2-Methoxyestrone (BioDeep_00000405183)

Main id: BioDeep_00000001218

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-Methoxy estrone

化学式: C19H24O3 (300.1725)
中文名称: 2-甲氧基雌素酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC3C(C1CCC2=O)CCC4=CC(=C(C=C34)OC)O
InChI: InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1

描述信息

A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group.
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

同义名列表

3 个代谢物同义名

2-Methoxy estrone; 2-Methoxyestrone; 2-Methoxyestrone



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AFP, ANG, BCL2, BCL2L1, CCND1, CXCR4, CYP1A1, MSMP, MTOR, RARG, TUBB4B, VEGFA
Peripheral membrane protein 3 CYP1A1, CYP1B1, MTOR
Endoplasmic reticulum membrane 5 BCL2, CYP19A1, CYP1A1, CYP1B1, MTOR
Mitochondrion membrane 1 BCL2L1
Nucleus 8 ANG, BCL2, CCND1, KLK3, MTOR, RARG, TUBB4B, VEGFA
cytosol 7 ANG, BCL2, BCL2L1, CCND1, COMT, MTOR, TUBB4B
dendrite 2 COMT, MTOR
phagocytic vesicle 1 MTOR
centrosome 2 BCL2L1, CCND1
nucleoplasm 4 ATP2B1, CCND1, MTOR, RARG
Cell membrane 3 ATP2B1, COMT, CXCR4
Cytoplasmic side 2 BCL2L1, MTOR
Multi-pass membrane protein 3 ATP2B1, CXCR4, CYP19A1
Golgi apparatus membrane 1 MTOR
Synapse 2 ATP2B1, COMT
cell junction 1 CXCR4
cell surface 2 CXCR4, VEGFA
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 VEGFA
Golgi membrane 2 INS, MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
mitochondrial inner membrane 2 BCL2L1, CYP1A1
neuronal cell body 1 ANG
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 BCL2L1
Lysosome 2 CXCR4, MTOR
plasma membrane 4 ATP2B1, COMT, CXCR4, KLK3
synaptic vesicle membrane 2 ATP2B1, BCL2L1
Membrane 9 ATP2B1, BCL2, COMT, CXCR4, CYP19A1, CYP1B1, MTOR, RARG, VEGFA
axon 1 COMT
basolateral plasma membrane 1 ATP2B1
extracellular exosome 6 ATP2B1, COMT, CXCR4, KLK3, SHBG, TUBB4B
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, BCL2L1, CYP19A1, VEGFA
extracellular space 7 AFP, AMH, ANG, INS, KLK3, MSMP, VEGFA
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 4 BCL2, BCL2L1, CYP1A1, CYP1B1
protein-containing complex 3 BCL2, CXCR4, KLK3
intracellular membrane-bounded organelle 4 ATP2B1, COMT, CYP1A1, CYP1B1
Microsome membrane 4 CYP19A1, CYP1A1, CYP1B1, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 7 AFP, AMH, ANG, INS, MSMP, SHBG, VEGFA
extracellular region 7 AMH, ANG, INS, KLK3, SHBG, TUBB4B, VEGFA
Mitochondrion outer membrane 3 BCL2, BCL2L1, MTOR
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 3 BCL2, BCL2L1, MTOR
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
Extracellular side 1 COMT
anchoring junction 1 CXCR4
transcription regulator complex 1 RARG
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 2 ATP2B1, BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CCND1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, CCND1
external side of plasma membrane 1 CXCR4
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
cytoplasmic vesicle 1 CXCR4
microtubule cytoskeleton 1 TUBB4B
nucleolus 1 ANG
Early endosome 1 CXCR4
Single-pass type II membrane protein 1 COMT
Mitochondrion inner membrane 1 CYP1A1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 1 TUBB4B
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 2 KLK3, VEGFA
lateral plasma membrane 1 ATP2B1
Late endosome 1 CXCR4
chromatin 1 RARG
cell leading edge 1 CXCR4
cell projection 1 ATP2B1
mitotic spindle 1 TUBB4B
Chromosome 1 ANG
cytoskeleton 1 TUBB4B
Nucleus, nucleolus 1 ANG
Basolateral cell membrane 1 ATP2B1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
axonemal microtubule 1 TUBB4B
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 AFP, INS
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
transport vesicle 1 INS
azurophil granule lumen 1 TUBB4B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
angiogenin-PRI complex 1 ANG
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
cyclin D1-CDK6 complex 1 CCND1
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

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