hypoxanthine (BioDeep_00000399879)

Main id: BioDeep_00000001351

Secondary id: BioDeep_00000229665

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


hypoxanthine

化学式: C5H4N4O (136.03850939999998)
中文名称: 次黄嘌呤, 6-羟基嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 0.15%

分子结构信息

SMILES: C1=NC2=C(N1)C(=O)N=CN2
InChI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

描述信息

C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C62554 - Poly (ADP-Ribose) Polymerase Inhibitor
A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
COVID info from COVID-19 Disease Map
C471 - Enzyme Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; FDGQSTZJBFJUBT_STSL_0163_Hypoxanthine_0125fmol_180430_S2_LC02_MS02_115; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

同义名列表

5 个代谢物同义名

hypoxanthine; Purin-6-ol; Sarcine; Hypoxanthine; 6H-Purin-6-one, 1,7-dihydro-



数据库引用编号

90 个数据库交叉引用编号

分类词条

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hannah J Irvine, Animesh Acharjee, Zoe Wolcott, Zsuzsanna Ament, H E Hinson, Bradley J Molyneaux, J Marc Simard, Kevin N Sheth, W Taylor Kimberly. Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide. Cell reports. Medicine. 2022 06; 3(6):100654. doi: 10.1016/j.xcrm.2022.100654. [PMID: 35700741]
  • Zhi Luo, Hetao Wang, Simin Lin, Lili Liao, Lishan Cai, Xiaoxu Zhang, Yangying Tan, Mei Shen. Study on the levels of N-nitrosamine compounds and untargeted metabolomics in patients with colorectal cancer. Analytical and bioanalytical chemistry. 2022 May; 414(11):3483-3496. doi: 10.1007/s00216-022-03969-w. [PMID: 35174409]
  • Stefano Fornasaro, Alessandro Esposito, Fiorella Florian, Alberto Pallavicini, Luigina De Leo, Tarcisio Not, Cristina Lagatolla, Marica Mezzarobba, Alessia Di Silvestre, Valter Sergo, Alois Bonifacio. Spectroscopic investigation of faeces with surface-enhanced Raman scattering: a case study with coeliac patients on gluten-free diet. Analytical and bioanalytical chemistry. 2022 May; 414(11):3517-3527. doi: 10.1007/s00216-022-03975-y. [PMID: 35258650]
  • Enrico Marchetti, Daniela Pigini, Mariangela Spagnoli, Giovanna Tranfo, Flavia Buonaurio, Fabio Sciubba, Ottavia Giampaoli, Alfredo Miccheli, Alessandro Pinto, Nazzareno De Angelis, Luigi Fattorini. Hyperbaric Exposure of Scuba Divers Affects the Urinary Excretion of Nucleic Acid Oxidation Products and Hypoxanthine. International journal of environmental research and public health. 2022 03; 19(5):. doi: 10.3390/ijerph19053005. [PMID: 35270697]
  • Dmitri Svistounov, Marit D Solbu, Trond G Jenssen, Ulla Dorte Mathisen, Terkel Hansen, Katja Benedikte Prestø Elgstøen, Svetlana N Zykova. Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry. Scandinavian journal of clinical and laboratory investigation. 2022 02; 82(1):37-49. doi: 10.1080/00365513.2021.2015799. [PMID: 35048747]
  • Yogaraje Gowda C Varadaiah, Senthilkumar Sivanesan, Shivananda B Nayak, Kashinath R Thirumalarao. Purine metabolites can indicate diabetes progression. Archives of physiology and biochemistry. 2022 Feb; 128(1):87-91. doi: 10.1080/13813455.2019.1663219. [PMID: 31517540]
  • Jinli Li, Yu Wu, Ying Qin, Mingwang Liu, Guojuan Chen, Liuyong Hu, Wenling Gu, Chengzhou Zhu. AgCu@CuO aerogels with peroxidase-like activities and photoelectric responses for sensitive biosensing. Chemical communications (Cambridge, England). 2021 Dec; 57(100):13788-13791. doi: 10.1039/d1cc06177a. [PMID: 34870654]
  • Guoshu Lin, Qiuxia Yu, Lieqiang Xu, Ziwei Huang, Liting Mai, Linyun Jiang, Ziren Su, Jianhui Xie, Yucui Li, Yuhong Liu, Zhixiu Lin, Jiannan Chen. Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. European journal of pharmacology. 2021 Dec; 912(?):174592. doi: 10.1016/j.ejphar.2021.174592. [PMID: 34699754]
  • Xiaoqing Li, Xiaoxiang Gao, Hui Zhang, Yuanyuan Liu, Md Moklesur Rahman Sarker, Yijing Wu, Xinhua Chen, Chao Zhao. The anti-hyperuricemic effects of green alga Enteromorpha prolifera polysaccharide via regulation of the uric acid transporters in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Dec; 158(?):112630. doi: 10.1016/j.fct.2021.112630. [PMID: 34687833]
  • Jiangchao Zhuang, Xie Zhou, Ting Liu, Shuai Zhang, Falei Yuan, Leifang Zhang, Zuisu Yang, Yan Chen. Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice. Die Pharmazie. 2021 11; 76(11):551-558. doi: 10.1691/ph.2021.1731. [PMID: 34782040]
  • Jinfen Chen, Lieqiang Xu, Linyun Jiang, Yulin Wu, Long Wei, Xiaoli Wu, Shihong Xiao, Yuhong Liu, Changjun Gao, Jian Cai, Ziren Su. Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice. Food & function. 2021 Oct; 12(19):9416-9431. doi: 10.1039/d1fo01830b. [PMID: 34606558]
  • Paola Toledo-Ibelles, Roxana Gutiérrez-Vidal, Sandra Calixto-Tlacomulco, Blanca Delgado-Coello, Jaime Mas-Oliva. Hepatic Accumulation of Hypoxanthine: A Link Between Hyperuricemia and Nonalcoholic Fatty Liver Disease. Archives of medical research. 2021 10; 52(7):692-702. doi: 10.1016/j.arcmed.2021.04.005. [PMID: 33966916]
  • Xiaofei Zhou, Bowei Zhang, Xiuli Zhao, Yongxi Lin, Jin Wang, Xiaowen Wang, Nan Hu, Shuo Wang. Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis. Food & function. 2021 Jun; 12(12):5637-5649. doi: 10.1039/d0fo03199b. [PMID: 34018499]
  • I T Gatchell, R B Huntley, N P Schultes, G S Mourad. The guanine-hypoxanthine permease GhxP of Erwinia amylovora facilitates the influx of the toxic guanine derivative 6-thioguanine. Journal of applied microbiology. 2021 Jun; 130(6):2018-2028. doi: 10.1111/jam.14925. [PMID: 33152175]
  • Takashi Nakamura, Mai Nampei, Takayo Murase, Etsuko Satoh, Seigo Akari, Noriaki Katoh, Hiroki Mizukami. Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice. Nutrition & diabetes. 2021 04; 11(1):12. doi: 10.1038/s41387-021-00155-2. [PMID: 33850106]
  • Lu Kang, Ju Liu, Hongyang Zhang, Min Jiang, Yidian Jin, Min Zhang, Ping Hu. Improved ultra-high performance liquid chromatographic method for simultaneous determination of five gout-related metabolites in human serum. Journal of separation science. 2021 Mar; 44(5):954-962. doi: 10.1002/jssc.202000974. [PMID: 33348445]
  • Bharathi Sinduja, N S K Gowthaman, S Abraham John. Fabrication of low-cost sustainable electrocatalyst: a diagnostic tool for multifunctional disorders in human fluids. Journal of materials chemistry. B. 2020 10; 8(41):9502-9511. doi: 10.1039/d0tb01681k. [PMID: 32996975]
  • Ruben A T Mars, Yi Yang, Tonya Ward, Mo Houtti, Sambhawa Priya, Heather R Lekatz, Xiaojia Tang, Zhifu Sun, Krishna R Kalari, Tal Korem, Yogesh Bhattarai, Tenghao Zheng, Noam Bar, Gary Frost, Abigail J Johnson, Will van Treuren, Shuo Han, Tamas Ordog, Madhusudan Grover, Justin Sonnenburg, Mauro D'Amato, Michael Camilleri, Eran Elinav, Eran Segal, Ran Blekhman, Gianrico Farrugia, Jonathan R Swann, Dan Knights, Purna C Kashyap. Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome. Cell. 2020 09; 182(6):1460-1473.e17. doi: 10.1016/j.cell.2020.08.007. [PMID: 32916129]
  • Maria Botou, Vassilis Yalelis, Panayiota Lazou, Iliana Zantza, Konstantinos Papakostas, Vassiliki Charalambous, Emmanuel Mikros, Emmanouil Flemetakis, Stathis Frillingos. Specificity profile of NAT/NCS2 purine transporters in Sinorhizobium (Ensifer) meliloti. Molecular microbiology. 2020 07; 114(1):151-171. doi: 10.1111/mmi.14503. [PMID: 32198949]
  • Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Takayo Murase, Takashi Nakamura, Megumi Matsumoto, Akiko Sakai, Hirofumi Ohnishi, Marenao Tanaka, Shigeyuki Saitoh, Norihito Moniwa, Kazuaki Shimamoto, Tetsuji Miura. Differential regulation of hypoxanthine and xanthine by obesity in a general population. Journal of diabetes investigation. 2020 Jul; 11(4):878-887. doi: 10.1111/jdi.13207. [PMID: 31916414]
  • Mingfeng Xiang, Feng Du, Jing Dai, Ling Chen, Ruijin Geng, Huiming Huang, Baogang Xie. Exploring serum metabolic markers for the discrimination of ccRCC from renal angiomyolipoma by metabolomics. Biomarkers in medicine. 2020 06; 14(8):675-682. doi: 10.2217/bmm-2019-0215. [PMID: 32613842]
  • Sarani Sen, Priyabrata Sarkar. A simple electrochemical approach to fabricate functionalized MWCNT-nanogold decorated PEDOT nanohybrid for simultaneous quantification of uric acid, xanthine and hypoxanthine. Analytica chimica acta. 2020 Jun; 1114(?):15-28. doi: 10.1016/j.aca.2020.03.060. [PMID: 32359511]
  • Jiahao Li, Lingjia Yu, Shigong Guo, Yu Zhao. Identification of the molecular mechanism and diagnostic biomarkers in the thoracic ossification of the ligamentum flavum using metabolomics and transcriptomics. BMC molecular and cell biology. 2020 May; 21(1):37. doi: 10.1186/s12860-020-00280-3. [PMID: 32404047]
  • Fouzia Haider, Halina I Falfushynska, Stefan Timm, Inna M Sokolova. Effects of hypoxia and reoxygenation on intermediary metabolite homeostasis of marine bivalves Mytilus edulis and Crassostrea gigas. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2020 04; 242(?):110657. doi: 10.1016/j.cbpa.2020.110657. [PMID: 31931108]
  • Xingbo Mo, Yufan Guo, Qiyu Qian, Mengzhen Fu, Huan Zhang. Phosphorylation-related SNPs influence lipid levels and rheumatoid arthritis risk by altering gene expression and plasma protein levels. Rheumatology (Oxford, England). 2020 04; 59(4):889-898. doi: 10.1093/rheumatology/kez466. [PMID: 31624844]
  • Guillermo Quintas, Xavier Reche, Juan Daniel Sanjuan-Herráez, Helena Martínez, Marta Herrero, Xavier Valle, Marc Masa, Gil Rodas. Urine metabolomic analysis for monitoring internal load in professional football players. Metabolomics : Official journal of the Metabolomic Society. 2020 03; 16(4):45. doi: 10.1007/s11306-020-01668-0. [PMID: 32222832]
  • Michał Włodarczyk, Krzysztof Kusy, Ewa Słomińska, Zbigniew Krasiński, Jacek Zieliński. Change in Lactate, Ammonia, and Hypoxanthine Concentrations in a 1-Year Training Cycle in Highly Trained Athletes: Applying Biomarkers as Tools to Assess Training Status. Journal of strength and conditioning research. 2020 Feb; 34(2):355-364. doi: 10.1519/jsc.0000000000003375. [PMID: 31469767]
  • Ivan Sebesta, Daisuke Miyamoto, Blanka Stiburkova, Sarka Blahova, Nana Sato, Koji Nagata, Ken Okamoto, Shuichi Tsuruoka, Kimiyoshi Ichida. Modified forearm ischemic test in hypouricemic patients. Nucleosides, nucleotides & nucleic acids. 2020; 39(10-12):1432-1439. doi: 10.1080/15257770.2020.1750636. [PMID: 32312155]
  • Hua-Xin Zhang, Dan Zhou, Qing-Hua Xia. Spectroscopic and computational exploration of hypoxanthine riboside interacting with plasma albumin. Luminescence : the journal of biological and chemical luminescence. 2019 Dec; 34(8):796-803. doi: 10.1002/bio.3674. [PMID: 31328371]
  • Zhichao Zhou, Ya Dong, Hanchi Zhou, Jia Liu, Wei Zhao. MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells. Biochemical and biophysical research communications. 2019 09; 517(3):413-420. doi: 10.1016/j.bbrc.2019.07.114. [PMID: 31378369]
  • Nayara Alves Chaves, Thiago Geronimo Pires Alegria, Lucas Souza Dantas, Luis Eduardo Soares Netto, Sayuri Miyamoto, Claudia Regina Bonini Domingos, Danilo Grünig Humberto da Silva. Impaired antioxidant capacity causes a disruption of metabolic homeostasis in sickle erythrocytes. Free radical biology & medicine. 2019 09; 141(?):34-46. doi: 10.1016/j.freeradbiomed.2019.05.034. [PMID: 31163255]
  • Jacek Zieliński, Ewa M Slominska, Magdalena Król-Zielińska, Zbigniew Krasiński, Krzysztof Kusy. Purine metabolism in sprint- vs endurance-trained athletes aged 20‒90 years. Scientific reports. 2019 08; 9(1):12075. doi: 10.1038/s41598-019-48633-z. [PMID: 31427706]
  • Yu Wang, Miao Deng, Binge Deng, Liming Ye, Xiaofan Fei, Zhigang Huang. Study on the diagnosis of gout with xanthine and hypoxanthine. Journal of clinical laboratory analysis. 2019 Jun; 33(5):e22868. doi: 10.1002/jcla.22868. [PMID: 30803031]
  • Evan L Pannkuk, Evagelia C Laiakis, Kirandeep Gill, Shreyans K Jain, Khyati Y Mehta, Denise Nishita, Kim Bujold, James Bakke, Janet Gahagen, Simon Authier, Polly Chang, Albert J Fornace. Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels. Journal of proteome research. 2019 05; 18(5):2260-2269. doi: 10.1021/acs.jproteome.9b00101. [PMID: 30843397]
  • Michał Włodarczyk, Krzysztof Kusy, Ewa Słomińska, Zbigniew Krasiński, Jacek Zieliński. Changes in Blood Concentration of Adenosine Triphosphate Metabolism Biomarkers During Incremental Exercise in Highly Trained Athletes of Different Sport Specializations. Journal of strength and conditioning research. 2019 May; 33(5):1192-1200. doi: 10.1519/jsc.0000000000003133. [PMID: 30908377]
  • Ramesh Dasari, Andrzej Błauż, Derek C Medellin, Roaa M Kassim, Carlos Viera, Maximo Santarosa, Alet E van der Westhuyzen, Willem A L van Otterlo, Taryn Olivas, Tugba Yildiz, Tania Betancourt, Charles B Shuster, Snezna Rogelj, Błażej Rychlik, Todd Hudnall, Liliya V Frolova, Alexander Kornienko. Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins. ChemMedChem. 2019 02; 14(3):322-333. doi: 10.1002/cmdc.201800658. [PMID: 30562414]
  • Mamta Raj, Jong-Min Moon, Rajendra N Goyal, Deog-Su Park, Yoon-Bo Shim. Simultaneous detection of ATP metabolites in human plasma and urine based on palladium nanoparticle and poly(bromocresol green) composite sensor. Biosensors & bioelectronics. 2019 Feb; 126(?):758-766. doi: 10.1016/j.bios.2018.11.056. [PMID: 30554097]
  • Synthia H Mellon, F Saverio Bersani, Daniel Lindqvist, Rasha Hammamieh, Duncan Donohue, Kelsey Dean, Marti Jett, Rachel Yehuda, Janine Flory, Victor I Reus, Linda M Bierer, Iouri Makotkine, Duna Abu Amara, Clare Henn Haase, Michelle Coy, Francis J Doyle, Charles Marmar, Owen M Wolkowitz. Metabolomic analysis of male combat veterans with post traumatic stress disorder. PloS one. 2019; 14(3):e0213839. doi: 10.1371/journal.pone.0213839. [PMID: 30883584]
  • Jiwon Park, Yumi Shin, Tae Hyun Kim, Dong-Hyun Kim, Anbok Lee. Plasma metabolites as possible biomarkers for diagnosis of breast cancer. PloS one. 2019; 14(12):e0225129. doi: 10.1371/journal.pone.0225129. [PMID: 31794572]
  • Yunpei Si, Jeong Won Park, Sunhee Jung, Geum-Sook Hwang, Eunseo Goh, Hye Jin Lee. Layer-by-layer electrochemical biosensors configuring xanthine oxidase and carbon nanotubes/graphene complexes for hypoxanthine and uric acid in human serum solutions. Biosensors & bioelectronics. 2018 Dec; 121(?):265-271. doi: 10.1016/j.bios.2018.08.074. [PMID: 30223102]
  • Mingxiao Yang, Zheng Yu, Xiaomin Chen, Zhenyu Guo, Shufang Deng, Lin Chen, Qiaofeng Wu, Fanrong Liang. Active Acupoints Differ from Inactive Acupoints in Modulating Key Plasmatic Metabolites of Hypertension: A Targeted Metabolomics Study. Scientific reports. 2018 12; 8(1):17824. doi: 10.1038/s41598-018-36199-1. [PMID: 30546033]
  • Jiale Ma, Xuwang Cai, Yinli Bao, Huochun Yao, Ganwu Li. Uropathogenic Escherichia coli preferentially utilize metabolites in urine for nucleotide biosynthesis through salvage pathways. International journal of medical microbiology : IJMM. 2018 Dec; 308(8):990-999. doi: 10.1016/j.ijmm.2018.08.006. [PMID: 30145133]
  • Tianqiao Yong, Dan Li, Muxia Li, Danling Liang, Xue Diao, Chenling Deng, Shaodan Chen, Yizhen Xie, Diling Chen, Dan Zuo. Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102671. [PMID: 30336599]
  • Liangqing Zhang, Zhihua Ruan, Jiuqing Liang, Yanmei Du, Zhiqi Lu, Du Feng, Shuyun Cai, Xuedi Zhang, Weihua Cai, Zhe Hu. Protective effect of propofol on ischemia-reperfusion injury detected by HPLC-MS/MS targeted metabolic profiling. European journal of pharmacology. 2018 Aug; 833(?):69-78. doi: 10.1016/j.ejphar.2018.05.039. [PMID: 29807030]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • O A Zeleznik, E M Poole, S Lindstrom, P Kraft, A Van Hylckama Vlieg, J A Lasky-Su, L B Harrington, K Hagan, J Kim, B A Parry, N Giordano, C Kabrhel. Metabolomic analysis of 92 pulmonary embolism patients from a nested case-control study identifies metabolites associated with adverse clinical outcomes. Journal of thrombosis and haemostasis : JTH. 2018 03; 16(3):500-507. doi: 10.1111/jth.13937. [PMID: 29285876]
  • Yanfen Niu, Yuanfang Zhou, Hua Lin, Li-Hui Gao, Wenyong Xiong, Huajie Zhu, Cheng-Gang Zou, Ling Li. Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice. Biological & pharmaceutical bulletin. 2018 Jan; 41(1):99-105. doi: 10.1248/bpb.b17-00655. [PMID: 29093325]
  • Chenzhi Hou, Ruowen Zhang, Kexia Zhang, Xiaohui Chen. Total glycosides of Paeony shows Neuroprotective effects against Semen Strychni-induced neurotoxicity by recovering secretion of hormones and improving brain energy metabolism. Metabolic brain disease. 2017 Dec; 32(6):2033-2044. doi: 10.1007/s11011-017-0082-5. [PMID: 28852923]
  • Lívia Gelain Castilhos, Juliana Sorraila de Oliveira, Stephen Adeniyi Adefegha, Luana Pereira Magni, Pedro Henrique Doleski, Fatima Husein Abdalla, Cínthia Melazzo de Andrade, Daniela Bitencourt Rosa Leal. Increased oxidative stress alters nucleosides metabolite levels in sickle cell anemia. Redox report : communications in free radical research. 2017 Nov; 22(6):451-459. doi: 10.1080/13510002.2017.1288973. [PMID: 28209096]
  • Yin Long, Beatriz Sanchez-Espiridion, Moubin Lin, Lindsey White, Lopa Mishra, Gottumakkala S Raju, Scott Kopetz, Cathy Eng, Michelle A T Hildebrandt, David W Chang, Yuanqing Ye, Dong Liang, Xifeng Wu. Global and targeted serum metabolic profiling of colorectal cancer progression. Cancer. 2017 Oct; 123(20):4066-4074. doi: 10.1002/cncr.30829. [PMID: 28640361]
  • Binbin Zhou, Shaofei Li, Xianghu Tang, Pan Li, Xiaomin Cao, Borong Yu, Liangbao Yang, Jinhuai Liu. Real-time monitoring of plasmon-induced proton transfer of hypoxanthine in serum. Nanoscale. 2017 Aug; 9(34):12307-12310. doi: 10.1039/c7nr04050d. [PMID: 28820221]
  • Julia Kuligowski, Rønnaug Solberg, Ángel Sánchez-Illana, Leonid Pankratov, Anna Parra-Llorca, Guillermo Quintás, Ola Didrik Saugstad, Máximo Vento. Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia. Redox biology. 2017 08; 12(?):1-7. doi: 10.1016/j.redox.2017.02.002. [PMID: 28209514]
  • V Nagaraj, L Skillman, D Li, Z Xie, G Ho. Control of biofouling by xanthine oxidase on seawater reverse osmosis membranes from a desalination plant: enzyme production and screening of bacterial isolates from the full-scale plant. Letters in applied microbiology. 2017 Jul; 65(1):73-81. doi: 10.1111/lam.12747. [PMID: 28418590]
  • Shourong Shi, Yiru Shen, Shan Zhang, Zhenhua Zhao, Zhuocheng Hou, Huaijun Zhou, Jianmin Zou, Yuming Guo. Combinatory Evaluation of Transcriptome and Metabolome Profiles of Low Temperature-induced Resistant Ascites Syndrome in Broiler Chickens. Scientific reports. 2017 05; 7(1):2389. doi: 10.1038/s41598-017-02492-8. [PMID: 28539642]
  • Lieke E J M Scheepers, Annelies Boonen, Wieke Pijnenburg, Jörgen Bierau, Jan A Staessen, Coen D A Stehouwer, Carel Thijs, Ilja C W Arts. Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study. Journal of hypertension. 2017 05; 35(5):982-993. doi: 10.1097/hjh.0000000000001270. [PMID: 28355168]
  • F-C Tang, C-C Chan. Contribution of branched-chain amino acids to purine nucleotide cycle: a pilot study. European journal of clinical nutrition. 2017 05; 71(5):587-593. doi: 10.1038/ejcn.2016.161. [PMID: 27677364]
  • Christoph Zutz, Yi Ming Chiang, Bettina Faehnrich, Markus Bacher, Roland Hellinger, Bernhard Kluger, Martin Wagner, Joseph Strauss, Kathrin Rychli. Butyrate influences intracellular levels of adenine and adenine derivatives in the fungus Penicillium restrictum. Microbiological research. 2017 Apr; 197(?):1-8. doi: 10.1016/j.micres.2016.12.013. [PMID: 28219521]
  • Leonie G M Wijermars, Jaap A Bakker, Dorottya K de Vries, Cornelis J F van Noorden, Jörgen Bierau, Sarantos Kostidis, Oleg A Mayboroda, Dimitrios Tsikas, Alexander F Schaapherder, Jan H N Lindeman. The hypoxanthine-xanthine oxidase axis is not involved in the initial phase of clinical transplantation-related ischemia-reperfusion injury. American journal of physiology. Renal physiology. 2017 03; 312(3):F457-F464. doi: 10.1152/ajprenal.00214.2016. [PMID: 28031169]
  • Tianqiao Yong, Minglong Zhang, Diling Chen, Ou Shuai, Shaodan Chen, Jiyan Su, Chunwei Jiao, Delong Feng, Yizhen Xie. Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthine. Journal of ethnopharmacology. 2016 Dec; 194(?):403-411. doi: 10.1016/j.jep.2016.10.001. [PMID: 27717908]
  • Takayo Murase, Mai Nampei, Mitsuru Oka, Atsushi Miyachi, Takashi Nakamura. A highly sensitive assay of human plasma xanthine oxidoreductase activity using stable isotope-labeled xanthine and LC/TQMS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Dec; 1039(?):51-58. doi: 10.1016/j.jchromb.2016.10.033. [PMID: 27816314]
  • Hye-Myung Ryu, You-Jin Kim, Eun-Joo Oh, Se-Hyun Oh, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Sun-Hee Park, Yong-Lim Kim. Hypoxanthine induces cholesterol accumulation and incites atherosclerosis in apolipoprotein E-deficient mice and cells. Journal of cellular and molecular medicine. 2016 11; 20(11):2160-2172. doi: 10.1111/jcmm.12916. [PMID: 27396856]
  • N Lavanya, C Sekar, R Murugan, G Ravi. An ultrasensitive electrochemical sensor for simultaneous determination of xanthine, hypoxanthine and uric acid based on Co doped CeO2 nanoparticles. Materials science & engineering. C, Materials for biological applications. 2016 Aug; 65(?):278-86. doi: 10.1016/j.msec.2016.04.033. [PMID: 27157753]
  • Tamaki Watanabe, Naoko Hara Tomioka, Shigekazu Watanabe, Yoshihiko Suzuki, Masao Tsuchiya, Makoto Hosoyamada. The Mechanism of False in Vitro Elevation of Uric Acid Level in Mouse Blood. Biological & pharmaceutical bulletin. 2016 Jul; 39(7):1081-4. doi: 10.1248/bpb.b15-01046. [PMID: 27170514]
  • Joanna Jakubiczka-Smorag, Jose Angel Santamaria-Araujo, Imke Metz, Avadh Kumar, Samy Hakroush, Wolfgang Brueck, Guenter Schwarz, Peter Burfeind, Jochen Reiss, Lukasz Smorag. Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients. Human genetics. 2016 07; 135(7):813-26. doi: 10.1007/s00439-016-1676-4. [PMID: 27138983]
  • Yating Xu, Ju Liu, Hongyang Zhang, Min Jiang, Lingling Cao, Min Zhang, Wei Sun, Shengli Ruan, Ping Hu. Hypercrosslinked strong cation-exchange polymers for selective extraction of serum purine metabolites associated with gout. Talanta. 2016 May; 151(?):172-178. doi: 10.1016/j.talanta.2016.01.014. [PMID: 26946024]
  • R S Barberino, V R P Barros, V G Menezes, L P Santos, V R Araújo, M A A Queiroz, J R G S Almeida, R C Palheta, M H T Matos. Amburana cearensis leaf extract maintains survival and promotes in vitro development of ovine secondary follicles. Zygote (Cambridge, England). 2016 Apr; 24(2):277-85. doi: 10.1017/s0967199415000179. [PMID: 26083197]
  • Roland Wolfgang Därr, Steffen Lenzner, Thomas Eggermann, Wolfgang Hermann Därr. [Xanthinuria type 1 in a woman with arthralgias: a combined clinical and molecular genetic investigation]. Deutsche medizinische Wochenschrift (1946). 2016 Apr; 141(8):571-4. doi: 10.1055/s-0041-106053. [PMID: 27078247]
  • Pollen K Yeung, Shyam S Kolathuru, Remigius U Agu. Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-'Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo. Drug metabolism letters. 2016; 10(3):219-226. doi: 10.2174/1872312810666160607013859. [PMID: 27280599]
  • Huiqing Zou, Mingfeng Xiang, Xinming Ye, Yuanzhen Xiong, Baogang Xie, Jianghua Shao. Reduction of urinary uric acid excretion in patients with proteinuria. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Dec; 1006(?):59-64. doi: 10.1016/j.jchromb.2015.10.027. [PMID: 26523664]
  • Junji Furukawa, Katsuhisa Inoue, Junya Maeda, Tomoya Yasujima, Kinya Ohta, Yoshikatsu Kanai, Tappei Takada, Hirotaka Matsuo, Hiroaki Yuasa. Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. Scientific reports. 2015 Oct; 5(?):15057. doi: 10.1038/srep15057. [PMID: 26455426]
  • Jacek Zieliński, Krzysztof Kusy. Hypoxanthine: A Universal Metabolic Indicator of Training Status in Competitive Sports. Exercise and sport sciences reviews. 2015 Oct; 43(4):214-21. doi: 10.1249/jes.0000000000000055. [PMID: 26196868]
  • Theresa A Laguna, Cavan S Reilly, Cynthia B Williams, Cole Welchlin, Chris H Wendt. Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis pulmonary exacerbation. Pediatric pulmonology. 2015 Sep; 50(9):869-77. doi: 10.1002/ppul.23225. [PMID: 26115542]
  • Qiong Li, Christopher Leija, Filipa Rijo-Ferreira, Jun Chen, Igor Cestari, Kenneth Stuart, Benjamin P Tu, Margaret A Phillips. GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway. Molecular microbiology. 2015 Sep; 97(5):1006-20. doi: 10.1111/mmi.13083. [PMID: 26043892]
  • Don E Farthing, Christine A Farthing, Lei Xi. Inosine and hypoxanthine as novel biomarkers for cardiac ischemia: from bench to point-of-care. Experimental biology and medicine (Maywood, N.J.). 2015 Jun; 240(6):821-31. doi: 10.1177/1535370215584931. [PMID: 25956679]
  • Rui Liu, Jin-ao Duan, Hao Wu, Pei Liu, Er-xin Shang, Da-wei Qian. [Analysis and identification of water soluble components of water buffalo horn]. Yao xue xue bao = Acta pharmaceutica Sinica. 2015 May; 50(5):594-8. doi: ". [PMID: 26234143]
  • Greta Del Mistro, Silvia Cervo, Elena Mansutti, Riccardo Spizzo, Alfonso Colombatti, Pietro Belmonte, Renzo Zucconelli, Agostino Steffan, Valter Sergo, Alois Bonifacio. Surface-enhanced Raman spectroscopy of urine for prostate cancer detection: a preliminary study. Analytical and bioanalytical chemistry. 2015 May; 407(12):3271-5. doi: 10.1007/s00216-015-8610-9. [PMID: 25791298]
  • Hüseyin Ulaş Pinar, Aşina Pinar, Ömür Mavioğlu, Nilgün Yener. Effect of hydroxyethyl starch 130/0.4 on ischemia-reperfusion determinants in minor lower extremity surgery with tourniquet application. Journal of clinical anesthesia. 2015 Mar; 27(2):105-10. doi: 10.1016/j.jclinane.2014.07.001. [PMID: 25577032]
  • Eva Kostalova, Karel Pavelka, Hana Vlaskova, Dita Musalkova, Blanka Stiburkova. Hyperuricemia and gout due to deficiency of hypoxanthine-guanine phosphoribosyltransferase in female carriers: New insight to differential diagnosis. Clinica chimica acta; international journal of clinical chemistry. 2015 Feb; 440(?):214-7. doi: 10.1016/j.cca.2014.11.026. [PMID: 25476133]
  • Jeeyoun Jung, Youngae Jung, Eun Jung Bang, Sung-il Cho, You-Jin Jang, Jung-Myun Kwak, Do Hyun Ryu, Sungsoo Park, Geum-Sook Hwang. Noninvasive diagnosis and evaluation of curative surgery for gastric cancer by using NMR-based metabolomic profiling. Annals of surgical oncology. 2014 Dec; 21 Suppl 4(?):S736-42. doi: 10.1245/s10434-014-3886-0. [PMID: 25092158]
  • Mihoko Takai, Takahiro Yamauchi, Miyuki Ookura, Yasufumi Matsuda, Katsunori Tai, Shinji Kishi, Akira Yoshida, Hiromichi Iwasaki, Toru Nakamura, Takanori Ueda. Febuxostat for management of tumor lysis syndrome including its effects on levels of purine metabolites in patients with hematological malignancies - a single institution's, pharmacokinetic and pilot prospective study. Anticancer research. 2014 Dec; 34(12):7287-96. doi: . [PMID: 25503162]
  • Lina Zou, Yinfeng Li, Shaokui Cao, Baoxian Ye. A new voltammetric sensor for sensitive and selective determination of xanthine based on DNA and polyaniline composite Langmuir-Blodgett film. Talanta. 2014 Nov; 129(?):346-51. doi: 10.1016/j.talanta.2014.05.057. [PMID: 25127605]
  • Harmanjit S Hira, Pryanka Samal, Amandeep Kaur, Seema Kapoor. Plasma level of hypoxanthine/xanthine as markers of oxidative stress with different stages of obstructive sleep apnea syndrome. Annals of Saudi medicine. 2014 Jul; 34(4):308-13. doi: 10.5144/0256-4947.2014.308. [PMID: 25811203]
  • André F Rodrigues, Roberto Roecker, Gustavo M Junges, Daniela Delwing de Lima, José G P da Cruz, Angela T S Wyse, Débora Delwing Dal Magro. Hypoxanthine induces oxidative stress in kidney of rats: protective effect of vitamins E plus C and allopurinol. Cell biochemistry and function. 2014 Jun; 32(4):387-94. doi: 10.1002/cbf.3029. [PMID: 24578313]
  • H Westerlinck, L Meylaerts, M R Van Hoestenberghe, A Rossi. Sulfite oxidase deficiency in a newborn. JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR). 2014 Mar; 97(2):113-4. doi: 10.5334/jbr-btr.40. [PMID: 25073245]
  • Tracey Gerber, Melissa Louise Borg, Alan Hayes, Christos George Stathis. High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling. European journal of applied physiology. 2014; 114(7):1513-20. doi: 10.1007/s00421-014-2878-x. [PMID: 24748529]
  • Jennifer Williamson, Donna Ryland, Miyoung Suh, Michel Aliani. The effect of chilled conditioning at 4°C on selected water and lipid-soluble flavor precursors in Bison bison longissimus dorsi muscle and their impact on sensory characteristics. Meat science. 2014 Jan; 96(1):136-46. doi: 10.1016/j.meatsci.2013.06.023. [PMID: 23896147]
  • J Zieliński, B Krasińska, K Kusy. Hypoxanthine as a predictor of performance in highly trained athletes. International journal of sports medicine. 2013 Dec; 34(12):1079-86. doi: 10.1055/s-0033-1337947. [PMID: 23670363]
  • S Nylander, E A Femia, M Scavone, P Berntsson, A-K Asztély, K Nelander, L Löfgren, R G Nilsson, M Cattaneo. Ticagrelor inhibits human platelet aggregation via adenosine in addition to P2Y12 antagonism. Journal of thrombosis and haemostasis : JTH. 2013 Oct; 11(10):1867-76. doi: 10.1111/jth.12360. [PMID: 23890048]
  • Lisa A Mestrinho, Tiago Gonçalves, Pedro B Parreira, Maria M R E Niza, Annick J Hamaide. Xanthine urolithiasis causing bilateral ureteral obstruction in a 10-month-old cat. Journal of feline medicine and surgery. 2013 Oct; 15(10):911-6. doi: 10.1177/1098612x13477413. [PMID: 23413269]
  • D A Jankowska, A Trautwein-Schult, A Cordes, P Hoferichter, C Klein, R Bode, K Baronian, G Kunze. Arxula adeninivorans xanthine oxidoreductase and its application in the production of food with low purine content. Journal of applied microbiology. 2013 Sep; 115(3):796-807. doi: 10.1111/jam.12284. [PMID: 23773263]
  • N V Senyavina, S A Khaustova, T K Grebennik, S V Pavlovich. Analysis of purine metabolites in maternal serum for evaluating the risk of gestosis. Bulletin of experimental biology and medicine. 2013 Sep; 155(5):682-4. doi: 10.1007/s10517-013-2225-y. [PMID: 24288739]
  • Morgahna Nathalie Wamser, Eduardo Fernandes Leite, Vinícius Vialle Ferreira, Daniela Delwing-de Lima, José Geraldo Pereira da Cruz, Angela T S Wyse, Débora Delwing-Dal Magro. Effect of hypoxanthine, antioxidants and allopurinol on cholinesterase activities in rats. Journal of neural transmission (Vienna, Austria : 1996). 2013 Sep; 120(9):1359-67. doi: 10.1007/s00702-013-0989-x. [PMID: 23400363]
  • A M L Jacinto, R J Mellanby, M Chandler, N X Bommer, H Carruthers, L D Fairbanks, A G Gow. Urine concentrations of xanthine, hypoxanthine and uric acid in UK Cavalier King Charles spaniels. The Journal of small animal practice. 2013 Aug; 54(8):395-8. doi: 10.1111/jsap.12106. [PMID: 23859747]
  • M Amal Raj, S Abraham John. Simultaneous determination of uric acid, xanthine, hypoxanthine and caffeine in human blood serum and urine samples using electrochemically reduced graphene oxide modified electrode. Analytica chimica acta. 2013 Apr; 771(?):14-20. doi: 10.1016/j.aca.2013.02.017. [PMID: 23522107]
  • Thaer Barri, Lars Ove Dragsted. UPLC-ESI-QTOF/MS and multivariate data analysis for blood plasma and serum metabolomics: effect of experimental artefacts and anticoagulant. Analytica chimica acta. 2013 Mar; 768(?):118-28. doi: 10.1016/j.aca.2013.01.015. [PMID: 23473258]
  • Cristina Müller, Josefine Reber, Claudia Schlup, Christopher P Leamon, Roger Schibli. In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research. Molecular pharmaceutics. 2013 Mar; 10(3):967-74. doi: 10.1021/mp300428p. [PMID: 23394590]
  • M Pittaluga, A Sgadari, B Tavazzi, C Fantini, S Sabatini, R Ceci, A M Amorini, P Parisi, D Caporossi. Exercise-induced oxidative stress in elderly subjects: the effect of red orange supplementation on the biochemical and cellular response to a single bout of intense physical activity. Free radical research. 2013 Mar; 47(3):202-11. doi: 10.3109/10715762.2012.761696. [PMID: 23297807]
  • Jacek Zieliński, Krzysztof Kusy, Ewa Słomińska. Alterations in purine metabolism in middle-aged elite, amateur, and recreational runners across a 1-year training cycle. European journal of applied physiology. 2013 Mar; 113(3):763-73. doi: 10.1007/s00421-012-2488-4. [PMID: 22965897]
  • E Mizuta, S B Utami, A Ohtahara, S Endo, M Mishima, A Hasegawa, K Yamada, M Kato, K Yamamoto, K Ogino, H Ninomiya, S Miyazaki, T Hamada, S-i Taniguchi, J Cheng, I Hisatome. A vasodilating β1 blocker celiprolol inhibits muscular release of uric acid precursor in patients with essential hypertension. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2013 Jan; 45(1):69-73. doi: 10.1055/s-0032-1321872. [PMID: 22893261]