Carnosic acid (BioDeep_00000406498)
Main id: BioDeep_00000000500
natural product PANOMIX_OTCML-2023
代谢物信息卡片
(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
化学式: C20H28O4 (332.19874880000003)
中文名称: 鼠尾草酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=C(C(=C2C(=C1)CCC3C2(CCCC3(C)C)C(=O)O)O)O
InChI: InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1
描述信息
D020011 - Protective Agents > D000975 - Antioxidants
D000890 - Anti-Infective Agents
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:65585
- KEGG: C21818
- PubChem: 65126
- Metlin: METLIN58123
- ChEMBL: CHEMBL484853
- CAS: 139236-75-2
- CAS: 3650-09-7
- MoNA: VF-NPL-LTQ006010
- MoNA: VF-NPL-LTQ006009
- MoNA: VF-NPL-QEHF002580
- MoNA: VF-NPL-QEHF002579
- MoNA: VF-NPL-QEHF002578
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
24 个相关的物种来源信息
- 48032 - Carum carvi: 10.1021/JF051513Y
- 128608 - Cinnamomum verum: 10.1021/JF051513Y
- 52462 - Cuminum cyminum: 10.1021/JF051513Y
- 124778 - Illicium verum: 10.1021/JF051513Y
- 85223 - Laurus nobilis: 10.1021/JF051513Y
- 980666 - Lepechinia hastata: 10.1016/0031-9422(91)83645-2
- 1405040 - Lepechinia meyenii: 10.1016/0031-9422(91)83645-2
- 1405045 - Lepechinia salviae: 10.1080/10575630290020631
- 51089 - Myristica fragrans: 10.1021/JF051513Y
- 1817 - Nocardia: 10.1021/NP020189N
- 13216 - Piper nigrum: 10.1021/JF051513Y
- 39354 - Salvia abrotanoides: 10.1016/J.BMC.2006.03.047
- 392646 - Salvia apiana:
- 1520008 - Salvia aurea: 10.1021/NP0680376
- 49210 - Salvia canariensis:
- 95165 - Salvia columbariae: 10.1016/S0031-9422(06)80130-5
- 392671 - Salvia mellifera:
- 392673 - Salvia munzii: 10.1016/0031-9422(93)85376-3
- 38868 - Salvia officinalis:
- 207759 - Salvia pachyphylla: 10.1021/NP060279I
- 39367 - Salvia rosmarinus:
- 1132405 - Salvia tomentosa:
- 219868 - Syzygium aromaticum: 10.1021/JF051513Y
- 4650 - Zingiber: 10.1021/JF051513Y
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Georgina Horváth, Edit Molnár, Zoltán Szabó, Gábor Kecskeméti, László Juhász, Szabolcs Péter Tallósy, József Nyári, Anita Bogdanov, Ferenc Somogyvári, Valéria Endrész, Katalin Burián, Dezső P Virok. Carnosic Acid Inhibits Herpes Simplex Virus Replication by Suppressing Cellular ATP Synthesis.
International journal of molecular sciences.
2024 May; 25(9):. doi:
10.3390/ijms25094983. [PMID: 38732202] - Matteo Nadile, Newman Siu Kwan Sze, Val A Fajardo, Evangelia Tsiani. Inhibition of Prostate Cancer Cell Survival and Proliferation by Carnosic Acid Is Associated with Inhibition of Akt and Activation of AMPK Signaling.
Nutrients.
2024 Apr; 16(9):. doi:
10.3390/nu16091257. [PMID: 38732504] - Panagiotis Kallimanis, Prokopios Magiatis, Angeliki Panagiotopoulou, Kostas Ioannidis, Ioanna Chinou. Extraction Optimization and Qualitative/Quantitative Determination of Bioactive Abietane-Type Diterpenes from Three Salvia Species (Common Sage, Greek Sage and Rosemary) by 1H-qNMR.
Molecules (Basel, Switzerland).
2024 Jan; 29(3):. doi:
10.3390/molecules29030625. [PMID: 38338370] - Rocío López-Cabeza, Samuel Rodríguez-Sabina, Carolina P Reyes, Daniela G Expósito, Cristina Giménez, Ignacio A Jiménez, Raimundo Cabrera, Isabel L Bazzocchi. Bio-guided isolation of aromatic abietane diterpenoids from Salvia canariensis as biopesticides in the control of phytopathogenic fungi.
Pest management science.
2024 Jan; ?(?):. doi:
10.1002/ps.7958. [PMID: 38258969] - Shuang-Shuang Wan, Xue-Yuan Li, Si-Rui Liu, Shu Tang. The function of carnosic acid in lipopolysaccharides-induced hepatic and intestinal inflammation in poultry.
Poultry science.
2023 Dec; 103(3):103415. doi:
10.1016/j.psj.2023.103415. [PMID: 38215508] - Danuta Jantas, Piotr Warszyński, Władysław Lasoń. Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage.
Molecules (Basel, Switzerland).
2023 Dec; 29(1):. doi:
10.3390/molecules29010119. [PMID: 38202702] - Chun-Huei Liao, Hsiao-Chien Hung, Chiao-Ni Lai, Yu-Hsin Liao, Pei-Tong Liu, Si-Min Lu, Hui-Chi Huang, Chia-Wen Tsai. Carnosic acid and rosemary extract reversed the lipid accumulation induced by bisphenol A in the 3T3-L1 preadipocytes and C57BL/6J mice via SIRT1/FoxO1 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Aug; 179(?):113996. doi:
10.1016/j.fct.2023.113996. [PMID: 37598852] - Agnieszka M Hrebień-Filisińska, Grzegorz Tokarczyk. The Use of Ultrasound-Assisted Maceration for the Extraction of Carnosic Acid and Carnosol from Sage (Salvia officinalis L.) Directly into Fish Oil.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28166094. [PMID: 37630345] - Chunyan Zhu, Yunchang Fan, Hongwei Wu. The Selective Separation of Carnosic Acid and Rosmarinic Acid by Solid-Phase Extraction and Liquid-Liquid Extraction: A Comparative Study.
Molecules (Basel, Switzerland).
2023 Jul; 28(14):. doi:
10.3390/molecules28145493. [PMID: 37513364] - Jennifer M Marsh, Shane Whitaker, Lijuan Li, Rui Fang, Monique S J Simmonds, Nikolaos Vagkidis, Victor Chechik. The key phytochemistry of Rosemary (Salvia rosmarinus) contributing to Hair Protection against UV.
International journal of cosmetic science.
2023 Jul; ?(?):. doi:
10.1111/ics.12883. [PMID: 37461190] - Rían W Manville, Derk Hogenkamp, Geoffrey W Abbott. Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener.
Communications biology.
2023 Jun; 6(1):644. doi:
10.1038/s42003-023-05021-8. [PMID: 37322081] - Shan Hu, Beilei Liu, Manqi Yang, Shuai Mao, Hao Ju, Zheyu Liu, Min Huang, Gang Wu. Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2/HO-1 pathway.
Food & function.
2023 Apr; ?(?):. doi:
10.1039/d2fo03904d. [PMID: 37013966] - Antonio Raffo, Irene Baiamonte, Laura De Benedetti, Elisabetta Lupotto, Ilaria Marchioni, Nicoletta Nardo, Claudio Cervelli. Exploring volatile aroma and non-volatile bioactive compounds diversity in wild populations of rosemary (Salvia rosmarinus Schleid.).
Food chemistry.
2023 Mar; 404(Pt A):134532. doi:
10.1016/j.foodchem.2022.134532. [PMID: 36242966] - Fatima Javed Mirza, Saadia Zahid, R M Damian Holsinger. Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action.
Molecules (Basel, Switzerland).
2023 Mar; 28(5):. doi:
10.3390/molecules28052306. [PMID: 36903551] - Danlu Han, Wenliang Li, Zhuangwei Hou, Chufang Lin, Yun Xie, Xiaofang Zhou, Yuan Gao, Junwen Huang, Jianbin Lai, Li Wang, Liangsheng Zhang, Chengwei Yang. The chromosome-scale assembly of the Salvia rosmarinus genome provides insight into carnosic acid biosynthesis.
The Plant journal : for cell and molecular biology.
2023 Feb; 113(4):819-832. doi:
10.1111/tpj.16087. [PMID: 36579923] - Nemesio Villa-Ruano, Néstor Hernández-Silva, Jenaro Leocadio Varela-Caselis, Sergio Alberto-Ramirez-Garcia, Clemente Mosso-González. Controlled Production of Carnosic Acid and Carnosol in Cell Suspensions of Lepechinia meyenii Treated with Different Elicitors and Biosynthetic Precursors.
Chemistry & biodiversity.
2023 Feb; 20(2):e202200733. doi:
10.1002/cbdv.202200733. [PMID: 36562957] - Rong-Mei Zuo, Jing-Ya Jiao, Nan Chen, Xue-Li Jiang, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Carnosic acid suppressed the formation of NETs in alcoholic hepatosteatosis based on P2X7R-NLRP3 axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Feb; 110(?):154599. doi:
10.1016/j.phymed.2022.154599. [PMID: 36577209] - Doaa M Samy, Dalia Kamal Mostafa, Samar R Saleh, Passainte S Hassaan, Teshreen M Zeitoun, Gamal A G Ammar, Nahed H Elsokkary. Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2/HO-1 Pathway.
Molecular neurobiology.
2023 Feb; 60(2):610-628. doi:
10.1007/s12035-022-03093-x. [PMID: 36331794] - Lu Han, Lei Li, Geng Wu. Induction of ferroptosis by carnosic acid-mediated inactivation of Nrf2/HO-1 potentiates cisplatin responsiveness in OSCC cells.
Molecular and cellular probes.
2022 08; 64(?):101821. doi:
10.1016/j.mcp.2022.101821. [PMID: 35490795] - Katren F Khella, Ahmed I Abd El Maksoud, Amr Hassan, Shaimaa E Abdel-Ghany, Rafaat M Elsanhoty, Mohammed Abdullah Aladhadh, Mohamed A Abdel-Hakeem. Carnosic Acid Encapsulated in Albumin Nanoparticles Induces Apoptosis in Breast and Colorectal Cancer Cells.
Molecules (Basel, Switzerland).
2022 Jun; 27(13):. doi:
10.3390/molecules27134102. [PMID: 35807348] - Danja J Den Hartogh, Filip Vlavcheski, Adria Giacca, Rebecca E K MacPherson, Evangelia Tsiani. Carnosic Acid Attenuates the Free Fatty Acid-Induced Insulin Resistance in Muscle Cells and Adipocytes.
Cells.
2022 01; 11(1):. doi:
10.3390/cells11010167. [PMID: 35011728] - Jung-Yeon Kim, Hyo-Lim Hong, Gyun Moo Kim, Jaechan Leem, Hyun Hee Kwon. Protective Effects of Carnosic Acid on Lipopolysaccharide-Induced Acute Kidney Injury in Mice.
Molecules (Basel, Switzerland).
2021 Dec; 26(24):. doi:
10.3390/molecules26247589. [PMID: 34946671] - Joe M McCord, Brooks M Hybertson, Adela Cota-Gomez, Bifeng Gao. Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19.
Free radical biology & medicine.
2021 11; 175(?):56-64. doi:
10.1016/j.freeradbiomed.2021.05.033. [PMID: 34058321] - Xin Liu, Shiyan Dong, Mingyuan Dong, Yuan Li, Zhen Sun, Xinrui Zhang, Yingwu Wang, Lesheng Teng, Di Wang. Transferrin-conjugated liposomes loaded with carnosic acid inhibit liver cancer growth by inducing mitochondria-mediated apoptosis.
International journal of pharmaceutics.
2021 Sep; 607(?):121034. doi:
10.1016/j.ijpharm.2021.121034. [PMID: 34425193] - Shun Hasei, Takeshi Yamamotoya, Yusuke Nakatsu, Yukino Ohata, Shota Itoga, Yuji Nonaka, Yasuka Matsunaga, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Tomoichiro Asano. Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22084040. [PMID: 33919842] - Izabel Cristina Custodio de Souza, Rênata Cristina Bertolini Gobbo, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira. Carnosic acid depends on glutathione to promote mitochondrial protection in methylglyoxal-exposed SH-SY5Y cells.
Metabolic brain disease.
2021 03; 36(3):471-481. doi:
10.1007/s11011-020-00651-x. [PMID: 33411218] - Jacob P Veenstra, Bhaskar Vemu, Restituto Tocmo, Mirielle C Nauman, Jeremy J Johnson. Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis.
Nutrients.
2021 Feb; 13(3):. doi:
10.3390/nu13030773. [PMID: 33673488] - Thibault Lefebvre, Emilie Destandau, Eric Lesellier. Sequential extraction of carnosic acid, rosmarinic acid and pigments (carotenoids and chlorophylls) from Rosemary by online supercritical fluid extraction-supercritical fluid chromatography.
Journal of chromatography. A.
2021 Feb; 1639(?):461709. doi:
10.1016/j.chroma.2020.461709. [PMID: 33234291] - Xiao-Qing Wang, Ya-Hui Tang, Gui-Rong Zeng, Li-Feng Wu, Ying-Jun Zhou, Ze-Neng Cheng, De-Jian Jiang. Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway.
Psychopharmacology.
2021 Feb; 238(2):501-516. doi:
10.1007/s00213-020-05699-2. [PMID: 33161473] - Jie Cheng, Tao Xu, Chuanhui Xun, Hailong Guo, Rui Cao, Shutao Gao, Weibin Sheng. Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway.
Life sciences.
2021 Feb; 266(?):118905. doi:
10.1016/j.lfs.2020.118905. [PMID: 33333051] - Zahra Sadeghi, Milena Masullo, Antonietta Cerulli, Filomena Nazzaro, Mahdi Moridi Farimani, Sonia Piacente. Terpenoid Constituents of Perovskia artemisioides Aerial Parts with Inhibitory Effects on Bacterial Biofilm Growth.
Journal of natural products.
2021 01; 84(1):26-36. doi:
10.1021/acs.jnatprod.0c00832. [PMID: 33378620] - Mudassar Azhar, Guirong Zeng, Ayaz Ahmed, Ahsana Dar Farooq, Muhammad I Choudhary, Jiang De-Jiang, Xinmin Liu. Carnosic acid ameliorates depressive-like symptoms along with the modulation of FGF9 in the hippocampus of middle carotid artery occlusion-induced Sprague Dawley rats.
Phytotherapy research : PTR.
2021 Jan; 35(1):384-391. doi:
10.1002/ptr.6810. [PMID: 32779789] - Siyu Zhang, Sarah A Willett, Joseph R Hyatt, Silvana Martini, Casimir C Akoh. Phenolic compounds as antioxidants to improve oxidative stability of menhaden oil-based structured lipid as butterfat analog.
Food chemistry.
2021 Jan; 334(?):127584. doi:
10.1016/j.foodchem.2020.127584. [PMID: 32711274] - Sana Bahri, Ridha Ben Ali, Raed Abdennabi, Afef Nahdi, Mona Mlika, Saloua Jameleddine. Industrial Elimination of Essential Oils from Rosmarinus Officinalis: In Support of the Synergic Antifibrotic Effect of Rosmarinic and Carnosic Acids in Bleomycin Model of Lung Fibrosis.
Nutrition and cancer.
2021; 73(11-12):2376-2387. doi:
10.1080/01635581.2020.1826991. [PMID: 33059466] - Thibault Lefebvre, Emilie Destandau, Caroline West, Eric Lesellier. Supercritical Fluid Chromatography development of a predictive analytical tool to selectively extract bioactive compounds by supercritical fluid extraction and pressurised liquid extraction.
Journal of chromatography. A.
2020 Nov; 1632(?):461582. doi:
10.1016/j.chroma.2020.461582. [PMID: 33035852] - Bibi Marjan Razavi, Amir Reza Abazari, Maryam Rameshrad, Hossein Hosseinzadeh. Carnosic acid prevented olanzapine-induced metabolic disorders through AMPK activation.
Molecular biology reports.
2020 Oct; 47(10):7583-7592. doi:
10.1007/s11033-020-05825-5. [PMID: 32929650] - Huijuan Zheng, Wahyu Wijaya, Hongwei Zhang, Konglong Feng, Qianru Liu, Ting Zheng, Zhiya Yin, Yong Cao, Qingrong Huang. Improving the bioaccessibility and bioavailability of carnosic acid using a lecithin-based nanoemulsion: complementary in vitro and in vivo studies.
Food & function.
2020 Sep; 11(9):8141-8149. doi:
10.1039/d0fo01098g. [PMID: 32870226] - Tian-Yu Lou, Bei-Bei Ma, Yao-Yue Liang, Chen-Xiao Wang, Jin-Hui Liu, Rui-Ji Li, Shang-Yue Yu, Zhi-Bin Wang. [Analysis of carnosic acid metabolites in rats by UHPLC-Q-Exactive MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Aug; 45(16):3952-3960. doi:
10.19540/j.cnki.cjcmm.20200519.201. [PMID: 32893594] - Mojtaba Hadi Soltanabad, Mohammad B Bagherieh-Najjar, Manijeh Mianabadi. Carnosic Acid Content Increased by Silver Nanoparticle Treatment in Rosemary (Rosmarinus officinalis L.).
Applied biochemistry and biotechnology.
2020 Jun; 191(2):482-495. doi:
10.1007/s12010-019-03193-w. [PMID: 31797151] - Abdullah A AlKahtane, Esraa Ghanem, Simona G Bungau, Saud Alarifi, Daoud Ali, Gadah AlBasher, Saad Alkahtani, Lotfi Aleya, Mohamed M Abdel-Daim. Carnosic acid alleviates chlorpyrifos-induced oxidative stress and inflammation in mice cerebral and ocular tissues.
Environmental science and pollution research international.
2020 Apr; 27(11):11663-11670. doi:
10.1007/s11356-020-07736-1. [PMID: 31965510] - María D Mira-Sánchez, Julián Castillo-Sánchez, Juana María Morillas-Ruiz. Comparative study of rosemary extracts and several synthetic and natural food antioxidants. Relevance of carnosic acid/carnosol ratio.
Food chemistry.
2020 Mar; 309(?):125688. doi:
10.1016/j.foodchem.2019.125688. [PMID: 31732249] - Qunfeng Wu, Xuening Wang, Kien Pham, Aesis Luna, George P Studzinski, Chen Liu. Enhancement of sorafenib-mediated death of Hepatocellular carcinoma cells by Carnosic acid and Vitamin D2 analog combination.
The Journal of steroid biochemistry and molecular biology.
2020 03; 197(?):105524. doi:
10.1016/j.jsbmb.2019.105524. [PMID: 31704246] - Tian-Qi Bao, Yi Li, Cheng Qu, Zu-Guo Zheng, Hua Yang, Ping Li. Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalis L.) and its Phenolic Components.
The American journal of Chinese medicine.
2020; 48(6):1353-1368. doi:
10.1142/s0192415x20500664. [PMID: 33016104] - Jiwoon Park, Shin-Joung Rho, Yong-Ro Kim. Enhancing antioxidant and antimicrobial activity of carnosic acid in rosemary (Rosmarinus officinalis L.) extract by complexation with cyclic glucans.
Food chemistry.
2019 Nov; 299(?):125119. doi:
10.1016/j.foodchem.2019.125119. [PMID: 31295638] - Sonjit Das, Saikat Dewanjee, Tarun K Dua, Swarnalata Joardar, Pratik Chakraborty, Shovonlal Bhowmick, Achintya Saha, Simanta Bhattacharjee, Vincenzo De Feo. Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling.
Molecules (Basel, Switzerland).
2019 Nov; 24(22):. doi:
10.3390/molecules24224176. [PMID: 31752142] - Sukru Gungor, Muhammed E Inanc, Caner Ozturk, Firat Korkmaz, Ilktan Bastan, Beste Cil, John P Kastelic. Gallic and carnosic acids improve quality of frozen-thawed ram spermatozoa.
Andrologia.
2019 Nov; 51(10):e13393. doi:
10.1111/and.13393. [PMID: 31423610] - Si-Jian Wang, Qian Chen, Meng-Yang Liu, Hai-Yang Yu, Jing-Qi Xu, Jia-Qi Wu, Yi Zhang, Tao Wang. Regulation effects of rosemary (Rosmarinus officinalis Linn.) on hepatic lipid metabolism in OA induced NAFLD rats.
Food & function.
2019 Nov; 10(11):7356-7365. doi:
10.1039/c9fo01677e. [PMID: 31650134] - Liqun Zhao, Juanni Zhang, Yinke Fan, Ya Li. Antiproliferative Activity of Carnosic Acid is Mediated via Inhibition of Cell Migration and Invasion, and Suppression of Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Oct; 25(?):7864-7871. doi:
10.12659/msm.917735. [PMID: 31631173] - Antonios Koutsoulas, Martina Čarnecká, Jiří Slanina, Jaroslav Tóth, Iva Slaninová. Characterization of Phenolic Compounds and Antiproliferative Effects of Salvia pomifera and Salvia fruticosa Extracts.
Molecules (Basel, Switzerland).
2019 Aug; 24(16):. doi:
10.3390/molecules24162921. [PMID: 31408993] - Yusong Jin, Yunhui Zhang, Dongmei Liu, Dewen Liu, Chunying Zhang, Huijuan Qi, Huiyan Gu, Lei Yang, Zhiqiang Zhou. Efficient Homogenization-Ultrasound-Assisted Extraction of Anthocyanins and Flavonols from Bog Bilberry (Vaccinium uliginosum L.) Marc with Carnosic Acid as an Antioxidant Additive.
Molecules (Basel, Switzerland).
2019 Jul; 24(14):. doi:
10.3390/molecules24142537. [PMID: 31336730] - Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao. Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models.
Molecular medicine reports.
2019 Jul; 20(1):495-504. doi:
10.3892/mmr.2019.10299. [PMID: 31180544] - X Wang, M Nachliely, J S Harrison, M Danilenko, G P Studzinski. Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen.
The Journal of steroid biochemistry and molecular biology.
2019 03; 187(?):166-173. doi:
10.1016/j.jsbmb.2018.11.015. [PMID: 30508644] - Qiu-Lan Zhang, Jing-Jie Yang, Hong-Sheng Zhang. Carvedilol (CAR) combined with carnosic acid (CAA) attenuates doxorubicin-induced cardiotoxicity by suppressing excessive oxidative stress, inflammation, apoptosis and autophagy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):71-83. doi:
10.1016/j.biopha.2018.07.037. [PMID: 30396094] - Yoon-Hee Lee, Whasun Lim, Mi-Kyung Sung. Carnosic Acid Modulates Increased Hepatic Lipogenesis and Adipocytes Differentiation in Ovariectomized Mice Fed Normal or High-Fat Diets.
Nutrients.
2018 Dec; 10(12):. doi:
10.3390/nu10121984. [PMID: 30558262] - Wen Liu, Tian-Cong Wu, Dong-Mei Hong, Yue Hu, Ting Fan, Wen-Jie Guo, Qiang Xu. Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells.
Chinese journal of natural medicines.
2018 Dec; 16(12):907-915. doi:
10.1016/s1875-5364(18)30132-8. [PMID: 30595215] - Luciana Ferella, Juan Ignacio Bastón, Mariela Andrea Bilotas, José Javier Singla, Alejandro Martín González, Carla Noemí Olivares, Gabriela Fabiana Meresman. Active compounds present inRosmarinus officinalis leaves andScutellaria baicalensis root evaluated as new therapeutic agents for endometriosis.
Reproductive biomedicine online.
2018 Dec; 37(6):769-782. doi:
10.1016/j.rbmo.2018.09.018. [PMID: 30446309] - Xujian Qiu, Charlotte Jacobsen, Ann-Dorit Moltke Sørensen. The effect of rosemary (Rosmarinus officinalis L.) extract on the oxidative stability of lipids in cow and soy milk enriched with fish oil.
Food chemistry.
2018 Oct; 263(?):119-126. doi:
10.1016/j.foodchem.2018.04.106. [PMID: 29784296] - Pınar Ercan, Sedef Nehir El. Bioaccessibility and inhibitory effects on digestive enzymes of carnosic acid in sage and rosemary.
International journal of biological macromolecules.
2018 Aug; 115(?):933-939. doi:
10.1016/j.ijbiomac.2018.04.139. [PMID: 29709538] - Zhisheng Xie, Lingjun Zhong, Yanrao Wu, Xiaomeng Wan, Hua Yang, Xiaojun Xu, Ping Li. Carnosic acid improves diabetic nephropathy by activating Nrf2/ARE and inhibition of NF-κB pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Aug; 47(?):161-173. doi:
10.1016/j.phymed.2018.04.031. [PMID: 30166101] - Hong-Mao Song, Xiang Li, Yuan-Yuan Liu, Wei-Ping Lu, Zhao-Hui Cui, Li Zhou, Di Yao, Hong-Man Zhang. Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS.
International journal of molecular medicine.
2018 Jul; 42(1):193-207. doi:
10.3892/ijmm.2018.3593. [PMID: 29620148] - Haroon Khan, Kannan R R Rengasamy, Aini Pervaiz, Seyed Mohammad Nabavi, Atanas G Atanasov, Mohammad A Kamal. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.
European journal of medicinal chemistry.
2018 Jun; 153(?):2-28. doi:
10.1016/j.ejmech.2017.12.059. [PMID: 29329790] - Kai-Li Liu, Wen-Chen Kuo, Chia-Yuan Lin, Chong-Kuei Lii, Yen-Lin Liu, Yun-Hsin Cheng, Chia-Wen Tsai. Prevention of 4-hydroxynonenal-induced lipolytic activation by carnosic acid is related to the induction of glutathione S-transferase in 3T3-L1 adipocytes.
Free radical biology & medicine.
2018 06; 121(?):1-8. doi:
10.1016/j.freeradbiomed.2018.04.567. [PMID: 29698741] - Deliang Liu, Biao Wang, Yuandong Zhu, Feng Yan, Weimin Dong. Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells via suppressing microRNA-708.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2018 May; 23(3):741-746. doi:
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Food & function.
2018 Feb; 9(2):851-860. doi:
10.1039/c7fo01508a. [PMID: 29372208] - Ümihan Taandscedilkoparan Yilmaz, Elif Calik, Bayram Akdulum, Hasim Yilmaz. Determination of carnosic acid in Rosmarinus officinalis L. using square wave voltammetry and electrochemical behavior.
Journal of food and drug analysis.
2018 01; 26(1):300-308. doi:
10.1016/j.jfda.2017.04.004. [PMID: 29389567] - Cathy Su, Jeffrey P Gius, Julia Van Steenberg, Alexis H Haskins, Kazuki Heishima, Chisato Omata, Masahiro Iwayama, Mami Murakami, Takashi Mori, Kohji Maruo, Takamitsu A Kato. Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity.
Scientific reports.
2017 12; 7(1):16704. doi:
10.1038/s41598-017-16795-3. [PMID: 29196727] - Margot Loussouarn, Anja Krieger-Liszkay, Ljubica Svilar, Antoine Bily, Simona Birtić, Michel Havaux. Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms.
Plant physiology.
2017 Nov; 175(3):1381-1394. doi:
10.1104/pp.17.01183. [PMID: 28916593] - Aishah Albalawi, Reem Hasaballah A Alhasani, Lincoln Biswas, James Reilly, Xinhua Shu. Protective effect of carnosic acid against acrylamide-induced toxicity in RPE cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Oct; 108(Pt B):543-553. doi:
10.1016/j.fct.2017.01.026. [PMID: 28159594] - Jordi Ortuño, Rafael Serrano, Sancho Bañón. Incorporating rosemary diterpenes in lamb diet to improve microbial quality of meat packed in different environments.
Animal science journal = Nihon chikusan Gakkaiho.
2017 Sep; 88(9):1436-1445. doi:
10.1111/asj.12768. [PMID: 28139059] - Codruta Ignea, Anastasia Athanasakoglou, Aggeliki Andreadelli, Maria Apostolaki, Minas Iakovides, Euripides G Stephanou, Antonios M Makris, Sotirios C Kampranis. Overcoming the plasticity of plant specialized metabolism for selective diterpene production in yeast.
Scientific reports.
2017 08; 7(1):8855. doi:
10.1038/s41598-017-09592-5. [PMID: 28821847] - E Arranz, A Guri, T Fornari, J A Mendiola, G Reglero, M Corredig. In vitro uptake and immune functionality of digested Rosemary extract delivered through food grade vehicles.
Food research international (Ottawa, Ont.).
2017 07; 97(?):71-77. doi:
10.1016/j.foodres.2017.03.033. [PMID: 28578067] - Chun Ling Seow, Aik Jiang Lau. Differential activation of pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid.
Pharmacological research.
2017 Jun; 120(?):23-33. doi:
10.1016/j.phrs.2017.03.007. [PMID: 28288941] - Juanying Ou, Junqing Huang, Mingfu Wang, Shiyi Ou. Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro.
Food chemistry.
2017 Apr; 221(?):1057-1061. doi:
10.1016/j.foodchem.2016.11.056. [PMID: 27979058] - Ting Xu, Junjun Zhou, Jie Zhu, Shuai Zhang, Ning Zhang, Yan Zhao, Chunchun Ding, Xue Shi, Jihong Yao. Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats.
Metabolic brain disease.
2017 04; 32(2):483-491. doi:
10.1007/s11011-016-9941-8. [PMID: 27957651] - Mary H Grace, Yin Qiang, Shengmin Sang, Mary Ann Lila. One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography.
Journal of separation science.
2017 Mar; 40(5):1057-1062. doi:
10.1002/jssc.201601063. [PMID: 28008719] - Madina Naimi, Filip Vlavcheski, Brennan Murphy, Tomas Hudlicky, Evangelia Tsiani. Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation.
Clinical and experimental pharmacology & physiology.
2017 01; 44(1):94-102. doi:
10.1111/1440-1681.12674. [PMID: 27716981] - Sana Bahri, Frédérique Mies, Ridha Ben Ali, Mona Mlika, Saloua Jameleddine, Kathleen Mc Entee, Vadim Shlyonsky. Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts.
PloS one.
2017; 12(9):e0184368. doi:
10.1371/journal.pone.0184368. [PMID: 28877257] - Romain Guitard, Jean-François Paul, Véronique Nardello-Rataj, Jean-Marie Aubry. Myricetin, rosmarinic and carnosic acids as superior natural antioxidant alternatives to α-tocopherol for the preservation of omega-3 oils.
Food chemistry.
2016 Dec; 213(?):284-295. doi:
10.1016/j.foodchem.2016.06.038. [PMID: 27451183] - Andrea Del Pilar Sánchez-Camargo, Virginia García-Cañas, Miguel Herrero, Alejandro Cifuentes, Elena Ibáñez. Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells.
International journal of molecular sciences.
2016 Dec; 17(12):. doi:
10.3390/ijms17122046. [PMID: 27941607] - Nicolás M Vázquez, Graciela Fiorilli, Paulo A Cáceres Guido, Silvia Moreno. Carnosic acid acts synergistically with gentamicin in killing methicillin-resistant Staphylococcus aureus clinical isolates.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Nov; 23(12):1337-1343. doi:
10.1016/j.phymed.2016.07.010. [PMID: 27765353] - Gerlon de A R Oliveira, Anselmo E de Oliveira, Edemílson C da Conceição, Maria I G Leles. Multiresponse optimization of an extraction procedure of carnosol and rosmarinic and carnosic acids from rosemary.
Food chemistry.
2016 Nov; 211(?):465-73. doi:
10.1016/j.foodchem.2016.05.042. [PMID: 27283656] - Matan Nachliely, Ehud Sharony, Andrzej Kutner, Michael Danilenko. Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.
The Journal of steroid biochemistry and molecular biology.
2016 11; 164(?):59-65. doi:
10.1016/j.jsbmb.2015.09.014. [PMID: 26365556] - Xuening Wang, Jonathan S Harrison, George P Studzinski. Enhancement of arabinocytosine (AraC) toxicity to AML cells by a differentiation agent combination.
The Journal of steroid biochemistry and molecular biology.
2016 11; 164(?):72-78. doi:
10.1016/j.jsbmb.2015.08.023. [PMID: 26319201] - Lorenzo Di Cesare Mannelli, Laura Micheli, Mario Maresca, Giancarlo Cravotto, Maria Bellumori, Marzia Innocenti, Nadia Mulinacci, Carla Ghelardini. Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors.
Scientific reports.
2016 10; 6(?):34832. doi:
10.1038/srep34832. [PMID: 27713514] - Ulschan Scheler, Wolfgang Brandt, Andrea Porzel, Kathleen Rothe, David Manzano, Dragana Božić, Dimitra Papaefthimiou, Gerd Ulrich Balcke, Anja Henning, Swanhild Lohse, Sylvestre Marillonnet, Angelos K Kanellis, Albert Ferrer, Alain Tissier. Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast.
Nature communications.
2016 10; 7(?):12942. doi:
10.1038/ncomms12942. [PMID: 27703160] - Danuta Jaworska, Marian Czauderna, Wiesław Przybylski, Agnieszka J Rozbicka-Wieczorek. Sensory quality and chemical composition of meat from lambs fed diets enriched with fish and rapeseed oils, carnosic acid and seleno-compounds.
Meat science.
2016 Sep; 119(?):185-92. doi:
10.1016/j.meatsci.2016.05.003. [PMID: 27214277] - Lili Gao, Wen Shan, Wenjing Zeng, Yan Hu, Guangzhi Wang, Xiaofeng Tian, Ning Zhang, Xue Shi, Yan Zhao, Chunchun Ding, Feng Zhang, Kexin Liu, Jihong Yao. Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats.
Molecular nutrition & food research.
2016 09; 60(9):1902-11. doi:
10.1002/mnfr.201500878. [PMID: 27125489] - Kyong-Jin Jung, Kyoung-Jin Min, Jeen-Woo Park, Kwon Moo Park, Taeg Kyu Kwon. Carnosic acid attenuates unilateral ureteral obstruction-induced kidney fibrosis via inhibition of Akt-mediated Nox4 expression.
Free radical biology & medicine.
2016 08; 97(?):50-57. doi:
10.1016/j.freeradbiomed.2016.05.020. [PMID: 27212017] - Matan Nachliely, Ehud Sharony, Narasimha Rao Bolla, Andrzej Kutner, Michael Danilenko. Prodifferentiation Activity of Novel Vitamin D₂ Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells.
International journal of molecular sciences.
2016 Jul; 17(7):. doi:
10.3390/ijms17071068. [PMID: 27399677] - Lan Ban, Brindha Narasimhamoorthy, Liuqing Zhao, John A Greaves, William D Schroeder. Antioxidant activities from different rosemary clonal lines.
Food chemistry.
2016 Jun; 201(?):259-63. doi:
10.1016/j.foodchem.2016.01.082. [PMID: 26868574] - Jonathan S Harrison, Xuening Wang, George P Studzinski. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts.
Oncotarget.
2016 Jun; 7(24):36447-36460. doi:
10.18632/oncotarget.8998. [PMID: 27144333] - Stella Pesakhov, Matan Nachliely, Zeev Barvish, Nasma Aqaqe, Bar Schwartzman, Elena Voronov, Yoav Sharoni, George P Studzinski, Daniel Fishman, Michael Danilenko. Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid.
Oncotarget.
2016 May; 7(22):31847-61. doi:
10.18632/oncotarget.7240. [PMID: 26870993] - Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chun. Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells.
Oncology reports.
2016 May; 35(5):2723-32. doi:
10.3892/or.2016.4642. [PMID: 26936454] - Codruta Ignea, Anastasia Athanasakoglou, Efstathia Ioannou, Panagiota Georgantea, Fotini A Trikka, Sofia Loupassaki, Vassilios Roussis, Antonios M Makris, Sotirios C Kampranis. Carnosic acid biosynthesis elucidated by a synthetic biology platform.
Proceedings of the National Academy of Sciences of the United States of America.
2016 Mar; 113(13):3681-6. doi:
10.1073/pnas.1523787113. [PMID: 26976595] - Codruta Ignea, Efstathia Ioannou, Panagiota Georgantea, Fotini A Trikka, Anastasia Athanasakoglou, Sofia Loupassaki, Vassilios Roussis, Antonios M Makris, Sotirios C Kampranis. Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities.
Microbial cell factories.
2016 Feb; 15(?):46. doi:
10.1186/s12934-016-0440-8. [PMID: 26920948] - Cengiz Kocak, Fatma Emel Kocak, Raziye Akcilar, Ozben Ozden Isiklar, Havva Kocak, Zeynep Bayat, Hasan Simsek, Figen Taser, Irfan Altuntas. Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats.
Life sciences.
2016 Feb; 147(?):15-23. doi:
10.1016/j.lfs.2016.01.038. [PMID: 26820671] - Minori Yamahara, Koji Sugimura, Ayako Kumagai, Hiroyuki Fuchino, Azusa Kuroi, Mai Kagawa, Yumi Itoh, Hidehisa Kawahara, Yasuo Nagaoka, Osamu Iida, Nobuo Kawahara, Hiroshi Takemori, Hideto Watanabe. Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.
Journal of natural medicines.
2016 Jan; 70(1):28-35. doi:
10.1007/s11418-015-0933-5. [PMID: 26267810] - Jordi Ortuño, Rafael Serrano, Sancho Bañón. Antioxidant and antimicrobial effects of dietary supplementation with rosemary diterpenes (carnosic acid and carnosol) vs vitamin E on lamb meat packed under protective atmosphere.
Meat science.
2015 Dec; 110(?):62-9. doi:
10.1016/j.meatsci.2015.07.011. [PMID: 26186399] - Sakina M Petiwala, Jeremy J Johnson. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity.
Cancer letters.
2015 Oct; 367(2):93-102. doi:
10.1016/j.canlet.2015.07.005. [PMID: 26170168]