Taxol (BioDeep_00000411036)

Main id: BioDeep_00000001632

 

PANOMIX_OTCML-2023


代谢物信息卡片


Paclitaxel

化学式: C47H51NO14 (853.3309386)
中文名称: 紫杉醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CD - Taxanes
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2310
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2].
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2].

同义名列表

2 个代谢物同义名

Paclitaxel; Taxol



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

43 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Emine Toraman, Büşra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacımüftüoğlu. Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue. Chemico-biological interactions. 2023 Nov; ?(?):110793. doi: 10.1016/j.cbi.2023.110793. [PMID: 37949423]
  • Meng Li, Xianlan She, Yufei Ou, Jiangxin Liu, Zaifeng Yuan, Qin-Shi Zhao. Design, synthesis and biological evaluation of a new class of Hsp90 inhibitors vibsanin C derivatives. European journal of medicinal chemistry. 2022 Dec; 244(?):114844. doi: 10.1016/j.ejmech.2022.114844. [PMID: 36274275]
  • Cihan Gur, Fatih Mehmet Kandemir, Cuneyt Caglayan, Emine Satıcı. Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways. Chemico-biological interactions. 2022 Sep; 365(?):110073. doi: 10.1016/j.cbi.2022.110073. [PMID: 35921949]
  • Feng Xiong, Lingmei Kong, Liang Chen, Minggao Xue, Feng Cao, Shuqun Zhang, Hongmei Li, Hui Yan, Yan Li, Zhili Zuo. Discovery of potential novel CRBN modulators by virtual screening and bioassay. European journal of medicinal chemistry. 2022 Jun; 236(?):114355. doi: 10.1016/j.ejmech.2022.114355. [PMID: 35413617]
  • Chen Chen, Yang Luo, Honglu Yin, Qiu Zhong, Shilong Zheng, Rui Liu, Chong Zhao, Guangdi Wang, Ling He. Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones. Bioorganic & medicinal chemistry. 2022 04; 60(?):116626. doi: 10.1016/j.bmc.2022.116626. [PMID: 35255412]
  • Hongwei Han, Cong He, Xingyu Chen, Yuelin Luo, Minkai Yang, Zhongling Wen, Jiabao Hu, Faxiang Lin, Mi Han, Tongming Yin, Rongwu Yang, Hongyan Lin, Jinliang Qi, Yonghua Yang. Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines. Bioorganic & medicinal chemistry letters. 2022 02; 57(?):128503. doi: 10.1016/j.bmcl.2021.128503. [PMID: 34922028]
  • Xuan-Ming Guo, Maruti Balaso Yadav, Mahjabin Khan, Chao-Wei Hao, Cheng-Yuan Lin, Tao Huang, Jiang Wu, Bao-Min Fan, Zhao-Xiang Bian. Bradykinin-Potentiating Peptide-Paclitaxel Conjugate Directed at Ectopically Expressed Angiotensin-Converting Enzyme in Triple-Negative Breast Cancer. Journal of medicinal chemistry. 2021 12; 64(23):17051-17062. doi: 10.1021/acs.jmedchem.1c00705. [PMID: 34699215]
  • Xiaosu Zou, Chang Liu, Congcong Li, Rong Fu, Wei Xu, Hongzhu Bian, Xun Dong, Xiaozhen Zhao, Zhenye Xu, Jinghua Zhang, Zhengwu Shen. Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents. European journal of medicinal chemistry. 2021 Dec; 225(?):113754. doi: 10.1016/j.ejmech.2021.113754. [PMID: 34399390]
  • Li Yin, Zeping Fan, Peng Liu, Lanying Chen, Ziyi Guan, Yahui Liu, Yingying Luo. Anemoside A3 activates TLR4-dependent M1-phenotype macrophage polarization to represses breast tumor growth and angiogenesis. Toxicology and applied pharmacology. 2021 12; 432(?):115755. doi: 10.1016/j.taap.2021.115755. [PMID: 34673087]
  • Xiao-Min Su, Qian Liang, Jia-Xin Hu, Xin-Min Zhang, Rong-Lin Jia, Wen-Hui Xu. Diterpenoids from the whole plants of Croton yunnanensis and their bioactivities. Bioorganic & medicinal chemistry. 2021 12; 51(?):116495. doi: 10.1016/j.bmc.2021.116495. [PMID: 34781083]
  • Khor Poh Yen, Johnson Stanslas, Tianshu Zhang, Hongyuan Li, Xiaohui Wang, Chan Kok Meng, Lam Kok Wai. Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines. Bioorganic & medicinal chemistry. 2021 11; 49(?):116442. doi: 10.1016/j.bmc.2021.116442. [PMID: 34600241]
  • Shuo Yuan, Bo Wang, Qing-Qing Dai, Xiao-Nan Zhang, Jing-Ya Zhang, Jia-Hui Zuo, Hui Liu, Zhe-Sheng Chen, Guo-Bo Li, Shaomeng Wang, Hong-Min Liu, Bin Yu. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. Journal of medicinal chemistry. 2021 10; 64(19):14895-14911. doi: 10.1021/acs.jmedchem.1c01452. [PMID: 34546748]
  • Kun Wang, Hui Zhong, Na Li, Nairong Yu, Yujin Wang, Li Chen, Jianbo Sun. Discovery of Novel Anti-Breast-Cancer Inhibitors by Synergistically Antagonizing Microtubule Polymerization and Aryl Hydrocarbon Receptor Expression. Journal of medicinal chemistry. 2021 09; 64(17):12964-12977. doi: 10.1021/acs.jmedchem.1c01099. [PMID: 34428056]
  • Bin Li, Yi Kuang, Yang Yi, Xue Qiao, Lei Liang, Min Ye. Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities. Bioorganic & medicinal chemistry letters. 2021 07; 43(?):128066. doi: 10.1016/j.bmcl.2021.128066. [PMID: 33915258]
  • Qianqian Qiu, Feng Zou, Huilan Li, Wei Shi, Daoguang Zhou, Ping Zhang, Teng Li, Ziyu Yin, Zilong Cai, Yuxuan Jiang, Wenlong Huang, Hai Qian. Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance. Journal of medicinal chemistry. 2021 05; 64(9):6179-6197. doi: 10.1021/acs.jmedchem.1c00246. [PMID: 33938746]
  • Elvis Otogo N'Nang, Pierre Le Pogam, Thiery Ndong Mba, Cédric Sima Obiang, Elisabeth Mouray, Philippe Grellier, Brice Kumulungui, Pierre Champy, Mehdi A Beniddir. Targeted Isolation of Hemitheion from Mostuea brunonis, a Proposed Biosynthetic Intermediate of Theionbrunonines. Journal of natural products. 2021 04; 84(4):1409-1413. doi: 10.1021/acs.jnatprod.1c00143. [PMID: 33825474]
  • Nham-Linh Nguyen, Thanh-Hoa Vo, Yu-Chi Lin, Chia-Ching Liaw, Mei-Kuang Lu, Jing-Jy Cheng, Mei-Chuan Chen, Yao-Haur Kuo. Arenarosides A-G, Polyhydroxylated Oleanane-Type Saponins from Polycarpaea arenaria and their Cytotoxic and Antiangiogenic Activities. Journal of natural products. 2021 02; 84(2):259-267. doi: 10.1021/acs.jnatprod.0c00919. [PMID: 33459007]
  • Minhao Huang, Yongjun Huang, Jing Guo, Lei Yu, Yu Chang, Xiaolu Wang, Jinfeng Luo, Yanhui Huang, Zhengchao Tu, Xiaoyun Lu, Yong Xu, Zhimin Zhang, Zhang Zhang, Ke Ding. Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors. European journal of medicinal chemistry. 2021 Feb; 211(?):113023. doi: 10.1016/j.ejmech.2020.113023. [PMID: 33248853]
  • Zhi Dai, Hui Liu, Bei Wang, Dong Yang, Yan-Yan Zhu, Huan Yan, Pei-Feng Zhu, Ya-Ping Liu, Hui-Cheng Chen, Yun-Li Zhao, Li-Xing Zhao, Xu-Dong Zhao, Hai-Yang Liu, Xiao-Dong Luo. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A. European journal of medicinal chemistry. 2021 Jan; 210(?):113068. doi: 10.1016/j.ejmech.2020.113068. [PMID: 33310292]
  • Ying-Jie Cui, Chao Liu, Chen-Chen Ma, Ya-Ting Ji, Yi-Li Yao, Long-Qian Tang, Cheng-Mei Zhang, Jing-De Wu, Zhao-Peng Liu. SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors. Journal of medicinal chemistry. 2020 12; 63(23):14840-14866. doi: 10.1021/acs.jmedchem.0c01345. [PMID: 33201714]
  • Abdul Rahim, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, Masuo Goto, Chin-Ho Chen, Gemini Alam, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto. Paliasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14-oxabicyclo[3.2.1]octane Unit from Melochia umbellata var. deglabrata. Journal of natural products. 2020 10; 83(10):2931-2939. doi: 10.1021/acs.jnatprod.0c00454. [PMID: 32946697]
  • Jian Song, Qiu-Lei Gao, Bo-Wen Wu, Ting Zhu, Xin-Xin Cui, Cheng-Jun Jin, Shu-Yu Wang, Sheng-Hui Wang, Dong-Jun Fu, Hong-Min Liu, Sai-Yang Zhang, Yan-Bing Zhang, Yong-Chun Li. Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway. European journal of medicinal chemistry. 2020 Oct; 203(?):112618. doi: 10.1016/j.ejmech.2020.112618. [PMID: 32682200]
  • Hao Li, Yu-Ru Liang, Shao-Xin Chen, Wen-Xuan Wang, Yike Zou, Selbi Nuryyeva, K N Houk, Juan Xiong, Jin-Feng Hu. Amentotaxins C-V, Structurally Diverse Diterpenoids from the Leaves and Twigs of the Vulnerable Conifer Amentotaxus argotaenia and Their Cytotoxic Effects. Journal of natural products. 2020 07; 83(7):2129-2144. doi: 10.1021/acs.jnatprod.0c00064. [PMID: 32633512]
  • Yongle Du, Brooke A Martin, Ana Lisa Valenciano, Jason A Clement, Michael Goetz, Maria B Cassera, David G I Kingston. Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis. Journal of natural products. 2020 04; 83(4):1043-1050. doi: 10.1021/acs.jnatprod.9b01064. [PMID: 32227943]
  • Mai T T Nguyen, Khang D H Nguyen, Phu H Dang, Hai X Nguyen, Suresh Awale, Nhan T Nguyen. Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity. Journal of natural products. 2020 02; 83(2):385-391. doi: 10.1021/acs.jnatprod.9b00875. [PMID: 31967821]
  • Yulin Ren, Qingwei Tan, Kimberly Heath, Sijin Wu, James R Wilson, Jinhong Ren, Pratik Shriwas, Chunhua Yuan, Tran Ngoc Ninh, Hee-Byung Chai, Xiaozhuo Chen, Djaja D Soejarto, Michael E Johnson, Xiaolin Cheng, Joanna E Burdette, A Douglas Kinghorn. Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper. Bioorganic & medicinal chemistry. 2020 02; 28(4):115301. doi: 10.1016/j.bmc.2019.115301. [PMID: 31953129]
  • Haoquan He, Zheng Liu, Wei Wang, Xiaojian Jiang. Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones. Bioorganic & medicinal chemistry. 2020 02; 28(3):115281. doi: 10.1016/j.bmc.2019.115281. [PMID: 31889606]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Zhi Xu, Shi-Jia Zhao, Yi Liu. 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. European journal of medicinal chemistry. 2019 Dec; 183(?):111700. doi: 10.1016/j.ejmech.2019.111700. [PMID: 31546197]
  • Wen-Xue Sun, Hong-Wei Han, Min-Kai Yang, Zhong-Ling Wen, Yin-Song Wang, Jiang-Yan Fu, Yun-Ting Lu, Ming-Yue Wang, Jia-Xin Bao, Gui-Hua Lu, Jin-Liang Qi, Xiao-Ming Wang, Hong-Yan Lin, Yong-Hua Yang. Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR. Bioorganic & medicinal chemistry. 2019 12; 27(23):115153. doi: 10.1016/j.bmc.2019.115153. [PMID: 31648877]
  • Liang-Liang Wang, Lingmei Kong, Hui Liu, Yunqin Zhang, Li Zhang, Xingyong Liu, Feng Yuan, Yan Li, Zhili Zuo. Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo. European journal of medicinal chemistry. 2019 Nov; 182(?):111665. doi: 10.1016/j.ejmech.2019.111665. [PMID: 31494469]
  • Longfei Zhang, Zhi Xu. Coumarin-containing hybrids and their anticancer activities. European journal of medicinal chemistry. 2019 Nov; 181(?):111587. doi: 10.1016/j.ejmech.2019.111587. [PMID: 31404864]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yue-Xun Tang, Wen-Wei Fu, Zhi-Chao Xi, Jin-Ling Yang, Chang-Wu Zheng, Yue Lu, Zhen-Wu Shen, Hong-Xi Xu. Xanthone derivatives from the leaves of Garcinia oligantha. European journal of medicinal chemistry. 2019 Nov; 181(?):111536. doi: 10.1016/j.ejmech.2019.07.039. [PMID: 31376561]
  • Katsunori Miyake, Chihiro Morita, Airi Suzuki, Natsuko Matsushita, Yohei Saito, Masuo Goto, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto. Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis. Journal of natural products. 2019 10; 82(10):2852-2858. doi: 10.1021/acs.jnatprod.9b00596. [PMID: 31550158]
  • Chenyin Wang, Laura Engelke, David Bickel, Alexandra Hamacher, Marian Frank, Peter Proksch, Holger Gohlke, Matthias U Kassack. The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. Bioorganic & medicinal chemistry. 2019 10; 27(19):115044. doi: 10.1016/j.bmc.2019.115044. [PMID: 31443950]
  • Xin He, Yongjiang Wang, Rong-Hua Luo, Liu-Meng Yang, Li Wang, Dale Guo, Jing Yang, Yun Deng, Yong-Tang Zheng, Sheng-Xiong Huang. Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces. Journal of natural products. 2019 07; 82(7):1813-1819. doi: 10.1021/acs.jnatprod.9b00022. [PMID: 31310115]
  • Zhen Liu, Jing-Yi Zhao, Sen-Feng Sun, Yong Li, Jing Qu, Hai-Tao Liu, Yun-Bao Liu. Sesquiterpenes from an Endophytic Aspergillus flavus. Journal of natural products. 2019 05; 82(5):1063-1071. doi: 10.1021/acs.jnatprod.8b01084. [PMID: 31050424]
  • Sebastián J Castro, Carina N Casero, José M Padrón, Viviana E Nicotra. Selective Antiproliferative Withanolides from Species in the Genera Eriolarynx and Deprea. Journal of natural products. 2019 05; 82(5):1338-1344. doi: 10.1021/acs.jnatprod.9b00117. [PMID: 31070367]
  • Xin-Wen Zhang, Shao-Qiang Fan, Fan Xia, Yan-Song Ye, Xing-Wei Yang, Xian-Wen Yang, Gang Xu. Prenylated Acylphloroglucinols from Hypericum faberi. Journal of natural products. 2019 05; 82(5):1367-1371. doi: 10.1021/acs.jnatprod.8b01006. [PMID: 31042380]
  • Xiaodong Ma, Jun Wei, Chang Wang, Dongyan Gu, Yongzhou Hu, Rong Sheng. Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies. European journal of medicinal chemistry. 2019 May; 170(?):112-125. doi: 10.1016/j.ejmech.2019.03.005. [PMID: 30878826]
  • María Goretti Arvizu-Espinosa, Gilsane Lino von Poser, Amelia Teresinha Henriques, Aniceto Mendoza-Ruiz, Anaberta Cardador-Martínez, Reinier Gesto-Borroto, Pablo Noé Núñez-Aragón, María Luisa Villarreal-Ortega, Ashutosh Sharma, Alexandre Cardoso-Taketa. Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum. Journal of natural products. 2019 04; 82(4):785-791. doi: 10.1021/acs.jnatprod.8b00677. [PMID: 30920216]
  • Guogang Deng, Bei Zhou, Jing Wang, Zhuo Chen, Liang Gong, Yaxiao Gong, Dongmei Wu, Yan Li, Hongbin Zhang, Xiaodong Yang. Synthesis and antitumor activity of novel steroidal imidazolium salt derivatives. European journal of medicinal chemistry. 2019 Apr; 168(?):232-252. doi: 10.1016/j.ejmech.2019.02.025. [PMID: 30822712]
  • Rolly G Fuentes, Kirk C Pearce, Yongle Du, Andriamalala Rakotondrafara, Ana L Valenciano, Maria B Cassera, Vincent E Rasamison, T Daniel Crawford, David G I Kingston. Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities. Journal of natural products. 2019 03; 82(3):431-439. doi: 10.1021/acs.jnatprod.8b00379. [PMID: 30354100]
  • Bang-Jau You, Li-Yun Chen, Po-Hsiang Hsu, Pei-Hsuan Sung, Yu-Ching Hung, Hong-Zin Lee. Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells. Chemical research in toxicology. 2019 02; 32(2):255-264. doi: 10.1021/acs.chemrestox.8b00269. [PMID: 30667213]
  • Xin-Ya Xu, Siu Wai Tsang, Yi-Fu Guan, Kang-Lun Liu, Wen-Hui Pan, Chu Shing Lam, Kwan Ming Lee, Yi-Xuan Xia, Wen-Jian Xie, Wing Yan Wong, Magnolia Muk Lan Lee, William Chi Shing Tai, Hong-Jie Zhang. In Vitro and in Vivo Antitumor Effects of Plant-Derived Miliusanes and Their Induction of Cellular Senescence. Journal of medicinal chemistry. 2019 02; 62(3):1541-1561. doi: 10.1021/acs.jmedchem.8b01742. [PMID: 30633861]
  • Ya-Liang Zhang, Bo-Yan Li, Rong Yang, Lin-Ying Xia, A-Li Fan, Yi-Chun Chu, Lin-Jian Wang, Zhong-Chang Wang, Ai-Qin Jiang, Hai-Liang Zhu. A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe. European journal of medicinal chemistry. 2019 Feb; 163(?):896-910. doi: 10.1016/j.ejmech.2018.12.030. [PMID: 30580241]
  • Chao-Wu Yu, Pei-Yun Hung, Hui-Ting Yang, Yi-Hsun Ho, Hsing-Yi Lai, Yi-Sheng Cheng, Ji-Wang Chern. Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer. Journal of medicinal chemistry. 2019 01; 62(2):857-874. doi: 10.1021/acs.jmedchem.8b01590. [PMID: 30525585]
  • Ling Feng, Yu Zhang, Yan-Chun Liu, Yan Liu, Shi-Hong Luo, Chun-Shuai Huang, Sheng-Hong Li. Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. Bioorganic & medicinal chemistry. 2019 01; 27(2):442-446. doi: 10.1016/j.bmc.2018.12.023. [PMID: 30579802]
  • Cheng Shang See, Mayumi Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine Wong, Sang Hyun Lee, Brian W Dymock. Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer. Bioorganic & medicinal chemistry letters. 2019 01; 29(2):216-219. doi: 10.1016/j.bmcl.2018.11.053. [PMID: 30503634]
  • Ploypat Niyomploy, Lai Yue Chan, Peta J Harvey, Aaron G Poth, Michelle L Colgrave, David J Craik. Discovery and Characterization of Cyclotides from Rinorea Species. Journal of natural products. 2018 11; 81(11):2512-2520. doi: 10.1021/acs.jnatprod.8b00572. [PMID: 30387611]
  • Ye Ye, Drolma Dawa, Guang-Hui Liu, Min Zhao, Dorje Tseden, Yu-Cheng Gu, Li-Sheng Ding, Zhi-Xing Cao, Yan Zhou. Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons. Journal of natural products. 2018 09; 81(9):1992-2003. doi: 10.1021/acs.jnatprod.8b00197. [PMID: 30212198]
  • Misa Takeuchi, Yohei Saito, Masuo Goto, Katsunori Miyake, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. Journal of natural products. 2018 08; 81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411. [PMID: 30106296]
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