Ginsenoside Rf (BioDeep_00000402733)

Main id: BioDeep_00000000155

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methyl-hept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-

化学式: C42H72O14 (800.4922)
中文名称: 人参皂苷Rf
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)O)C)O)C
InChI: InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,52)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-37-34(32(50)30(48)25(19-44)55-37)56-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3

描述信息

Constituent of Panax ginseng (ginseng). The first pure ginseng constituent to show nearly all the activities of the plant extract. Ginsenoside Rf is found in tea.
Annotation level-1
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

同义名列表

10 个代谢物同义名

Ginsenoside Rf; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methyl-hept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-; (2S,3R,4S,5S,6R)-2-[[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(1S)-1-hydroxy-1,5-dimethylhex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6; 52286-58-5; C08945; Ginsenoside Rf/Rg1; Panaxoside Rf; Ginsenoside Rf



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

108 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANXA2, BCL2, BDNF, CASP3, MAPK14, MITF, NTRK2, POMC, PPARG, PRKAA2, PRKX, PTGS2, RB1, STMN4, TYR
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 NTRK2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 12 ANXA2, BAZ1A, BCL2, CASP3, DNMT3L, MAPK14, MITF, PPARG, PRKAA2, PRKX, RB1, RBL2
cytosol 11 ANXA2, BCL2, CASP3, DNMT3L, MAPK14, MITF, NTRK2, PPARG, PRKAA2, RB1, RBL2
dendrite 3 BDNF, NTRK2, PRKAA2
nucleoplasm 8 CASP3, MAPK14, MITF, PPARG, PRKAA2, PRKX, RB1, RBL2
RNA polymerase II transcription regulator complex 2 ANXA2, PPARG
Cell membrane 2 GPRC5A, NTRK2
Cell projection, axon 2 NTRK2, STMN4
Cell projection, growth cone 1 STMN4
Early endosome membrane 1 NTRK2
Multi-pass membrane protein 1 GPRC5A
cell surface 1 ANXA2
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 2 PRKAA2, STMN4
growth cone 1 STMN4
lysosomal membrane 2 ANXA2, MITF
neuronal cell body 2 CASP3, PRKAA2
sarcolemma 1 ANXA2
synaptic vesicle 1 BDNF
Lysosome 1 TYR
endosome 1 ANXA2
plasma membrane 3 ANXA2, GPRC5A, NTRK2
terminal bouton 1 NTRK2
Membrane 5 ANXA2, BCL2, BDNF, NTRK2, PRKAA2
axon 3 BDNF, NTRK2, PRKAA2
basolateral plasma membrane 1 ANXA2
caveola 1 PTGS2
extracellular exosome 4 ANXA2, GPRC5A, MMP9, RBL2
Lysosome membrane 1 MITF
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 4 ANXA2, BDNF, MMP9, POMC
perinuclear region of cytoplasm 4 BDNF, NTRK2, PPARG, TYR
adherens junction 1 ANXA2
mitochondrion 2 BCL2, MAPK14
protein-containing complex 3 BCL2, MITF, PTGS2
intracellular membrane-bounded organelle 3 GPRC5A, PPARG, TYR
Microsome membrane 1 PTGS2
postsynaptic density 2 CASP3, NTRK2
ESC/E(Z) complex 1 DNMT3L
pericentric heterochromatin 1 BAZ1A
Single-pass type I membrane protein 2 NTRK2, TYR
Secreted 2 BDNF, POMC
extracellular region 5 ANXA2, BDNF, MAPK14, MMP9, POMC
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 1 RBL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Secreted, extracellular space, extracellular matrix 1 MMP9
dendritic spine 1 NTRK2
nucleolus 2 GPRC5A, RBL2
Melanosome membrane 1 TYR
midbody 1 ANXA2
Early endosome 2 ANXA2, NTRK2
Golgi-associated vesicle 1 TYR
vesicle 2 ANXA2, GPRC5A
Cytoplasm, perinuclear region 1 NTRK2
heterochromatin 1 DNMT3L
pore complex 1 BCL2
spindle 1 RB1
basement membrane 1 ANXA2
PML body 1 RB1
collagen-containing extracellular matrix 2 ANXA2, MMP9
secretory granule 1 POMC
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 3 GPRC5A, NTRK2, PPARG
neuron projection 2 PTGS2, STMN4
chromatin 4 MITF, PPARG, RB1, RBL2
Late endosome membrane 1 ANXA2
Chromosome 1 RBL2
plasma membrane protein complex 1 ANXA2
spindle pole 1 MAPK14
nuclear chromosome 1 BAZ1A
Lipid droplet 1 ANXA2
Cornified envelope 1 ANXA2
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 1 NTRK2
Melanosome 2 ANXA2, TYR
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 MAPK14, MMP9
secretory granule lumen 2 MAPK14, POMC
endoplasmic reticulum lumen 2 BDNF, PTGS2
nuclear matrix 1 ANXA2
axon terminus 1 NTRK2
tertiary granule lumen 1 MMP9
Schmidt-Lanterman incisure 1 ANXA2
azurophil granule lumen 1 ANXA2
SWI/SNF complex 1 RB1
condensed nuclear chromosome 1 DNMT3L
vesicle membrane 1 ANXA2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
ACF complex 1 BAZ1A
CHRAC 1 BAZ1A
Secreted, extracellular space, extracellular matrix, basement membrane 1 ANXA2
catalytic complex 1 DNMT3L
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
AnxA2-p11 complex 1 ANXA2
myelin sheath adaxonal region 1 ANXA2
PCSK9-AnxA2 complex 1 ANXA2
BAD-BCL-2 complex 1 BCL2
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF


文献列表

  • Shuai Zhang, Hui Wang, Jing Wang, Wenqi Jin, Xiuci Yan, Xuenan Chen, Dandan Wang, Daqing Zhao, Yufeng Wang, Deyu Cong, Liwei Sun. Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy. European journal of pharmacology. 2022 May; 922(?):174887. doi: 10.1016/j.ejphar.2022.174887. [PMID: 35306001]
  • Lichun Chen, Liziniu Wang, Weizhen Ao, Yu Chen, Songjian Li, Zhiguan Huang, Dan Yu, Yanwen Dong, Jiangyong Gu, Huiyan Zeng. Bioinformatics study of the potential therapeutic effects of ginsenoside Rf in reversing nonalcoholic fatty liver disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112879. doi: 10.1016/j.biopha.2022.112879. [PMID: 35358801]
  • Min Li, Fen Liu, Yong-Ri Jin, Xiao-Zhong Wang, Qian Wu, Ying Liu, Xu-Wen Li. Five New Triterpenoid Saponins from the Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity. Planta medica. 2017 Feb; 83(3-04):351-357. doi: 10.1055/s-0042-117554. [PMID: 27676700]
  • Yujie Chen, Zhongzhen Zhao, Hubiao Chen, Tao Yi, Minjian Qin, Zhitao Liang. Chemical differentiation and quality evaluation of commercial Asian and American ginsengs based on a UHPLC-QTOF/MS/MS metabolomics approach. Phytochemical analysis : PCA. 2015 Mar; 26(2):145-60. doi: 10.1002/pca.2546. [PMID: 25448530]
  • Wen-Ji Shangguan, He Li, Yue-Hui Zhang. Induction of G2/M phase cell cycle arrest and apoptosis by ginsenoside Rf in human osteosarcoma MG‑63 cells through the mitochondrial pathway. Oncology reports. 2014 Jan; 31(1):305-13. doi: 10.3892/or.2013.2815. [PMID: 24173574]
  • Eun-Young Park, Mi-Hwi Kim, Eung-Hwi Kim, Eun-Kyu Lee, In-Sun Park, Duck-Choon Yang, Hee-Sook Jun. Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters. The American journal of Chinese medicine. 2014; 42(1):173-87. doi: 10.1142/s0192415x14500128. [PMID: 24467543]
  • Hsiu-Hui Chan, Tsong-Long Hwang, Mopur Vijaya Bhaskar Reddy, Ding-Tzai Li, Keduo Qian, Kenneth F Bastow, Kuo-Hsiung Lee, Tian-Shung Wu. Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds. Journal of natural products. 2011 Apr; 74(4):796-802. doi: 10.1021/np100851s. [PMID: 21417387]
  • Yue Li, Qi Wang, Xiaomin Yao, Yan Li. Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways. European journal of pharmacology. 2010 Aug; 640(1-3):46-54. doi: 10.1016/j.ejphar.2010.05.017. [PMID: 20580705]
  • Li Li, Guo-An Luo, Qiong-Lin Liang, Ping Hu, Yi-Ming Wang. Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS. Journal of pharmaceutical and biomedical analysis. 2010 May; 52(1):66-72. doi: 10.1016/j.jpba.2009.12.017. [PMID: 20079592]
  • Eun-Ah Bae, Myung Joo Han, Yong-Wook Shin, Dong-Hyun Kim. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biological & pharmaceutical bulletin. 2006 Sep; 29(9):1862-7. doi: 10.1248/bpb.29.1862. [PMID: 16946499]
  • Hyunghee Lee, Frank J Gonzalez, Michung Yoon. Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha. Biochemical and biophysical research communications. 2006 Jan; 339(1):196-203. doi: 10.1016/j.bbrc.2005.10.197. [PMID: 16297877]
  • De-qiang Dou, Jie Ren, Ying Chen, Yu-ping Pei, Ying-jie Chen. [Study on the chemical constituents of the roots of commercial ginseng]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2003 Jun; 28(6):522-4. doi: . [PMID: 15015330]
  • J J Nah, J Y Song, S Choi, S C Kim, H W Rhim, T H Oh, S M Lee, S Y Nah. Preparation of monoclonal antibody against ginsenoside Rf and its enzyme immunoassay. Biological & pharmaceutical bulletin. 2000 May; 23(5):523-6. doi: 10.1248/bpb.23.523. [PMID: 10823656]
  • G L Henderson, M R Harkey, M E Gershwin, R M Hackman, J S Stern, D M Stresser. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life sciences. 1999; 65(15):PL209-14. doi: 10.1016/s0024-3205(99)00407-5. [PMID: 10574228]
  • S R Yoon, J J Nah, S K Kim, S C Kim, K Y Nam, D W Jung, S Y Nah. Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay. Chemical & pharmaceutical bulletin. 1998 Jul; 46(7):1144-7. doi: 10.1248/cpb.46.1144. [PMID: 9692222]