clofazimine (BioDeep_00000405784)
Main id: BioDeep_00000003113
natural product
代谢物信息卡片
clofazimine
化学式: C27H22Cl2N4 (472.1221)
中文名称: 氯法齐明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1
InChI: InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3
描述信息
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04B - Drugs for treatment of lepra > J04BA - Drugs for treatment of lepra
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007917 - Leprostatic Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C254 - Anti-Infective Agent > C258 - Antibiotic
D000893 - Anti-Inflammatory Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:3749
- KEGG: C06915
- KEGGdrug: D00278
- PubChem: 2794
- DrugBank: DB00845
- ChEMBL: CHEMBL1083384
- ChEMBL: CHEMBL1292
- MeSH: Clofazimine
- CAS: 2458811-14-6
- CAS: 2030-63-9
- MoNA: FiehnHILIC001842
- MoNA: FiehnHILIC000268
- PubChem: 9132
- NIKKAJI: J9.543E
- RefMet: Clofazimine
- KNApSAcK: 3749
- LOTUS: LTS0241466
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 2 - Bacteria: LTS0241466
- 1883 - Streptomyces: LTS0241466
- 1912 - Streptomyces hygroscopicus: 10.1021/NP400145U
- 1912 - Streptomyces hygroscopicus: LTS0241466
- 2062 - Streptomycetaceae: LTS0241466
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gautam Kumar, Shobhna Kapoor. Targeting mycobacterial membranes and membrane proteins: Progress and limitations.
Bioorganic & medicinal chemistry.
2023 03; 81(?):117212. doi:
10.1016/j.bmc.2023.117212. [PMID: 36804747] - Xintong Zhang, Yulong Shi, Zhihao Guo, Xiaoqiang Zhao, Jiajing Wu, Shouchun Cao, Yonghua Liu, Yuhua Li, Weijin Huang, Youchun Wang, Qiang Liu, Yinghong Li, Danqing Song. Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism.
European journal of medicinal chemistry.
2022 Apr; 234(?):114209. doi:
10.1016/j.ejmech.2022.114209. [PMID: 35279610] - Julia Kokesch-Himmelreich, Axel Treu, Alan M Race, Kerstin Walter, Christoph Hölscher, Andreas Römpp. Do Anti-tuberculosis Drugs Reach Their Target?─High-Resolution Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Provides Information on Drug Penetration into Necrotic Granulomas.
Analytical chemistry.
2022 04; 94(14):5483-5492. doi:
10.1021/acs.analchem.1c03462. [PMID: 35344339] - Abdullah Egiz, Dhir Gala. Clofazimine: another potential magic bullet for the treatment of COVID-19?.
Postgraduate medical journal.
2022 03; 98(e2):e124. doi:
10.1136/postgradmedj-2021-140143. [PMID: 35232867] - S E M Vonk, S W J Terheggen-Lagro, L M Mouissie, R A A Mathôt, E M Kemper. No drug-drug interaction between tezacaftor-ivacaftor and clofazimine: A case report.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2022 01; 21(1):e5-e7. doi:
10.1016/j.jcf.2021.10.003. [PMID: 34756823] - Alessandra Scagliola, Annarita Miluzio, Gabriele Ventura, Stefania Oliveto, Chiara Cordiglieri, Nicola Manfrini, Delia Cirino, Sara Ricciardi, Luca Valenti, Guido Baselli, Roberta D'Ambrosio, Marco Maggioni, Daniela Brina, Alberto Bresciani, Stefano Biffo. Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Nature communications.
2021 08; 12(1):4878. doi:
10.1038/s41467-021-25195-1. [PMID: 34385447] - Py Iroh Tam, S L M Arnold, L K Barrett, C R Chen, T M Conrad, E Douglas, M A Gordon, D Hebert, M Henrion, D Hermann, B Hollingsworth, E Houpt, K C Jere, R Lindblad, M S Love, L Makhaza, C W McNamara, W Nedi, J Nyirenda, D J Operario, J Phulusa, G V Quinnan, L A Sawyer, H Thole, N Toto, A Winter, W C Van Voorhis. Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 07; 73(2):183-191. doi:
10.1093/cid/ciaa421. [PMID: 32277809] - Selma Regina Penha Silva Cerqueira, Patrícia Duarte Deps, Débora Vilela Cunha, Natanael Victor Furtunato Bezerra, Daniel Holanda Barroso, Ana Bárbara Sapienza Pinheiro, Gecilmara Salviato Pillegi, Taynah Alves Rocha Repsold, Patrícia Shu Kurizky, Simon M Collin, Ciro Martins Gomes. The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study.
PLoS neglected tropical diseases.
2021 07; 15(7):e0009635. doi:
10.1371/journal.pntd.0009635. [PMID: 34319982] - Mahmoud Tareq Abdelwahab, Richard Court, Daniel Everitt, Andreas H Diacon, Rodney Dawson, Elin M Svensson, Gary Maartens, Paolo Denti. Effect of Clofazimine Concentration on QT Prolongation in Patients Treated for Tuberculosis.
Antimicrobial agents and chemotherapy.
2021 06; 65(7):e0268720. doi:
10.1128/aac.02687-20. [PMID: 33875426] - Renata Ribeiro de Castro, Flavia Almada do Carmo, Cláudia Martins, Alice Simon, Valeria Pereira de Sousa, Carlos Rangel Rodrigues, Lucio Mendes Cabral, Bruno Sarmento. Clofazimine functionalized polymeric nanoparticles for brain delivery in the tuberculosis treatment.
International journal of pharmaceutics.
2021 Jun; 602(?):120655. doi:
10.1016/j.ijpharm.2021.120655. [PMID: 33915184] - Areej Mohamed Ateya. Clofazimine: A potential therapeutic option for severe COVID-19.
Medical hypotheses.
2021 05; 150(?):110535. doi:
10.1016/j.mehy.2021.110535. [PMID: 33735762] - Shuofeng Yuan, Xin Yin, Xiangzhi Meng, Jasper Fuk-Woo Chan, Zi-Wei Ye, Laura Riva, Lars Pache, Chris Chun-Yiu Chan, Pok-Man Lai, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Andrew Chak-Yiu Lee, Naoko Matsunaga, Yuan Pu, Chun-Kit Yuen, Jianli Cao, Ronghui Liang, Kaiming Tang, Li Sheng, Yushen Du, Wan Xu, Chit-Ying Lau, Ko-Yung Sit, Wing-Kuk Au, Runming Wang, Yu-Yuan Zhang, Yan-Dong Tang, Thomas Mandel Clausen, Jessica Pihl, Juntaek Oh, Kong-Hung Sze, Anna Jinxia Zhang, Hin Chu, Kin-Hang Kok, Dong Wang, Xue-Hui Cai, Jeffrey D Esko, Ivan Fan-Ngai Hung, Ronald Adolphus Li, Honglin Chen, Hongzhe Sun, Dong-Yan Jin, Ren Sun, Sumit K Chanda, Kwok-Yung Yuen. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Nature.
2021 05; 593(7859):418-423. doi:
10.1038/s41586-021-03431-4. [PMID: 33727703] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Wael A Alghamdi, Mohammad H Al-Shaer, Maia Kipiani, Ketevan Barbakadze, Lali Mikiashvili, Russell R Kempker, Charles A Peloquin. Pharmacokinetics of bedaquiline, delamanid and clofazimine in patients with multidrug-resistant tuberculosis.
The Journal of antimicrobial chemotherapy.
2021 03; 76(4):1019-1024. doi:
10.1093/jac/dkaa550. [PMID: 33378452] - Tulshidas S Patil, Ashwini S Deshpande. Nanostructured lipid carrier-mediated lung targeted drug delivery system to enhance the safety and bioavailability of clofazimine.
Drug development and industrial pharmacy.
2021 Mar; 47(3):385-393. doi:
10.1080/03639045.2021.1892743. [PMID: 33646851] - Nathan D Helgert, Debra L Miller, Jacqueline C Whittemore, Mee-Ja M Sula. Intrahistiocytic Storage of Clofazimine Crystals in a Cat.
Veterinary pathology.
2021 03; 58(2):396-400. doi:
10.1177/0300985820980717. [PMID: 33327886] - Archana Pinapala, Lee Jin Koh, Kar-Hui Ng, Paul A Tambyah, Hui-Kim Yap. Clofazimine in Mycobacterium abscessus peritonitis: A pediatric case report.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2021 01; 41(1):104-109. doi:
10.1177/0896860820909702. [PMID: 32148178] - Mohammad M Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S Anderson, William L Jorgensen. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.
ACS medicinal chemistry letters.
2020 Dec; 11(12):2526-2533. doi:
10.1021/acsmedchemlett.0c00521. [PMID: 33324471] - Mahmoud Tareq Abdelwahab, Sean Wasserman, James C M Brust, Neel R Gandhi, Graeme Meintjes, Daniel Everitt, Andreas Diacon, Rodney Dawson, Lubbe Wiesner, Elin M Svensson, Gary Maartens, Paolo Denti. Clofazimine pharmacokinetics in patients with TB: dosing implications.
The Journal of antimicrobial chemotherapy.
2020 11; 75(11):3269-3277. doi:
10.1093/jac/dkaa310. [PMID: 32747933] - Jong-Hoon Lee, Ha Kyeu An, Mun-Gi Sohn, Paul Kivela, Sangsuk Oh. 4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21175953. [PMID: 32824985] - Joseph George. Metabolism and interactions of antileprosy drugs.
Biochemical pharmacology.
2020 07; 177(?):113993. doi:
10.1016/j.bcp.2020.113993. [PMID: 32339493] - Gaber El-Saber Batiha, Amany Magdy Beshbishy, Oluyomi Stephen Adeyemi, Eman Nadwa, Eman Rashwan, Naoaki Yokoyama, Ikuo Igarashi. Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.
PloS one.
2020; 15(2):e0228996. doi:
10.1371/journal.pone.0228996. [PMID: 32053698] - N Misra, N Padayatchi, P Naidoo. Dose-related adverse events in South African patients prescribed clofazimine for drug-resistant tuberculosis.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
2019 Dec; 110(1):32-37. doi:
10.7196/samj.2019.v110i1.13954. [PMID: 31865940] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Brandon Banaschewski, Deepshikha Verma, Lian J Pennings, Matthew Zimmerman, Qihua Ye, Jake Gadawa, Veronique Dartois, Diane Ordway, Jakko van Ingen, Stefan Ufer, Kevin Stapleton, Thomas Hofmann. Clofazimine inhalation suspension for the aerosol treatment of pulmonary nontuberculous mycobacterial infections.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2019 09; 18(5):714-720. doi:
10.1016/j.jcf.2019.05.013. [PMID: 31138497] - Malinda Salim, Gisela Ramirez, Andrew J Clulow, Yingyue Zhang, Kurt D Ristroph, Jie Feng, Simon A McManus, Adrian Hawley, Robert K Prud'homme, Ben J Boyd. Solid-State Behavior and Solubilization of Flash Nanoprecipitated Clofazimine Particles during the Dispersion and Digestion of Milk-Based Formulations.
Molecular pharmaceutics.
2019 06; 16(6):2755-2765. doi:
10.1021/acs.molpharmaceut.9b00276. [PMID: 31038976] - Shengyuan Wu, Liai Lan, Jingjing Jiang, Xianting Ding, Chih-Ming Ho, Yuefen Lou, Guorong Fan. Simultaneous determination of the potent anti-tuberculosis regimen-Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC-MS/MS method coupled with 96-well format plate.
Journal of pharmaceutical and biomedical analysis.
2019 May; 168(?):44-54. doi:
10.1016/j.jpba.2019.02.006. [PMID: 30784889] - Mohammad Rehan Ajmal, Fahad Almutairi, Nida Zaidi, Parvez Alam, Mohammad Khursheed Siddiqi, Mohsin Vahid Khan, Masihuz Zaman, Mohd Ishtikhar, Rizwan Hasan Khan. Biophysical insights into the interaction of clofazimine with human alpha 1-acid glycoprotein: a multitechnique approach.
Journal of biomolecular structure & dynamics.
2019 04; 37(6):1390-1401. doi:
10.1080/07391102.2018.1461686. [PMID: 29669491] - Yagmur Caliskan, Ali Deniz Dalgic, Selin Gerekci, Ezgi A Gulec, Aysen Tezcaner, Can Ozen, Dilek Keskin. A new therapeutic combination for osteosarcoma: Gemcitabine and Clofazimine co-loaded liposomal formulation.
International journal of pharmaceutics.
2019 Feb; 557(?):97-104. doi:
10.1016/j.ijpharm.2018.12.041. [PMID: 30586631] - Yuri de Deus Mont'alverne Parente, Amanda Lopes de Castro, Flávio Bezerra de Araújo, André Costa Teixeira, Ítalo Criszostomo Lima, Elizabeth De Francesco Daher. Acute renal failure by rapidly progressive glomerulonephritis with IgA deposition in a patient concomitantly diagnosed with multibacillary Hansen's disease: a case report.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2019 Jan; 41(1):152-156. doi:
10.1590/2175-8239-jbn-2018-0056. [PMID: 30160772] - Nafees Ahmad, Shama D Ahuja, Onno W Akkerman, Jan-Willem C Alffenaar, Laura F Anderson, Parvaneh Baghaei, Didi Bang, Pennan M Barry, Mayara L Bastos, Digamber Behera, Andrea Benedetti, Gregory P Bisson, Martin J Boeree, Maryline Bonnet, Sarah K Brode, James C M Brust, Ying Cai, Eric Caumes, J Peter Cegielski, Rosella Centis, Pei-Chun Chan, Edward D Chan, Kwok-Chiu Chang, Macarthur Charles, Andra Cirule, Margareth Pretti Dalcolmo, Lia D'Ambrosio, Gerard de Vries, Keertan Dheda, Aliasgar Esmail, Jennifer Flood, Gregory J Fox, Mathilde Fréchet-Jachym, Geisa Fregona, Regina Gayoso, Medea Gegia, Maria Tarcela Gler, Sue Gu, Lorenzo Guglielmetti, Timothy H Holtz, Jennifer Hughes, Petros Isaakidis, Leah Jarlsberg, Russell R Kempker, Salmaan Keshavjee, Faiz Ahmad Khan, Maia Kipiani, Serena P Koenig, Won-Jung Koh, Afranio Kritski, Liga Kuksa, Charlotte L Kvasnovsky, Nakwon Kwak, Zhiyi Lan, Christoph Lange, Rafael Laniado-Laborín, Myungsun Lee, Vaira Leimane, Chi-Chiu Leung, Eric Chung-Ching Leung, Pei Zhi Li, Phil Lowenthal, Ethel L Maciel, Suzanne M Marks, Sundari Mase, Lawrence Mbuagbaw, Giovanni B Migliori, Vladimir Milanov, Ann C Miller, Carole D Mitnick, Chawangwa Modongo, Erika Mohr, Ignacio Monedero, Payam Nahid, Norbert Ndjeka, Max R O'Donnell, Nesri Padayatchi, Domingo Palmero, Jean William Pape, Laura J Podewils, Ian Reynolds, Vija Riekstina, Jérôme Robert, Maria Rodriguez, Barbara Seaworth, Kwonjune J Seung, Kathryn Schnippel, Tae Sun Shim, Rupak Singla, Sarah E Smith, Giovanni Sotgiu, Ganzaya Sukhbaatar, Payam Tabarsi, Simon Tiberi, Anete Trajman, Lisa Trieu, Zarir F Udwadia, Tjip S van der Werf, Nicolas Veziris, Piret Viiklepp, Stalz Charles Vilbrun, Kathleen Walsh, Janice Westenhouse, Wing-Wai Yew, Jae-Joon Yim, Nicola M Zetola, Matteo Zignol, Dick Menzies. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.
Lancet (London, England).
2018 09; 392(10150):821-834. doi:
10.1016/s0140-6736(18)31644-1. [PMID: 30215381] - Patrick Nachipo, David Hermann, Gerald Quinnan, Melita A Gordon, Wesley C Van Voorhis, Pui-Ying Iroh Tam. Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial.
Trials.
2018 Aug; 19(1):456. doi:
10.1186/s13063-018-2846-6. [PMID: 30139372] - Miguel A Chavez, A Clinton White. Novel treatment strategies and drugs in development for cryptosporidiosis.
Expert review of anti-infective therapy.
2018 08; 16(8):655-661. doi:
10.1080/14787210.2018.1500457. [PMID: 30003818] - Hendra Gunawan, Muljaningsih Sasmojo, Helena Eka Putri, Erda Avriyanti, Reti Hindritiani, Oki Suwarsa. Clinical pilot study: Clarithromycin efficacy in multibacillary leprosy therapy.
International journal of mycobacteriology.
2018 Apr; 7(2):152-155. doi:
10.4103/ijmy.ijmy_58_18. [PMID: 29900892] - Luíse L Chaves, Sofia Lima, Alexandre C C Vieira, Domingos Ferreira, Bruno Sarmento, Salette Reis. Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles.
Journal of the Royal Society, Interface.
2018 02; 15(139):. doi:
10.1098/rsif.2017.0932. [PMID: 29436513] - Ramachandra Sangana, Helen Gu, Dung Yu Chun, Heidi J Einolf. Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches.
Drug metabolism and disposition: the biological fate of chemicals.
2018 01; 46(1):26-32. doi:
10.1124/dmd.117.077834. [PMID: 29038231] - Julie Trexel, Gi S Yoon, Rahul K Keswani, Cora McHugh, Larisa Yeomans, Victor Vitvitsky, Ruma Banerjee, Sudha Sud, Yihan Sun, Gus R Rosania, Kathleen A Stringer. Macrophage-Mediated Clofazimine Sequestration Is Accompanied by a Shift in Host Energy Metabolism.
Journal of pharmaceutical sciences.
2017 04; 106(4):1162-1174. doi:
10.1016/j.xphs.2016.12.009. [PMID: 28007559] - İpek Z Durusu, Hazal H Hüsnügil, Heval Ataş, Ayşenur Biber, Selin Gerekçi, Ezgi A Güleç, Can Özen. Anti-cancer effect of clofazimine as a single agent and in combination with cisplatin on U266 multiple myeloma cell line.
Leukemia research.
2017 04; 55(?):33-40. doi:
10.1016/j.leukres.2017.01.019. [PMID: 28122281] - Nicole C Ammerman, Rosemary V Swanson, Asa Tapley, Chivonne Moodley, Bongani Ngcobo, John Adamson, Afton Dorasamy, Sashen Moodley, Zinhle Mgaga, Linda A Bester, Sanil D Singh, Deepak V Almeida, Jacques H Grosset. Clofazimine has delayed antimicrobial activity against Mycobacterium tuberculosis both in vitro and in vivo.
The Journal of antimicrobial chemotherapy.
2017 02; 72(2):455-461. doi:
10.1093/jac/dkw417. [PMID: 27798204] - Mohammad Rehan Ajmal, Nida Zaidi, Parvez Alam, Saima Nusrat, Mohd Khursheed Siddiqi, Gamal Badr, Mohamed H Mahmoud, Rizwan Hasan Khan. Insight into the interaction of antitubercular and anticancer compound clofazimine with human serum albumin: spectroscopy and molecular modelling.
Journal of biomolecular structure & dynamics.
2017 Jan; 35(1):46-57. doi:
10.1080/07391102.2015.1132258. [PMID: 27207224] - Rahul K Keswani, Gi S Yoon, Sudha Sud, Kathleen A Stringer, Gus R Rosania. A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2015 Sep; 87(9):855-67. doi:
10.1002/cyto.a.22706. [PMID: 26109497] - Rahul K Keswani, Jason Baik, Larisa Yeomans, Chuck Hitzman, Allison M Johnson, Ashtamurthy S Pawate, Paul J A Kenis, Nair Rodriguez-Hornedo, Kathleen A Stringer, Gus R Rosania. Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition.
Molecular pharmaceutics.
2015 Jul; 12(7):2528-36. doi:
10.1021/acs.molpharmaceut.5b00032. [PMID: 25926092] - Priyanka Tyagi, Allimuthu T Dharmaraja, Ashima Bhaskar, Harinath Chakrapani, Amit Singh. Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide.
Free radical biology & medicine.
2015 Jul; 84(?):344-354. doi:
10.1016/j.freeradbiomed.2015.03.008. [PMID: 25819161] - P F Cariello, E J Kwak, R C Abdel-Massih, F P Silveira. Safety and tolerability of clofazimine as salvage therapy for atypical mycobacterial infection in solid organ transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2015 Feb; 17(1):111-8. doi:
10.1111/tid.12340. [PMID: 25620390] - Rosemary V Swanson, John Adamson, Chivonne Moodley, Bongani Ngcobo, Nicole C Ammerman, Afton Dorasamy, Sashen Moodley, Zinhle Mgaga, Asa Tapley, Linda A Bester, Sanil Singh, Jacques H Grosset, Deepak V Almeida. Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis.
Antimicrobial agents and chemotherapy.
2015; 59(6):3042-51. doi:
10.1128/aac.00260-15. [PMID: 25753644] - Cheruvu Hanumanth Srikanth, Pankaj Joshi, Anil Kumar Bikkasani, Konica Porwal, Jiaur R Gayen. Bone distribution study of anti leprotic drug clofazimine in rat bone marrow cells by a sensitive reverse phase liquid chromatography method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jun; 960(?):82-6. doi:
10.1016/j.jchromb.2014.04.022. [PMID: 24792531] - Weijie Zhao, Zhenyong Guo, Meiqin Zheng, Jinfu Zhang, Bin Wang, Peng Li, Lei Fu, Shuo Liu. Activity of linezolid-containing regimens against multidrug-resistant tuberculosis in mice.
International journal of antimicrobial agents.
2014 Feb; 43(2):148-53. doi:
10.1016/j.ijantimicag.2013.10.010. [PMID: 24290060] - Taysa Ribeiro Schalcher, Rosivaldo S Borges, Michael D Coleman, João Batista Júnior, Claudio G Salgado, Jose Luiz F Vieira, Pedro R T Romão, Fabio R Oliveira, Marta Chagas Monteiro. Clinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidation.
PloS one.
2014; 9(1):e85712. doi:
10.1371/journal.pone.0085712. [PMID: 24465659] - Jakko van Ingen, Eric F Egelund, Adrah Levin, Sarah E Totten, Martin J Boeree, Johan W Mouton, Rob E Aarnoutse, Leonid B Heifets, Charles A Peloquin, Charles L Daley. The pharmacokinetics and pharmacodynamics of pulmonary Mycobacterium avium complex disease treatment.
American journal of respiratory and critical care medicine.
2012 Sep; 186(6):559-65. doi:
10.1164/rccm.201204-0682oc. [PMID: 22744719] - K R Caleffi, R D C Hirata, M H Hirata, E R Caleffi, V L D Siqueira, R F Cardoso. Use of the polymerase chain reaction to detect Mycobacterium leprae in urine.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2012 Feb; 45(2):153-7. doi:
10.1590/s0100-879x2012007500011. [PMID: 22286535] - Yang Degang, Takeshi Akama, Takeshi Hara, Kazunari Tanigawa, Yuko Ishido, Masaichi Gidoh, Masahiko Makino, Norihisa Ishii, Koichi Suzuki. Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages.
PLoS neglected tropical diseases.
2012; 6(12):e1936. doi:
10.1371/journal.pntd.0001936. [PMID: 23236531] - Antoinette Labuschagné, Ahmed A Hussein, Benjamín Rodríguez, Namrita Lall. Synergistic Antimycobacterial Actions of Knowltonia vesicatoria (L.f) Sims.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):808979. doi:
10.1155/2012/808979. [PMID: 22611433] - Jason Baik, Gus R Rosania. Molecular imaging of intracellular drug-membrane aggregate formation.
Molecular pharmaceutics.
2011 Oct; 8(5):1742-9. doi:
10.1021/mp200101b. [PMID: 21800872] - Justin D Clifton, Edinson Lucumi, Michael C Myers, Andrew Napper, Kotaro Hama, Steven A Farber, Amos B Smith, Donna M Huryn, Scott L Diamond, Michael Pack. Identification of novel inhibitors of dietary lipid absorption using zebrafish.
PloS one.
2010 Aug; 5(8):e12386. doi:
10.1371/journal.pone.0012386. [PMID: 20811635] - Vanessa Amaral Mendonça, Rosane Dias Costa, Sandra Lyon, Rachel Adriana Penido, Valdinéria Oliveira Borges, Thales Lage Bretas, Carlos Mauricio Antunes, Mauro Martins Teixeira, Antonio Lúcio Teixeira. Plasma levels of chemokines during leprosy specific treatment.
Acta tropica.
2010 Feb; 113(2):151-4. doi:
10.1016/j.actatropica.2009.10.010. [PMID: 19874796] - Larry Becker, Cathy Kowalewski, John M Martin. Nonpruritic erythematous plaques.
The Journal of family practice.
2009 Dec; 58(12):657-9. doi:
NULL. [PMID: 19961820] - S Guditi, R Ram, K M Ismal, M Sahay, K V Dakshinamurthy, N Girish, N Prasad. Leprosy in a renal transplant recipient: review of the literature.
Transplant infectious disease : an official journal of the Transplantation Society.
2009 Dec; 11(6):557-62. doi:
10.1111/j.1399-3062.2009.00428.x. [PMID: 19656347] - Yu Lu, Mei-Qin Zheng, Bin Wang, Wei-Jie Zhao, Lei Fu, Peng Li, Bo-Wen Liang, Nai-Hui Chu. [Tissue distribution and deposition of clofazimine in mice following oral administration of isoniazid].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2009 Sep; 32(9):694-7. doi:
NULL. [PMID: 20079285] - Manju Y Krishnan, Elizabeth J B Manning, Michael T Collins. Comparison of three methods for susceptibility testing of Mycobacterium avium subsp. paratuberculosis to 11 antimicrobial drugs.
The Journal of antimicrobial chemotherapy.
2009 Aug; 64(2):310-6. doi:
10.1093/jac/dkp184. [PMID: 19457932] - Patrícia Sammarco Rosa, Cleverson Teixeira Soares, Andréa de Faria Fernandes Belone, Raquel Vilela, Somei Ura, Milton Cury Filho, Leonel Mendoza. Accidental Jorge Lobo's disease in a worker dealing with Lacazia loboi infected mice: a case report.
Journal of medical case reports.
2009 Feb; 3(?):67. doi:
10.1186/1752-1947-3-67. [PMID: 19220901] - Flávia Aparecida Paina, Regina Helena Costa Queiroz, Ana Maria de Souza. [Hematological, hemostatic and biochemical alterations induced by clofazimine and clarithromycin, in single and multiple doses, in rats].
Revista da Sociedade Brasileira de Medicina Tropical.
2008 May; 41(3):282-7. doi:
10.1590/s0037-86822008000300011. [PMID: 18719809] - Jason T Lewis, Joseph N Candelora, Reed B Hogan, Frank R Briggs, Susan C Abraham. Crystal-storing histiocytosis due to massive accumulation of charcot-leyden crystals: a unique association producing colonic polyposis in a 78-year-old woman with eosinophilic colitis.
The American journal of surgical pathology.
2007 Mar; 31(3):481-5. doi:
10.1097/01.pas.0000213420.46127.9c. [PMID: 17325492] - Krishnamurthy Venkatesan, Nirmala Deo, Umesh Dutt Gupta. Tissue distribution and deposition of clofazimine in mice following oral administration with or without isoniazid.
Arzneimittel-Forschung.
2007; 57(7):472-4. doi:
10.1055/s-0031-1296634. [PMID: 17803061] - Simon Townson, Senyo Tagboto, Helen F McGarry, Gillian L Egerton, Mark J Taylor. Onchocerca parasites and Wolbachia endosymbionts: evaluation of a spectrum of antibiotic types for activity against Onchocerca gutturosa in vitro.
Filaria journal.
2006 Mar; 5(?):4. doi:
10.1186/1475-2883-5-4. [PMID: 16563157] - M Bayes, X Rabasseda, J R Prous. Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology.
2006 Mar; 28(2):121-42. doi:
. [PMID: 16636723] - Randolph M Baral, Steven S Metcalfe, Mark B Krockenberger, Melissa J Catt, Vanessa R Barrs, Carol McWhirter, Christina A Hutson, Denise I Wigney, Patricia Martin, Sharon C A Chen, David H Mitchell, Richard Malik. Disseminated Mycobacterium avium infection in young cats: overrepresentation of Abyssinian cats.
Journal of feline medicine and surgery.
2006 Feb; 8(1):23-44. doi:
10.1016/j.jfms.2005.06.004. [PMID: 16226469] - Edson N Alves-Rodrigues, Luciano C Ribeiro, Margareth D Silva, Arley Takiuchi, Osvaldo C Rabel-Filho, Dino Martini-Filho, Cor J F Fontes. Renal hypersensitivity vasculitis associated with dapsone.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2005 Oct; 46(4):e51-3. doi:
10.1053/j.ajkd.2005.06.022. [PMID: 16183407] - R Vijayaraghavan, C S Suribabu, B Sekar, P K Oommen, S N Kavithalakshmi, N Madhusudhanan, C Panneerselvam. Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients.
European journal of clinical nutrition.
2005 Oct; 59(10):1121-8. doi:
10.1038/sj.ejcn.1602221. [PMID: 16015260] - Hung-Chun Shih, Tung-Wei Hung, Jong-Da Lian, Shih-Ming Tsao, Nan-Kuang Hsieh, Jen-Hung Yang. Leprosy in a renal transplant recipient: a case report and literature review.
The Journal of dermatology.
2005 Aug; 32(8):661-6. doi:
10.1111/j.1346-8138.2005.tb00818.x. [PMID: 16334868] - Edson Nogueira Alves-Rodrigues, Luciano Correa Ribeiro, Margareth Dióz Silva, Arley Takiuchi, Cor Jesus Fernandes Fontes. Dapsone syndrome with acute renal failure during leprosy treatment: case report.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.
2005 Feb; 9(1):84-6. doi:
10.1590/s1413-86702005000100014. [PMID: 15947852] - Fábio Bucaretchi, Danielly C Vicente, Ricardo M Pereira, Antonia T Tresoldi. Dapsone hypersensitivity syndrome in an adolescent during treatment during of leprosy.
Revista do Instituto de Medicina Tropical de Sao Paulo.
2004 Nov; 46(6):331-4. doi:
10.1590/s0036-46652004000600006. [PMID: 15654479] - V M Katoch. Infections due to non-tuberculous mycobacteria (NTM).
The Indian journal of medical research.
2004 Oct; 120(4):290-304. doi:
. [PMID: 15520483] - Ernestas Janulionis, Carolina Sofer, Ho-Yeon Song, Robert S Wallis. Lack of activity of orally administered clofazimine against intracellular Mycobacterium tuberculosis in whole-blood culture.
Antimicrobial agents and chemotherapy.
2004 Aug; 48(8):3133-5. doi:
10.1128/aac.48.8.3133-3135.2004. [PMID: 15273133] - Mohammad H Pourgholami, Ying Lu, Lisa Wang, Ross W Stephens, David L Morris. Regression of Novikoff rat hepatocellular carcinoma following locoregional administration of a novel formulation of clofazimine in lipiodol.
Cancer letters.
2004 Apr; 207(1):37-47. doi:
10.1016/j.canlet.2003.11.019. [PMID: 15050732] - D E David E Nix, R D Rodney D Adam, Barbara Auclair, T S Todd S Krueger, P G Paul G Godo, C A Charles A Peloquin. Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid.
Tuberculosis (Edinburgh, Scotland).
2004; 84(6):365-73. doi:
10.1016/j.tube.2004.04.001. [PMID: 15525560] - R Pérez-Calderón, M A Gonzalo-Garijo, A Chaves, D de Argila. Cheilitis granulomatosa of Melkersson-Rosenthal syndrome: treatment with intralesional corticosteroid injections.
Allergologia et immunopathologia.
2004 Jan; 32(1):36-8. doi:
10.1016/s0301-0546(04)79221-6. [PMID: 14980194] - Rustin R Ross, Mark D Herron, Scott R Florell. Lepromatous leprosy and reversal reaction in a Micronesian immigrant.
International journal of dermatology.
2003 Nov; 42(11):893-4. doi:
10.1046/j.1365-4362.2003.01969.x. [PMID: 14636206] - R H C Queiroz, R C Pereira, M A Gotardo, D S Cordeiro, E Melchior. Determination of clofazimine in leprosy patients by high-performance liquid chromatography.
Journal of analytical toxicology.
2003 Sep; 27(6):377-80. doi:
10.1093/jat/27.6.377. [PMID: 14516492] - Preya Kullavanijaya, Niramol Rattana-Apiromyakij, Palachart Sukonthapirom-Napattalung, Supreeya Sirimachand, Imelda Duangdeeden. Disseminated Mycobacterium chelonae cutaneous infection: recalcitrant to combined antibiotic therapy.
The Journal of dermatology.
2003 Jun; 30(6):485-91. doi:
10.1111/j.1346-8138.2003.tb00421.x. [PMID: 12810998] - Ben Cliff, Nicholas Lockyer, Harald Jungnickel, Gill Stephens, John C Vickerman. Probing cell chemistry with time-of-flight secondary ion mass spectrometry: development and exploitation of instrumentation for studies of frozen-hydrated biological material.
Rapid communications in mass spectrometry : RCM.
2003; 17(19):2163-7. doi:
10.1002/rcm.1169. [PMID: 14515313] - Ewa Krauze, Anna Lis, Grazyna Kamińska-Budzińska, Mariola Wygledowska-Kania, Ewa Pierzchała, Ligia Brzezińska-Wcisło. [Pyoderma gangrenosum--positive effect of cyclosporin A therapy ].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2002 Oct; 13(76):336-40. doi:
NULL. [PMID: 12557445] - Regina Helena Costa Queiroz, Ana Maria de Souza, Suely Vilela Sampaio, Enzo Melchior. Biochemical and hematological side effects of clofazimine in leprosy patients.
Pharmacological research.
2002 Aug; 46(2):191-4. doi:
10.1016/s1043-6618(02)00086-5. [PMID: 12220960] - A Dolo, K Diane, I Coulibaly, S Sow, H Konare Diawara, A Fomba, M A Thera, A Diallo, S Keita, O Doumbo. [Systematic search for parasites among leprosy patients in Mali].
Medecine tropicale : revue du Corps de sante colonial.
2002; 62(5):503-6. doi:
NULL. [PMID: 12616942] - C A Peloquin, M Zhu, R D Adam, M D Singleton, D E Nix. Pharmacokinetics of para-aminosalicylic acid granules under four dosing conditions.
The Annals of pharmacotherapy.
2001 Nov; 35(11):1332-8. doi:
10.1345/aph.1a088. [PMID: 11724078] - M Zhu, D E Nix, R D Adam, J M Childs, C A Peloquin. Pharmacokinetics of cycloserine under fasting conditions and with high-fat meal, orange juice, and antacids.
Pharmacotherapy.
2001 Aug; 21(8):891-7. doi:
10.1592/phco.21.11.891.34524. [PMID: 11718495] - R Schwarzenbach, D Djawari. [Disseminated small-node cutaneous sarcoidosis].
Deutsche medizinische Wochenschrift (1946).
2000 May; 125(18):560-2. doi:
10.1055/s-2007-1024341. [PMID: 10835982] - R S Malone, D N Fish, D M Spiegel, J M Childs, C A Peloquin. The effect of hemodialysis on cycloserine, ethionamide, para-aminosalicylate, and clofazimine.
Chest.
1999 Oct; 116(4):984-90. doi:
10.1378/chest.116.4.984. [PMID: 10531163] - V B Patel, A N Misra, Y S Marfatia. A topical dosage form of liposomal clofazimine: research and clinical implications.
Die Pharmazie.
1999 Jun; 54(6):448-51. doi:
". [PMID: 10399190] - M Barral-Netto, S Santos, I Santos, R von Sohsten, A L Bittencourt, E M Carvalho, A Barral, M Waters. Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
Acta tropica.
1999 Mar; 72(2):185-201. doi:
10.1016/s0001-706x(98)00097-7. [PMID: 10206118] - S MacLean, K Stietenroth, H Prange, V V Pai, R Ganapati. Serum markers of treatment success in leprosy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1999 Mar; 67(1):19-23. doi:
NULL. [PMID: 10407625] - K Borner, H Hartwig, S Leitzke, H Hahn, R H Müller, S Ehlers. HPLC determination of clofazimine in tissues and serum of mice after intravenous administration of nanocrystalline or liposomal formulations.
International journal of antimicrobial agents.
1999 Jan; 11(1):75-9. doi:
10.1016/s0924-8579(98)00065-x. [PMID: 10075282] - L Horgen, A Jerome, N Rastogi. Pulsed-exposure and postantibiotic leukocyte enhancement effects of amikacin, clarithromycin, clofazimine, and rifampin against intracellular Mycobacterium avium.
Antimicrobial agents and chemotherapy.
1998 Nov; 42(11):3006-8. doi:
10.1128/aac.42.11.3006. [PMID: 9797242] - A D Moubasher, N A Kamel, H Zedan, D D Raheem. Cytokines in leprosy, II. Effect of treatment on serum cytokines in leprosy.
International journal of dermatology.
1998 Oct; 37(10):741-6. doi:
10.1046/j.1365-4362.1998.00382.x. [PMID: 9802683] - L Horgen, E Legrand, N Rastogi. Postantibiotic effect of amikacin, rifampin, sparfloxacin, clofazimine and clarithromycin against Mycobacterium avium.
Research in microbiology.
1997 Nov; 148(8):673-81. doi:
10.1016/s0923-2508(99)80066-7. [PMID: 9765852] - K Venkatesan, A Mathur, A Girdhar, B K Girdhar. Excretion of clofazimine in human milk in leprosy patients.
Leprosy review.
1997 Sep; 68(3):242-6. doi:
10.5935/0305-7518.19970033. [PMID: 9364825] - D R Krishna, R N Mamidi, U Hofmann, C M Prabhakar. Characterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry.
Arzneimittel-Forschung.
1997 Mar; 47(3):303-6. doi:
NULL. [PMID: 9105550] - N Rastogi, K S Goh, A Bryskier, A Devallois. Spectrum of activity of levofloxacin against nontuberculous mycobacteria and its activity against the Mycobacterium avium complex in combination with ethambutol, rifampin, roxithromycin, amikacin, and clofazimine.
Antimicrobial agents and chemotherapy.
1996 Nov; 40(11):2483-7. doi:
10.1128/aac.40.11.2483. [PMID: 8913450] - N Rastogi, V Labrousse, K S Goh. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages.
Current microbiology.
1996 Sep; 33(3):167-75. doi:
10.1007/s002849900095. [PMID: 8672093] - R M Hoetelmans, J M Otten, C H Koks, M Soesan, J H Beijnen. Combined dapsone and clofazimine intoxication.
Human & experimental toxicology.
1996 Aug; 15(8):625-8. doi:
10.1177/096032719601500805. [PMID: 8863056]
