Sulindac (BioDeep_00000408955)
Main id: BioDeep_00000002700
natural product
代谢物信息卡片
Sulindac aka 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
化学式: C20H17FO3S (356.0882)
中文名称: 舒林酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC/1=C(CC(=O)O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(=O)C
InChI: InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:93811
- ChEBI: CHEBI:9352
- KEGG: C01531
- KEGGdrug: D00120
- PubChem: 1548887
- DrugBank: DB00605
- ChEMBL: CHEMBL15770
- MeSH: Sulindac
- CAS: 38194-50-2
- MoNA: CCMSLIB00000077059
- MoNA: WA002494
- MoNA: WA002493
- MoNA: WA002492
- MoNA: WA002491
- PubChem: 4693
- NIKKAJI: J3.501G
- RefMet: Sulindac
- KNApSAcK: 9352
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shufa Tan, Yan Ou, Yunyi Yang, Shuilan Huang, Shikai Chen, Qiangqiang Gao. Preventive effects of chemical drugs on recurrence of colorectal adenomas: systematic review and Bayesian network meta-analysis.
European journal of gastroenterology & hepatology.
2023 Nov; ?(?):. doi:
10.1097/meg.0000000000002676. [PMID: 37942763] - Rosa María García-Núñez, Julio César Buendía-Espinoza, Selene Del Carmen Arrazate-Jiménez, Elisa Del Carmen Martínez-Ochoa. Effects of copal resin extraction on the diversity and composition of species in tropical deciduous forests.
Scientific reports.
2023 03; 13(1):4199. doi:
10.1038/s41598-023-31423-z. [PMID: 36918726] - David Peris, Jörg U Hammel, Chenyang Cai, Mónica M Solórzano-Kraemer. First record of Jacobsoniidae (Coleoptera) on the African continent in Holocene copal from Tanzania: biogeography since the Cretaceous.
Scientific reports.
2023 03; 13(1):3735. doi:
10.1038/s41598-023-30368-7. [PMID: 36878923] - Yanchao Xing, Qiao Yu, Lin Zhou, Wen Cai, Yuxin Zhang, Yajuan Bi, Youcai Zhang, Zhifei Fu, Lifeng Han. Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Feb; 112(?):154710. doi:
10.1016/j.phymed.2023.154710. [PMID: 36805481] - Yessica Rico, Gustavo P Lorenzana, Carlos A Benítez-Pineda, Bode A Olukolu. Development of Genomic Resources in Mexican Bursera (Section: Bullockia: Burseraceae): Genome Assembly, Annotation, and Marker Discovery for Three Copal Species.
Genes.
2022 Sep; 13(10):. doi:
10.3390/genes13101741. [PMID: 36292626] - Suhail Razak, Tayyaba Afsar, Nousheen Bibi, Mahmoud Abulmeaty, Mashooq Ahmad Bhat, Anam Inam, Janeen H Trembley, Ali Almajwal, Maria Shabbir, Nawaf W Alruwaili, Abdulrahman Algarni. Sulindac acetohydrazide derivative attenuates against cisplatin induced organ damage by modulation of antioxidant and inflammatory signaling pathways.
Scientific reports.
2022 07; 12(1):11749. doi:
10.1038/s41598-022-15950-9. [PMID: 35817806] - Charles M Bowen, Lewins Walter, Ester Borras, Wenhui Wu, Zuhal Ozcan, Kyle Chang, Prashant V Bommi, Melissa W Taggart, Selvi Thirumurthi, Patrick M Lynch, Laura Reyes-Uribe, Paul A Scheet, Krishna M Sinha, Eduardo Vilar. Combination of Sulindac and Bexarotene for Prevention of Intestinal Carcinogenesis in Familial Adenomatous Polyposis.
Cancer prevention research (Philadelphia, Pa.).
2021 09; 14(9):851-862. doi:
10.1158/1940-6207.capr-20-0496. [PMID: 34266857] - Hua Li, Xiaofan Li, Boyu Yang, Junnan Su, Shaofang Cai, Jinmei Huang, Tianfu Hu, Lijuan Chen, Yaping Xu, Yuhang Li. The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis.
Scientific reports.
2021 08; 11(1):16956. doi:
10.1038/s41598-021-96517-y. [PMID: 34417523] - Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity.
Cell biology and toxicology.
2021 04; 37(2):151-175. doi:
10.1007/s10565-020-09537-1. [PMID: 32535746] - Glenn Lemmens, Joachim Brouwers, Jan Snoeys, Patrick Augustijns, Tim Vanuytsel. Insight into the Colonic Disposition of Sulindac in Humans.
Journal of pharmaceutical sciences.
2021 01; 110(1):259-267. doi:
10.1016/j.xphs.2020.09.034. [PMID: 33002468] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Qing Long, Liang Ao, Kuo Li, Yan Li. The efficacy and safety of sulindac for colorectal polyps: A protocol for systematic review and meta-analysis.
Medicine.
2020 Oct; 99(41):e22402. doi:
10.1097/md.0000000000022402. [PMID: 33031275] - Si Sheng, Xiaoying Yin, Fangmei Chen, Yixin Lv, Lin Zhang, Menghui Cao, Yun Sun. Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology.
AAPS PharmSciTech.
2020 Jul; 21(5):199. doi:
10.1208/s12249-020-01715-y. [PMID: 32676796] - Gergő Dargó, Dávid Bajusz, Kristóf Simon, Judit Müller, György T Balogh. Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Journal of medicinal chemistry.
2020 02; 63(4):1763-1774. doi:
10.1021/acs.jmedchem.0c00046. [PMID: 31995375] - Jin Won Sung, Hwi-Yeol Yun, Sunny Park, Young Ju Kim, Jeong Yee, Kyung Eun Lee, Byungjeong Song, Jee Eun Chung, Hye Sun Gwak. Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor.
Pharmaceutical research.
2020 Jan; 37(3):44. doi:
10.1007/s11095-020-2765-6. [PMID: 31993760] - Linghong Shen, Zhe Sun, Peng Nie, Ruosen Yuan, Zhaohua Cai, Caizhe Wu, Liuhua Hu, Shuxuan Jin, Hu Zhou, Xiaokun Zhang, Ben He. Sulindac-derived retinoid X receptor-α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE-/- mice.
British journal of pharmacology.
2019 07; 176(14):2559-2572. doi:
10.1111/bph.14682. [PMID: 30943581] - Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11.
Chemico-biological interactions.
2019 May; 305(?):12-20. doi:
10.1016/j.cbi.2019.03.026. [PMID: 30926317] - Min Zhang, Manakan B Srichai, Min Zhao, Jian Chen, Linda S Davis, Guanqing Wu, Matthew D Breyer, Chuan-Ming Hao. Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease.
International journal of medical sciences.
2019; 16(1):180-188. doi:
10.7150/ijms.27719. [PMID: 30662341] - Seyedeh Atekeh Torabizadeh, Mehdi Rezaeifar, Ali Jomehzadeh, Farzaneh Nabizadeh Haghighi, Mehdi Ansari. Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation.
Drug design, development and therapy.
2019; 13(?):4127-4134. doi:
10.2147/dddt.s218022. [PMID: 31827319] - Nahed M A Hassanein, Eman S G Hassan, Amany M Hegab, Helmy M Sayd Elahl. Chemopreventive effect of sulindac in combination with epigallocatechin gallate or kaempferol against 1,2-dimethyl hydrazine-induced preneoplastic lesions in rats: A Comparative Study.
Journal of biochemical and molecular toxicology.
2018 Oct; 32(10):e22198. doi:
10.1002/jbt.22198. [PMID: 29999212] - Yong-Jun Tang, Kai Hu, Wei-Hua Huang, Chong-Zhi Wang, Zhi Liu, Yao Chen, Dong-Sheng Ouyang, Zhi-Rong Tan, Hong-Hao Zhou, Chun-Su Yuan. Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers.
BioMed research international.
2017; 2017(?):4189678. doi:
10.1155/2017/4189678. [PMID: 28331852] - Barbara J Bałan, Andrzej K Siwicki, Krzysztof Pastewka, Urszula Demkow, Piotr Skopiński, Ewa Skopińska-Różewska, Sławomir Lewicki, Robert Zdanowski. Synergistic Activity for Natural and Synthetic Inhibitors of Angiogenesis Induced by Murine Sarcoma L-1 and Human Kidney Cancer Cells.
Advances in experimental medicine and biology.
2017 ; 1020(?):91-104. doi:
10.1007/5584_2017_17. [PMID: 28456932] - Giulia Gigliarelli, Judith X Becerra, Massimo Curini, Maria Carla Marcotullio. Chemical Composition and Biological Activities of Fragrant Mexican Copal (Bursera spp.).
Molecules (Basel, Switzerland).
2015 Dec; 20(12):22383-94. doi:
10.3390/molecules201219849. [PMID: 26703535] - Khosrow Kashfi, Mitali Chattopadhyay, Ravinder Kodela. NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties.
Redox biology.
2015 Dec; 6(?):287-296. doi:
10.1016/j.redox.2015.08.012. [PMID: 26298203] - Venkata Charepalli, Lavanya Reddivari, Sridhar Radhakrishnan, Ramakrishna Vadde, Rajesh Agarwal, Jairam K P Vanamala. Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells.
The Journal of nutritional biochemistry.
2015 Dec; 26(12):1641-9. doi:
10.1016/j.jnutbio.2015.08.005. [PMID: 26383537] - Chi C Wong, Ka-Wing Cheng, Ioannis Papayannis, George Mattheolabakis, Liqun Huang, Gang Xie, Nengtai Ouyang, Basil Rigas. Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: implications for their clinical pharmacology.
Pharmaceutical research.
2015 May; 32(5):1663-75. doi:
10.1007/s11095-014-1565-2. [PMID: 25392229] - Marta M Wells, Tommy S Tillman, David D Mowrey, Tianmo Sun, Yan Xu, Pei Tang. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain.
Journal of medicinal chemistry.
2015 Apr; 58(7):2958-2966. doi:
10.1021/jm501873p. [PMID: 25790278] - M Maciążek-Jurczyk, A Sułkowska. Spectroscopic analysis of the impact of oxidative stress on the structure of human serum albumin (HSA) in terms of its binding properties.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Feb; 136 Pt B(?):265-82. doi:
10.1016/j.saa.2014.09.034. [PMID: 25448930] - John L Vaughn, Kejal V Shah, Maroun M Ghossein, William L Meyer, Robert B Kirkpatrick. Acute kidney injury, hyperbilirubinemia, and ischemic skin necrosis due to massive sulindac overdose.
Current drug safety.
2015; 10(2):190-2. doi:
10.2174/157488631002150515150729. [PMID: 25986039] - Gang Xie, Ka-Wing Cheng, Liqun Huang, Basil Rigas. The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent.
Biochemical pharmacology.
2014 Sep; 91(2):249-55. doi:
10.1016/j.bcp.2014.07.007. [PMID: 25044307] - Joanna Lenik. Preparation and characterization of a sulindac sensor based on PVC/TOA-SUL membrane.
Materials science & engineering. C, Materials for biological applications.
2014 Apr; 37(?):383-9. doi:
10.1016/j.msec.2014.01.030. [PMID: 24582264] - Daphna Laifenfeld, Luping Qiu, Rachel Swiss, Jennifer Park, Michael Macoritto, Yvonne Will, Husam S Younis, Michael Lawton. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):234-48. doi:
10.1093/toxsci/kft232. [PMID: 24136188] - Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):189-211. doi:
10.1093/toxsci/kft223. [PMID: 24085192] - Sunny Park, Na Ra Lee, Kyung Eun Lee, Jin Young Park, Young Ju Kim, Hye Sun Gwak. Effects of single-nucleotide polymorphisms of FMO3 and FMO6 genes on pharmacokinetic characteristics of sulindac sulfide in premature labor.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Jan; 42(1):40-3. doi:
10.1124/dmd.113.054106. [PMID: 24173915] - Linda Saxe Einbond, Jason Mighty, Ryota Kashiwazaki, Mario Figueroa, Filza Jalees, Ulyana Munoz Acuna, Onica Le Gendre, David A Foster, Edward J Kennelly. Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric.
Anti-cancer agents in medicinal chemistry.
2013 Dec; 13(10):1540-50. doi:
10.2174/18715206113139990095. [PMID: 23848206] - Ramesh Verma, Mahesh Brahmankar, Lokendra Kushwah, Balakrishnan Suresh. Evaluating the inhibitory potential of sulindac against the bleomycin-induced pulmonary fibrosis in wistar rats.
Environmental toxicology and pharmacology.
2013 Nov; 36(3):769-78. doi:
10.1016/j.etap.2013.07.011. [PMID: 23958969] - Haonan Li, Allison L Yang, Yeon Tae Chung, Wanying Zhang, Jie Liao, Guang-Yu Yang. Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10).
Carcinogenesis.
2013 Sep; 34(9):2090-8. doi:
10.1093/carcin/bgt170. [PMID: 23689354] - George Mattheolabakis, Gerardo G Mackenzie, Liqun Huang, Nengtai Ouyang, Ka Wing Cheng, Basil Rigas. Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats.
Pharmaceutical research.
2013 Jun; 30(6):1471-82. doi:
10.1007/s11095-012-0953-8. [PMID: 23483440] - P Skopiński, B J Bałan, J Kocik, R Zdanowski, S Lewicki, M Niemcewicz, K Gawrychowski, E Skopińska-Różewska, W Stankiewicz. Inhibitory effect of herbal remedy PERVIVO and anti-inflammatory drug sulindac on L-1 sarcoma tumor growth and tumor angiogenesis in Balb/c mice.
Mediators of inflammation.
2013; 2013(?):289789. doi:
10.1155/2013/289789. [PMID: 23935247] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Clara Curiel-Lewandrowski, Susan M Swetter, Janine G Einspahr, Chiu-Hsieh Hsu, Ray Nagle, Paul Sagerman, Joseph Tangrea, Howard Parnes, David S Alberts, Hsiao-Hui Chow. Randomized, double-blind, placebo-controlled trial of sulindac in individuals at risk for melanoma: evaluation of potential chemopreventive activity.
Cancer.
2012 Dec; 118(23):5848-56. doi:
10.1002/cncr.27540. [PMID: 22605570] - Rongrong Zhu, Ka-Wing Cheng, Gerardo Mackenzie, Liqun Huang, Yu Sun, Gang Xie, Kveta Vrankova, Panayiotis P Constantinides, Basil Rigas. Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles.
Pharmaceutical research.
2012 Nov; 29(11):3090-101. doi:
10.1007/s11095-012-0801-x. [PMID: 22723123] - Howard S Moskowitz, William E Gooding, Sufi M Thomas, Maria L Freilino, Neil Gross, Athanassios Argiris, Jennifer R Grandis, Robert L Ferris. Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer.
Oral oncology.
2012 Nov; 48(11):1136-45. doi:
10.1016/j.oraloncology.2012.05.015. [PMID: 22732263] - G Xie, T Nie, G G Mackenzie, Y Sun, L Huang, N Ouyang, N Alston, C Zhu, O T Murray, P P Constantinides, L Kopelovich, B Rigas. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.
British journal of pharmacology.
2012 Apr; 165(7):2152-66. doi:
10.1111/j.1476-5381.2011.01705.x. [PMID: 21955327] - Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
Journal of medicinal chemistry.
2012 Mar; 55(5):2287-300. doi:
10.1021/jm201528b. [PMID: 22263894] - Chi C Wong, Ka-Wing Cheng, Gang Xie, Dingying Zhou, Cai-Hua Zhu, Panayiotis P Constantinides, Basil Rigas. Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity.
The Journal of pharmacology and experimental therapeutics.
2012 Feb; 340(2):422-32. doi:
10.1124/jpet.111.188508. [PMID: 22085648] - Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
10.1124/dmd.111.040758. [PMID: 21965623] - Vivek Vaish, Sankar Nath Sanyal. Non steroidal anti-inflammatory drugs modulate the physicochemical properties of plasma membrane in experimental colorectal cancer: a fluorescence spectroscopic study.
Molecular and cellular biochemistry.
2011 Dec; 358(1-2):161-71. doi:
10.1007/s11010-011-0931-1. [PMID: 21725642] - Hsin-Hsiung Tai, Xiuling Chi, Min Tong. Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Prostaglandins & other lipid mediators.
2011 Nov; 96(1-4):37-40. doi:
10.1016/j.prostaglandins.2011.06.005. [PMID: 21763448] - Pieter Friederich, Jelle Verschuur, Bjorn W H van Heumen, Hennie M J Roelofs, Marloes Berkhout, Iris D Nagtegaal, Martijn G H van Oijen, Johannes H J M van Krieken, Wilbert H M Peters, Fokko M Nagengast. Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis.
International journal of colorectal disease.
2011 May; 26(5):575-82. doi:
10.1007/s00384-010-1127-y. [PMID: 21243500] - L Huang, Gg Mackenzie, N Ouyang, Y Sun, G Xie, F Johnson, D Komninou, B Rigas. The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats.
British journal of pharmacology.
2011 Apr; 162(7):1521-33. doi:
10.1111/j.1476-5381.2010.01162.x. [PMID: 21175575] - Toshihisa Koga, Ryoichi Fujiwara, Miki Nakajima, Tsuyoshi Yokoi. Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Jan; 39(1):54-60. doi:
10.1124/dmd.110.035600. [PMID: 20926620] - Svenja D Steinbrink, Carlo Pergola, Ulrike Bühring, Sven George, Julia Metzner, Astrid S Fischer, Ann-Kathrin Häfner, Joanna M Wisniewska, Gerd Geisslinger, Oliver Werz, Dieter Steinhilber, Thorsten J Maier. Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.
Cellular and molecular life sciences : CMLS.
2010 Mar; 67(5):797-806. doi:
10.1007/s00018-009-0206-0. [PMID: 20091083] - Wei Zou, Kevin M Beggs, Erica M Sparkenbaugh, A Daniel Jones, Husam S Younis, Robert A Roth, Patricia E Ganey. Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.
The Journal of pharmacology and experimental therapeutics.
2009 Oct; 331(1):114-21. doi:
10.1124/jpet.109.156331. [PMID: 19638570] - Gary A Piazza, Adam B Keeton, Heather N Tinsley, Bernard D Gary, Jason D Whitt, Bini Mathew, Jose Thaiparambil, Lori Coward, Gregory Gorman, Yonghe Li, Brahma Sani, Judith V Hobrath, Yulia Y Maxuitenko, Robert C Reynolds. A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.
Cancer prevention research (Philadelphia, Pa.).
2009 Jun; 2(6):572-80. doi:
10.1158/1940-6207.capr-09-0001. [PMID: 19470791] - Wei Zou, Sachin S Devi, Erica Sparkenbaugh, Husam S Younis, Robert A Roth, Patricia E Ganey. Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Mar; 108(1):184-93. doi:
10.1093/toxsci/kfn259. [PMID: 19074762] - C L O'Bryant, C H Lieu, S Leong, R Boinpally, M Basche, L Gore, K Leonardi, M K Schultz, S Hariharan, L Chow, S Diab, A Gibbs, S G Eckhardt. A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state.
Cancer chemotherapy and pharmacology.
2009 Feb; 63(3):477-89. doi:
10.1007/s00280-008-0761-3. [PMID: 18509645] - Fernando Santos, Lígia Teixeira, Marlene Lúcio, Helena Ferreira, Diana Gaspar, José L F C Lima, Salette Reis. Interactions of sulindac and its metabolites with phospholipid membranes: an explanation for the peroxidation protective effect of the bioactive metabolite.
Free radical research.
2008 Jul; 42(7):639-50. doi:
10.1080/10715760802270326. [PMID: 18654879] - Martin Gamerdinger, Angela B Clement, Christian Behl. Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.
Neuropharmacology.
2008 May; 54(6):998-1005. doi:
10.1016/j.neuropharm.2008.02.009. [PMID: 18359496] - Bhagavathi A Narayanan, Bandaru S Reddy, Maarten C Bosland, Dominick Nargi, Lori Horton, Carla Randolph, Narayanan K Narayanan. Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Oct; 13(19):5965-73. doi:
10.1158/1078-0432.ccr-07-0744. [PMID: 17908994] - Amichand Dairam, Adrienne C Müller, Santy Daya. Non-steroidal anti-inflammatory agents, tolmetin and sulindac attenuate quinolinic acid (QA)-induced oxidative stress in primary hippocampal neurons and reduce QA-induced spatial reference memory deficits in male Wistar rats.
Life sciences.
2007 Mar; 80(15):1431-8. doi:
10.1016/j.lfs.2007.01.006. [PMID: 17266991] - Gerd Bobe, Bing Wang, Navindra P Seeram, Muraleedharan G Nair, Leslie D Bourquin. Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac.
Journal of agricultural and food chemistry.
2006 Dec; 54(25):9322-8. doi:
10.1021/jf0612169. [PMID: 17147414] - I M Kapetanovic, R Krishnaraj, T Martin-Jimenez, L Yuan, R B van Breemen, A Lyubimov. Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics.
Chemico-biological interactions.
2006 Dec; 164(1-2):68-75. doi:
10.1016/j.cbi.2006.08.019. [PMID: 17027946] - Virginie Quidville, Nadine Segond, Sylvie Lausson, Melinee Frenkian, Regis Cohen, Annick Jullienne. 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line.
Prostaglandins & other lipid mediators.
2006 Oct; 81(1-2):14-30. doi:
10.1016/j.prostaglandins.2006.06.004. [PMID: 16997128] - Amichand Dairam, Prakash Chetty, Santy Daya. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons.
Metabolic brain disease.
2006 Sep; 21(2-3):221-33. doi:
10.1007/s11011-006-9014-5. [PMID: 16850258] - Yen-Ling Chen, Yuh-Jyh Jong, Shou-Mei Wu. Capillary electrophoresis combining field-amplified sample stacking and electroosmotic flow suppressant for analysis of sulindac and its two metabolites in plasma.
Journal of chromatography. A.
2006 Jun; 1119(1-2):176-82. doi:
10.1016/j.chroma.2006.02.054. [PMID: 16530777] - Hadas Dvory-Sobol, Diana Kazanov, Eliezer Liberman, Shlomo Birkenfeld, Benny Bulvik, Pauline Luk, Moshe Leshno, Nadir Arber. MF tricyclic and sulindac retard tumor formation in an animal model.
International journal of cancer.
2006 Jan; 118(1):11-6. doi:
10.1002/ijc.21218. [PMID: 16003752] - Loretta Aureli, Gabriele Cruciani, Maria Candida Cesta, Roberto Anacardio, Lucio De Simone, Alessio Moriconi. Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
Journal of medicinal chemistry.
2005 Apr; 48(7):2469-79. doi:
10.1021/jm049227l. [PMID: 15801837] - Thomas A Lanz, Gregory J Fici, Kalpana M Merchant. Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures.
The Journal of pharmacology and experimental therapeutics.
2005 Jan; 312(1):399-406. doi:
10.1124/jpet.104.073965. [PMID: 15340006] - Samir E Witta, Daniel L Gustafson, A Scott Pierson, Alexander Menter, Scott N Holden, Michele Basche, Martha Persky, Cindy L O'Bryant, Chan Zeng, Anna Baron, Michael E Long, Amy Gibbs, Karen Kelly, Paul A Bunn, Daniel C Chan, Patrick Pallansch, S Gail Eckhardt. A phase I and pharmacokinetic study of exisulind and docetaxel in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2004 Nov; 10(21):7229-37. doi:
10.1158/1078-0432.ccr-03-0181. [PMID: 15534096] - Piotr Skopinski, Jerzy Szaflik, Barbara Duda-Król, Jadwiga Nartowska, Ewa Sommer, Joanna Chorostowska-Wynimko, Urszula Demkow, Ewa Skopinska-Rózewska. Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone.
International journal of molecular medicine.
2004 Oct; 14(4):707-11. doi:
10.3892/ijmm.14.4.707. [PMID: 15375605] - Patrick C Fraering, Wenjuan Ye, Jean-Marc Strub, Georgia Dolios, Matthew J LaVoie, Beth L Ostaszewski, Alain van Dorsselaer, Rong Wang, Dennis J Selkoe, Michael S Wolfe. Purification and characterization of the human gamma-secretase complex.
Biochemistry.
2004 Aug; 43(30):9774-89. doi:
10.1021/bi0494976. [PMID: 15274632] - Betty Schwartz, Yehudit Birk, Amiram Raz, Zecharia Madar. Nutritional-pharmacological combinations--a novel approach to reducing colon cancer incidence.
European journal of nutrition.
2004 Aug; 43(4):221-9. doi:
10.1007/s00394-004-0462-6. [PMID: 15309441] - Mark S Dykewicz. Cough and angioedema from angiotensin-converting enzyme inhibitors: new insights into mechanisms and management.
Current opinion in allergy and clinical immunology.
2004 Aug; 4(4):267-70. doi:
10.1097/01.all.0000136759.43571.7f. [PMID: 15238791] - Neil Kaplowitz. Drug-induced liver injury.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2004 Mar; 38 Suppl 2(?):S44-8. doi:
10.1086/381446. [PMID: 14986274] - Frantzy Etienne, Lionel Resnick, Daphna Sagher, Nathan Brot, Herbert Weissbach. Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system.
Biochemical and biophysical research communications.
2003 Dec; 312(4):1005-10. doi:
10.1016/j.bbrc.2003.10.203. [PMID: 14651971] - Jenifer A Z Loudon, Kate M Groom, Philip R Bennett. Prostaglandin inhibitors in preterm labour.
Best practice & research. Clinical obstetrics & gynaecology.
2003 Oct; 17(5):731-44. doi:
10.1016/s1521-6934(03)00047-6. [PMID: 12972011] - T A Gardiner, H R Anderson, T Degenhardt, S R Thorpe, J W Baynes, D B Archer, A W Stitt. Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug.
Diabetologia.
2003 Sep; 46(9):1269-75. doi:
10.1007/s00125-003-1147-z. [PMID: 12861449] - Jilly F Evans. Rofecoxib (Vioxx), a specific cyclooxygenase-2 inhibitor, is chemopreventive in a mouse model of colon cancer.
American journal of clinical oncology.
2003 Aug; 26(4):S62-5. doi:
10.1097/01.coc.0000074159.05087.50. [PMID: 12902858] - J K Grover, S Yadav, V Vats, Y K Joshi. Cyclo-oxygenase 2 inhibitors: emerging roles in the gut.
International journal of colorectal disease.
2003 Jul; 18(4):279-91. doi:
10.1007/s00384-002-0443-2. [PMID: 12774242] - Robert J Sawdy, Shiromi Lye, Nicholas M Fisk, Phillip R Bennett. A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor.
American journal of obstetrics and gynecology.
2003 Apr; 188(4):1046-51. doi:
10.1067/mob.2003.255. [PMID: 12712108] - Zhong Jian Cheng, Piet Finckenberg, Marjut Louhelainen, Saara Merasto, Ilkka Tikkanen, Heikki Vapaatalo, Eero M A Mervaala. Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27).
European journal of pharmacology.
2003 Feb; 461(2-3):159-69. doi:
10.1016/s0014-2999(03)01307-4. [PMID: 12586211] - Hirota Fujiki, Masami Suganuma, Miki Kurusu, Sachiko Okabe, Yoko Imayoshi, Shoko Taniguchi, Takashi Yoshida. New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen.
Mutation research.
2003 Feb; 523-524(?):119-25. doi:
10.1016/s0027-5107(02)00327-5. [PMID: 12628509] - Zvetanka D Zhivkova, Veska N Russeva. Thermodynamic characterization of the binding process of sulindac to human serum albumin.
Arzneimittel-Forschung.
2003; 53(1):53-6. doi:
10.1055/s-0031-1297070. [PMID: 12608015] - Veska N Russeva, Zvetanka D Zhivkova. Molecular basis of sulindac competition with specific markers for the major binding sites on human serum albumin.
Arzneimittel-Forschung.
2003; 53(3):174-81. doi:
10.1055/s-0031-1297091. [PMID: 12705172] - Maria Leuschner, Julia Holtmeier, Hanns Ackermann, Ulrich Leuschner. The influence of sulindac on patients with primary biliary cirrhosis that responds incompletely to ursodeoxycholic acid: a pilot study.
European journal of gastroenterology & hepatology.
2002 Dec; 14(12):1369-76. doi:
10.1097/00042737-200212000-00014. [PMID: 12468960] - Mette Olesen, Elizabeth Kwong, Arguello Meztli, Frederic Kontny, Ingebjörg Seljeflot, Harald Arnesen, Line Lyngdorf, Erling Falk. No effect of cyclooxygenase inhibition on plaque size in atherosclerosis-prone mice.
Scandinavian cardiovascular journal : SCJ.
2002 Dec; 36(6):362-7. doi:
10.1080/140174302762659094. [PMID: 12626204] - Suparat Khamdang, Michio Takeda, Rie Noshiro, Shinichi Narikawa, Atsushi Enomoto, Naohiko Anzai, Pawinee Piyachaturawat, Hitoshi Endou. Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs.
The Journal of pharmacology and experimental therapeutics.
2002 Nov; 303(2):534-9. doi:
10.1124/jpet.102.037580. [PMID: 12388633] - Daniel J Berg, Juan Zhang, Joel V Weinstock, Hanan F Ismail, Keith A Earle, Hector Alila, Rifat Pamukcu, Steven Moore, Richard G Lynch. Rapid development of colitis in NSAID-treated IL-10-deficient mice.
Gastroenterology.
2002 Nov; 123(5):1527-42. doi:
10.1053/gast.2002.1231527. [PMID: 12404228] - Weijing Sun, James P Stevenson, James M Gallo, Maryann Redlinger, Daniel Haller, Kenneth Algazy, Bruce Giantonio, Hector Alila, Peter J O'Dwyer. Phase I and pharmacokinetic trial of the proapoptotic sulindac analog CP-461 in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2002 Oct; 8(10):3100-4. doi:
NULL. [PMID: 12374677] - Gayle A Orner, Wan-Mohaiza Dashwood, Carmen A Blum, G Darío Díaz, Qingjie Li, Mohamad Al-Fageeh, Niall Tebbutt, Joan K Heath, Matthias Ernst, Roderick H Dashwood. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Mutation research.
2002 Sep; 506-507(?):121-7. doi:
10.1016/s0027-5107(02)00158-6. [PMID: 12351151] - Xiaosong Wu, Yi Zhou. Observation on the therapeutic effect of Shu Feng Huo Luo Pian for treatment of osseous arthritis.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2002 Mar; 22(1):12-4. doi:
". [PMID: 11977509] - A Asea, R Mallick, S Lechpammer, G Ara, B A Teicher, S Fiorentino, M A Stevenson, S K Calderwood. Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.
2001 Sep; 17(5):401-14. doi:
10.1080/02656730110058600. [PMID: 11587078] - H Weiss, A Amberger, M Widschwendter, R Margreiter, D Ofner, P Dietl. Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells.
International journal of cancer.
2001 Jun; 92(6):877-82. doi:
10.1002/ijc.1280. [PMID: 11351310] - S Jones, S Jones, A O Phillips. Regulation of renal proximal tubular epithelial cell hyaluronan generation: implications for diabetic nephropathy.
Kidney international.
2001 May; 59(5):1739-49. doi:
10.1046/j.1523-1755.2001.0590051739.x. [PMID: 11318944] - Y Naishiro, T Yamada, A S Takaoka, R Hayashi, F Hasegawa, K Imai, S Hirohashi. Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation.
Cancer research.
2001 Mar; 61(6):2751-8. doi:
NULL. [PMID: 11289158] - M Oshima, N Murai, S Kargman, M Arguello, P Luk, E Kwong, M M Taketo, J F Evans. Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor.
Cancer research.
2001 Feb; 61(4):1733-40. doi:
. [PMID: 11245490] - M Suganuma, Y Ohkura, S Okabe, H Fujiki. Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice.
Journal of cancer research and clinical oncology.
2001 Jan; 127(1):69-72. doi:
10.1007/s004320000189. [PMID: 11206275] - M Richter, M Weiss, I Weinberger, G Fürstenberger, B Marian. Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors.
Carcinogenesis.
2001 Jan; 22(1):17-25. doi:
10.1093/carcin/22.1.17. [PMID: 11159736]
