3-Methoxytyramine (BioDeep_00000400002)

Main id: BioDeep_00000001873

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4-(2-Aminoethyl)-2-methoxyphenol

化学式: C9H13NO2 (167.09462380000002)
中文名称: 3 Methoxytyramine
谱图信息: 最多检出来源 Homo sapiens(blood) 0.16%

分子结构信息

SMILES: COC1=C(C=CC(=C1)CCN)O
InChI: InChI=1S/C9H13NO2/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,11H,4-5,10H2,1H3

描述信息

A monomethoxybenzene that is dopamine in which the hydroxy group at position 3 is replaced by a methoxy group. It is a metabolite of the neurotransmitter dopamine and considered a potential biomarker of pheochromocytomas and paragangliomas.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
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COVID-19
SARS-CoV
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SARS
3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.

同义名列表

3 个代谢物同义名

4-(2-Aminoethyl)-2-methoxyphenol; 3-Methoxytyramine; 3-O-methyl Dopamine



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Joanna Kokoszka, Marta Opalinska, Katarzyna Sitarz, Magdalena Kolasa, Monika Szewczyk, Jolanta Bugajska, Joanna Berska, Krystyna Sztefko, Alicja Hubalewska-Dydejczyk. 24-hours urine metanephrines excretion in patients diagnosed with adrenal incidentaloma: impact of commonly used drugs on clinical decision. Polish archives of internal medicine. 2024 Jan; ?(?):. doi: 10.20452/pamw.16646. [PMID: 38164744]
  • Hongyu Zeng, Xiaoqing Zhang, Qianna Zhen, Yifan He, Haoran Wang, Yang Zhu, Qi Sun, Min Ding. Dual-Template Magnetic Molecularly Imprinted Polymer for Simultaneous Determination of Spot Urine Metanephrines and 3-Methoxytyramine for the Diagnosis of Pheochromocytomas and Paragangliomas. Molecules (Basel, Switzerland). 2022 May; 27(11):. doi: 10.3390/molecules27113520. [PMID: 35684457]
  • Madysen Elbourne, Adam Cawley, Shawn Stanley, Christopher Bowen, Shanlin Fu. Intelligence benefit of the 3-methoxytyramine to tyramine ratio in equine urine. Drug testing and analysis. 2022 May; 14(5):936-942. doi: 10.1002/dta.3264. [PMID: 35343638]
  • Songlin Yu, Weiyan Zhou, Jialei Yu, Ming Li, Shenyan Zhang, Xu Jiang, Huanhong Wang, Xiaoli Ma, Yutong Zou, Danchen Wang, Qian Cheng, Shaowei Xie, Wei Luo, Xiuzhi Guo, Ling Qiu. An automated magnetic bead extraction method for measuring plasma metanephrines and 3-methoxytyramine using liquid chromatography tandem mass spectrometry. Analytical and bioanalytical chemistry. 2022 May; 414(11):3541-3549. doi: 10.1007/s00216-022-03984-x. [PMID: 35234981]
  • Susan Richter, Bei Qiu, Mirthe Ghering, Carola Kunath, Georgiana Constantinescu, Charlotte Luths, Christina Pamporaki, Nicole Bechmann, Leah Meuter, Aleksandra Kwapiszewska, Timo Deutschbein, Svenja Nölting, Mirko Peitzsch, Mercedes Robledo, Aleksander Prejbisz, Karel Pacak, Volker Gudziol, Henri J L M Timmers, Graeme Eisenhofer. Head/neck paragangliomas: focus on tumor location, mutational status and plasma methoxytyramine. Endocrine-related cancer. 2022 03; 29(4):213-224. doi: 10.1530/erc-21-0359. [PMID: 35171114]
  • Lu Liu, Wenchun Xie, Zhijing Song, Tianyu Wang, Xuesong Li, Ying Gao, Yan Li, Junqing Zhang, Xiaohui Guo. Addition of 3-methoxytyramine or chromogranin A to plasma free metanephrines as the initial test for pheochromocytoma and paraganglioma: Which is the best diagnostic strategy. Clinical endocrinology. 2022 02; 96(2):132-138. doi: 10.1111/cen.14585. [PMID: 34486152]
  • Youhei Obata, Mie Kubota-Sakashita, Takaoki Kasahara, Masafumi Mizuno, Takahiro Nemoto, Tadafumi Kato. Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus. Scientific reports. 2022 01; 12(1):17. doi: 10.1038/s41598-021-03885-6. [PMID: 34996979]
  • Iedan R N Verly, Yvette A H Matser, René Leen, Rutger Meinsma, Marta Fiocco, Jan Koster, Richard Volckmann, Dilara Savci-Heijink, Giuliana Cangemi, Sebastiano Barco, Linda J Valentijn, Godelieve A M Tytgat, André B P van Kuilenburg. Urinary 3-Methoxytyramine Is a Biomarker for MYC Activity in Patients With Neuroblastoma. JCO precision oncology. 2022 01; 6(?):e2000447. doi: 10.1200/po.20.00447. [PMID: 35085004]
  • Kaijuan Wang, Xiaojing Gao, Wei Zhang, Nian Sun, Lan Xie, Hongying Cong, Yutong Guo, Xiaocui Shi, Zhou Zhou. Study of stability and interference for catecholamines and metanephrines, 3-methoxytyramine: key point of an accurate diagnosis for pheochromocytoma and paraganglioma. Scandinavian journal of clinical and laboratory investigation. 2021 Nov; 81(7):564-572. doi: 10.1080/00365513.2021.1980901. [PMID: 34570657]
  • Mirko Peitzsch, Talia Novos, Denise Kaden, Max Kurlbaum, Antonius E van Herwaarden, Daniel Müller, Jo Adaway, Eric Grouzmann, Brett McWhinney, Kirsten Hoad, Gerald Woollard, Ido Kema, Christopher Boot, Martin Fassnacht, Fred Sweep, Tze P Loh, Andrea R Horvath, Graeme Eisenhofer. Harmonization of LC-MS/MS Measurements of Plasma Free Normetanephrine, Metanephrine, and 3-Methoxytyramine. Clinical chemistry. 2021 08; 67(8):1098-1112. doi: 10.1093/clinchem/hvab060. [PMID: 33993248]
  • Christina Pamporaki, Aleksander Prejbisz, Robert Małecki, Frank Pistrosch, Mirko Peitzsch, Steffen Bishoff, Petra Mueller, Iris Meyer, Doreen Reimann, Katarzyna Hanus, Andrzej Januszewicz, Stefan R Bornstein, Simon Parmentier, Carola Kunath, Jacques W M Lenders, Graeme Eisenhofer, Jens Passauer. Optimized procedures for testing plasma metanephrines in patients on hemodialysis. Scientific reports. 2021 07; 11(1):14706. doi: 10.1038/s41598-021-94104-9. [PMID: 34282182]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Meiling Jian, Honglang Huang, Kecheng Li, Liangmin Chuan, Lin Li, Li Jiang. A 3-min UPLC-MS/MS method for the simultaneous determination of plasma catecholamines and their metabolites: Method verification and diagnostic efficiency. Clinical biochemistry. 2021 Jan; 87(?):67-73. doi: 10.1016/j.clinbiochem.2020.10.009. [PMID: 33096053]
  • Haoran Wang, Xiaoqing Zhang, Qianna Zhen, Wenbi Zou, Hong Chen, Can Luo, Min Ding. Detection of spot urinary free metanephrines and 3-methoxytyramine with internal reference correction for the diagnosis of pheochromocytomas and paragangliomas. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov; 1156(?):122306. doi: 10.1016/j.jchromb.2020.122306. [PMID: 32829134]
  • Graeme Eisenhofer, Timo Deutschbein, Georgiana Constantinescu, Katharina Langton, Christina Pamporaki, Bruna Calsina, Maria Monteagudo, Mirko Peitzsch, Stephanie Fliedner, Henri J L M Timmers, Nicole Bechmann, Maria Fankhauser, Svenja Nölting, Felix Beuschlein, Anthony Stell, Martin Fassnacht, Aleksander Prejbisz, Jacques W M Lenders, Mercedes Robledo. Plasma metanephrines and prospective prediction of tumor location, size and mutation type in patients with pheochromocytoma and paraganglioma. Clinical chemistry and laboratory medicine. 2020 10; 59(2):353-363. doi: 10.1515/cclm-2020-0904. [PMID: 33001846]
  • Jiaxi Yao, Jun Wang, Linlin Wu, Haihua Lu, Zhonghe Wang, Pengfei Yu, Hang Xiao, Rong Gao, Jing Yu. Perinatal exposure to bisphenol A causes a disturbance of neurotransmitter metabolic pathways in female mouse offspring: A focus on the tryptophan and dopamine pathways. Chemosphere. 2020 Sep; 254(?):126715. doi: 10.1016/j.chemosphere.2020.126715. [PMID: 32334245]
  • Emilia Sbardella, Zoe Maunsell, Christine J H May, Michael Tadman, Tim James, Bahram Jafar-Mohammadi, Andrea M Isidori, Ashley B Grossman, Brian Shine. Random 'spot' urinary metanephrines compared with 24-h-urinary and plasma results in phaeochromocytomas and paragangliomas. European journal of endocrinology. 2020 Aug; 183(2):129-139. doi: 10.1530/eje-19-0809. [PMID: 32413848]
  • Martijn van Faassen, Rainer Bischoff, Karin Eijkelenkamp, Wilhelmina H A de Jong, Claude P van der Ley, Ido P Kema. In Matrix Derivatization Combined with LC-MS/MS Results in Ultrasensitive Quantification of Plasma Free Metanephrines and Catecholamines. Analytical chemistry. 2020 07; 92(13):9072-9078. doi: 10.1021/acs.analchem.0c01263. [PMID: 32484659]
  • Kaijuan Wang, Xiaojing Gao, Hongying Cong, Wei Zhang, Xiaocui Shi, Shuming Dai, Zhou Zhou. Stability and reference intervals of spot urinary fractionated metanephrines and methoxytyramine by tandem mass spectrometry as a screening method for pheochromocytoma and paraganglioma. Endocrine. 2020 07; 69(1):188-195. doi: 10.1007/s12020-020-02267-8. [PMID: 32222878]
  • Mirko Peitzsch, Denise Kaden, Christina Pamporaki, Katharina Langton, Georgiana Constantinescu, Catleen Conrad, Stephanie Fliedner, Richard O Sinnott, Aleksander Prejbisz, Roland Därr, Jacques W M Lenders, Michael Bursztyn, Graeme Eisenhofer. Overnight/first-morning urine free metanephrines and methoxytyramine for diagnosis of pheochromocytoma and paraganglioma: is this an option?. European journal of endocrinology. 2020 May; 182(5):499-509. doi: 10.1530/eje-19-1016. [PMID: 32187575]
  • Zebin Lin, Yuancheng Chen, Jiaolun Li, Zhiru Xu, Hao Wang, Junyi Lin, Xing Ye, Ziqin Zhao, Yiwen Shen, Yurong Zhang, Shuiqing Zheng, Yulan Rao. Pharmacokinetics of N-ethylpentylone and its effect on increasing levels of dopamine and serotonin in the nucleus accumbens of conscious rats. Addiction biology. 2020 05; 25(3):e12755. doi: 10.1111/adb.12755. [PMID: 30985062]
  • Mirko Peitzsch, Elizabeth R Butch, Elizabeth Lovorn, Anastasios Mangelis, Wayne L Furman, Victor M Santana, Barbara Hero, Frank Berthold, Barry L Shulkin, Angela Huebner, Graeme Eisenhofer. Biochemical testing for neuroblastoma using plasma free 3-O-methyldopa, 3-methoxytyramine, and normetanephrine. Pediatric blood & cancer. 2020 02; 67(2):e28081. doi: 10.1002/pbc.28081. [PMID: 31724812]
  • Songlin Yu, Yicong Yin, Qianqian Li, Jialei Yu, Wenjing Liu, Danchen Wang, Qian Cheng, Shaowei Xie, Xinqi Cheng, Ling Qiu. Validation of an improved liquid chromatography tandem mass spectrometry method for rapid and simultaneous analysis of plasma catecholamine and their metabolites. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121805. doi: 10.1016/j.jchromb.2019.121805. [PMID: 31670057]
  • Mirko Peitzsch, Anastasios Mangelis, Graeme Eisenhofer, Angela Huebner. Age-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: Particular importance for early infancy. Clinica chimica acta; international journal of clinical chemistry. 2019 Jul; 494(?):100-105. doi: 10.1016/j.cca.2019.03.1620. [PMID: 30904545]
  • Haithem Chtioui, Samira M Sadowski, Bettina Winzeler, Oliver Tschopp, Eric Grouzmann, Karim Abid. High concentration of plasma methoxytyramine: dopamine-producing tumour or Parkinson's disease therapy?. Annals of clinical biochemistry. 2019 07; 56(4):466-471. doi: 10.1177/0004563219835263. [PMID: 30974961]
  • Victoria Treasure, Royce P Vincent, David R Taylor. Falsely elevated plasma 3-methoxytyramine in a patient receiving midodrine therapy. Annals of clinical biochemistry. 2019 05; 56(3):415-416. doi: 10.1177/0004563218818199. [PMID: 30813742]
  • Sebastiano Barco, Iedan Verly, Maria Valeria Corrias, Stefania Sorrentino, Massimo Conte, Gino Tripodi, Godelieve Tytgat, André van Kuilenburg, Maria van der Ham, Monique de Sain-van der Velden, Alberto Garaventa, Giuliana Cangemi. Plasma free metanephrines for diagnosis of neuroblastoma patients. Clinical biochemistry. 2019 Apr; 66(?):57-62. doi: 10.1016/j.clinbiochem.2019.02.012. [PMID: 30822416]
  • Lu Sun, Chanxi Zhang, Chen Xue, Chuanxin Liu, Yumei Wang, Lei Chen, Yanping Deng, Jianmei Huang, Haifeng Zhai. Anxiolytic effect of a novel 9,10-dihydrophenanthrene, juncuenin H, is associated with metabolic changes in cortical serotonin/dopamine levels in mice. Fitoterapia. 2019 Apr; 134(?):165-171. doi: 10.1016/j.fitote.2019.02.030. [PMID: 30825572]
  • Graeme Eisenhofer, Mirko Peitzsch, Denise Kaden, Katharina Langton, Anastasios Mangelis, Christina Pamporaki, Jimmy Masjkur, Aikaterini Geroula, Max Kurlbaum, Timo Deutschbein, Felix Beuschlein, Aleksander Prejbisz, Stefan R Bornstein, Jacques W M Lenders. Reference intervals for LC-MS/MS measurements of plasma free, urinary free and urinary acid-hydrolyzed deconjugated normetanephrine, metanephrine and methoxytyramine. Clinica chimica acta; international journal of clinical chemistry. 2019 Mar; 490(?):46-54. doi: 10.1016/j.cca.2018.12.019. [PMID: 30571948]
  • Giuseppe Di Stolfo, Sandra Mastroianno, Angela Maggio, Giovanni De Luca, Domenico R Potenza, Mauro Pellegrino Salvatori, Aldo Russo. Electrical Remodeling of Ventricular Repolarization Abnormality after Treatment in Pheochromocytoma: U Wave Finding in a Retrospective Analysis. BioMed research international. 2019; 2019(?):2605323. doi: 10.1155/2019/2605323. [PMID: 31093497]
  • Graeme Eisenhofer, Aleksander Prejbisz, Mirko Peitzsch, Christina Pamporaki, Jimmy Masjkur, Natalie Rogowski-Lehmann, Katharina Langton, Elena Tsourdi, Mariola Pęczkowska, Stephanie Fliedner, Timo Deutschbein, Felix Megerle, Henri J L M Timmers, Richard Sinnott, Felix Beuschlein, Martin Fassnacht, Andrzej Januszewicz, Jacques W M Lenders. Biochemical Diagnosis of Chromaffin Cell Tumors in Patients at High and Low Risk of Disease: Plasma versus Urinary Free or Deconjugated O-Methylated Catecholamine Metabolites. Clinical chemistry. 2018 11; 64(11):1646-1656. doi: 10.1373/clinchem.2018.291369. [PMID: 30097498]
  • A S Davison, J A Harrold, G Hughes, B P Norman, J Devine, J Usher, A T Hughes, M Khedr, J A Gallagher, A M Milan, Halford J C G, L R Ranganath. Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone. Molecular genetics and metabolism. 2018 09; 125(1-2):135-143. doi: 10.1016/j.ymgme.2018.07.008. [PMID: 30049652]
  • I R N Verly, A B P van Kuilenburg, N G G M Abeling, S M I Goorden, M Fiocco, F M Vaz, M M van Noesel, C M Zwaan, G J L Kaspers, J H M Merks, H N Caron, G A M Tytgat. 3-Methoxytyramine: An independent prognostic biomarker that associates with high-risk disease and poor clinical outcome in neuroblastoma patients. European journal of cancer (Oxford, England : 1990). 2018 02; 90(?):102-110. doi: 10.1016/j.ejca.2017.11.025. [PMID: 29274926]
  • Kirk L Pappan, Adam D Kennedy, Pilar L Magoulas, Neil A Hanchard, Qin Sun, Sarah H Elsea. Clinical Metabolomics to Segregate Aromatic Amino Acid Decarboxylase Deficiency From Drug-Induced Metabolite Elevations. Pediatric neurology. 2017 Oct; 75(?):66-72. doi: 10.1016/j.pediatrneurol.2017.06.014. [PMID: 28823629]
  • Dipti Rao, Mirko Peitzsch, Aleksander Prejbisz, Katarzyna Hanus, Martin Fassnacht, Felix Beuschlein, Christina Brugger, Stephanie Fliedner, Katharina Langton, Christina Pamporaki, Volker Gudziol, Anthony Stell, Andrzej Januszewicz, Henri J L M Timmers, Jacques W M Lenders, Graeme Eisenhofer. Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma. European journal of endocrinology. 2017 Aug; 177(2):103-113. doi: 10.1530/eje-17-0077. [PMID: 28476870]
  • Leo Lam, Gerald A Woollard, Lochie Teague, James S Davidson. Clinical validation of urine 3-methoxytyramine as a biomarker of neuroblastoma and comparison with other catecholamine-related biomarkers. Annals of clinical biochemistry. 2017 Mar; 54(2):264-272. doi: 10.1177/0004563216654723. [PMID: 27235704]
  • Franck Patin, Lise Crinière, Thomas Francia, Sandra Kassem, Peggy Pierre, Clément Bruno, Caroline Vayne, Patrick Vourc'h, Isabelle Benz-de Bretagne, Christian R Andres, Hélène Blasco. Low specificity of urinary 3-methoxytyramine in screening of dopamine-secreting pheochromocytomas and paragangliomas. Clinical biochemistry. 2016 Oct; 49(15):1205-1208. doi: 10.1016/j.clinbiochem.2016.05.008. [PMID: 27208558]
  • Tania Hervet, Eric Grouzmann, Silke Grabherr, Patrice Mangin, Cristian Palmiere. Determination of urinary catecholamines and metanephrines in cardiac deaths. International journal of legal medicine. 2016 Jul; 130(4):995-1001. doi: 10.1007/s00414-015-1303-2. [PMID: 26690910]
  • Alexander G Zestos, Sarah R Mikelman, Robert T Kennedy, Margaret E Gnegy. PKCβ Inhibitors Attenuate Amphetamine-Stimulated Dopamine Efflux. ACS chemical neuroscience. 2016 06; 7(6):757-66. doi: 10.1021/acschemneuro.6b00028. [PMID: 26996926]
  • Tania Hervet, Grzegorz Teresiński, Petr Hejna, Emilienne Descloux, Eric Grouzmann, Cristian Palmiere. Catecholamines and their O-methylated metabolites in vitreous humor in hypothermia cases. Forensic science, medicine, and pathology. 2016 06; 12(2):163-9. doi: 10.1007/s12024-016-9764-2. [PMID: 27017494]
  • Lucyna Konieczna, Anna Roszkowska, Maciej Niedźwiecki, Tomasz Bączek. Hydrophilic interaction chromatography combined with dispersive liquid-liquid microextraction as a preconcentration tool for the simultaneous determination of the panel of underivatized neurotransmitters in human urine samples. Journal of chromatography. A. 2016 Jan; 1431(?):111-121. doi: 10.1016/j.chroma.2015.12.062. [PMID: 26747692]
  • Yasushi Ishida, Kosuke Ebihara, Masahiro Tabuchi, Sachiko Imamura, Kyoji Sekiguchi, Kazushige Mizoguchi, Yoshio Kase, Go Koganemaru, Hiroshi Abe, Yasushi Ikarashi. Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT. Biological & pharmaceutical bulletin. 2016; 39(1):104-13. doi: 10.1248/bpb.b15-00691. [PMID: 26725433]
  • Constantin Tuleasca, Yves Jaquet, Valerie Schweizer, Laura Negretti, Vera Magaddino, Philippe Maeder, Karim-Alexandre Abid, Benoit Lhermitte, Eric Grouzmann, Marc Levivier. Clinical and biochemical responses after Gamma Knife surgery for a dopamine-secreting paraganglioma: case report. Hormones (Athens, Greece). 2016 Jan; 15(1):106-12. doi: 10.14310/horm.2002.1605. [PMID: 26188236]
  • Dawid Nieć, Paweł K Kunicki. Validation of an assay for quantification of free normetanephrine, metanephrine and methoxytyramine in plasma by high performance liquid chromatography with coulometric detection: Comparison of peak-area vs. peak-height measurements. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Oct; 1002(?):63-70. doi: 10.1016/j.jchromb.2015.07.004. [PMID: 26310898]
  • Caroline G M de Theije, Lieke W J van den Elsen, Linette E M Willemsen, Vanja Milosevic, Gerdien A H Korte-Bouws, Sofia Lopes da Silva, Laus M Broersen, S Mechiel Korte, Berend Olivier, Johan Garssen, Aletta D Kraneveld. Dietary long chain n-3 polyunsaturated fatty acids prevent impaired social behaviour and normalize brain dopamine levels in food allergic mice. Neuropharmacology. 2015 Mar; 90(?):15-22. doi: 10.1016/j.neuropharm.2014.11.001. [PMID: 25445491]
  • R Bílek, T Zelinka, P Vlček, J Dušková, D Michalský, K Novák, J Bešťák, J Widimský. Deconjugated urinary metanephrine, normetanephrine and 3-methoxytyramine in laboratory diagnosis of pheochromocytoma and paraganglioma. Physiological research. 2015; 64(Suppl 2):S313-22. doi: 10.33549/physiolres.933109. [PMID: 26680494]
  • Thamara E Osinga, Esther Korpershoek, Ronald R de Krijger, Michiel N Kerstens, Robin P F Dullaart, Ido P Kema, Bernard F A M van der Laan, Anouk N A van der Horst-Schrivers, Thera P Links. Catecholamine-Synthesizing Enzymes Are Expressed in Parasympathetic Head and Neck Paraganglioma Tissue. Neuroendocrinology. 2015; 101(4):289-95. doi: 10.1159/000377703. [PMID: 25677368]
  • Graeme Eisenhofer, Mirko Peitzsch. Laboratory evaluation of pheochromocytoma and paraganglioma. Clinical chemistry. 2014 Dec; 60(12):1486-99. doi: 10.1373/clinchem.2014.224832. [PMID: 25332315]
  • Cristian Palmiere, Grzegorz Teresiński, Petr Hejna, Patrice Mangin, Eric Grouzmann. Diagnostic performance of urinary metanephrines for the postmortem diagnosis of hypothermia. Forensic science, medicine, and pathology. 2014 Dec; 10(4):518-25. doi: 10.1007/s12024-014-9585-0. [PMID: 25034267]
  • Roland Därr, Christina Pamporaki, Mirko Peitzsch, Konstanze Miehle, Aleksander Prejbisz, Mariola Peczkowska, Dirk Weismann, Felix Beuschlein, Richard Sinnott, Stefan R Bornstein, Hartmut P Neumann, Andrzej Januszewicz, Jacques Lenders, Graeme Eisenhofer. Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions. Clinical endocrinology. 2014 Apr; 80(4):478-86. doi: 10.1111/cen.12327. [PMID: 24102244]
  • A van Berkel, J W M Lenders, H J L M Timmers. Diagnosis of endocrine disease: Biochemical diagnosis of phaeochromocytoma and paraganglioma. European journal of endocrinology. 2014 Mar; 170(3):R109-19. doi: 10.1530/eje-13-0882. [PMID: 24347425]
  • Carine Garcia Hejl, Emmanuel Dedome, Denis Chianea, Jose Ramirez Martinez, Philippe Vest. Pheochromocytoma: yes or no?. Clinical chemistry. 2014 Mar; 60(3):565-6. doi: 10.1373/clinchem.2013.209924. [PMID: 24584411]
  • Graeme Eisenhofer, Sebastian Brown, Mirko Peitzsch, Daniela Pelzel, Peter Lattke, Stephan Glöckner, Anthony Stell, Aleksander Prejbisz, Martin Fassnacht, Felix Beuschlein, Andrzej Januszewicz, Gabriele Siegert, Heinz Reichmann. Levodopa therapy in Parkinson's disease: influence on liquid chromatographic tandem mass spectrometric-based measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine. Annals of clinical biochemistry. 2014 Jan; 51(Pt 1):38-46. doi: 10.1177/0004563213487894. [PMID: 23873873]
  • N van Duinen, E P M Corssmit, W H A de Jong, D Brookman, I P Kema, J A Romijn. Plasma levels of free metanephrines and 3-methoxytyramine indicate a higher number of biochemically active HNPGL than 24-h urinary excretion rates of catecholamines and metabolites. European journal of endocrinology. 2013 Sep; 169(3):377-82. doi: 10.1530/eje-13-0529. [PMID: 23832865]
  • Mirko Peitzsch, Aleksander Prejbisz, Matthias Kroiß, Felix Beuschlein, Wiebke Arlt, Andrzej Januszewicz, Gabriele Siegert, Graeme Eisenhofer. Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma. Annals of clinical biochemistry. 2013 Mar; 50(Pt 2):147-55. doi: 10.1258/acb.2012.012112. [PMID: 23512172]
  • Mohamed Bouri, M Jesús Lerma-García, Rachid Salghi, Mohammed Zougagh, Angel Ríos. Selective extraction and determination of catecholamines in urine samples by using a dopamine magnetic molecularly imprinted polymer and capillary electrophoresis. Talanta. 2012 Sep; 99(?):897-903. doi: 10.1016/j.talanta.2012.07.053. [PMID: 22967640]
  • Graeme Eisenhofer, Jacques W M Lenders, Gabriele Siegert, Stefan R Bornstein, Peter Friberg, Dragana Milosevic, Massimo Mannelli, W Marston Linehan, Karen Adams, Henri J Timmers, Karel Pacak. Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status. European journal of cancer (Oxford, England : 1990). 2012 Jul; 48(11):1739-49. doi: 10.1016/j.ejca.2011.07.016. [PMID: 22036874]
  • Aurélien Le Jacques, Jean-Hervé Abalain, Fabienne Le Saos, Jean-Luc Carré. [Significance of 3-methoxytyramine urine measurement in the diagnosis of pheochromocytomas and paragangliomas: about 28 patients]. Annales de biologie clinique. 2011 Sep; 69(5):555-9. doi: 10.1684/abc.2011.0612. [PMID: 22008135]
  • Bérengère Claude, Reine Nehmé, Philippe Morin. Analysis of urinary neurotransmitters by capillary electrophoresis: sensitivity enhancement using field-amplified sample injection and molecular imprinted polymer solid phase extraction. Analytica chimica acta. 2011 Aug; 699(2):242-8. doi: 10.1016/j.aca.2011.05.014. [PMID: 21704780]
  • Graeme Eisenhofer, Jacques W M Lenders, Henri Timmers, Massimo Mannelli, Stefan K Grebe, Lorenz C Hofbauer, Stefan R Bornstein, Oliver Tiebel, Karen Adams, Gennady Bratslavsky, W Marston Linehan, Karel Pacak. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clinical chemistry. 2011 Mar; 57(3):411-20. doi: 10.1373/clinchem.2010.153320. [PMID: 21262951]
  • Anouk N A Van Der Horst-Schrivers, Thamara E Osinga, Ido P Kema, Bernard F A M Van Der Laan, Robin P F Dullaart. Dopamine excess in patients with head and neck paragangliomas. Anticancer research. 2010 Dec; 30(12):5153-8. doi: . [PMID: 21187504]
  • Tsai-Hsiu Yang, Mei-Fen Shih, Yi-Szu Wen, Wen-Yueh Ho, Kuen-Lin Leu, Mei-Ying Wang, Chia-Chyuan Liu. Attenuation of circulatory shock and cerebral ischemia injury in heat stroke by combination treatment with dexamethasone and hydroxyethyl starch. Experimental & translational stroke medicine. 2010 Oct; 2(1):19. doi: 10.1186/2040-7378-2-19. [PMID: 20937119]
  • Michael A Siuta, Sabrina D Robertson, Heidi Kocalis, Christine Saunders, Paul J Gresch, Vivek Khatri, Chiyo Shiota, J Philip Kennedy, Craig W Lindsley, Lynette C Daws, Daniel B Polley, Jeremy Veenstra-Vanderweele, Gregg D Stanwood, Mark A Magnuson, Kevin D Niswender, Aurelio Galli. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS biology. 2010 Jun; 8(6):e1000393. doi: 10.1371/journal.pbio.1000393. [PMID: 20543991]
  • Dilo Pillai, Shaw Callen. Pilot quality assurance programme for plasma metanephrines. Annals of clinical biochemistry. 2010 Mar; 47(Pt 2):137-42. doi: 10.1258/acb.2009.009153. [PMID: 20144968]
  • Tsukasa Sasaki, Takeshi Fukushima, Kazuhide Yamashita, Toshimasa Toyo'oka. Stereoselective effect of kynurenine enantiomers on the excretion of serotonin and its metabolite in rat urine. Chirality. 2010 Feb; 22(2):258-61. doi: 10.1002/chir.20737. [PMID: 19496137]
  • N van Duinen, D Steenvoorden, I P Kema, J C Jansen, A H J T Vriends, J P Bayley, J W A Smit, J A Romijn, E P M Corssmit. Increased urinary excretion of 3-methoxytyramine in patients with head and neck paragangliomas. The Journal of clinical endocrinology and metabolism. 2010 Jan; 95(1):209-14. doi: 10.1210/jc.2009-1632. [PMID: 19897674]
  • Liaoyuan A Hu, Tian Zhou, Jinwoo Ahn, Shuli Wang, Julia Zhou, Yi Hu, Qingyun Liu. Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. The Biochemical journal. 2009 Oct; 424(1):39-45. doi: 10.1042/bj20090998. [PMID: 19725810]
  • A Vonaparti, E Lyris, I Panderi, M Koupparis, C Georgakopoulos. Direct injection horse-urine analysis for the quantification and confirmation of threshold substances for doping control. IV. Determination of 3-methoxytyramine by hydrophilic interaction liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug testing and analysis. 2009 Aug; 1(8):365-71. doi: 10.1002/dta.70. [PMID: 20355216]
  • Wilhelmina H A de Jong, Graeme Eisenhofer, Wendy J Post, Frits A J Muskiet, Elisabeth G E de Vries, Ido P Kema. Dietary influences on plasma and urinary metanephrines: implications for diagnosis of catecholamine-producing tumors. The Journal of clinical endocrinology and metabolism. 2009 Aug; 94(8):2841-9. doi: 10.1210/jc.2009-0303. [PMID: 19567530]
  • Marc Morissette, Thérèse Di Paolo. Effect of estradiol on striatal dopamine activity of female hemiparkinsonian monkeys. Journal of neuroscience research. 2009 May; 87(7):1634-44. doi: 10.1002/jnr.21977. [PMID: 19115413]
  • Mohammed Ahmed, Abdullah Al-Ghamdi, Mohammed Al-Omari, Mahmoud Aljurf, Yusuf Al-Kadhi. Autologous bone marrow transplanation for extramedullary plasmacytoma presenting as adrenal incidentaloma. Annals of Saudi medicine. 2009 May; 29(3):219-22. doi: 10.4103/0256-4947.51785. [PMID: 19448366]
  • Hang Xiao, Kirk Parkin. Isolation and identification of phase II enzyme-inducing agents from nonpolar extracts of green onion (Allium spp.). Journal of agricultural and food chemistry. 2006 Nov; 54(22):8417-24. doi: 10.1021/jf061582s. [PMID: 17061815]
  • Ilona Klejbor, Jason M Myers, Kathy Hausknecht, Thomas D Corso, Angelo S Gambino, Janusz Morys, Pamela A Maher, Robert Hard, Jerry Richards, Ewa K Stachowiak, Michal K Stachowiak. Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice. Journal of neurochemistry. 2006 Jun; 97(5):1243-58. doi: 10.1111/j.1471-4159.2006.03754.x. [PMID: 16524369]
  • Benjamin J Copeland, Norton H Neff, Maria Hadjiconstantinou. Enhanced dopamine uptake in the striatum following repeated restraint stress. Synapse (New York, N.Y.). 2005 Sep; 57(3):167-74. doi: 10.1002/syn.20169. [PMID: 15945060]
  • Krystyna Ossowska, Jadwiga Wardas, Katarzyna Kuter, Przemysław Nowak, Joanna Dabrowska, Aleksandra Bortel, Łukasz Labus, Adam Kwieciński, Anna Krygowska-Wajs, Stainsław Wolfarth. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacological reports : PR. 2005 May; 57(3):330-5. doi: . [PMID: 15985715]
  • Graeme Eisenhofer, David S Goldstein, Patricia Sullivan, Gyorgy Csako, Frederieke M Brouwers, Edwin W Lai, Karen T Adams, Karel Pacak. Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine. The Journal of clinical endocrinology and metabolism. 2005 Apr; 90(4):2068-75. doi: 10.1210/jc.2004-2025. [PMID: 15644397]
  • Paul M Wynne, John H Vine, R Gary Amiet. 3-Methoxytyramine as an indicator of dopaminergic manipulation in the equine athlete. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Nov; 811(1):93-101. doi: 10.1016/j.jchromb.2004.03.078. [PMID: 15458727]
  • Kunio Yui, Kimihiko Goto, Shigenori Ikemoto. The role of noradrenergic and dopaminergic hyperactivity in the development of spontaneous recurrence of methamphetamine psychosis and susceptibility to episode recurrence. Annals of the New York Academy of Sciences. 2004 Oct; 1025(?):296-306. doi: 10.1196/annals.1316.037. [PMID: 15542730]
  • P Houpert, P Lestaevel, C Amourette, B Dhieux, C Bussy, F Paquet. Effect of U and 137Cs chronic contamination on dopamine and serotonin metabolism in the central nervous system of the rat. Canadian journal of physiology and pharmacology. 2004 Feb; 82(2):161-6. doi: 10.1139/y04-012. [PMID: 15052298]
  • Youngleem Kim, Mi Seon Han, Ji Suk Lee, Jinwoong Kim, Young Choong Kim. Inhibitory phenolic amides on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells from Beta vulgaris var. cicla seeds. Phytotherapy research : PTR. 2003 Sep; 17(8):983-5. doi: 10.1002/ptr.1232. [PMID: 13680842]
  • Stanislaw J Chrapusta, Michael F Egan, Richard J Wyatt, Daniel R Weinberger, Barbara K Lipska. Neonatal ventral hippocampal damage modifies serum corticosterone and dopamine release responses to acute footshock in adult Sprague-Dawley rats. Synapse (New York, N.Y.). 2003 Mar; 47(4):270-7. doi: 10.1002/syn.10179. [PMID: 12539200]
  • J J Willemsen, H A Ross, B G Wolthers, C G Sweep, I P Kema. Evaluation of specific high-performance liquid-chromatographic determinations of urinary metanephrine and normetanephrine by comparison with isotope dilution mass spectrometry. Annals of clinical biochemistry. 2001 Nov; 38(Pt 6):722-30. doi: 10.1258/0004563011900984. [PMID: 11732660]
  • W Schliemann, Y Cai, T Degenkolb, J Schmidt, H Corke. Betalains of Celosia argentea. Phytochemistry. 2001 Sep; 58(1):159-65. doi: 10.1016/s0031-9422(01)00141-8. [PMID: 11524126]
  • J J Willemsen, H A Ross, B G Wolthers, C G Sweep, I P Kema. Evaluation of specific high-performance liquid-chromatographic determinations of urinary adrenaline and noradrenaline by comparison with isotope dilution mass spectrometry. Annals of clinical biochemistry. 2001 Jul; 38(Pt 4):356-64. doi: NULL. [PMID: 11471877]
  • M A Vieira-Coelho, P Serrão, J T Guimarães, M Pestana, P Soares-da-Silva. Concerted action of dopamine on renal and intestinal Na(+)-K(+)-ATPase in the rat remnant kidney. American journal of physiology. Renal physiology. 2000 Dec; 279(6):F1033-44. doi: 10.1152/ajprenal.2000.279.6.f1033. [PMID: 11097621]
  • N G Abeling, C Bräutigam, G F Hoffmann, P G Barth, R A Wevers, J Jaeken, A Fiumara, A Knust, A H van Gennip. Pathobiochemical implications of hyperdopaminuria in patients with aromatic L-amino acid decarboxylase deficiency. Journal of inherited metabolic disease. 2000 Jun; 23(4):325-8. doi: 10.1023/a:1005650325003. [PMID: 10896285]
  • C G Charlton, B Crowell. Effects of dopamine metabolites on locomotor activities and on the binding of dopamine: relevance to the side effects of L-dopa. Life sciences. 2000 Apr; 66(22):2159-71. doi: 10.1016/s0024-3205(00)00543-9. [PMID: 10834300]
  • K Yui, T Ishiguro, K Goto, S Ikemoto, Y Kamata. Spontaneous recurrence of methampetamine psychosis: increased sensitivity to stress associated with noradrenergic hyperactivity and dopaminergic change. European archives of psychiatry and clinical neuroscience. 1999; 249(2):103-11. doi: 10.1007/s004060050073. [PMID: 10369157]
  • M Pestana, M S Faria, J G Oliveira, J Baldaia, A Santos, L E Guerra, P Soares-da-Silva. Assessment of renal dopaminergic system activity during the recovery of renal function in human kidney transplant recipients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1997 Dec; 12(12):2667-72. doi: 10.1093/ndt/12.12.2667. [PMID: 9430869]
  • M A Vieira-Coelho, M Pestana, P Soares-da-Silva. High sodium intake increases the urinary excretion of L-3,4-dihydroxyphenylalanine but fails to alter the urinary excretion of dopamine and amine metabolites in Wistar rats. General pharmacology. 1996 Dec; 27(8):1421-7. doi: 10.1016/s0306-3623(96)00064-x. [PMID: 9304419]
  • M Candito, C Soler, A Deville, S Bekri, P Chambon, A Thyss. Urinary excretion of methylated catecholamine metabolites in a child with neuroblastoma maturing into ganglioneuroma. Medical and pediatric oncology. 1996 Jan; 26(1):57-60. doi: 10.1002/(sici)1096-911x(199601)26:1<57::aid-mpo8>3.0.co;2-u. [PMID: 7494513]
  • F Mashige, Y Matsushima, C Miyata, R Yamada, H Kanazawa, I Sakuma, N Takai, N Shinozuka, A Ohkubo, K Nakahara. Simultaneous determination of catecholamines, their basic metabolites and serotonin in urine by high-performance liquid chromatography using a mixed-mode column and an eight-channel electrochemical detector. Biomedical chromatography : BMC. 1995 Sep; 9(5):221-5. doi: 10.1002/bmc.1130090506. [PMID: 8593422]
  • C M de Groot, R A Bornstein, G B Baker. Obsessive-compulsive symptom clusters and urinary amine correlates in Tourette syndrome. The Journal of nervous and mental disease. 1995 Apr; 183(4):224-30. doi: 10.1097/00005053-199504000-00007. [PMID: 7536233]
  • M Radjaipour, H Raster, H M Liebich. Quantification of urinary catecholamines, their abundant metabolites, and 5-hydroxyindoleacetic acid by high performance liquid chromatography and electrochemical detection, using a single mobile phase and uniform isocratic conditions. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 1994 Aug; 32(8):609-13. doi: 10.1515/cclm.1994.32.8.609. [PMID: 7529572]
  • C Proye, N Racadot-Leroy, M Vix, B Vermesse, B Carnaille. [Comparative secretory profiles of benign and malignant pheochromocytomas]. Annales de chirurgie. 1994; 48(5):430-4. doi: NULL. [PMID: 7810975]
  • H Ishii, D B Stanimirovic, C J Chang, B B Mrsulja, M Spatz. Dopamine metabolism and free-radical related mitochondrial injury during transient brain ischemia in gerbils. Neurochemical research. 1993 Nov; 18(11):1193-201. doi: 10.1007/bf00978373. [PMID: 8255372]
  • I P Kema, G Meiborg, G T Nagel, G J Stob, F A Muskiet. Isotope dilution ammonia chemical ionization mass fragmentographic analysis of urinary 3-O-methylated catecholamine metabolites. Rapid sample clean-up by derivatization and extraction of lyophilized samples. Journal of chromatography. 1993 Aug; 617(2):181-9. doi: 10.1016/0378-4347(93)80486-n. [PMID: 8408382]
  • L Naudon, I Leroux-Nicollet, J Costentin. Consequences of an intrastriatal injection of kainic acid on the dopaminergic neuronal and vesicular uptake systems. Brain research. 1992 Oct; 593(1):32-8. doi: 10.1016/0006-8993(92)91259-h. [PMID: 1360863]
  • P Volin. Determination of urinary normetanephrine, metanephrine and 3-methoxytyramine by high-performance liquid chromatography with electrochemical detection: comparison between automated column-switching and manual dual-column sample purification methods. Journal of chromatography. 1992 Jul; 578(2):165-74. doi: 10.1016/0378-4347(92)80413-k. [PMID: 1400794]