3-Methoxytyramine (BioDeep_00000001873)

 

Secondary id: BioDeep_00000400002

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


4-(2-aminoethyl)-2-methoxyphenol

化学式: C9H13NO2 (167.0946)
中文名称: 3-甲氧基酪胺
谱图信息: 最多检出来源 Homo sapiens(blood) 20.05%

Reviewed

Last reviewed on 2024-11-05.

Cite this Page

3-Methoxytyramine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/3-methoxytyramine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001873). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(ccc(cc1OC)CCN)O
InChI: InChI=1S/C9H13NO2/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,11H,4-5,10H2,1H3

描述信息

3-methoxytyramine, also known as 4-(2-amino-Ethyl)-2-methoxy-phenol or 3-O-Methyldopamine, is classified as a member of the Methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. 3-methoxytyramine is considered to be slightly soluble (in water) and acidic. 3-methoxytyramine can be found primarily in human brain and most tissues tissues; and in blood, cerebrospinal fluid (csf) or urine. Within a cell, 3-methoxytyramine is primarily located in the cytoplasm
The O-methylated derivative of dopamine. Dopamine is methylated by catechol-O-methyltransferase (COMT) to make 3-Methoxytyramine. This compound can be broken down to homovanillic acid by monoamine oxidase and aldehyde dehydrogenase. Elevated concentrations of this compound are indicated for a variety of brain and carcinoid tumors as well as certain mental disorders. [HMDB]
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.

同义名列表

12 个代谢物同义名

3-Methoxy-4-hydroxyphenylethyl amine; 4-(2-Amino-ethyl)-2-methoxy-phenol; 4-(2-Aminoethyl)-2-methoxy-phenol; 4-(2-Aminoethyl)-2-methoxyphenol; 3-Methoxytyramine hydrochloride; 5-(2-Aminoethyl)guaiacol; 3-O-Methyldopamine; 3-Methoxytyramine; Methoxytyramine; 3-Methoxytyramine; 3-O-methyl Dopamine; 3-Methoxytyramine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

92 个相关的代谢反应过程信息。

Reactome(62)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(24)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CASP3, DBH, MT1E, MT3, PGLS, SLC6A3, SNCA, TH
Peripheral membrane protein 2 SDHB, VHL
Endoplasmic reticulum membrane 2 DRD1, TAAR1
Nucleus 9 CASP3, DRD1, FOS, MT1E, MT3, MYCN, SNCA, TH, VHL
cytosol 8 CASP3, COMT, FOS, MT3, PGLS, SNCA, TH, VHL
dendrite 3 COMT, DRD2, TH
mitochondrial membrane 1 SDHB
nucleoplasm 5 CASP3, FOS, MYCN, SDHB, VHL
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 6 COMT, DRD1, DRD2, SLC6A3, TAAR1, VHL
Cell projection, axon 3 SLC6A3, SNCA, TH
Multi-pass membrane protein 5 DRD1, DRD2, SDHD, SLC6A3, TAAR1
Golgi apparatus membrane 1 DRD2
Synapse 4 COMT, DBH, DRD2, SNCA
cell cortex 1 SNCA
cell surface 1 SLC6A3
glutamatergic synapse 3 CASP3, DRD1, DRD2
Golgi membrane 2 DRD2, INS
growth cone 1 SNCA
mitochondrial inner membrane 2 SDHB, SDHD
neuronal cell body 3 CASP3, SLC6A3, SNCA
postsynapse 1 SNCA
presynaptic membrane 3 DRD1, DRD2, SLC6A3
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 MT3, TH
Cytoplasmic vesicle, secretory vesicle 1 CHGA
Lysosome 1 SNCA
acrosomal vesicle 1 DRD2
plasma membrane 8 COMT, DRD1, DRD2, SDHB, SLC6A3, SNCA, TAAR1, VHL
synaptic vesicle membrane 2 DRD2, SNCA
terminal bouton 1 TH
Membrane 5 COMT, DBH, MYCN, SLC6A3, SNCA
axon 6 COMT, DRD2, MT3, SLC6A3, SNCA, TH
extracellular exosome 2 COMT, PGLS
endoplasmic reticulum 3 DBH, FOS, VHL
extracellular space 6 CHGA, DBH, IL6, INS, MT3, SNCA
perinuclear region of cytoplasm 4 CHGA, MT3, SNCA, TH
mitochondrion 5 SDHB, SDHD, SNCA, TH, VHL
protein-containing complex 1 SNCA
intracellular membrane-bounded organelle 2 COMT, DBH
postsynaptic density 1 CASP3
Secreted 5 CHGA, DBH, IL6, INS, SNCA
extracellular region 5 CHGA, DBH, IL6, INS, SNCA
cytoplasmic side of plasma membrane 1 TH
mitochondrial outer membrane 1 MT3
astrocyte end-foot 1 MT3
neuronal cell body membrane 1 SLC6A3
mitochondrial matrix 1 SDHB
Extracellular side 1 COMT
centriolar satellite 1 DBH
ciliary membrane 2 DRD1, DRD2
actin cytoskeleton 1 SNCA
dendritic spine 3 DRD1, DRD2, MT3
perikaryon 2 DRD2, TH
cytoplasmic vesicle 1 TH
nucleolus 1 MYCN
Melanosome membrane 1 TH
Single-pass type II membrane protein 2 COMT, DBH
postsynaptic membrane 3 DRD1, DRD2, SLC6A3
Cytoplasm, perinuclear region 1 TH
Mitochondrion inner membrane 2 SDHB, SDHD
Matrix side 1 SDHB
Membrane raft 1 SLC6A3
microtubule 1 MT3
GABA-ergic synapse 2 DRD1, DRD2
flotillin complex 1 SLC6A3
Cell projection, dendritic spine 1 DRD1
secretory granule 1 CHGA
lateral plasma membrane 1 DRD2
Cell projection, neuron projection 1 SLC6A3
neuron projection 2 SLC6A3, TH
cilium 2 DRD1, DRD2
chromatin 2 FOS, MYCN
supramolecular fiber 1 SNCA
non-motile cilium 2 DRD1, DRD2
sperm flagellum 1 DRD2
Endomembrane system 1 TAAR1
endosome lumen 1 INS
Cell projection, dendrite 1 DRD1
[Isoform 1]: Cytoplasm 1 VHL
[Isoform 3]: Cytoplasm 1 VHL
secretory granule lumen 2 DBH, INS
secretory granule membrane 1 DBH
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
nuclear matrix 1 FOS
axon terminus 3 DRD2, SLC6A3, SNCA
endocytic vesicle 1 DRD2
transport vesicle 2 CHGA, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
mitochondrial envelope 1 SDHD
respiratory chain complex II (succinate dehydrogenase) 2 SDHB, SDHD
neuronal dense core vesicle 1 CHGA
protein-DNA complex 1 FOS
death-inducing signaling complex 1 CASP3
dopaminergic synapse 2 DRD2, SLC6A3
intracellular non-membrane-bounded organelle 1 VHL
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
Cell projection, cilium membrane 1 DRD1
ribosome 1 MT3
transcription factor AP-1 complex 1 FOS
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 CHGA
transport vesicle membrane 1 DBH
inclusion body 2 MT3, SNCA
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
chromaffin granule 1 CHGA
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
[Serpinin]: Secreted 1 CHGA
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT


文献列表

  • Joanna Kokoszka, Marta Opalinska, Katarzyna Sitarz, Magdalena Kolasa, Monika Szewczyk, Jolanta Bugajska, Joanna Berska, Krystyna Sztefko, Alicja Hubalewska-Dydejczyk. 24-hours urine metanephrines excretion in patients diagnosed with adrenal incidentaloma: impact of commonly used drugs on clinical decision. Polish archives of internal medicine. 2024 Jan; ?(?):. doi: 10.20452/pamw.16646. [PMID: 38164744]
  • Hongyu Zeng, Xiaoqing Zhang, Qianna Zhen, Yifan He, Haoran Wang, Yang Zhu, Qi Sun, Min Ding. Dual-Template Magnetic Molecularly Imprinted Polymer for Simultaneous Determination of Spot Urine Metanephrines and 3-Methoxytyramine for the Diagnosis of Pheochromocytomas and Paragangliomas. Molecules (Basel, Switzerland). 2022 May; 27(11):. doi: 10.3390/molecules27113520. [PMID: 35684457]
  • Madysen Elbourne, Adam Cawley, Shawn Stanley, Christopher Bowen, Shanlin Fu. Intelligence benefit of the 3-methoxytyramine to tyramine ratio in equine urine. Drug testing and analysis. 2022 May; 14(5):936-942. doi: 10.1002/dta.3264. [PMID: 35343638]
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  • Lu Liu, Wenchun Xie, Zhijing Song, Tianyu Wang, Xuesong Li, Ying Gao, Yan Li, Junqing Zhang, Xiaohui Guo. Addition of 3-methoxytyramine or chromogranin A to plasma free metanephrines as the initial test for pheochromocytoma and paraganglioma: Which is the best diagnostic strategy. Clinical endocrinology. 2022 02; 96(2):132-138. doi: 10.1111/cen.14585. [PMID: 34486152]
  • Youhei Obata, Mie Kubota-Sakashita, Takaoki Kasahara, Masafumi Mizuno, Takahiro Nemoto, Tadafumi Kato. Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus. Scientific reports. 2022 01; 12(1):17. doi: 10.1038/s41598-021-03885-6. [PMID: 34996979]
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  • Kaijuan Wang, Xiaojing Gao, Wei Zhang, Nian Sun, Lan Xie, Hongying Cong, Yutong Guo, Xiaocui Shi, Zhou Zhou. Study of stability and interference for catecholamines and metanephrines, 3-methoxytyramine: key point of an accurate diagnosis for pheochromocytoma and paraganglioma. Scandinavian journal of clinical and laboratory investigation. 2021 Nov; 81(7):564-572. doi: 10.1080/00365513.2021.1980901. [PMID: 34570657]
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  • Mirko Peitzsch, Denise Kaden, Christina Pamporaki, Katharina Langton, Georgiana Constantinescu, Catleen Conrad, Stephanie Fliedner, Richard O Sinnott, Aleksander Prejbisz, Roland Därr, Jacques W M Lenders, Michael Bursztyn, Graeme Eisenhofer. Overnight/first-morning urine free metanephrines and methoxytyramine for diagnosis of pheochromocytoma and paraganglioma: is this an option?. European journal of endocrinology. 2020 May; 182(5):499-509. doi: 10.1530/eje-19-1016. [PMID: 32187575]
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