N-acetyl-L-aspartic acid (BioDeep_00000399929)
Main id: BioDeep_00000001686
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
N-acetyl-L-aspartic acid
化学式: C6H9NO5 (175.0480704)
中文名称: N-乙酰-L-天门冬氨酸, N-乙酰基-L-天冬氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=N[C@@H](CC(=O)O)C(=O)O)O
InChI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1
描述信息
An N-acyl-L-aspartic acid in which the acyl group is specified as acetyl.
D018377 - Neurotransmitter Agents > D018846 - Excitatory Amino Acids
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; OTCCIMWXFLJLIA-BYPYZUCNSA-N_STSL_0218_N-Acetyl-L-aspartic acid_2000fmol_190326_S2_LC02MS02_065; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
N-Acetyl-L-aspartic acid is a derivative of aspartic acid.
同义名列表
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:21547
- KEGG: C01042
- KEGGdrug: D70679
- PubChem: 65065
- ChEMBL: CHEMBL1162494
- CAS: 997-55-7
- MoNA: CCMSLIB00005720407
- MoNA: CCMSLIB00005720705
- MoNA: EMBL-MCF_spec46388
- MoNA: MoNA010219
- MoNA: MoNA010218
- MoNA: MoNA010217
- MoNA: MoNA010216
- MoNA: MoNA010215
- MoNA: MoNA010214
- MoNA: MoNA001859
- MoNA: MoNA001858
- MoNA: MoNA001856
- MoNA: HMDB0000812_ms_ms_1162
- MoNA: HMDB0000812_ms_ms_1163
- MoNA: HMDB0000812_ms_ms_1161
- MoNA: CCMSLIB00000578206
- MoNA: CCMSLIB00000577971
- MetaboLights: MTBLC21547
- ChEBI: CHEBI:16953
- PubChem: 4284
- PDB-CCD: KKD
- 3DMET: B00227
- NIKKAJI: J62.824G
- medchemexpress: HY-113524
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-182
- KNApSAcK: 16953
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anoushka Lotun, Danning Li, Hongxia Xu, Qin Su, Serafettin Tuncer, Julio Sanmiguel, Morgan Mooney, Christina E Baer, Russell Ulbrich, Stephen J Eyles, Lara Strittmatter, Lawrence J Hayward, Dominic J Gessler, Guangping Gao. Renewal of Oligodendrocyte Lineage Reverses Dysmyelination and CNS Neurodegeneration Through Corrected N-acetylaspartate Metabolism.
Progress in neurobiology.
2023 May; ?(?):102460. doi:
10.1016/j.pneurobio.2023.102460. [PMID: 37149081] - Eleni Rebelos, Giuseppe Daniele, Beatrice Campi, Alessandro Saba, Kalle Koskensalo, Jukka Ihalainen, Ekaterina Saukko, Pirjo Nuutila, Walter H Backes, Jacobus F A Jansen, Pieter C Dagnelie, Sebastian Köhler, Bastiaan E de Galan, Thomas T van Sloten, Coen D A Stehouwer, Ele Ferrannini. Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans.
Scientific reports.
2022 Jul; 12(1):11530. doi:
10.1038/s41598-022-15670-0. [PMID: 35798828] - Thaysa Mara Gazzotto Neves, Estefania Simoes, Maria Concepcíon García Otaduy, Elie Leal de Barros Calfat, Pâmela Bertolazzi, Naomi Antunes da Costa, Fábio Luís de Souza Duran, Joanna Correia-Lima, Maria da Graça Morais Martin, Marília Cerqueira Leite Seelander, Victor Henrique Oyamada Otani, Thais Zélia Dos Santos Otani, Daniel Augusto Corrêa Vasques, Geraldo Busatto Filho, Cristiane Kochi, Ricardo Riyoiti Uchida. Inverse Association Between Hypothalamic N-Acetyl Aspartate/Creatine Ratio and Indices of Body Mass in Adolescents with Obesity.
The Journal of nutrition.
2022 03; 152(3):663-670. doi:
10.1093/jn/nxab415. [PMID: 34888674] - Kimberly A Lewis, Nico Osier, Ruy Carrasco, Jennifer Chiou, Patricia Carter, Alexandra Garcia, Elena Flowers, Efstathios D Gennatas, Christina Nguyen, Ambreen Rana, Sharon A Brown, Stefano Tiziani. Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study.
Pediatric rheumatology online journal.
2022 Feb; 20(1):12. doi:
10.1186/s12969-022-00672-z. [PMID: 35144633] - Laura L Gramegna, Stefania Evangelisti, Lidia Di Vito, Chiara La Morgia, Alessandra Maresca, Leonardo Caporali, Giulia Amore, Lia Talozzi, Claudio Bianchini, Claudia Testa, David N Manners, Irene Cortesi, Maria L Valentino, Rocco Liguori, Valerio Carelli, Caterina Tonon, Raffaele Lodi. Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations.
Annals of clinical and translational neurology.
2021 06; 8(6):1200-1211. doi:
10.1002/acn3.51329. [PMID: 33951347] - Umit Haluk Yesilkaya, Meltem Sen, Yasin Hasan Balcioglu. COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 May; 87(?):153-155. doi:
10.1016/j.jocn.2021.03.007. [PMID: 33863524] - Beatrice Campi, Simone Codini, Giuseppe Daniele, Antonella Marvelli, Giovanni Ceccarini, Ferruccio Santini, Riccardo Zucchi, Ele Ferrannini, Alessandro Saba. Plasma N-acetylaspartate: Development and validation of a quantitative assay based on HPLC-MS-MS and sample derivatization.
Clinica chimica acta; international journal of clinical chemistry.
2020 Sep; 508(?):146-153. doi:
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Biological research.
2020 Aug; 53(1):36. doi:
10.1186/s40659-020-00303-5. [PMID: 32843088] - Jiachen Wang, Tong Zhou, Jihua Liu, Jingjun Shangguan, Xuejun Liu, Zhiming Li, Xiaoming Zhou, Yande Ren, Chengjian Wang. Application of 1H-MRS in end-stage renal disease with depression.
BMC nephrology.
2020 06; 21(1):225. doi:
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Neuropsychobiology.
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Frontiers in endocrinology.
2020; 11(?):216. doi:
10.3389/fendo.2020.00216. [PMID: 32362872] - Joshua Chiappelli, Laura M Rowland, S Andrea Wijtenburg, Hongji Chen, Andrew A Maudsley, Sulaiman Sheriff, Shuo Chen, Anya Savransky, Wyatt Marshall, Meghann C Ryan, Heather A Bruce, Alan R Shuldiner, Braxton D Mitchell, Peter Kochunov, L Elliot Hong. Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns.
Proceedings of the National Academy of Sciences of the United States of America.
2019 12; 116(50):25243-25249. doi:
10.1073/pnas.1907730116. [PMID: 31754041] - Dina C Hofer, Gabriel Zirkovits, Helmut J Pelzmann, Katharina Huber, Ariane R Pessentheiner, Wenmin Xia, Kyosuke Uno, Toh Miyazaki, Kanta Kon, Hiroshi Tsuneki, Tobias Pendl, Wael Al Zoughbi, Corina T Madreiter-Sokolowski, Gert Trausinger, Mahmoud Abdellatif, Gabriele Schoiswohl, Renate Schreiber, Tobias Eisenberg, Christoph Magnes, Simon Sedej, Matthias Eckhardt, Masakiyo Sasahara, Toshiyasu Sasaoka, Atsumi Nitta, Gerald Hoefler, Wolfgang F Graier, Dagmar Kratky, Johan Auwerx, Juliane G Bogner-Strauss. N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 12; 33(12):13808-13824. doi:
10.1096/fj.201801323r. [PMID: 31638418] - Min-Zhi Peng, Yan-Na Cai, Yong-Xian Shao, Lu Zhao, Min-Yan Jiang, Yun-Ting Lin, Xi Yin, Hui-Ying Sheng, Li Liu. Simultaneous quantification of 48 plasma amino acids by liquid chromatography-tandem mass spectrometry to investigate urea cycle disorders.
Clinica chimica acta; international journal of clinical chemistry.
2019 Aug; 495(?):406-416. doi:
10.1016/j.cca.2019.05.011. [PMID: 31095934] - Jameen Arm, Oun Al-Iedani, Rod Lea, Jeannette Lechner-Scott, Saadallah Ramadan. Diurnal variability of cerebral metabolites in healthy human brain with 2D localized correlation spectroscopy (2D L-COSY).
Journal of magnetic resonance imaging : JMRI.
2019 08; 50(2):592-601. doi:
10.1002/jmri.26642. [PMID: 30629765] - Barbora Vorlova, Tomas Knedlik, Jan Tykvart, Jan Konvalinka. GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.
Frontiers in bioscience (Landmark edition).
2019 03; 24(4):648-687. doi:
10.2741/4742. [PMID: 30844704] - Katharina Huber, Dina C Hofer, Sophie Trefely, Helmut J Pelzmann, Corina Madreiter-Sokolowski, Madalina Duta-Mare, Stefanie Schlager, Gert Trausinger, Sarah Stryeck, Wolfgang F Graier, Dagmar Kolb, Christoph Magnes, Nathaniel W Snyder, Andreas Prokesch, Dagmar Kratky, Tobias Madl, Kathryn E Wellen, Juliane G Bogner-Strauss. N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Biochimica et biophysica acta. Molecular cell research.
2019 03; 1866(3):337-348. doi:
10.1016/j.bbamcr.2018.08.017. [PMID: 30595160] - Joseph P Dewulf, Elsa Wiame, Imen Dorboz, Monique Elmaleh-Bergès, Apolline Imbard, Dana Dumitriu, Malgorzata Rak, Agnès Bourillon, Raphaël Helaers, Alisha Malla, Florence Renaldo, Odile Boespflug-Tanguy, Marie-Françoise Vincent, Jean-François Benoist, Ron A Wevers, Avner Schlessinger, Emile Van Schaftingen, Marie-Cécile Nassogne, Manuel Schiff. SLC13A3 variants cause acute reversible leukoencephalopathy and α-ketoglutarate accumulation.
Annals of neurology.
2019 03; 85(3):385-395. doi:
10.1002/ana.25412. [PMID: 30635937] - Omkar B Ijare, David S Baskin, Kumar Pichumani. Ex Vivo 1H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes.
Scientific reports.
2019 02; 9(1):3007. doi:
10.1038/s41598-019-38542-6. [PMID: 30816132] - Aljoharah Alakkas, Ronald J Ellis, Caitlin Wei-Ming Watson, Anya Umlauf, Robert K Heaton, Scott Letendre, Ann Collier, Christina Marra, David B Clifford, Benjamin Gelman, Ned Sacktor, Susan Morgello, David Simpson, J Allen McCutchan, Asha Kallianpur, Sara Gianella, Thomas Marcotte, Igor Grant, Christine Fennema-Notestine. White matter damage, neuroinflammation, and neuronal integrity in HAND.
Journal of neurovirology.
2019 02; 25(1):32-41. doi:
10.1007/s13365-018-0682-9. [PMID: 30291567] - I I Miroshnichenko, O B Yakovleva, T P Safarova, E S Shipilova, N V Baymeeva. [The content of N-acetylaspartate in depressed elderly patients during therapy with antidepressants and actovegin].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2019; 119(4):38-42. doi:
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NeuroImage.
2018 12; 183(?):336-345. doi:
10.1016/j.neuroimage.2018.08.032. [PMID: 30125713] - Talitha C Ford, Luke A Downey, Tamara Simpson, Grace McPhee, Chris Oliver, Con Stough. The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.
Nutrients.
2018 Dec; 10(12):. doi:
10.3390/nu10121860. [PMID: 30513795] - Xueying Ma, Yan Zhang, Shaohui Ma, Peng Li, Dun Ding, Hua Liu, Jixin Liu, Ming Zhang. Association between abnormal thalamic metabolites and sleep disturbance in patients with end-stage renal disease.
Metabolic brain disease.
2018 10; 33(5):1641-1648. doi:
10.1007/s11011-018-0272-9. [PMID: 29974312] - Paul Chang, Sahar Nassirpour, Nikolai Avdievitch, Anke Henning. Non-water-suppressed 1 H FID-MRSI at 3T and 9.4T.
Magnetic resonance in medicine.
2018 08; 80(2):442-451. doi:
10.1002/mrm.27049. [PMID: 29285781] - Ruhui Lin, Long Li, Yingzheng Zhang, Sheng Huang, Shangjie Chen, Jiao Shi, Peiyuan Zhuo, Hao Jin, Zuanfang Li, Weilin Liu, Zhifu Wang, Lidian Chen, Jing Tao. Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice.
Biological research.
2018 Jul; 51(1):21. doi:
10.1186/s40659-018-0166-7. [PMID: 29980225] - Monika Karczewska-Kupczewska, Agnieszka Nikolajuk, Remigiusz Filarski, Radoslaw Majewski, Eugeniusz Tarasów. Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.
The Journal of clinical endocrinology and metabolism.
2018 07; 103(7):2563-2570. doi:
10.1210/jc.2018-00107. [PMID: 29860500] - Ye-Ha Jung, Hyeonjin Kim, So Yeon Jeon, Jeong Min Kwon, Dasom Lee, Soo-Hee Choi, Do-Hyung Kang. Aberrant interactions of peripheral measures and neurometabolites with lipids in complex regional pain syndrome using magnetic resonance spectroscopy: A pilot study.
Molecular pain.
2018 Jan; 14(?):1744806917751323. doi:
10.1177/1744806917751323. [PMID: 29336203] - Emin Fidan, Lesley M Foley, Lee Ann New, Henry Alexander, Patrick M Kochanek, T Kevin Hitchens, Hülya Bayır. Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats.
ASN neuro.
2018 Jan; 10(?):1759091418770543. doi:
10.1177/1759091418770543. [PMID: 29741097] - Claire J Scavuzzo, Christopher J Moulton, Ryan J Larsen. The use of magnetic resonance spectroscopy for assessing the effect of diet on cognition.
Nutritional neuroscience.
2018 Jan; 21(1):1-15. doi:
10.1080/1028415x.2016.1218191. [PMID: 27571302] - Kazuyuki Sumi, Kyosuke Uno, Hiroshi Noike, Takenori Tomohiro, Yasumaru Hatanaka, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta. Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development.
Scientific reports.
2017 12; 7(1):16872. doi:
10.1038/s41598-017-17151-1. [PMID: 29203794] - Austin T Mudd, Kirsten Berding, Mei Wang, Sharon M Donovan, Ryan N Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig.
Gut microbes.
2017 11; 8(6):589-600. doi:
10.1080/19490976.2017.1353849. [PMID: 28703640] - Gaetano Barbagallo, Gennarina Arabia, Maurizio Morelli, Rita Nisticò, Fabiana Novellino, Maria Salsone, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone. Thalamic neurometabolic alterations in tremulous Parkinson's disease: A preliminary proton MR spectroscopy study.
Parkinsonism & related disorders.
2017 Oct; 43(?):78-84. doi:
10.1016/j.parkreldis.2017.07.028. [PMID: 28774469] - Nina Kemala Sari, Siti Setiati, Akmal Taher, Martina Wiwie, Samsuridjal Djauzi, Jacub Pandelaki, Jan Sudir Purba, Mohamad Sadikin. The role of autosuggestion in geriatric patients' quality of life: a study on psycho-neuro-endocrine-immunology pathway.
Social neuroscience.
2017 10; 12(5):551-559. doi:
10.1080/17470919.2016.1196243. [PMID: 27376875] - Frederic Sampedro, Mario de la Fuente Revenga, Marta Valle, Natalia Roberto, Elisabet Domínguez-Clavé, Matilde Elices, Luís Eduardo Luna, José Alexandre S Crippa, Jaime E C Hallak, Draulio B de Araujo, Pablo Friedlander, Steven A Barker, Enrique Álvarez, Joaquim Soler, Juan C Pascual, Amanda Feilding, Jordi Riba. Assessing the Psychedelic 'After-Glow' in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities.
The international journal of neuropsychopharmacology.
2017 09; 20(9):698-711. doi:
10.1093/ijnp/pyx036. [PMID: 28525587] - Shin-Eui Park, Nam-Gil Choi, Gwang-Woo Jeong. Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder: proton magnetic resonance spectroscopy.
Acta neuropsychiatrica.
2017 Jun; 29(3):164-169. doi:
10.1017/neu.2016.48. [PMID: 27748207] - S-Y Wang, M Wang, X-X Wang, W Chen, C Sheng, Z-K Gong. Study on the clinical application of the MRS in the cognitive assessment after stroke.
European review for medical and pharmacological sciences.
2017 05; 21(10):2437-2442. doi:
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The Journal of infectious diseases.
2017 04; 215(7):1132-1140. doi:
10.1093/infdis/jix013. [PMID: 28368497] - Moran Artzi, Gilad Liberman, Nachum Vaisman, Felix Bokstein, Faina Vitinshtein, Orna Aizenstein, Dafna Ben Bashat. Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors: 1H-MRS study.
Journal of neuro-oncology.
2017 04; 132(2):267-275. doi:
10.1007/s11060-016-2364-x. [PMID: 28074323] - L J Peng, H R Qian, L L Mao, D Y Xia, X K Qi. [A clinical analysis of 5 patients with infratentorial primary angiitis of central nervous system].
Zhonghua nei ke za zhi.
2017 Apr; 56(4):284-289. doi:
10.3760/cma.j.issn.0578-1426.2017.04.009. [PMID: 28355722] - Ana I Amaral, Mussie Ghezu Hadera, Mark Kotter, Ursula Sonnewald. Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro.
Neurochemical research.
2017 Mar; 42(3):827-837. doi:
10.1007/s11064-016-1985-y. [PMID: 27394419] - Sergej M Ostojic, Jelena Ostojic, Patrik Drid, Milan Vranes, Pavle Jovanov. Dietary guanidinoacetic acid increases brain creatine levels in healthy men.
Nutrition (Burbank, Los Angeles County, Calif.).
2017 Jan; 33(?):149-156. doi:
10.1016/j.nut.2016.06.001. [PMID: 27497517] - Ruth Schneider, Barbara Bellenberg, Robert Hoepner, Eva-Maria Kolb, Gisa Ellrichmann, Aiden Haghikia, Ralf Gold, Carsten Lukas. Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephalopathy (PML).
PloS one.
2017; 12(4):e0176415. doi:
10.1371/journal.pone.0176415. [PMID: 28445498] - N K Singhal, H Huang, S Li, R Clements, J Gadd, A Daniels, E E Kooijman, P Bannerman, T Burns, F Guo, D Pleasure, E Freeman, L Shriver, J McDonough. The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition.
Experimental brain research.
2017 01; 235(1):279-292. doi:
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Journal of inherited metabolic disease.
2016 11; 39(6):869-876. doi:
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Journal of neuro-oncology.
2016 10; 130(1):171-179. doi:
10.1007/s11060-016-2229-3. [PMID: 27535746] - Monika Cichocka, Justyna Kozub, Paulina Karcz, Andrzej Urbanik. Differences in Metabolite Concentrations Between the Hemispheres of the Brain in Healthy Children: A Proton Magnetic Resonance Spectroscopy Study (1HMRS).
Journal of child neurology.
2016 10; 31(11):1296-301. doi:
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Magnetic resonance in medicine.
2016 09; 76(3):733-41. doi:
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Experimental animals.
2016 Jul; 65(3):293-301. doi:
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BMC neurology.
2016 Jul; 16(?):99. doi:
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Metabolic brain disease.
2016 Apr; 31(2):475-9. doi:
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