A1, ERBB2
basolateral plasma membrane 2 ERBB2, ERBB4
extracellular exosome 7 AKR1A1, CDK1, GAPDH, GLO1, MPO, RYR1, SERPINI1
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, KDR
extracellular space 3 AKR1A1, MPO, SERPINI1
perinuclear region of cytoplasm 2 ERBB2, GAPDH
mitochondrion 2 CDK1, ERBB4
protein-containing complex 2 HDAC1, HDAC2
intracellular membrane-bounded organelle 4 GAPDH, HPGDS, HSD17B6, MPO
Microsome membrane 1 HSD17B6
ESC/E(Z) complex 1 HDAC2
Single-pass type I membrane protein 3 AGER, ERBB2, ERBB4
Secreted 1 SERPINI1
extracellular region 5 AGER, ERBB2, ERBB4, KDR, MPO
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 2 CDK1, ERBB4
Cytoplasmic vesicle lumen 1 SERPINI1
anchoring junction 1 KDR
transcription regulator complex 1 CDK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK1, CDK2
nuclear membrane 2 GAPDH, PML
external side of plasma membrane 1 KDR
perikaryon 1 SERPINI1
Z disc 1 RYR1
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 1 GAPDH
nucleolus 2 PML, SIN3A
midbody 1 CDK1
Early endosome 2 ERBB2, KDR
vesicle 1 GAPDH
postsynaptic membrane 1 ERBB4
Apical cell membrane 1 AKR1A1
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 2 ERBB2, GAPDH
heterochromatin 1 HDAC1
Membrane raft 1 KDR
Cytoplasm, cytoskeleton 1 GAPDH
GABA-ergic synapse 1 ERBB4
sarcoplasmic reticulum 1 RYR1
Nucleus, PML body 1 PML
PML body 1 PML
secretory granule 1 MPO
receptor complex 3 ERBB2, ERBB4, KDR
chromatin 4 HDAC1, HDAC2, HDAC3, SIN3A
mitotic spindle 2 CDK1, HDAC3
Chromosome 1 HDAC3
cytoskeleton 1 GAPDH
Nucleus, nucleolus 1 SIN3A
chromosome, telomeric region 4 CDK1, CDK2, HDAC2, PML
organelle membrane 1 RYR1
fibrillar center 1 AGER
nuclear envelope 1 CDK2
sorting endosome 1 KDR
Lipid droplet 1 GAPDH
I band 1 RYR1
myelin sheath 1 ERBB2
basal plasma membrane 2 ERBB2, ERBB4
azurophil granule 1 MPO
secretory granule lumen 1 SERPINI1
nuclear matrix 1 PML
transcription repressor complex 3 HDAC1, HDAC3, SIN3A
male germ cell nucleus 1 CDK2
kinetochore 1 SIN3A
histone deacetylase complex 4 HDAC1, HDAC2, HDAC3, SIN3A
azurophil granule lumen 1 MPO
Sarcoplasmic reticulum membrane 1 RYR1
NuRD complex 2 HDAC1, HDAC2
postsynaptic density membrane 1 ERBB4
semaphorin receptor complex 1 ERBB2
calcium channel complex 1 RYR1
junctional sarcoplasmic reticulum membrane 1 RYR1
phagocytic vesicle lumen 1 MPO
Cajal body 1 CDK2
ribonucleoprotein complex 1 GAPDH
Sin3-type complex 3 HDAC1, HDAC2, SIN3A
spindle microtubule 1 CDK1
[Isoform 1]: Cell membrane 2 AGER, ERBB2
condensed chromosome 1 CDK2
GAIT complex 1 GAPDH
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
terminal cisterna 1 RYR1
cyclin-dependent protein kinase holoenzyme complex 2 CDK1, CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
Cytoplasmic vesicle, secretory vesicle lumen 1 SERPINI1
ERBB3:ERBB2 complex 1 ERBB2
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
cyclin A2-CDK2 complex 1 CDK2
ryanodine receptor complex 1 RYR1
cyclin A1-CDK2 complex 1 CDK2
[Isoform 10]: Cell membrane 1 AGER
[ERBB4 intracellular domain]: Nucleus 1 ERBB4


文献列表

  • Shiori Fujimoto, Yoto Murakami, Haruna Miyake, Fumitaka Hayase, Hirohito Watanabe. Identification of a novel advanced glycation end product derived from lactaldehyde. Bioscience, biotechnology, and biochemistry. 2019 Jun; 83(6):1136-1145. doi: 10.1080/09168451.2019.1585745. [PMID: 30822216]
  • Constantina Nasopoulou, Johanna Pohjanen, Janne J Koskimäki, Ioannis Zabetakis, Anna Maria Pirttilä. Localization of strawberry (Fragaria x ananassa) and Methylobacterium extorquens genes of strawberry flavor biosynthesis in strawberry tissue by in situ hybridization. Journal of plant physiology. 2014 Aug; 171(13):1099-105. doi: 10.1016/j.jplph.2014.03.018. [PMID: 24973582]
  • S M TING, O N MILLER, O Z SELLINGER. THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER. Biochimica et biophysica acta. 1965 Mar; 97(?):407-15. doi: 10.1016/0304-4165(65)90151-0. [PMID: 14323585]