Lactucin (BioDeep_00000004307)

 

Secondary id: BioDeep_00000410905

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methylidene-2H,3H,3aH,4H,5H,7H,9aH,9bH-azuleno[4,5-b]furan-2,7-dione

化学式: C15H16O5 (276.0998)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 30.14%

分子结构信息

SMILES: C=C1C(=O)OC2C3C(CO)=CC(=O)C3=C(C)CC(O)C12
InChI: InChI=1S/C15H16O5/c1-6-3-9(17)12-7(2)15(19)20-14(12)13-8(5-16)4-10(18)11(6)13/h4,9,12-14,16-17H,2-3,5H2,1H3

描述信息

Lactucin is found in chicory. Lactucin is a constituent of Cichorium intybus (chicory) Lactucin is a bitter substance that forms a white crystalline solid and belongs to the group of sesquiterpene lactones. It is found in some varieties of lettuce and is an ingredient of lactucarium. It has been shown to have analgesic and sedative properties
Constituent of Cichorium intybus (chicory)

同义名列表

4 个代谢物同义名

4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methylidene-2H,3H,3aH,4H,5H,7H,9aH,9bH-azuleno[4,5-b]furan-2,7-dione; 11beta,13-Dihydrolactucin; Lactucin; Lactucin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

116 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADAM17, ADIG, AIMP2, BCL2, CFLAR, JAK2, LDHA, PKM, PTEN, PTGS2, SQSTM1, STAT3
Peripheral membrane protein 4 ACHE, CYP1B1, JAK2, PTGS2
Endoplasmic reticulum membrane 3 BCL2, CYP1B1, PTGS2
Cytoplasmic vesicle, autophagosome 1 SQSTM1
Nucleus 11 ACHE, ADIG, AIMP2, BCL2, JAK2, LDHA, MYB, PKM, PTEN, SQSTM1, STAT3
autophagosome 1 SQSTM1
cytosol 12 ADAM17, AIMP2, BCL2, CFLAR, JAK2, KRT83, LDHA, MYB, PKM, PTEN, SQSTM1, STAT3
dendrite 1 HTR1A
nucleoplasm 5 JAK2, MYB, PTEN, SQSTM1, STAT3
RNA polymerase II transcription regulator complex 2 MYB, STAT3
Cell membrane 3 ACHE, ADAM17, HTR1A
Multi-pass membrane protein 1 HTR1A
Synapse 2 ACHE, HTR1A
cell surface 2 ACHE, ADAM17
glutamatergic synapse 2 JAK2, SQSTM1
Golgi apparatus 1 ACHE
Golgi membrane 1 ADAM17
mitochondrial inner membrane 1 HADHA
neuromuscular junction 1 ACHE
postsynapse 1 JAK2
Cytoplasm, cytosol 2 AIMP2, SQSTM1
Lysosome 1 SQSTM1
plasma membrane 6 ACHE, ADAM17, HTR1A, JAK2, PTEN, STAT3
Membrane 9 ACHE, ADAM17, ADIG, AIMP2, BCL2, CYP1B1, JAK2, LDHA, MYB
apical plasma membrane 2 ADAM17, PTEN
caveola 2 JAK2, PTGS2
extracellular exosome 3 LDHA, PKM, SQSTM1
endoplasmic reticulum 3 BCL2, PTGS2, SQSTM1
extracellular space 2 ACHE, KRT83
perinuclear region of cytoplasm 1 ACHE
mitochondrion 6 BCL2, CYP1B1, HADHA, LDHA, PKM, SQSTM1
protein-containing complex 2 BCL2, PTGS2
intracellular membrane-bounded organelle 2 CYP1B1, SQSTM1
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 PTEN
Single-pass type I membrane protein 1 ADAM17
Secreted 2 ACHE, ADIG
extracellular region 5 ACHE, ADIG, MLN, PKM, PTEN
cytoplasmic side of plasma membrane 2 JAK2, PTEN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 3 ADIG, BCL2, MLN
mitochondrial outer membrane 1 BCL2
Extracellular side 1 ACHE
transcription regulator complex 1 STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Extracellular vesicle 1 PKM
actin cytoskeleton 1 ADAM17
dendritic spine 1 PTEN
cytoplasmic vesicle 1 SQSTM1
P-body 1 SQSTM1
vesicle 1 PKM
Mitochondrion inner membrane 1 HADHA
Membrane raft 2 ADAM17, JAK2
pore complex 1 BCL2
focal adhesion 1 JAK2
mitochondrial nucleoid 1 HADHA
basement membrane 1 ACHE
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 2 PTEN, SQSTM1
PML body 2 PTEN, SQSTM1
collagen-containing extracellular matrix 1 PKM
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cytoplasm, myofibril, sarcomere 1 SQSTM1
Late endosome 1 SQSTM1
sarcomere 1 SQSTM1
Cell projection, neuron projection 1 PTEN
neuron projection 2 PTEN, PTGS2
cilium 1 PKM
chromatin 1 STAT3
cell projection 1 PTEN
cytoskeleton 1 JAK2
sperm midpiece 1 SQSTM1
Lipid-anchor, GPI-anchor 1 ACHE
Endomembrane system 1 JAK2
endosome lumen 1 JAK2
Lipid droplet 1 ADIG
phagophore assembly site 1 SQSTM1
Cell projection, dendrite 1 HTR1A
euchromatin 1 JAK2
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 1 PKM
endoplasmic reticulum lumen 2 ADAM17, PTGS2
nuclear matrix 1 MYB
Schmidt-Lanterman incisure 1 PTEN
Sarcoplasmic reticulum membrane 1 MLN
mitochondrial fatty acid beta-oxidation multienzyme complex 1 HADHA
aggresome 1 SQSTM1
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
synaptic cleft 1 ACHE
CD95 death-inducing signaling complex 1 CFLAR
death-inducing signaling complex 1 CFLAR
ripoptosome 1 CFLAR
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
intracellular non-membrane-bounded organelle 1 SQSTM1
Rough endoplasmic reticulum 1 PKM
keratin filament 1 KRT83
Lewy body 1 SQSTM1
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
Preautophagosomal structure 1 SQSTM1
oxidoreductase complex 1 LDHA
Autolysosome 1 SQSTM1
inclusion body 1 SQSTM1
myelin sheath adaxonal region 1 PTEN
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[Isoform H]: Cell membrane 1 ACHE
amphisome 1 SQSTM1


文献列表

  • Yejin Ahn, Hee Hwan Lee, Byung-Hak Kim, Sang Jae Park, Young Suk Kim, Hyung Joo Suh, Kyungae Jo. Heukharang lettuce (Lactuca sativa L.) leaf extract displays sleep-promoting effects through GABAA receptor. Journal of ethnopharmacology. 2023 May; ?(?):116602. doi: 10.1016/j.jep.2023.116602. [PMID: 37149068]
  • Khandaker Md Sharif Uddin Imam, Yu Tian, Fengjiao Xin, Yingying Xie, Boting Wen. Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217358. [PMID: 36364182]
  • Yilizere Aibaidula, Mutalifu Aimaiti, Huiwen Tan, Bingting Chen, Jian Yang, Xiaoli Ma. Lactucin & Lactucopicrin ameliorates FFA-induced steatosis in HepG2 cells via modulating lipid metabolism. Journal of pharmacological sciences. 2022 Oct; 150(2):110-122. doi: 10.1016/j.jphs.2022.07.007. [PMID: 36055749]
  • Klaudia Michalska, Janusz Malarz, Anna Stojakowska. Chemical constituents from Lactuca plumieri (L.) Gren. & Godr. (Asteraceae). Natural product research. 2022 Oct; 36(20):5337-5341. doi: 10.1080/14786419.2021.1920583. [PMID: 33969755]
  • Carlos J García, David Beltrán, Francisco A Tomás-Barberán. Human Gut Microbiota Metabolism of Dietary Sesquiterpene Lactones: Untargeted Metabolomics Study of Lactucopicrin and Lactucin Conversion In Vitro and In Vivo. Molecular nutrition & food research. 2020 11; 64(21):e2000619. doi: 10.1002/mnfr.202000619. [PMID: 32970341]
  • Xin Wang, Min Liu, Guo He Cai, Yan Chen, Xiao Chen Shi, Cong Cong Zhang, Bo Xia, Bao Cai Xie, Huan Liu, Rui Xin Zhang, Jun Feng Lu, Meng Qing Zhu, Shi Zhen Yang, Xin Yi Chu, Dan Yang Zhang, Yong Liang Wang, Jiang Wei Wu. A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion. Cells. 2020 01; 9(2):. doi: 10.3390/cells9020331. [PMID: 32023857]
  • Hyo-Won Kim, Hyung Joo Suh, Hyeon-Son Choi, Ki-Bae Hong, Kyungae Jo. Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (Lactuca sativa) in a Rodent Model. Biological & pharmaceutical bulletin. 2019; 42(10):1726-1732. doi: 10.1248/bpb.b19-00454. [PMID: 31582660]
  • Victoria C Wilkinson-Smith, Giles Major, Lucy Ashleigh, Kathryn Murray, Caroline L Hoad, Luca Marciani, Penny A Gowland, Robin C Spiller. Insights Into the Different Effects of Food on Intestinal Secretion Using Magnetic Resonance Imaging. JPEN. Journal of parenteral and enteral nutrition. 2018 11; 42(8):1342-1348. doi: 10.1002/jpen.1157. [PMID: 29603286]
  • Martin Krøyer Rasmussen, Christina Lindgaard Klausen, Bo Ekstrand. Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.). Food chemistry. 2014 Mar; 146(?):255-63. doi: 10.1016/j.foodchem.2013.09.068. [PMID: 24176340]
  • A Wesołowska, A Nikiforuk, K Michalska, W Kisiel, E Chojnacka-Wójcik. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. Journal of ethnopharmacology. 2006 Sep; 107(2):254-8. doi: 10.1016/j.jep.2006.03.003. [PMID: 16621374]
  • G SCHENCK, H LOTH, W REUBERT. [Research on the preparation of lactucin and lactucopicrin from Lactuca virosa plants. 15. On the enzymatic and non-enzymatic oxidation of therapeutically active plant substances]. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. 1961 Jan; 294/66(?):17-24. doi: 10.1002/ardp.19612940105. [PMID: 13747469]