loperamide (BioDeep_00000402560)
Main id: BioDeep_00000001488
代谢物信息卡片
loperamide
化学式: C29H33ClN2O2 (476.223)
中文名称: 洛哌丁胺
谱图信息:
最多检出来源 Homo sapiens(blood) 46.02%
分子结构信息
SMILES: C(C3)N(CCC3(O)c(c4)ccc(c4)Cl)CCC(C(N(C)C)=O)(c(c2)cccc2)c(c1)cccc1
InChI: InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
描述信息
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07D - Antipropulsives > A07DA - Antipropulsives
C78276 - Agent Affecting Digestive System or Metabolism > C266 - Antidiarrheal Agent
D005765 - Gastrointestinal Agents > D000930 - Antidiarrheals
CONFIDENCE standard compound; INTERNAL_ID 2504
CONFIDENCE standard compound; INTERNAL_ID 8489
同义名列表
3 个代谢物同义名
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:6532
- KEGG: C07080
- KEGGdrug: D08144
- PubChem: 3955
- DrugBank: DB00836
- ChEMBL: CHEMBL841
- MeSH: Loperamide
- CAS: 53179-11-6
- MoNA: AU250406
- MoNA: AU250405
- MoNA: AU250404
- MoNA: AU250403
- MoNA: AU250402
- MoNA: AU250401
- MoNA: WA001429
- MoNA: WA001428
- MoNA: WA001427
- MoNA: WA001426
- MoNA: WA001425
- MoNA: WA001424
- MoNA: HMDB0004999_ms_ms_2430
- MoNA: HMDB0004999_ms_ms_2431
- MoNA: HMDB0004999_ms_ms_2432
- MoNA: SM848903
- PubChem: 9291
- NIKKAJI: J10.085D
- RefMet: Loperamide
- KNApSAcK: 6532
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ling-Ling Qin, Meng Yu, Peng Yang, Zhong-Mei Zou. The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism.
Journal of ethnopharmacology.
2024 Mar; 322(?):117637. doi:
10.1016/j.jep.2023.117637. [PMID: 38135226] - Ze-Fei Jia, Jia-Li Wang, Wen Pan, Jing Hu. Croton tiglium L. seeds ameliorate loperamide-induced constipation via regulating gastrointestinal hormones and gut microbiota before and after processing.
Journal of ethnopharmacology.
2024 Jan; 319(Pt 3):117378. doi:
10.1016/j.jep.2023.117378. [PMID: 37923254] - Liuping Wang, Shiyuan Xie, Xuan Jiang, Caini Xu, Youqiong Wang, Jianfang Feng, Bin Yang. Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice.
Pharmaceutical biology.
2023 Dec; 61(1):125-134. doi:
10.1080/13880209.2022.2157841. [PMID: 36582187] - Wenjie Xu, Shanshan Xu, Ruobing Feng, Li Zeng. Yunpi Tongbian Fang alleviates slow transit constipation induced by loperamide by regulating intestinal microbiota and short-chain fatty acids in rats.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Oct; 69(10):23-29. doi:
10.14715/cmb/2023.69.10.4. [PMID: 37953588] - Huang Xi, Xia Youguang, Han Kai, Q I Weiwei, Linghu Qing, Zhang Qing, Xue Jingbo. Hetong decoction relieves loperamide-induced constipation in rats by regulating expression of aquaporins.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Oct; 43(6):1160-1167. doi:
10.19852/j.cnki.jtcm.2023.06.008. [PMID: 37946478] - Menghui Fei, Jiwen Zhang, Cuicui Zhu, Ming Luo, Lina Zhang, Yongmei Wu. Effects of Modified Baizhu Shaoyao San on Postoperative Diarrhea in Colorectal Cancer Patients: A Single-Blind, Randomized Controlled Trial.
Complementary medicine research.
2023; 30(1):37-44. doi:
10.1159/000527706. [PMID: 36349756] - Qian Lin, Man Liu, Famous Erhunmwunsee, Bing Li, Yanfang Mou, Sen Wang, Guimin Zhang, Jun Tian. Chinese patent medicine shouhui tongbian capsule attenuated loperamide-induced constipation through modulating the gut microbiota in rat.
Journal of ethnopharmacology.
2022 Nov; 298(?):115575. doi:
10.1016/j.jep.2022.115575. [PMID: 35934189] - Jinzhao Bai, Yajie Cai, Zhiyan Huang, Yiqing Gu, Nana Huang, Rong Sun, Guimin Zhang, Runping Liu. Shouhui Tongbian Capsule ameliorates constipation via gut microbiota-5-HT-intestinal motility axis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113627. doi:
10.1016/j.biopha.2022.113627. [PMID: 36058152] - Fatma Arrari, Mohamed-Amine Jabri, Imen Hammami, Hichem Sebai. Extraction of Pectin from Orange Peel and Study of Its Protective Effect Against Loperamide-Induced Impaired Gastrointestinal Motor Functions and Oxidative Stress in Rats.
Journal of medicinal food.
2022 Sep; 25(9):892-901. doi:
10.1089/jmf.2021.0091. [PMID: 35143346] - Zili Lei, Hedong Rong, Yanhong Yang, Siping Yu, Tianle Zhang, Lei Chen, Ya Nie, Qi Song, Qing Hu, Jiao Guo. Loperamide induces excessive accumulation of bile acids in the liver of mice with different diets.
Toxicology.
2022 07; 477(?):153278. doi:
10.1016/j.tox.2022.153278. [PMID: 35926757] - Chih-Ming Chen, Chien-Chen Wu, Chin-Lin Huang, Min-Yu Chang, Shih-Hsuan Cheng, Ching-Ting Lin, Ying-Chieh Tsai. Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice.
Probiotics and antimicrobial proteins.
2022 06; 14(3):535-545. doi:
10.1007/s12602-021-09814-3. [PMID: 34327633] - Pengkui Xia, Xia Liu, Tao Hou, Fuchao Zhan, Fang Geng, Ziyang Zhang, Bin Li. Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice.
Food & function.
2022 May; 13(10):5690-5700. doi:
10.1039/d2fo00067a. [PMID: 35510626] - Xiaoyu Zhang, Baifei Hu, Guangjun Sun, Junping Zheng, Haiming Hu, Huabing Yang, Xue Cheng, Aizhen Lin, Hongtao Liu. Plasma metabolomic profiles reveal regulatory effect of chitosan oligosaccharides on loperamide-induced constipation in mice.
Journal of pharmaceutical and biomedical analysis.
2022 Mar; 211(?):114590. doi:
10.1016/j.jpba.2022.114590. [PMID: 35063864] - Juqing Huang, Bin Lin, Ying Zhang, Zhenglu Xie, Yi Zheng, Qi Wang, Hang Xiao. Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice.
Carbohydrate polymers.
2022 Jan; 276(?):118761. doi:
10.1016/j.carbpol.2021.118761. [PMID: 34823784] - Tcharé Assiki, Aboudoulatif Diallo, Essotolom Badjabaïssi, Mindédé Assih, Tchazou Kpatcha, Kokou Idoh, Kossivi Dosseh, Amegnona Agbonon. Antidiarrheal Activity of Dialium guineense Willd Fruit Pulp in Wistar Rats.
BioMed research international.
2022; 2022(?):4161714. doi:
10.1155/2022/4161714. [PMID: 36317113] - Yun Ju Choi, Ji Eun Kim, Su Jin Lee, Jeong Eun Gong, Miran Jang, Jin Tae Hong, Dae Youn Hwang. Loperamide-induced Constipation Activates Inflammatory Signaling Pathways in the Mid Colon of SD Rats Via Complement C3 and its Receptors.
Current molecular medicine.
2022; 22(5):458-469. doi:
10.2174/1566524021666210618124220. [PMID: 34148539] - Jessica I Griffith, Minjee Kim, Daniel J Bruce, Cristina D Peterson, Kelley F Kitto, Afroz S Mohammad, Sneha Rathi, Carolyn A Fairbanks, George L Wilcox, William F Elmquist. Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity.
The Journal of pharmacology and experimental therapeutics.
2022 01; 380(1):34-46. doi:
10.1124/jpet.121.000821. [PMID: 34663676] - Takio Inatomi, Mihoko Honma. Effects of probiotics on loperamide-induced constipation in rats.
Scientific reports.
2021 12; 11(1):24098. doi:
10.1038/s41598-021-02931-7. [PMID: 34916548] - Tultul Saha, Joydeep Aoun, Paramita Sarkar, Andrea J Bourdelais, Daniel G Baden, Normand Leblanc, John M Hamlyn, Owen M Woodward, Kazi Mirajul Hoque. Cucumis sativus extract elicits chloride secretion by stimulation of the intestinal TMEM16A ion channel.
Pharmaceutical biology.
2021 Dec; 59(1):1008-1015. doi:
10.1080/13880209.2021.1949357. [PMID: 34362288] - Ji-Eun Kim, Yun-Ju Choi, Su-Jin Lee, Jeong-Eun Gong, You-Jung Jin, So-Hae Park, Hee-Seob Lee, Young-Whan Choi, Jin-Tae Hong, Dae-Youn Hwang. Laxative Effects of Phlorotannins Derived from Ecklonia cava on Loperamide-Induced Constipation in SD Rats.
Molecules (Basel, Switzerland).
2021 Nov; 26(23):. doi:
10.3390/molecules26237209. [PMID: 34885790] - Nina Meyer, Lisa Henkel, Benedikt Linder, Svenja Zielke, Georg Tascher, Sandra Trautmann, Gerd Geisslinger, Christian Münch, Simone Fulda, Irmgard Tegeder, Donat Kögel. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Autophagy.
2021 11; 17(11):3424-3443. doi:
10.1080/15548627.2021.1874208. [PMID: 33461384] - Ju-Ryun Na, Ki Hoon Lee, Eun Kim, Kwontack Hwang, Chang-Su Na, Sunoh Kim. Laxative Effects of a Standardized Extract of Dendropanax morbiferus H. Léveille Leaves on Experimental Constipation in Rats.
Medicina (Kaunas, Lithuania).
2021 Oct; 57(11):. doi:
10.3390/medicina57111147. [PMID: 34833365] - Yiling Zhang, Tao Lu, Yan Dong, Yan Chen, Jiande D Z Chen. Auricular vagal nerve stimulation enhances gastrointestinal motility and improves interstitial cells of Cajal in rats treated with loperamide.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2021 10; 33(10):e14163. doi:
10.1111/nmo.14163. [PMID: 33991455] - Mengmeng Hu, Changqian Fang, Youqian Liu, Meng Gao, Dongjian Zhang, Gaofeng Shi, Zhiqi Yin, Rendong Zheng, Jian Zhang. Comparative study of the laxative effects of konjac oligosaccharides and konjac glucomannan on loperamide-induced constipation in rats.
Food & function.
2021 Sep; 12(17):7709-7717. doi:
10.1039/d1fo01237a. [PMID: 34286775] - Abul Kalam Azad, Abd Almonem Doolaanea, Sinan Mohammed Abdullah Al-Mahmood, John F Kennedy, Bappaditya Chatterjee, Hriday Bera. Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery.
International journal of biological macromolecules.
2021 Aug; 185(?):861-875. doi:
10.1016/j.ijbiomac.2021.07.019. [PMID: 34237363] - Flavia Storelli, Olena Anoshchenko, Jashvant D Unadkat. Successful Prediction of Human Steady-State Unbound Brain-to-Plasma Concentration Ratio of P-gp Substrates Using the Proteomics-Informed Relative Expression Factor Approach.
Clinical pharmacology and therapeutics.
2021 08; 110(2):432-442. doi:
10.1002/cpt.2227. [PMID: 33675056] - Michael Levine, Frank Lovecchio. New Designer Drugs.
Emergency medicine clinics of North America.
2021 Aug; 39(3):677-687. doi:
10.1016/j.emc.2021.04.013. [PMID: 34215409] - Mao Chai, Linlin Wang, Xinping Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen. Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation.
Food & function.
2021 Jul; 12(13):6058-6069. doi:
10.1039/d1fo00559f. [PMID: 34038494] - Md Munsur Alam, Nazim Uddin Emon, Safaet Alam, Sajib Rudra, Nahid Akhter, Md Masudur Rahman Mamun, Amlan Ganguly. Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111644. doi:
10.1016/j.biopha.2021.111644. [PMID: 33945914] - Pei-Qin Cao, Xiu-Ping Li, Jian Ou-Yang, Rong-Gang Jiang, Fang-Fang Huang, Bei-Bei Wen, Xiang-Na Zhang, Jian-An Huang, Zhong-Hua Liu. The protective effects of yellow tea extract against loperamide-induced constipation in mice.
Food & function.
2021 Jun; 12(12):5621-5636. doi:
10.1039/d0fo02969f. [PMID: 34018494] - Onur Cil, Peter M Haggie, Joseph-Anthony Tapia Tan, Amber A Rivera, Alan S Verkman. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine.
JCI insight.
2021 06; 6(11):. doi:
10.1172/jci.insight.147699. [PMID: 34100381] - Houcem Sammari, Saber Jedidi, Houcine Selmi, Kais Rtibi, Mohamed-Amine Jabri, Mourad Jridi, Nacim Zouari, Lamjed Toumi, Hichem Sebai. Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil-induced diarrhea, oxidative stress, and inflammation in rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2021 06; 33(6):e14065. doi:
10.1111/nmo.14065. [PMID: 33320393] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Qi Zhang, Dian Zhong, Yuan-Yuan Ren, Zi-Kuan Meng, Ronald B Pegg, Geng Zhong. Effect of konjac glucomannan on metabolites in the stomach, small intestine and large intestine of constipated mice and prediction of the KEGG pathway.
Food & function.
2021 Apr; 12(7):3044-3056. doi:
10.1039/d0fo02682d. [PMID: 33710209] - Mubarak Hussaini Ahmad, Abdulkadir Umar Zezi, Sherifat Bola Anafi, Zakariyya Alhassan, Mustapha Mohammed, Rabi'u Nuhu Danraka. Mechanisms of antidiarrhoeal activity of methanol leaf extract of Combretum hypopilinum diels (combretaceae): Involvement of opioidergic and (α1 and β)-adrenergic pathways.
Journal of ethnopharmacology.
2021 Apr; 269(?):113750. doi:
10.1016/j.jep.2020.113750. [PMID: 33359856] - Qi Zhang, Dian Zhong, Rui Sun, Yang Zhang, Ronald B Pegg, Geng Zhong. Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation.
Carbohydrate polymers.
2021 Mar; 256(?):117418. doi:
10.1016/j.carbpol.2020.117418. [PMID: 33483010] - Xiaoyu Zhang, Junping Zheng, Nan Jiang, Guangjun Sun, Xinkun Bao, Mingwang Kong, Xue Cheng, Aizhen Lin, Hongtao Liu. Modulation of gut microbiota and intestinal metabolites by lactulose improves loperamide-induced constipation in mice.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Mar; 158(?):105676. doi:
10.1016/j.ejps.2020.105676. [PMID: 33310029] - Tian Li, Mengmeng Hu, Cuihua Jiang, Dongjian Zhang, Meng Gao, Jianwei Xia, Mengqi Miao, Gaofeng Shi, Hui Li, Jian Zhang, Zhiqi Yin. Laxative effect and mechanism of Tiantian Capsule on loperamide-induced constipation in rats.
Journal of ethnopharmacology.
2021 Feb; 266(?):113411. doi:
10.1016/j.jep.2020.113411. [PMID: 32980482] - Johanna Catalan-Figueroa, Mauricio A García, Pilar Contreras, Constanza B Boisset, Pablo M Gonzalez, Jenny L Fiedler, Mariela F Pérez, Javier O Morales. Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia.
Molecular pharmaceutics.
2021 02; 18(2):743-750. doi:
10.1021/acs.molpharmaceut.0c00623. [PMID: 33044825] - Xiaoyu Zhang, Huabing Yang, Junping Zheng, Nan Jiang, Guangjun Sun, Xinkun Bao, Aizhen Lin, Hongtao Liu. Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice.
Carbohydrate polymers.
2021 Feb; 253(?):117218. doi:
10.1016/j.carbpol.2020.117218. [PMID: 33278982] - Shu-Ze Zheng, Qiang Guo, Gui-Min Zhang, Li-Hong Pan, Ke-Wu Zeng. [Therapeutic effect and mechanism of Shouhui Tongbian Capsules on slow transit constipation model mice].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Feb; 46(3):520-525. doi:
10.19540/j.cnki.cjcmm.20201125.401. [PMID: 33645015] - Sana Nazir, Haroon Khan, Sajjad Ali Khan, Waqas Alam, Rukhsana Ghaffar, Sayed Hurmat Ali Khan, Maria Daglia. In vivo acute toxicity, laxative and antiulcer effect of the extract of Dryopteris Ramose.
Cellular and molecular biology (Noisy-le-Grand, France).
2021 Jan; 67(1):9-16. doi:
10.14715/cmb/2021.67.1.2. [PMID: 34817374] - Seon-Ah Park, Geum-Hwa Lee, The-Hiep Hoang, Hwa-Young Lee, In-Yeong Kang, Myong-Ja Chung, Jong-Sik Jin, Han-Jung Chae. Heat-inactivated Lactobacillus plantarum nF1 promotes intestinal health in Loperamide-induced constipation rats.
PloS one.
2021; 16(4):e0250354. doi:
10.1371/journal.pone.0250354. [PMID: 33872333] - Yutaka Makizaki, Taiki Uemoto, Haruka Yokota, Miyuki Yamamoto, Yoshiki Tanaka, Hiroshi Ohno. Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.
PloS one.
2021; 16(3):e0248584. doi:
10.1371/journal.pone.0248584. [PMID: 33750988] - Hao Wu, Yijun Chen, Beibei Huang, Yingting Yu, Shujun Zhao, Jie Liu, Zhixin Jia, Hongbin Xiao. Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca2+ influx.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):111005. doi:
10.1016/j.biopha.2020.111005. [PMID: 33378996] - Ji Eun Kim, Yun Ju Choi, Su Jin Lee, Jeong Eun Gong, Young Ju Lee, Ji Eun Sung, Young Suk Jung, Hee Seob Lee, Jin Tae Hong, Dae Youn Hwang. Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats.
PloS one.
2021; 16(2):e0246363. doi:
10.1371/journal.pone.0246363. [PMID: 33626068] - Shuai Yan, Yinzi Yue, Mingming Sun, Yinghui Chen, Xiaopeng Wang, Haihua Qian. Comparative Transcriptome Analysis Reveals Relationship among mRNAs, lncRNAs, and circRNAs of Slow Transit Constipation.
BioMed research international.
2021; 2021(?):6672899. doi:
10.1155/2021/6672899. [PMID: 34513995] - Peng-Chao Huo, Xiao-Qing Guan, Peng Liu, Yun-Qing Song, Meng-Ru Sun, Rong-Jing He, Li-Wei Zou, Li-Juan Xue, Jin-Hui Shi, Nan Zhang, Zhi-Guo Liu, Guang-Bo Ge. Design, synthesis and biological evaluation of indanone-chalcone hybrids as potent and selective hCES2A inhibitors.
European journal of medicinal chemistry.
2021 Jan; 209(?):112856. doi:
10.1016/j.ejmech.2020.112856. [PMID: 33007602] - Anastasia Mentessidou, Anastasia Livani, George Chrousos, Petros Mirilas. Ileocecal Valve Removal Reverses the Constipating Effects of Loperamide in Rats.
The Journal of surgical research.
2020 11; 255(?):371-377. doi:
10.1016/j.jss.2020.05.002. [PMID: 32599457] - Najla Hajji, Dalanda Wannes, Mohamed-Amine Jabri, Kais Rtibi, Haifa Tounsi, Afifa Abdellaoui, Hichem Sebai. Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats.
Neurogastroenterology and motility.
2020 08; 32(8):e13858. doi:
10.1111/nmo.13858. [PMID: 32337785] - Qiulan He, Changpeng Han, Liang Huang, Haojie Yang, Jiancong Hu, Huaxian Chen, Ruoxu Dou, Donglin Ren, Hongcheng Lin. Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation.
Journal of cellular and molecular medicine.
2020 08; 24(16):9349-9361. doi:
10.1111/jcmm.15586. [PMID: 32628809] - Juqing Huang, Suyi Li, Qi Wang, Xuefang Guan, Lei Qian, Jie Li, Yi Zheng, Bin Lin. Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice.
Food & function.
2020 Jun; 11(6):5607-5620. doi:
10.1039/d0fo00208a. [PMID: 32525185] - Kyo-Nyeo Oh, Yujin Kim, Eun Jin Choi, Hyunmi Lee, Ji Ae Hong, Miri Kim, Dool-Ri Oh, Myung-A Jung, Ro-Dong Park, Seong-Il Kim, Ju-Seon Yong, Hui-Seop Lee, SangOh Ban, Chul-Yung Choi. Laxative Activity of the Hot-Water Extract Mixture of Hovenia dulcis Thunb. and Phyllostachys pubescens Mazel in Chronic Constipation Model SD Rats.
Journal of microbiology and biotechnology.
2020 May; 30(5):649-661. doi:
10.4014/jmb.1911.11051. [PMID: 32482930] - Blanka Miková, Miloš Dvořák, Lenka Ryšavá, Pavel Kubáň. Hollow Fiber Liquid-Phase Microextraction At-Line Coupled to Capillary Electrophoresis for Direct Analysis of Human Body Fluids.
Analytical chemistry.
2020 05; 92(10):7171-7178. doi:
10.1021/acs.analchem.0c00697. [PMID: 32289222] - Fittree Hayeeawaema, Santad Wichienchot, Pissared Khuituan. Amelioration of gut dysbiosis and gastrointestinal motility by konjac oligo-glucomannan on loperamide-induced constipation in mice.
Nutrition (Burbank, Los Angeles County, Calif.).
2020 05; 73(?):110715. doi:
10.1016/j.nut.2019.110715. [PMID: 32135415] - Yuki Narita, Koichi Fukumoto, Masaki Fukunaga, Yuki Kondo, Yoichi Ishitsuka, Hirofumi Jono, Tetsumi Irie, Hideyuki Saito, Daisuke Kadowaki, Sumio Hirata. Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model.
International journal of molecular sciences.
2020 Apr; 21(7):. doi:
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European journal of medicinal chemistry.
2020 Jan; 185(?):111813. doi:
10.1016/j.ejmech.2019.111813. [PMID: 31732255] - Mulusew Yemiru Tessema, Zewdu Birhanu Wubneh, Assefa Belay Asrie. Laxative Activities of 80\% Methanolic Extract of the Leaves of Grewia ferruginea Hochst Ex A Rich in Mice.
Journal of evidence-based integrative medicine.
2020 Jan; 25(?):2515690X20926922. doi:
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Frontiers in cellular and infection microbiology.
2020; 10(?):423. doi:
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Journal of medicinal food.
2019 Dec; 22(12):1235-1245. doi:
10.1089/jmf.2019.0051. [PMID: 31313944] - Ruokun Yi, Peng Peng, Jing Zhang, Muying Du, Lingxia Lan, Yu Qian, Jie Zhou, Xin Zhao. Lactobacillus plantarum CQPC02-Fermented Soybean Milk Improves Loperamide-Induced Constipation in Mice.
Journal of medicinal food.
2019 Dec; 22(12):1208-1221. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2019 11; 317(5):G609-G617. doi:
10.1152/ajpgi.00150.2018. [PMID: 31411502] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Clinical toxicology (Philadelphia, Pa.).
2019 Nov; 57(11):1118-1122. doi:
10.1080/15563650.2019.1580370. [PMID: 30806091] - C Michael White. Loperamide: A Readily Available but Dangerous Opioid Substitute.
Journal of clinical pharmacology.
2019 09; 59(9):1165-1169. doi:
10.1002/jcph.1449. [PMID: 31116446] - Xiaomao Li, Yan Liu, Wei Guan, Yonggang Xia, Yuanyuan Zhou, Bingyou Yang, Haixue Kuang. Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats.
Journal of ethnopharmacology.
2019 Aug; 240(?):111961. doi:
10.1016/j.jep.2019.111961. [PMID: 31102614] - Yoo-Jin Jeon, Jin-Seok Lee, Yong-Rae Cho, Sung-Bae Lee, Won-Young Kim, Seong-Soo Roh, Jin-Yong Joung, Hwa-Dong Lee, Sung-Ok Moon, Jung-Hyo Cho, Chang-Gue Son. Banha-sasim-tang improves gastrointestinal function in loperamide-induced functional dyspepsia mouse model.
Journal of ethnopharmacology.
2019 Jun; 238(?):111834. doi:
10.1016/j.jep.2019.111834. [PMID: 30940567] - Jong-Min Lim, Young Dae Kim, Chang-Hyun Song, Su-Jin Park, Dong-Chan Park, Hyung-Rae Cho, Go-Woon Jung, Khawaja Muhammad Imran Bashir, Sae Kwang Ku, Jae-Suk Choi. Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats.
BMC complementary and alternative medicine.
2019 Jun; 19(1):143. doi:
10.1186/s12906-019-2557-x. [PMID: 31226979] - Giles A D Major, David Gunn. Chronic diarrhoea in adults: what not to miss.
Current opinion in gastroenterology.
2019 05; 35(3):206-212. doi:
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Journal of biochemical and molecular toxicology.
2019 Apr; 33(4):e22278. doi:
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Molecules (Basel, Switzerland).
2019 Mar; 24(5):. doi:
10.3390/molecules24050896. [PMID: 30836659] - Seyed Mostafa Mirakbari, Mohammad Hadi Shirazi. Poisoning with Tasty and Sweet Seed Pods of Bird of Paradise Plant Caesalpinia gilliessii.
Wilderness & environmental medicine.
2019 Mar; 30(1):99-100. doi:
10.1016/j.wem.2018.09.001. [PMID: 30528075] - Ji Eun Kim, Woo Bin Yun, Mi Lim Lee, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Jin Tae Hong, Hyun Keun Song, Dae Youn Hwang. Synergic Laxative Effects of an Herbal Mixture of Liriope platyphylla, Glycyrrhiza uralensis, and Cinnamomum cassia in Loperamide-Induced Constipation of Sprague Dawley Rats.
Journal of medicinal food.
2019 Mar; 22(3):294-304. doi:
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International journal of molecular sciences.
2019 Feb; 20(4):. doi:
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Food research international (Ottawa, Ont.).
2019 02; 116(?):1173-1182. doi:
10.1016/j.foodres.2018.09.062. [PMID: 30716903] - Dong-Sung Lee, Hee Geun Jo, Min Ji Kim, Hwan Lee, Sun Hee Cheong. Laxative Effects of Taurine on Loperamide-Induced Constipation in Rats.
Advances in experimental medicine and biology.
2019; 1155(?):261-271. doi:
10.1007/978-981-13-8023-5_25. [PMID: 31468405] - Alexander K C Leung, Amy A M Leung, Alex H C Wong, Kam L Hon. Travelers' Diarrhea: A Clinical Review.
Recent patents on inflammation & allergy drug discovery.
2019; 13(1):38-48. doi:
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The journal of physical chemistry. B.
2018 12; 122(49):11571-11578. doi:
10.1021/acs.jpcb.8b07442. [PMID: 30247032] - Mário L de Lemos, Jolene Guenter, Victoria Kletas. Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea?.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2018 Dec; 24(8):634-636. doi:
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The Journal of parasitology.
2018 10; 104(5):574-575. doi:
10.1645/17-93. [PMID: 30019983] - Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Surya P Lamichhane, Bharathi Avula, XiangDi Wang, Monica M Jablonski, Ikhlas A Khan, Soumyajit Majumdar. Retina Compatible Interactions and Effective Modulation of Blood Ocular Barrier P-gp Activity by Third-Generation Inhibitors Improve the Ocular Penetration of Loperamide.
Journal of pharmaceutical sciences.
2018 08; 107(8):2128-2135. doi:
10.1016/j.xphs.2018.04.008. [PMID: 29678592] - Akshaya Tatke, Karthik Yadav Janga, Bharathi Avula, XiangDi Wang, Monica M Jablonski, Ikhlas A Khan, Soumyajit Majumdar. P-glycoprotein Restricts Ocular Penetration of Loperamide across the Blood-Ocular Barriers: a Comparative Study in Mdr1a Knock-out and Wild Type Sprague Dawley Rats.
AAPS PharmSciTech.
2018 May; 19(4):1662-1671. doi:
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Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2018 05; 30(5):e13272. doi:
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Beneficial microbes.
2018 Apr; 9(3):453-464. doi:
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European journal of medicinal chemistry.
2018 Feb; 145(?):717-725. doi:
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International journal of molecular medicine.
2018 Feb; 41(2):649-658. doi:
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Bioorganic & medicinal chemistry letters.
2018 02; 28(3):446-451. doi:
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PloS one.
2018; 13(4):e0195624. doi:
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Journal of food science.
2018 Jan; 83(1):205-211. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
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Journal of basic and clinical physiology and pharmacology.
2017 Sep; 28(5):483-492. doi:
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Annals of emergency medicine.
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Zebrafish.
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Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2017 May; 27(3):357-361. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
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International journal of molecular sciences.
2017 Feb; 18(2):. doi:
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Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
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Drug metabolism and disposition: the biological fate of chemicals.
2017 02; 45(2):190-197. doi:
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