Lactucin (BioDeep_00000004307)

 

Secondary id: BioDeep_00000410905

human metabolite PANOMIX_OTCML-2023 Endogenous Volatile Flavor Compounds natural product


代谢物信息卡片


4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methylidene-2H,3H,3aH,4H,5H,7H,9aH,9bH-azuleno[4,5-b]furan-2,7-dione

化学式: C15H16O5 (276.0997686)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 29.89%

分子结构信息

SMILES: C=C1C(=O)OC2C3C(CO)=CC(=O)C3=C(C)CC(O)C12
InChI: InChI=1S/C15H16O5/c1-6-3-9(17)12-7(2)15(19)20-14(12)13-8(5-16)4-10(18)11(6)13/h4,9,12-14,16-17H,2-3,5H2,1H3

描述信息

Lactucin is found in chicory. Lactucin is a constituent of Cichorium intybus (chicory) Lactucin is a bitter substance that forms a white crystalline solid and belongs to the group of sesquiterpene lactones. It is found in some varieties of lettuce and is an ingredient of lactucarium. It has been shown to have analgesic and sedative properties
Constituent of Cichorium intybus (chicory)

同义名列表

4 个代谢物同义名

4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methylidene-2H,3H,3aH,4H,5H,7H,9aH,9bH-azuleno[4,5-b]furan-2,7-dione; 11beta,13-Dihydrolactucin; Lactucin; Lactucin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

116 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yejin Ahn, Hee Hwan Lee, Byung-Hak Kim, Sang Jae Park, Young Suk Kim, Hyung Joo Suh, Kyungae Jo. Heukharang lettuce (Lactuca sativa L.) leaf extract displays sleep-promoting effects through GABAA receptor. Journal of ethnopharmacology. 2023 May; ?(?):116602. doi: 10.1016/j.jep.2023.116602. [PMID: 37149068]
  • Khandaker Md Sharif Uddin Imam, Yu Tian, Fengjiao Xin, Yingying Xie, Boting Wen. Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217358. [PMID: 36364182]
  • Yilizere Aibaidula, Mutalifu Aimaiti, Huiwen Tan, Bingting Chen, Jian Yang, Xiaoli Ma. Lactucin & Lactucopicrin ameliorates FFA-induced steatosis in HepG2 cells via modulating lipid metabolism. Journal of pharmacological sciences. 2022 Oct; 150(2):110-122. doi: 10.1016/j.jphs.2022.07.007. [PMID: 36055749]
  • Klaudia Michalska, Janusz Malarz, Anna Stojakowska. Chemical constituents from Lactuca plumieri (L.) Gren. & Godr. (Asteraceae). Natural product research. 2022 Oct; 36(20):5337-5341. doi: 10.1080/14786419.2021.1920583. [PMID: 33969755]
  • Carlos J García, David Beltrán, Francisco A Tomás-Barberán. Human Gut Microbiota Metabolism of Dietary Sesquiterpene Lactones: Untargeted Metabolomics Study of Lactucopicrin and Lactucin Conversion In Vitro and In Vivo. Molecular nutrition & food research. 2020 11; 64(21):e2000619. doi: 10.1002/mnfr.202000619. [PMID: 32970341]
  • Xin Wang, Min Liu, Guo He Cai, Yan Chen, Xiao Chen Shi, Cong Cong Zhang, Bo Xia, Bao Cai Xie, Huan Liu, Rui Xin Zhang, Jun Feng Lu, Meng Qing Zhu, Shi Zhen Yang, Xin Yi Chu, Dan Yang Zhang, Yong Liang Wang, Jiang Wei Wu. A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion. Cells. 2020 01; 9(2):. doi: 10.3390/cells9020331. [PMID: 32023857]
  • Hyo-Won Kim, Hyung Joo Suh, Hyeon-Son Choi, Ki-Bae Hong, Kyungae Jo. Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (Lactuca sativa) in a Rodent Model. Biological & pharmaceutical bulletin. 2019; 42(10):1726-1732. doi: 10.1248/bpb.b19-00454. [PMID: 31582660]
  • Victoria C Wilkinson-Smith, Giles Major, Lucy Ashleigh, Kathryn Murray, Caroline L Hoad, Luca Marciani, Penny A Gowland, Robin C Spiller. Insights Into the Different Effects of Food on Intestinal Secretion Using Magnetic Resonance Imaging. JPEN. Journal of parenteral and enteral nutrition. 2018 11; 42(8):1342-1348. doi: 10.1002/jpen.1157. [PMID: 29603286]
  • Martin Krøyer Rasmussen, Christina Lindgaard Klausen, Bo Ekstrand. Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.). Food chemistry. 2014 Mar; 146(?):255-63. doi: 10.1016/j.foodchem.2013.09.068. [PMID: 24176340]
  • A Wesołowska, A Nikiforuk, K Michalska, W Kisiel, E Chojnacka-Wójcik. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. Journal of ethnopharmacology. 2006 Sep; 107(2):254-8. doi: 10.1016/j.jep.2006.03.003. [PMID: 16621374]
  • G SCHENCK, H LOTH, W REUBERT. [Research on the preparation of lactucin and lactucopicrin from Lactuca virosa plants. 15. On the enzymatic and non-enzymatic oxidation of therapeutically active plant substances]. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. 1961 Jan; 294/66(?):17-24. doi: 10.1002/ardp.19612940105. [PMID: 13747469]