4-Aminosalicylic acid (BioDeep_00000409330)

Main id: BioDeep_00000001699

 


代谢物信息卡片


4-Aminosalicylic acid

化学式: C7H7NO3 (153.0425912)
中文名称: 对氨基水杨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1N)O)C(=O)O
InChI: InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

描述信息

J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AA - Aminosalicylic acid and derivatives
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; WUBBRNOQWQTFEX-UHFFFAOYSA-N_STSL_0188_4-Aminosalicylic Acid_0125fmol_180831_S2_L02M02_81; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.

同义名列表

1 个代谢物同义名

4-Aminosalicylic acid



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Xiaocui Wu, Guangkun Tan, Wei Sha, Haican Liu, Jinghui Yang, Yinjuan Guo, Xin Shen, Zheyuan Wu, Hongbo Shen, Fangyou Yu. Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures. Microbiology spectrum. 2022 04; 10(2):e0251621. doi: 10.1128/spectrum.02516-21. [PMID: 35311541]
  • Md Masud Parvez, Said Kalkisim, Phuong Thi Thu Nguyen, Jin Ah Jung, Jeong-Kon Park, Jong-Lyul Ghim, Eun-Young Kim, Yong-Soon Cho, Melih O Babaoglu, Jae-Gook Shin. Para-aminosalicylic acid significantly reduced tenofovir exposure in human subjects: Mismatched findings from in vitro to in vivo translational research. British journal of clinical pharmacology. 2022 03; 88(3):1159-1169. doi: 10.1111/bcp.15056. [PMID: 34432302]
  • Denny L Cottle, Gloria M A Ursino, Lynelle K Jones, Ming Shen Tham, Allara K Zylberberg, Ian M Smyth. Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis. Cell reports. Medicine. 2020 11; 1(8):100129. doi: 10.1016/j.xcrm.2020.100129. [PMID: 33294854]
  • Ahmed A Abulfathi, Peter R Donald, Kim Adams, Elin M Svensson, Andreas H Diacon, Helmuth Reuter. The pharmacokinetics of para-aminosalicylic acid and its relationship to efficacy and intolerance. British journal of clinical pharmacology. 2020 11; 86(11):2123-2132. doi: 10.1111/bcp.14395. [PMID: 32470182]
  • Julia Wohl, Maike Petersen. Phenolic metabolism in the hornwort Anthoceros agrestis: 4-coumarate CoA ligase and 4-hydroxybenzoate CoA ligase. Plant cell reports. 2020 Sep; 39(9):1129-1141. doi: 10.1007/s00299-020-02552-w. [PMID: 32405654]
  • Kim T Adams, Peter R Donald, Ahmed A Abulfathi, Andreas H Diacon, Marietjie A Stander, Helmuth Reuter. Pharmacokinetics of Para-Aminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance. Journal of clinical pharmacology. 2020 04; 60(4):489-494. doi: 10.1002/jcph.1542. [PMID: 31682027]
  • Dong-Jie Peng, Yu-Wen Zhang, Zhao-Cong Li, Shao-Jun Li, Mei Cai, Wen-Xia Qin, Shi-Yan Ou, Xiao-Wei Huang, Zong-Xiang Yuan, Yue-Ming Jiang. Preventive impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2019 Jul; 54(?):134-141. doi: 10.1016/j.jtemb.2019.04.013. [PMID: 31109603]
  • Taotao Li, Dingding Shi, Qixian Wu, Zhengke Zhang, Hongxia Qu, Yueming Jiang. Sodium para-aminosalicylate delays pericarp browning of litchi fruit by inhibiting ROS-mediated senescence during postharvest storage. Food chemistry. 2019 Apr; 278(?):552-559. doi: 10.1016/j.foodchem.2018.11.099. [PMID: 30583410]
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  • Sang-In Park, Jaeseong Oh, Kyungho Jang, Jangsoo Yoon, Seol Ju Moon, Jong Sun Park, Jae Ho Lee, Junghan Song, In-Jin Jang, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers. Antimicrobial agents and chemotherapy. 2015 Aug; 59(8):4429-35. doi: 10.1128/aac.00354-15. [PMID: 25987620]
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  • Tarek Baati, Patricia Horcajada, Ruxandra Gref, Patrick Couvreur, Christian Serre. Quantification of fumaric acid in liver, spleen and urine by high-performance liquid chromatography coupled to photodiode-array detection. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(4):758-62. doi: 10.1016/j.jpba.2011.07.011. [PMID: 21820831]
  • Lan Hong, Wendy Jiang, Hao Pan, Yueming Jiang, Su Zeng, Wei Zheng. Brain regional pharmacokinetics of p-aminosalicylic acid and its N-acetylated metabolite: effectiveness in chelating brain manganese. Drug metabolism and disposition: the biological fate of chemicals. 2011 Oct; 39(10):1904-9. doi: 10.1124/dmd.111.040915. [PMID: 21768272]
  • Eva Vavříková, Slovenko Polanc, Marijan Kočevar, Kata Horváti, Szilvia Bosze, Jiřina Stolaříková, Kateřina Vávrová, Jarmila Vinšová. New fluorine-containing hydrazones active against MDR-tuberculosis. European journal of medicinal chemistry. 2011 Oct; 46(10):4937-45. doi: 10.1016/j.ejmech.2011.07.052. [PMID: 21855181]
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  • Tarek Baati, Patricia Horcajada, Ruxandra Gref, Patrick Couvreur, Christian Serre. Quantification of trimesic acid in liver, spleen and urine by high-performance liquid chromatography coupled to a photodiode-array detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Aug; 879(23):2311-4. doi: 10.1016/j.jchromb.2011.06.020. [PMID: 21727049]
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  • Lan Hong, Wendy Jiang, Wei Zheng, Su Zeng. HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues. Journal of pharmaceutical and biomedical analysis. 2011 Apr; 54(5):1101-9. doi: 10.1016/j.jpba.2010.11.031. [PMID: 21159459]
  • Marcos Abdo Arbex, Marília de Castro Lima Varella, Hélio Ribeiro de Siqueira, Fernando Augusto Fiúza de Mello. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2010 Sep; 36(5):641-56. doi: 10.1590/s1806-37132010000500017. [PMID: 21085831]
  • Michael J Hearn, Michael H Cynamon, Michaeline F Chen, Rebecca Coppins, Jessica Davis, Helen Joo-On Kang, Abigail Noble, Becky Tu-Sekine, Marianne S Terrot, Daniella Trombino, Minh Thai, Eleanor R Webster, Rebecca Wilson. Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid. European journal of medicinal chemistry. 2009 Oct; 44(10):4169-78. doi: 10.1016/j.ejmech.2009.05.009. [PMID: 19524330]
  • Phey Yen Han, P Nicholas Shaw, Carl M J Kirkpatrick. Determination of para-aminohippuric acid (PAH) in human plasma and urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Oct; 877(27):3215-20. doi: 10.1016/j.jchromb.2009.08.037. [PMID: 19733518]
  • H W Lee, D W Kim, J H Park, S-D Kim, M-S Lim, P B Phapale, E-H Kim, S K Park, Y-R Yoon. Pharmacokinetics of prothionamide in patients with multidrug-resistant tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2009 Sep; 13(9):1161-6. doi: NULL. [PMID: 19723408]
  • Xinfeng Zhang, Yuelan Xuan, Aimin Sun, Yi Lv, Xiandeng Hou. Simultaneous determination of isoniazid and p-aminosalicylic acid by capillary electrophoresis using chemiluminescence detection. Luminescence : the journal of biological and chemical luminescence. 2009 Jul; 24(4):243-9. doi: 10.1002/bio.1107. [PMID: 19248184]
  • Wei Zheng, Yue-Ming Jiang, Yanshu Zhang, Wendy Jiang, Xueqian Wang, Dallas M Cowan. Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats. Neurotoxicology. 2009 Mar; 30(2):240-8. doi: 10.1016/j.neuro.2008.12.007. [PMID: 19150464]
  • I I Miroshnichenko, G B Sokolova, L V Mokhireva. [Clinical pharmacokinetics of para-aminosalicylic acid tablets]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 2009; 54(1-2):20-4. doi: NULL. [PMID: 19499713]
  • Caroline B Michielse, Ringo van Wijk, Linda Reijnen, Ben J C Cornelissen, Martijn Rep. Insight into the molecular requirements for pathogenicity of Fusarium oxysporum f. sp. lycopersici through large-scale insertional mutagenesis. Genome biology. 2009; 10(1):R4. doi: 10.1186/gb-2009-10-1-r4. [PMID: 19134172]
  • Elisabetta Pastorini, Marcello Locatelli, Patrizia Simoni, Giulia Roda, Enrico Roda, Aldo Roda. Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicylic acid and its major metabolite N-acetyl-5-aminosalicylic acid in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Sep; 872(1-2):99-106. doi: 10.1016/j.jchromb.2008.07.026. [PMID: 18691952]
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