Ligustilide (BioDeep_00000407596)

Main id: BioDeep_00000000328

Secondary id: BioDeep_00000018945, BioDeep_00001867489

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(1E)-2-(4-Chlorophenyl)-3-(4-morpholinyl)-N-[(Z)-4-pyridinylmethylidene]-3-thioxo-1-propen-1-amine

化学式: C12H14O2 (190.09937440000002)
中文名称: 藁本内酯, 蒿本内酯, 蒿本内酯 A
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.52%

分子结构信息

SMILES: CCCC=C1C2=C(C=CCC2)C(=O)O1
InChI: InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7-8H,2-4,6H2,1H3/b11-8-

描述信息

同义名列表

23 个代谢物同义名

(1E)-2-(4-Chlorophenyl)-3-(4-morpholinyl)-N-[(Z)-4-pyridinylmethylidene]-3-thioxo-1-propen-1-amine; 2-(4-Chlorophenyl)-1-morpholin-4-yl-3-(pyridin-4-ylmethylenamino)-prop-2-en-1-thione; (3Z)-3-butylidene-4,5-dihydroisobenzofuran-1-one; (3Z)-3-butylidene-4,5-dihydro-2-benzofuran-1-one; 3-butylidene-4,5-dihydro-2-benzofuran-1-one; 3-butylidene-4,5-dihydroisobenzofuran-1-one; Ligustilide, (Z)-; Ligustilide, (E)-; trans-ligustilide; Spectrum4_001816; Spectrum5_000551; (E)-Ligustilide; SpecPlus_000585; Spectrum_001702; Z-ligustilide; KBioGR_002456; DivK1c_006681; KBioSS_002182; KBio1_001625; KBio2_004750; KBio2_002182; KBio2_007318; Ligustilide



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kaixue Zhang, Wenjuan Liu, Fukui Shen, Guoqing Luan, Yanqi Han, Jun Xu, Cheng Fu, Weidong Wu, Yuanyuan Hou, Min Jiang, Tiejun Zhang, Gang Bai. Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury. Journal of ethnopharmacology. 2024 Aug; 330(?):118217. doi: 10.1016/j.jep.2024.118217. [PMID: 38641072]
  • Lianyu Zhou, Peiyan Jiang, Linyang Zhao, Xinghang Fei, Yexi Tang, Yi Luo, Hong Gong, Xiaqing Wang, Xin Li, Song Li, Chunqing Zhang, Hui Yang, Xiaotang Fan. Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155443. doi: 10.1016/j.phymed.2024.155443. [PMID: 38394737]
  • Zhigang Chen, Qiang Zhu, Xingyu Qi, Li-Rong Yang, Yu-Xia Rong, Qi Wei, Shi-Qi Wu, Qian-Wei Lu, Li Li, Ming-Dong Jiang, Hongyi Qi. Dual role of Nrf2/HO-1 pathway in Z-ligustilide-induced ferroptosis against AML cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155288. doi: 10.1016/j.phymed.2023.155288. [PMID: 38183698]
  • Hong-Xu Yang, Xue-Li Jiang, Rong-Mei Zuo, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Targeting RXFP1 by Ligustilide: A novel therapeutic approach for alcoholic hepatic steatosis. International immunopharmacology. 2024 Jan; 127(?):111460. doi: 10.1016/j.intimp.2023.111460. [PMID: 38157696]
  • Xie Xu, Nana Tao, Caihua Sun, Robert D Hoffman, Dongling Shi, Yuyuan Ying, Shujie Dong, Jianli Gao. Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155216. doi: 10.1016/j.phymed.2023.155216. [PMID: 38061285]
  • Pengyu Geng, Jinhui Zhao, Qi Li, Xiaolin Wang, Wangshu Qin, Ting Wang, Xianzhe Shi, Xinyu Liu, Jia Chen, Hongdeng Qiu, Guowang Xu. Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer. International journal of molecular sciences. 2023 Dec; 24(23):. doi: 10.3390/ijms242317046. [PMID: 38069368]
  • Kaixue Zhang, Fukui Shen, Wei Lei, Yanqi Han, Xiaoyao Ma, Yujie Lu, Yuanyuan Hou, Wenjuan Liu, Min Jiang, Tiejun Zhang, Gang Bai. Ligustilide covalently binds to Cys129 of HMGCS1 to ameliorate dyslipidemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115323. doi: 10.1016/j.biopha.2023.115323. [PMID: 37579692]
  • Juan Gao, Gang Su, Wei Chen, Qionghui Wu, Junxi Liu, Jifei Liu, Miao Chai, Ying Dong, He Wang, Lixia Chen, Zhenchang Zhang, Manxia Wang. Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification. Clinical and experimental pharmacology & physiology. 2023 Jun; ?(?):. doi: 10.1111/1440-1681.13784. [PMID: 37308175]
  • Lei Shi, Chen-Chen Jiang, Jia-Jun Lu, Zi-Xu Li, Wang-Jie Li, Xiu-Yun Yin, Zhuo Chen, Xin-Ya Zhao, Hui Zhang, Hao-Ran Hu, Lu-Tan Zhou, Jun Han. [Molecular mechanism of ligustilide attenuating OGD/R injury in PC12 cells by inhibiting ferroptosis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jun; 48(11):3046-3054. doi: 10.19540/j.cnki.cjcmm.20221201.401. [PMID: 37381963]
  • Nuerbiye Aobulikasimu, Hang Lv, Peipei Guan, Lu Cao, Xueshi Huang, Li Han. Levistolide A ameliorates fibrosis in chronic kidney disease via modulating multitarget actions in vitro and in vivo. Life sciences. 2023 May; 320(?):121565. doi: 10.1016/j.lfs.2023.121565. [PMID: 36921687]
  • Xuejiao Song, Chang Liu, Yang Zhang, Xiaoyue Xiao, Guorui Han, Kedi Sun, Shuoqi Liu, Zhiyun Zhang, Chunliu Dong, Yadan Zheng, Xueying Chen, Tong Xu, Yanyan Liu, Yanhua Li. Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities. Ultrasonics sonochemistry. 2023 Feb; 94(?):106344. doi: 10.1016/j.ultsonch.2023.106344. [PMID: 36871526]
  • Xueqin Chen, Jingyue Yu, Huan Lei, Lei Li, Xupin Liu, Bo Liu, Yanfei Xie, Haihong Fang. Exploring the Mechanism of Buyang Huanwu Decoction Alleviating Restenosis by Regulating VSMC Phenotype Switching and Proliferation by Network Pharmacology and Molecular Docking. Current computer-aided drug design. 2023 Feb; ?(?):. doi: 10.2174/1573409919666230203144207. [PMID: 36740793]
  • Yu-Jie Lu, Lin Niu, Fu-Kui Shen, Wen Yang, Yang Xie, Su-Yun Li, Min Jiang, Gang Bai. Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3-SARA interaction. Phytotherapy research : PTR. 2023 Feb; 37(2):717-730. doi: 10.1002/ptr.7655. [PMID: 36216328]
  • Kesara Na-Bangchang, Monthaka Teerachaisakul, Phunuch Muhamad, Yositha Kasemnitichok, Nattida Sangnarong, Kanyarat Boonprasert, Mayuri Tarasuk, Tullayakorn Plengsuriyakarn. Antiproliferative and Anti-Inflammatory Activities of Deprungsith Formulation and Its Bioactive Compounds Against Mild Psoriasis and Potential of Metabolic Herb-Drug Interactions. Journal of evidence-based integrative medicine. 2023 Jan; 28(?):2515690X231191101. doi: 10.1177/2515690x231191101. [PMID: 37553989]
  • Chang-Woo Ha, Eun-Hwa Sohn, Sung-Hyeok Kim, Sohee Jang, Myung-Rye Park, Youn-Kyu Kim, In-Young Bae. Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012072. [PMID: 36292928]
  • Zhiguo Mao, Liyu Tian, Jiao Liu, Qian Wu, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto. Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 101(?):154111. doi: 10.1016/j.phymed.2022.154111. [PMID: 35512628]
  • Zicen Fang, Zhenhui Luo, Yanying Ji, Rihong Yang, Jintian Gao, Nana Zhang. A network pharmacology technique used to investigate the potential mechanism of Ligustilide's effect on atherosclerosis. Journal of food biochemistry. 2022 07; 46(7):e14146. doi: 10.1111/jfbc.14146. [PMID: 35365921]
  • Dong Peng, Han-Zi Qiao, Hong-Yu Tan, Yi-Xue Wang, Dan Luo, Li-Jun Qiao, Ye-Feng Cai, Shi-Jie Zhang, Qi Wang, Li Guan. Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat. Metabolic brain disease. 2022 06; 37(5):1401-1414. doi: 10.1007/s11011-022-00947-0. [PMID: 35420377]
  • Yujie Lu, Jie Ji, Simeng Chu, Fukui Shen, Wen Yang, Wei Lei, Min Jiang, Gang Bai. CaMKII, that binds with ligustilide, as a potential drug target of Suxiao jiuxin pill, a traditional Chinese medicine to dilate thoracic aorta. Clinical and translational medicine. 2022 06; 12(6):e907. doi: 10.1002/ctm2.907. [PMID: 35678102]
  • Qian Wu, Jiao Liu, Li-Yu Tian, Ning Wang. [Mitophagy mediated by ligustilide relieves OGD/R-induced injury in HT22 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Apr; 47(7):1897-1903. doi: 10.19540/j.cnki.cjcmm.20211029.404. [PMID: 35534260]
  • Han Dong, Meiling Li, Ling Jin, Xiaorong Xie, Mengfei Li, Jianhe Wei. Cool Temperature Enhances Growth, Ferulic Acid and Flavonoid Biosynthesis While Inhibiting Polysaccharide Biosynthesis in Angelica sinensis. Molecules (Basel, Switzerland). 2022 Jan; 27(1):. doi: 10.3390/molecules27010320. [PMID: 35011549]
  • Qian Wu, Jiao Liu, Zhiguo Mao, Liyu Tian, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto. Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153884. doi: 10.1016/j.phymed.2021.153884. [PMID: 34929562]
  • Bin Zhang, Donghai Wu, Limei Hu, Xiaofeng Cha, Yilai Liu, Jujie Li, Bo Xie, Bin Li, Lei Zheng. Ligustilide inhibits the proliferation of human osteoblastoma MG63 cells through the TLR4-ERK pathway. Life sciences. 2022 Jan; 288(?):118993. doi: 10.1016/j.lfs.2020.118993. [PMID: 33545202]
  • Zhenhui Luo, Ao Zeng, Yuankun Chen, Shumiao He, Siqing He, Xiaobao Jin, Chunmei Li, Wenjie Mei, Qun Lu. Ligustilide inhibited Angiotensin II induced A7r5 cell autophagy via Akt/mTOR signaling pathway. European journal of pharmacology. 2021 Aug; 905(?):174184. doi: 10.1016/j.ejphar.2021.174184. [PMID: 34004211]
  • Li-Juan Gao, Ping Li, Tengyun Ma, Zhan-Qiong Zhong, Shi-Jun Xu. Ligustilide alleviates neurotoxicity in SH-SY5Y cells induced by Aβ25-35 via regulating endoplasmic reticulum stress and autophagy. Phytotherapy research : PTR. 2021 Mar; 35(3):1572-1584. doi: 10.1002/ptr.6925. [PMID: 33111362]
  • Sujuan Guo, Guofeng Wang, Zhengxiong Yang. Ligustilide alleviates the insulin resistance, lipid accumulation, and pathological injury with elevated phosphorylated AMPK level in rats with diabetes mellitus. Journal of receptor and signal transduction research. 2021 Feb; 41(1):85-92. doi: 10.1080/10799893.2020.1789877. [PMID: 32643505]
  • Xiufeng Jiang, Wei Zhao, Feng Zhu, Hui Wu, Xiao Ding, Jinmei Bai, Xiaoqing Zhang, Meifang Qian. Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism. Toxicology and applied pharmacology. 2021 01; 410(?):115336. doi: 10.1016/j.taap.2020.115336. [PMID: 33212065]
  • Yu-Miao Gan, Dong-Ling Liu, Chu Chen, Wei Duan, Yu-Xin Yang, Jun-Rong Du. Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation. European journal of pharmacology. 2020 Nov; 886(?):173552. doi: 10.1016/j.ejphar.2020.173552. [PMID: 32926919]
  • Xiaoxiao Wang, Yixin Yao, Chang An, Xi Li, Fangtao Xiang, Yangli Dong, Maosen Li. Simultaneous determination of 20 bioactive components in Chuanxiong Rhizoma from different production origins in Sichuan province by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry combined with multivariate statistical analysis. Electrophoresis. 2020 10; 41(18-19):1606-1616. doi: 10.1002/elps.202000082. [PMID: 32557720]
  • Qingxuan Xie, Linlin Zhang, Long Xie, Yu Zheng, Kai Liu, Hailong Tang, Yanmei Liao, Xiaofang Li. Z-ligustilide: A review of its pharmacokinetics and pharmacology. Phytotherapy research : PTR. 2020 Aug; 34(8):1966-1991. doi: 10.1002/ptr.6662. [PMID: 32135035]
  • Yanxia Zhang, Yaming Zhang, Yanming Han, Ye Tian, Pengcheng Wu, Aiyi Xin, Xiaoning Wei, Yanbin Shi, Zhenchang Zhang, Gang Su, Yanping Shi, Junxi Liu. Pharmacokinetics, tissue distribution, and safety evaluation of a ligustilide derivative (LIGc). Journal of pharmaceutical and biomedical analysis. 2020 Apr; 182(?):113140. doi: 10.1016/j.jpba.2020.113140. [PMID: 32036300]
  • Xiaoqiong Xu, Tiantian Zhu, Tingting Shi, Juan Chen, Ling Jin. Quality suitability regionalization analysis of Angelica sinensis in Gansu, China. PloS one. 2020; 15(12):e0243750. doi: 10.1371/journal.pone.0243750. [PMID: 33315941]
  • Qinhui Wang, Tao Yan, Wei Jiang, Na Hu, Song Zhang, Peng Yang, Wenjuan Zhang, Lei Shi, Linna Liu. Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4625. doi: 10.1002/bmc.4625. [PMID: 31222844]
  • Kemal Duric, Yang Liu, Shao-Nong Chen, David C Lankin, Dejan Nikolic, James B McAlpine, J Brent Friesen, Guido F Pauli. Studying Mass Balance and the Stability of (Z)-Ligustilide from Angelica sinensis Helps to Bridge a Botanical Instability-Bioactivity Chasm. Journal of natural products. 2019 09; 82(9):2400-2408. doi: 10.1021/acs.jnatprod.8b00962. [PMID: 31478376]
  • Wei Lei, Yan-Fang Deng, Xue-Yan Hu, Jia-Nan Ni, Min Jiang, Gang Bai. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Sep; 117(?):109074. doi: 10.1016/j.biopha.2019.109074. [PMID: 31177061]
  • Wonseok Lee, Hye Ryoung Koo, You-Jin Choi, Jin Gyu Choi, Myung Sook Oh, Xing Jin, Munki Choo, Sunghyouk Park, Yoo-Seong Jeong, Suk-Jae Chung, Byung-Hoon Lee. Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo. Planta medica. 2019 Jul; 85(9-10):719-728. doi: 10.1055/a-0901-1307. [PMID: 31137047]
  • Alice M S Rodrigues, Véronique Eparvier, Guillaume Odonne, Nadine Amusant, Didier Stien, Emeline Houël. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Scientific reports. 2019 06; 9(1):8729. doi: 10.1038/s41598-019-45222-y. [PMID: 31217530]
  • Wei-Hua Yan, Hong-Hong Cao, Shuang Guo, Li-Ya Gu, Wei Hu, Ming Cheng, De-Tao Bai, Jie Chen, Chun-Qin Mao, Lin Li, Tu-Lin Lu. [UPLC fingerprint and multi-components content determination of different processed products of Angelica sinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Jun; 44(12):2499-2510. doi: 10.19540/j.cnki.cjcmm.20190321.311. [PMID: 31359717]
  • F Yang, Z W Lin, T Y Huang, T T Chen, J Cui, M Y Li, Y Q Hua. Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway. Scientific reports. 2019 05; 9(1):6991. doi: 10.1038/s41598-019-43518-7. [PMID: 31061445]
  • Sipeng Wu, Ning Wang, Jing Li, Guangyun Wang, Sai Wang Seto, Dennis Chang, Huazheng Liang. Ligustilide Ameliorates the Permeability of the Blood-Brain Barrier Model In Vitro During Oxygen-Glucose Deprivation Injury Through HIF/VEGF Pathway. Journal of cardiovascular pharmacology. 2019 05; 73(5):316-325. doi: 10.1097/fjc.0000000000000664. [PMID: 30855407]
  • Yao Zhu, Yajie Zhang, Xia Huang, Yong Xie, Yuan Qu, Hongyan Long, Ning Gu, Weimin Jiang. Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes. Atherosclerosis. 2019 05; 284(?):110-120. doi: 10.1016/j.atherosclerosis.2019.02.010. [PMID: 30897380]
  • Fangfang Lang, Jinfeng Qu, Haiqin Yin, Lanyu Li, Yuanyuan Zhi, Yanping Liu, Zhenghui Fang, Enkui Hao. Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Nov; 121(?):631-638. doi: 10.1016/j.fct.2018.09.041. [PMID: 30243965]
  • Yuna Park, Dayoung Kim, Inho Yang, Bomee Choi, Jin Woo Lee, Seung Namkoong, Hyun Jung Koo, Sung Ryul Lee, Myung Rye Park, Hyosun Lim, Youn Kyu Kim, Sang Jip Nam, Eun-Hwa Sohn. Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells. Journal of microbiology and biotechnology. 2018 Jul; 28(7):1061-1067. doi: 10.4014/jmb.1812.02044. [PMID: 29913552]
  • Feipeng Duan, Wenjuan Xu, Jie Liu, Zhixin Jia, Kuikui Chen, Yijun Chen, Mingxia Wang, Kaiyue Ma, Jiaojiao Dong, Lianming Chen, Hongbin Xiao. Preparing the key metabolite of Z-ligustilide in vivo by a specific electrochemical reaction. Journal of separation science. 2018 Jul; 41(13):2799-2807. doi: 10.1002/jssc.201800164. [PMID: 29663726]
  • Hyun Kyung Kim, Seung Ju Lee, Bang-Yeon Hwang, Jong Ung Yoon, Gil-Hah Kim. Acaricidal and repellent effects of Cnidium officinale-derived material against Dermanyssus gallinae (Acari: Dermanyssidae). Experimental & applied acarology. 2018 Apr; 74(4):403-414. doi: 10.1007/s10493-018-0249-8. [PMID: 29569074]
  • Qin Zheng, Yu Tang, Peng-Yi Hu, Dan Liu, Delin Zhang, Pengfei Yue, Yuanyuan Guo, Ming Yang. The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model. Phytotherapy research : PTR. 2018 Mar; 32(3):426-435. doi: 10.1002/ptr.5985. [PMID: 29193364]
  • Yi-Jun Xu, Yu Mei, Zi-Ling Qu, Shi-Jie Zhang, Wei Zhao, Jian-Song Fang, Jun Wu, Cong Yang, Si-Jun Liu, Yong-Qi Fang, Qi Wang, Yong-Bin Zhang. Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction. BioMed research international. 2018; 2018(?):4606752. doi: 10.1155/2018/4606752. [PMID: 30079347]
  • Yang Yi, Guojun Dou, Zanyang Yu, Hui He, Chengqiang Wang, Li Li, Jia Zhou, Dejun Liu, Jianyou Shi, Guanrong Li, Lei Pang, Na Yang, Qinwan Huang, Hongyi Qi. Z-Ligustilide Exerted Hormetic Effect on Growth and Detoxification Enzymes of Spodoptera litura Larvae. Evidence-based complementary and alternative medicine : eCAM. 2018; 2018(?):7104513. doi: 10.1155/2018/7104513. [PMID: 30057645]
  • Iveta Bartoňková, Zdeněk Dvořák. Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Jan; 111(?):374-384. doi: 10.1016/j.fct.2017.11.049. [PMID: 29191726]
  • Xin-Guo Zhang, Ying Lu, Wen-Na Wang, Zi-Yu Liu, Jin-Wen Liu, Xiao-Qian Chen. A novel enzyme-assisted approach for efficient extraction of Z-ligustilide from Angelica sinensis plants. Scientific reports. 2017 08; 7(1):9783. doi: 10.1038/s41598-017-10004-x. [PMID: 28852066]
  • Hui Ma, Li Li, Guojun Dou, Chengqiang Wang, Juan Li, Hui He, Mingxia Wu, Hongyi Qi. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr; 8(17):29328-29345. doi: 10.18632/oncotarget.16440. [PMID: 28415616]
  • Y Gao, R Chen, N Gu, X L He, Z J Yang, K K Zuo. [Effects of ligustilide on the extracellular recombinant human heat shock protein 60 induced inflammatory reactions in the THP-1 cells and the related mechanisms]. Zhonghua xin xue guan bing za zhi. 2016 Sep; 44(9):793-798. doi: 10.3760/cma.j.issn.0253-3758.2016.09.012. [PMID: 27667279]
  • Peng-Yi Hu, Dan Liu, Qin Zheng, Qing Wu, Yu Tang, Ming Yang. Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model. Molecules (Basel, Switzerland). 2016 Mar; 21(3):300. doi: 10.3390/molecules21030300. [PMID: 26950101]
  • Yizhen Guo, Beiran Lv, Jingjuan Wang, Yang Liu, Suqin Sun, Yao Xiao, Lina Lu, Li Xiang, Yanfang Yang, Lei Qu, Qinghong Meng. Analysis of Chuanxiong Rhizoma and its active components by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2016 Jan; 153(?):550-9. doi: 10.1016/j.saa.2015.09.036. [PMID: 26439523]
  • Xu Liu, Xiuzhong Li, Songgang Ji, Xiaobo Cui, Mingchun Li. Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 40(3-4):770-780. doi: 10.1159/000453137. [PMID: 27915331]
  • Niloofar Barzegar-Fallah, Nasrin Baery, Majid Soleymankhani, Nafiseh Malekmohammadi, Houman Alimoradi, Abdolhamid Parsa, Anita Barzegar-Fallah. Kelussia odoratissima Mozaff attenuates thromboembolic brain injury, possibly due to its Z-ligustilide content. Brain injury. 2016; 30(7):926-32. doi: 10.3109/02699052.2016.1144083. [PMID: 27029466]
  • Takuhiro Uto, Nguyen Huu Tung, Risa Taniyama, Tosihide Miyanowaki, Osamu Morinaga, Yukihiro Shoyama. Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa. Phytotherapy research : PTR. 2015 Dec; 29(12):1956-63. doi: 10.1002/ptr.5490. [PMID: 26463105]
  • Qiong Zeng, Yan-Wei Jia, Pei-Li Xu, Meng-Wei Xiao, Yi-Ming Liu, Shu-Lin Peng, Xun Liao. Quick and selective extraction of Z-ligustilide from Angelica sinensis using magnetic multiwalled carbon nanotubes. Journal of separation science. 2015 Dec; 38(24):4269-75. doi: 10.1002/jssc.201500862. [PMID: 26496363]
  • Tingting Chen, Xiting Zhu, Qi Chen, Ming Ge, Xueping Jia, Xiang Wang, Cunwang Ge. Interaction between Z-ligustilide from Radix Angelica sinensis and human serum albumin. Food chemistry. 2015 Nov; 186(?):292-7. doi: 10.1016/j.foodchem.2014.11.041. [PMID: 25976824]
  • Liqin Huo, Jingze Zhang, Zhuo Qu, Hong Chen, Yuming Li, Wenyuan Gao. Vasorelaxant effects of Shunaoxin pill are mediated by NO/cGMP pathway, HO/CO pathway and calcium channel blockade in isolated rat thoracic aorta. Journal of ethnopharmacology. 2015 Sep; 173(?):352-60. doi: 10.1016/j.jep.2015.07.048. [PMID: 26239154]
  • Zhouwei Wu, Hiroshi Uchi, Saori Morino-Koga, Weimin Shi, Masutaka Furue. Z-ligustilide ameliorated ultraviolet B-induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO-1 and suppression of NF-κB pathway. Experimental dermatology. 2015 Sep; 24(9):703-8. doi: 10.1111/exd.12758. [PMID: 25977183]
  • Yan Yang, Jin-hai Yi, Zhi-fang Huang, Yun-hua Liu, Yu-hong Liu, Yan Chen. [Comparative Study on Volatile Oil Composition of Chuanxiong Rhizoma, Angelicae Sinensis Radix and Ligustici Rhizoma et Radix]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jun; 38(6):1212-6. doi: . [PMID: 26762063]
  • Valérian Bunel, Marie-Hélène Antoine, Joëlle Nortier, Pierre Duez, Caroline Stévigny. Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Apr; 29(3):458-67. doi: 10.1016/j.tiv.2014.12.017. [PMID: 25561245]
  • Ying Shi, Liming Xiao, Yi Yin, Lianbo Wei. Ligustilide inhibits tumour necrosis factor-alpha-induced autophagy during C2C12 cells differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2015 Feb; 69(?):42-6. doi: 10.1016/j.biopha.2014.11.002. [PMID: 25661336]
  • Megumi Sumino, Yuko Saito, Fumio Ikegami, Takao Namiki. A simultaneous determination of principal compounds in tokishakuyakusan by high-performance liquid chromatography with diode array detector. Journal of chromatographic science. 2015 Feb; 53(2):320-4. doi: 10.1093/chromsci/bmu062. [PMID: 24981981]
  • Jie-Jia Li, Qing Zhu, Ya-Peng Lu, Peng Zhao, Zhan-Bo Feng, Zhong-Ming Qian, Li Zhu. Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain. Brain research. 2015 Jan; 1595(?):19-28. doi: 10.1016/j.brainres.2014.10.012. [PMID: 25446001]
  • Weidong Xiao, Aixi Yu, Danli Liu, Jun Shen, Zhigao Xu. Ligustilide treatment promotes functional recovery in a rat model of spinal cord injury via preventing ROS production. International journal of clinical and experimental pathology. 2015; 8(10):12005-13. doi: . [PMID: 26722386]
  • Mitsuo Miyazawa, Hiroshi Nakahashi, Yusei Kashima, Ryota Motooka, Nobuyuki Hara, Hiroki Nakagawa, Takashi Yoshii, Atsushi Usami, Shinsuke Marumoto. Chemical Composition and Aroma Evaluation of Essential Oils from Skunk Cabbage (Symplocarpus foetidus). Journal of oleo science. 2015; 64(12):1329-36. doi: 10.5650/jos.ess15161. [PMID: 26632948]
  • Zhi-rong Gu, Ya-li Wang, Yu-jing Sun, Jun-xia Dind. [Application of entropy-weight TOPSIS model in synthetical quality evaluation of Angelica sinensis growing in Gansu Province]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Sep; 37(9):1549-53. doi: ". [PMID: 25857151]
  • Yapeng Lu, Siyuan Liu, Yu Zhao, Li Zhu, Shuqin Yu. Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability. Acta pharmaceutica (Zagreb, Croatia). 2014 Jun; 64(2):211-22. doi: 10.2478/acph-2014-0012. [PMID: 24914721]
  • Zhouwei Wu, Hiroshi Uchi, Saori Morino-Koga, Akiko Nakamura-Satomura, Kazuyo Kita, Weimin Shi, Masutaka Furue. Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation. Experimental dermatology. 2014 Apr; 23(4):260-5. doi: 10.1111/exd.12360. [PMID: 24588654]
  • Ying Shi, Dongtao Wang, Lu Lu, Yi Yin, Ming Wang, Chengjie Li, Jianxin Diao, Yanjing Wang, Lianbo Wei. Ligustilide prevents the apoptosis effects of tumour necrosis factor-alpha during C2C12 cell differentiation. International immunopharmacology. 2014 Apr; 19(2):358-64. doi: 10.1016/j.intimp.2014.02.007. [PMID: 24560902]
  • Kai Wu, Zhan-Zhang Wang, Dan Liu, Xian-Rong Qi. Pharmacokinetics, brain distribution, release and blood-brain barrier transport of Shunaoxin pills. Journal of ethnopharmacology. 2014 Feb; 151(3):1133-1140. doi: 10.1016/j.jep.2013.12.027. [PMID: 24373808]
  • Mingfei Zeng, Jing Zhang, Yifang Yang, Yan Jin, Wei Xiao, Zhenzhong Wang, Gang Ding, Renjie Yan. An automated dual-gradient liquid chromatography-MS/MS method for the simultaneous determination of ferulic acid, ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):354-63. doi: 10.1016/j.jpba.2013.08.038. [PMID: 24140450]
  • Xiao Yun Zhang, Hua Qiao, Yan Bin Shi. HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics. Pharmaceutical biology. 2014 Jan; 52(1):21-30. doi: 10.3109/13880209.2013.805790. [PMID: 24044763]
  • Jian Huang, Xiao-Qing Lu, Cui Zhang, Jin Lu, Guo-Yu Li, Rui-Chao Lin, Jin-Hui Wang. Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort. Fitoterapia. 2013 Dec; 91(?):21-27. doi: 10.1016/j.fitote.2013.08.013. [PMID: 23973655]
  • Jiawei Xin, Junjian Zhang, Ying Yang, Min Deng, Xiaofeng Xie. Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment. Current neurovascular research. 2013 Nov; 10(4):304-15. doi: 10.2174/15672026113109990023. [PMID: 23937197]
  • Xiong Liu, Li-ping Chen, Peng-fei Xia, Feng-lin Liu, Qin Fan, Lei Zhao. [Optimation the extracting technology of Angelica sinensis by central composite design and response surface methodology]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Nov; 36(11):1853-7. doi: ". [PMID: 24956828]
  • Lee-Hsin Shaw, Wei-Ming Chen, Tung-Hu Tsai. Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. Molecules (Basel, Switzerland). 2013 Sep; 18(9):11281-98. doi: 10.3390/molecules180911281. [PMID: 24036516]
  • Constance Lay Lay Saw, Qing Wu, Zheng-Yuan Su, Hu Wang, Yinhua Yang, Xiaoting Xu, Ying Huang, Tin Oo Khor, Ah-Ng Tony Kong. Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation. Biopharmaceutics & drug disposition. 2013 Sep; 34(6):303-11. doi: 10.1002/bdd.1846. [PMID: 23640758]
  • Xi Li, Li-Hong Zhang, Guang-Hua Lv, Xiao-Xiao Wang, Wei-Dong Jiang, Yu-Qing Jin, Zhong-Zhen Zhao. [Comparison on content of ligustilides in different danggui samples]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Sep; 38(17):2838-43. doi: ". [PMID: 24380307]
  • Juan David Guzman, Dimitrios Evangelopoulos, Antima Gupta, Jose M Prieto, Simon Gibbons, Sanjib Bhakta. Antimycobacterials from lovage root (Ligusticum officinale Koch). Phytotherapy research : PTR. 2013 Jul; 27(7):993-8. doi: 10.1002/ptr.4823. [PMID: 22899555]
  • Pei Liu, Zhenhao Li, Dawei Qian, Wei Li, Er-Xin Shang, Jin-Ao Duan. Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Jun; 929(?):63-9. doi: 10.1016/j.jchromb.2013.04.022. [PMID: 23665892]
  • Ai-Hua Zuo, Meng-Chun Cheng, Rong-Jie Zhuo, Li Wang, Hong-Bin Xiao. Structure elucidation of degradation products of Z-ligustilide by UPLC-QTOF-MS and NMR spectroscopy. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Jun; 48(6):911-6. doi: ". [PMID: 23984528]
  • Zhaoji Ma, Lunhao Bai. Anti-inflammatory effects of Z-ligustilide nanoemulsion. Inflammation. 2013 Apr; 36(2):294-9. doi: 10.1007/s10753-012-9546-2. [PMID: 23007925]
  • Qin Fan, Yin-Quan Wang, Pei-Kun An, Zeng-Xiang Guo, Qi Xia. [Effects of conjunctive application of Chinese herbal medicine residue compost and chemical fertilizer on ferulic acid and ligustilide contents in Angelica sinensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Feb; 36(2):176-80. doi: ". [PMID: 23901638]
  • Hong Zhang, Ting Han, Cheng-Hao Yu, Yi-Ping Jiang, Cheng Peng, Xia Ran, Lu-Ping Qin. Analysis of the chemical composition, acute toxicity and skin sensitivity of essential oil from rhizomes of Ligusticum chuanxiong. Journal of ethnopharmacology. 2012 Dec; 144(3):791-6. doi: 10.1016/j.jep.2012.10.010. [PMID: 23085396]
  • Zhanbo Feng, Yapeng Lu, Xiaomei Wu, Peng Zhao, Jiejia Li, Bin Peng, Zhongming Qian, Li Zhu. Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. Journal of ethnopharmacology. 2012 Nov; 144(2):313-21. doi: 10.1016/j.jep.2012.09.014. [PMID: 23022689]
  • Ri-Na Sa, Ya-Li Wang, Shu-Qiang Zhu, Xin-Bo Pan, Ying-Wen Yang, Yu-Jing Sun. [Study on the dynamic variations of Z-ligustilide and n-butylidenephthalide content in essential oil of radix angelicae sinensis from different growth period]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Nov; 35(11):1738-42. doi: . [PMID: 23627080]
  • Hongyi Qi, Jia Zhao, Yifan Han, Allan S Y Lau, Jianhui Rong. Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells. Neurotoxicity research. 2012 Nov; 22(4):345-54. doi: 10.1007/s12640-012-9319-6. [PMID: 22451226]
  • Shao-Hong Li, Peng-Fei Xia, Xiao Ma, Huan Shao. [Study on quality evaluation of Angelica sinensis by grey incidence degree method]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Nov; 35(11):1742-6. doi: ". [PMID: 23627081]
  • Sang Min Lee, Hye-Jin Kim, Young Pyo Jang. Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint. Phytochemical analysis : PCA. 2012 Sep; 23(5):508-12. doi: 10.1002/pca.2348. [PMID: 22271502]
  • Wendy Li Zhang, Ken Yu-Zhong Zheng, Kevin Yue Zhu, Janis Ya-Xian Zhan, Cathy Wen-Chuan Bi, Jian-Ping Chen, Crystal Ying-Qing Du, Kui-Jun Zhao, David Tai-Wai Lau, Tina Ting-Xia Dong, Karl Wah-Keung Tsim. Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Aug; 19(11):1042-8. doi: 10.1016/j.phymed.2012.07.009. [PMID: 22902230]
  • Yuzhi Zhou, Yanling Ren, Zhijie Ma, Guangcheng Jia, Xiaoxia Gao, Lizeng Zhang, Xuemei Qin. Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry. Journal of ethnopharmacology. 2012 May; 141(1):187-92. doi: 10.1016/j.jep.2012.02.018. [PMID: 22366681]
  • Ju-Ching Yeh, Ian J Garrard, Chin-Wen Chantal Cho, S W Annie Bligh, Guang-hua Lu, Tai-Ping Fan, Derek Fisher. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. Journal of chromatography. A. 2012 May; 1236(?):132-8. doi: 10.1016/j.chroma.2012.03.013. [PMID: 22458966]
  • Wen Ding, Dawei Qian, Pei Liu, Jin'ao Duan, Erxin Shang, Yuping Tang, Jing Wu. [Influence of different solutions on extracting of active components in Danggui Chishao drug pair]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Apr; 37(7):916-9. doi: . [PMID: 22792788]
  • Isabel Rivero, Krutzkaya Juárez, Magda Zuluaga, Robert Bye, Rachel Mata. Quantitative HPLC method for determining two of the major active phthalides from Ligusticum porteri roots. Journal of AOAC International. 2012 Jan; 95(1):84-91. doi: 10.5740/jaoacint.11-151. [PMID: 22468345]
  • Jian Zhong, Federica Pollastro, Jean Prenen, Zhiming Zhu, Giovanni Appendino, Bernd Nilius. Ligustilide: a novel TRPA1 modulator. Pflugers Archiv : European journal of physiology. 2011 Dec; 462(6):841-9. doi: 10.1007/s00424-011-1021-7. [PMID: 21894528]
  • Li-Ling Cheng, Xi-Nan Chen, Yu Wang, Lu Yu, Xi Kuang, Lu-Lu Wang, Wen Yang, Jun-Rong Du. Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice. Fitoterapia. 2011 Oct; 82(7):1128-32. doi: 10.1016/j.fitote.2011.07.011. [PMID: 21807074]