probenecid (BioDeep_00000399160)
Main id: BioDeep_00000002156
natural product
代谢物信息卡片
Probenecid (Benemid)
化学式: C13H19NO4S (285.1034734)
中文名称: 丙磺舒
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=CC(=C1)C(=O)O)S(N(CCC)CCC)(=O)=O
InChI: InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
描述信息
M - Musculo-skeletal system > M04 - Antigout preparations > M04A - Antigout preparations > M04AB - Preparations increasing uric acid excretion
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants > D014528 - Uricosuric Agents
C26170 - Protective Agent > C921 - Uricosuric Agent
D010592 - Pharmaceutic Aids
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:8426
- KEGG: C07372
- KEGGdrug: D92177
- KEGGdrug: D00475
- PubChem: 4911
- DrugBank: DB01032
- ChEMBL: CHEMBL897
- MeSH: Probenecid
- CAS: 57-66-9
- MoNA: CCMSLIB00000078627
- PubChem: 9576
- PDB-CCD: RTO
- NIKKAJI: J1.382J
- RefMet: Probenecid
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Aijie Zhang, Fanlong Yang, Yang Yuan, Cai Li, Xiaokui Huo, Jing Liu, Shenzhi Zhou, Wei Li, Na Zhang, Jianfeng Liu, Shiqi Dong, Huirong Fan, Ying Peng, Jiang Zheng. OAT3 Participates in Drug-Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8-A Metabolite of Bentysrepinine-In Rats and Humans In Vitro.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041995. [PMID: 36838982] - Xiaoxing Wang, Martin E Dowty, Ann Wouters, Svitlana Tatulych, Carol A Connell, Vu H Le, Sakambari Tripathy, Melissa T O'Gorman, Jennifer A Winton, Natalie Yin, Hernan Valdez, Bimal K Malhotra. Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals.
European journal of drug metabolism and pharmacokinetics.
2022 May; 47(3):419-429. doi:
10.1007/s13318-021-00745-6. [PMID: 35226304] - Kazuhiko Ikeuchi, Kazuaki Fukushima, Masaru Tanaka, Keishiro Yajima, Akifumi Imamura. Clinical efficacy and tolerability of 1.5 g/day oral amoxicillin therapy without probenecid for the treatment of syphilis.
Sexually transmitted infections.
2022 05; 98(3):173-177. doi:
10.1136/sextrans-2020-054823. [PMID: 33782148] - Jackelyn Murray, Harrison C Bergeron, Les P Jones, Zachary Beau Reener, David E Martin, Fred D Sancilio, Ralph A Tripp. Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication.
Viruses.
2022 04; 14(5):. doi:
10.3390/v14050912. [PMID: 35632652] - Yan Zhou, Mengmeng Wei, Mingkang Zhang, Jianping Zhang, Fabing Tang, Xin'an Wu. Adefovir accumulation in the renal interstitium triggers mast cell degranulation and promotes renal interstitial fibrosis.
Toxicology letters.
2022 Apr; 359(?):10-21. doi:
10.1016/j.toxlet.2022.01.018. [PMID: 35114312] - George G Zhanel, Marianna Pozdirca, Alyssa R Golden, Courtney K Lawrence, Sheryl Zelenitsky, Liam Berry, Frank Schweizer, Denice Bay, Heather Adam, Michael A Zhanel, Philippe Lagacé-Wiens, Andrew Walkty, Neal Irfan, Kurt Naber, Joseph P Lynch, James A Karlowsky. Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria.
Drugs.
2022 Apr; 82(5):533-557. doi:
10.1007/s40265-022-01688-1. [PMID: 35294769] - Jingjing Wang, Wenjing Yuan, Qingqing Shen, Qipeng Wu, Zhenzhou Jiang, Wei Wu, Luyong Zhang, Xin Huang. The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate.
Journal of biochemical and molecular toxicology.
2022 Apr; 36(4):e22983. doi:
10.1002/jbt.22983. [PMID: 35019195] - Ralph A Tripp, David E Martin. Repurposing Probenecid to Inhibit SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus (RSV) Replication.
Viruses.
2022 03; 14(3):. doi:
10.3390/v14030612. [PMID: 35337018] - Juan Güiza, Aníbal García, Javiera Arriagada, Camila Gutiérrez, Jorge González, Valeria Márquez-Miranda, Melissa Alegría-Arcos, Yorley Duarte, Maximiliano Rojas, Fernando González-Nilo, Juan C Sáez, José L Vega. Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites.
Journal of cellular physiology.
2022 02; 237(2):1547-1560. doi:
10.1002/jcp.30626. [PMID: 34779505] - Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K Holenarsipur, T Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W Griffith Humphreys, Yurong Lai. Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition.
Drug metabolism and disposition: the biological fate of chemicals.
2021 12; 49(12):1063-1069. doi:
10.1124/dmd.121.000486. [PMID: 34599018] - Mariana Camargo, Emad Ibrahim, Teodoro C Aballa, Karina H M Cardozo, Valdemir M Carvalho, Charles M Lynne, Nancy L Brackett, Ricardo P Bertolla. Proteomic insight of seminal plasma in spinal cord injured men submitted to oral probenecid treatment for improved motility.
The journal of spinal cord medicine.
2021 Nov; 44(6):966-971. doi:
10.1080/10790268.2020.1722937. [PMID: 32043922] - Nina Hanke, José David Gómez-Mantilla, Naoki Ishiguro, Peter Stopfer, Valerie Nock. Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions.
Pharmaceutical research.
2021 Oct; 38(10):1645-1661. doi:
10.1007/s11095-021-03109-6. [PMID: 34664206] - Chad R Schultz, Matthew A Swanson, Thomas C Dowling, André S Bachmann. Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma.
Cancer chemotherapy and pharmacology.
2021 10; 88(4):607-617. doi:
10.1007/s00280-021-04309-y. [PMID: 34129075] - Jackelyn Murray, Robert J Hogan, David E Martin, Kathy Blahunka, Fred D Sancilio, Rajiv Balyan, Mark Lovern, Richard Still, Ralph A Tripp. Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro.
Scientific reports.
2021 09; 11(1):18085. doi:
10.1038/s41598-021-97658-w. [PMID: 34508172] - Richard J Everts, Sharon J Gardiner, Mei Zhang, Ronald Begg, Stephen T Chambers, John Turnidge, Evan J Begg. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers.
The Journal of infection.
2021 08; 83(2):182-189. doi:
10.1016/j.jinf.2021.05.037. [PMID: 34081957] - Alan Ducatman, Michael Luster, Tony Fletcher. Perfluoroalkyl substance excretion: Effects of organic anion-inhibiting and resin-binding drugs in a community setting.
Environmental toxicology and pharmacology.
2021 Jul; 85(?):103650. doi:
10.1016/j.etap.2021.103650. [PMID: 33819618] - H Markus Weiss, Thomas Langenickel, Meredith Cain, Swarupa Kulkarni, Bharti Shah, Janardhana Vemula, Gholamreza Rahmanzadeh, Birk Poller. Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator.
Drug metabolism and disposition: the biological fate of chemicals.
2021 05; 49(5):389-394. doi:
10.1124/dmd.120.000273. [PMID: 33632715] - Azusa Futatsugi, Yusuke Masuo, Yukio Kato. Effects of Probenecid on Hepatic and Renal Disposition of Hexadecanedioate, an Endogenous Substrate of Organic Anion Transporting Polypeptide 1B in Rats.
Journal of pharmaceutical sciences.
2021 05; 110(5):2274-2284. doi:
10.1016/j.xphs.2021.02.011. [PMID: 33607188] - Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami-Hodjegan, Aleksandra Galetin. Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters.
CPT: pharmacometrics & systems pharmacology.
2021 05; 10(5):467-477. doi:
10.1002/psp4.12610. [PMID: 33704919] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Sabrina T Wiebe, Thomas Giessmann, Kathrin Hohl, Sven Schmidt-Gerets, Edith Hauel, Alen Jambrecina, Kerstin Bader, Naoki Ishiguro, Mitchell E Taub, Ashish Sharma, Thomas Ebner, Gerd Mikus, Martin F Fromm, Fabian Müller, Peter Stopfer. Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Clinical pharmacokinetics.
2020 12; 59(12):1627-1639. doi:
10.1007/s40262-020-00907-w. [PMID: 32504272] - Hannah Britz, Nina Hanke, Mitchell E Taub, Ting Wang, Bhagwat Prasad, Éric Fernandez, Peter Stopfer, Valerie Nock, Thorsten Lehr. Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions.
Pharmaceutical research.
2020 Nov; 37(12):250. doi:
10.1007/s11095-020-02964-z. [PMID: 33237382] - Yueping Zhang, Vinay K Holenarsipur, Hamza Kandoussi, Jianing Zeng, T Thanga Mariappan, Michael Sinz, Hong Shen. Detection of Weak Organic Anion-Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans.
Drug metabolism and disposition: the biological fate of chemicals.
2020 10; 48(10):841-848. doi:
10.1124/dmd.120.000076. [PMID: 32723847] - Sil-Ling Pruis, Yunjoo Karris Jeon, Fiona Pearce, Bernard Yu-Hor Thong, Mohamed Ismail Abdul Aziz. Cost-effectiveness of sequential urate lowering therapies for the management of gout in Singapore.
Journal of medical economics.
2020 Aug; 23(8):838-847. doi:
10.1080/13696998.2020.1757456. [PMID: 32301360] - Shelia B Dunaway, Clare L Maxwell, Lauren C Tantalo, Sharon K Sahi, Christina M Marra. Neurosyphilis Treatment Outcomes After Intravenous Penicillin G Versus Intramuscular Procaine Penicillin Plus Oral Probenecid.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 07; 71(2):267-273. doi:
10.1093/cid/ciz795. [PMID: 31504293] - Cheryl K T Chua, Peter P Cheung, Amelia Santosa, Anita Y N Lim, Gim Gee Teng. Burden and management of gout in a multi-ethnic Asian cohort.
Rheumatology international.
2020 Jul; 40(7):1029-1035. doi:
10.1007/s00296-019-04475-6. [PMID: 31758246] - Angela Ostuni, Monica Carmosino, Rocchina Miglionico, Vittorio Abruzzese, Fabio Martinelli, Daniela Russo, Ilaria Laurenzana, Agata Petillo, Faustino Bisaccia. Inhibition of ABCC6 Transporter Modifies Cytoskeleton and Reduces Motility of HepG2 Cells via Purinergic Pathway.
Cells.
2020 06; 9(6):. doi:
10.3390/cells9061410. [PMID: 32517079] - Stephanie N Liu, Brandon T Gufford, Jessica Bo Li Lu, Lane R Bushman, Peter L Anderson, Richard F Bergstrom, Zeruesenay Desta, Samir K Gupta. Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis.
Clinical pharmacology and therapeutics.
2020 05; 107(5):1200-1208. doi:
10.1002/cpt.1714. [PMID: 31675437] - Peter Hemmersbach. The Probenecid-story - A success in the fight against doping through out-of-competition testing.
Drug testing and analysis.
2020 May; 12(5):589-594. doi:
10.1002/dta.2727. [PMID: 31797550] - Im-Sook Song, Hyeon-Uk Jeong, Min-Koo Choi, Mihwa Kwon, Yongho Shin, Jeong Han Kim, Hye-Suk Lee. Interactions between cyazofamid and human drug transporters.
Journal of biochemical and molecular toxicology.
2020 Apr; 34(4):e22459. doi:
10.1002/jbt.22459. [PMID: 32003934] - Fan Hong, Aijuan Zheng, Pengfei Xu, Jialin Wang, Tingting Xue, Shu Dai, Shijia Pan, Yuan Guo, Xinlu Xie, Letong Li, Xiaoxiao Qiao, Guohua Liu, Yonggong Zhai. High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout.
International journal of molecular sciences.
2020 Mar; 21(6):. doi:
10.3390/ijms21062147. [PMID: 32245084] - Dandan Zhou, Yunting Xu, Yedong Wang, Jiajun Li, Chunshan Gui, Hongjian Zhang. Interaction of Organic Anion Transporter 3-Mediated Uptake of Steviol Acyl Glucuronide, a Major Metabolite of Rebaudioside A, with Selected Drugs.
Journal of agricultural and food chemistry.
2020 Feb; 68(6):1579-1587. doi:
10.1021/acs.jafc.9b05808. [PMID: 31760750] - Stephanie N Liu, Zeruesenay Desta, Brandon T Gufford. Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis.
CPT: pharmacometrics & systems pharmacology.
2020 01; 9(1):40-47. doi:
10.1002/psp4.12481. [PMID: 31749296] - Xiao-Ying Liao, Qiang-Qiang Deng, Li Han, Zhi-Tao Wu, Zhao-Liang Peng, Yuan Xie, Guang-Ji Wang, Ji-Ye Aa, Guo-Yu Pan. Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2.
Acta pharmacologica Sinica.
2020 Jan; 41(1):129-137. doi:
10.1038/s41401-019-0283-z. [PMID: 31341258] - Richard J Everts, Ronald Begg, Sharon J Gardiner, Mei Zhang, John Turnidge, Stephen T Chambers, Evan J Begg. Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers.
The Journal of infection.
2020 01; 80(1):42-53. doi:
10.1016/j.jinf.2019.09.004. [PMID: 31521742] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Alexander F Flynn, M Gordon Joyce, Rebekah T Taylor, Sasisekhar Bennuru, Alyssa R Lindrose, Spencer L Sterling, C Paul Morris, Thomas B Nutman, Edward Mitre. Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis.
PLoS neglected tropical diseases.
2019 09; 13(9):e0007687. doi:
10.1371/journal.pntd.0007687. [PMID: 31513587] - Susan Burks, James Raymick, Bonnie Robinson, Joseph Hanig, Sumit Sarkar. Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects.
Neuroscience letters.
2019 06; 703(?):86-95. doi:
10.1016/j.neulet.2019.03.015. [PMID: 30890473] - Michael Chen-Xu, Chio Yokose, Sharan K Rai, Michael H Pillinger, Hyon K Choi. Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016.
Arthritis & rheumatology (Hoboken, N.J.).
2019 06; 71(6):991-999. doi:
10.1002/art.40807. [PMID: 30618180] - Xiaoying Han, Jing Yang, Dong Li, Zewei Guo. Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells.
Oncology research.
2019 May; 27(5):533-540. doi:
10.3727/096504018x15199489058224. [PMID: 29523220] - Xue Li, Yilin Qiao, Xue Wang, Ruicong Ma, Tianxiang Li, Youcai Zhang, Robert P Borris. Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3.
Journal of natural products.
2019 04; 82(4):832-839. doi:
10.1021/acs.jnatprod.8b00888. [PMID: 30892891] - Xue Xue, Weiwei Zhang, Jifeng Zhu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Gang Hu, Chuan Su. Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.
Journal of cellular and molecular medicine.
2019 04; 23(4):2568-2582. doi:
10.1111/jcmm.14147. [PMID: 30680924] - Xinrui Li, Jing Liu, Liang Ma, Ping Fu. Pharmacological urate-lowering approaches in chronic kidney disease.
European journal of medicinal chemistry.
2019 Mar; 166(?):186-196. doi:
10.1016/j.ejmech.2019.01.043. [PMID: 30769179] - Bahar Matin, Ahmad A Sherbini, Novera Alam, Jerold S Harmatz, David J Greenblatt. Resveratrol glucuronidation in vitro: potential implications of inhibition by probenecid.
The Journal of pharmacy and pharmacology.
2019 Mar; 71(3):371-378. doi:
10.1111/jphp.13037. [PMID: 30417385] - Yilin Qiao, Xueling Liu, Xue Li, Xue Wang, Caiyu Li, Manana Khutsishvili, Valida Alizade, Daniel Atha, Youcai Zhang, Robert P Borris. Biflavonoids from Juniperus oblonga inhibit organic anion transporter 3.
Biochemical and biophysical research communications.
2019 02; 509(4):931-936. doi:
10.1016/j.bbrc.2019.01.039. [PMID: 30648554] - Brendan J Tunstall, Irene Lorrai, Sam A McConnell, Katrina L Gazo, Lia J Zallar, Giordano de Guglielmo, Ivy Hoang, Carolina L Haass-Koffler, Vez Repunte-Canonigo, George F Koob, Leandro F Vendruscolo, Pietro Paolo Sanna. Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder?.
Alcohol and alcoholism (Oxford, Oxfordshire).
2019 Jan; 54(5):497-502. doi:
10.1093/alcalc/agz054. [PMID: 31535696] - Philip C Robinson. Gout - An update of aetiology, genetics, co-morbidities and management.
Maturitas.
2018 Dec; 118(?):67-73. doi:
10.1016/j.maturitas.2018.10.012. [PMID: 30415758] - Huaiwu He, Dawei Liu, Yun Long, Xiaoting Wang, Bo Yao. The Pannexin-1 Channel Inhibitor Probenecid Attenuates Skeletal Muscle Cellular Energy Crisis and Histopathological Injury in a Rabbit Endotoxemia Model.
Inflammation.
2018 Dec; 41(6):2030-2040. doi:
10.1007/s10753-018-0846-z. [PMID: 30014232] - Mei Zhang, Grant A Moore, Paul K L Chin, Richard Everts, Evan J Begg. Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography-Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma.
Therapeutic drug monitoring.
2018 12; 40(6):682-692. doi:
10.1097/ftd.0000000000000555. [PMID: 30015652] - Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook Oh. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice.
Journal of the neurological sciences.
2018 09; 392(?):77-82. doi:
10.1016/j.jns.2018.07.011. [PMID: 30031172] - Lawrence H Lash, Caroline A Lee, Clynn Wilker, Vishal Shah. Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells.
Toxicology.
2018 07; 404-405(?):10-24. doi:
10.1016/j.tox.2018.05.002. [PMID: 29738843] - Tom T G Nieskens, Janny G P Peters, Dina Dabaghie, Daphne Korte, Katja Jansen, Alexander H Van Asbeck, Neslihan N Tavraz, Thomas Friedrich, Frans G M Russel, Rosalinde Masereeuw, Martijn J Wilmer. Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity.
Drug metabolism and disposition: the biological fate of chemicals.
2018 05; 46(5):592-599. doi:
10.1124/dmd.117.079384. [PMID: 29514829] - Seoyoung C Kim, Tuhina Neogi, Eun Ha Kang, Jun Liu, Rishi J Desai, MaryAnn Zhang, Daniel H Solomon. Cardiovascular Risks of Probenecid Versus Allopurinol in Older Patients With Gout.
Journal of the American College of Cardiology.
2018 03; 71(9):994-1004. doi:
10.1016/j.jacc.2017.12.052. [PMID: 29496000] - Abhishek Abhishek. New urate-lowing therapies.
Current opinion in rheumatology.
2018 03; 30(2):177-182. doi:
10.1097/bor.0000000000000476. [PMID: 29251661] - Shijie Wen, Changyuan Wang, Yingjie Duan, Xiaokui Huo, Qiang Meng, Zhihao Liu, Shilei Yang, Yanna Zhu, Huijun Sun, Xiaodong Ma, Siyun Yang, Kexin Liu. OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam.
International journal of pharmaceutics.
2018 Feb; 537(1-2):172-182. doi:
10.1016/j.ijpharm.2017.12.037. [PMID: 29277663] - Hong Shen, David M Nelson, Regina V Oliveira, Yueping Zhang, Colleen A Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D Reily, Petia A Shipkova, Jinping Gan, Yurong Lai, Punit Marathe, W Griffith Humphreys. Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.
Drug metabolism and disposition: the biological fate of chemicals.
2018 02; 46(2):178-188. doi:
10.1124/dmd.117.077586. [PMID: 29162614] - Xue Wang, Lifeng Han, Gentao Li, Wei Peng, Xiumei Gao, Curtis D Klaassen, Guanwei Fan, Youcai Zhang. From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 02; 161(2):321-334. doi:
10.1093/toxsci/kfx216. [PMID: 29045746] - Robert Case, Brian Wentworth, Grant Jester. Effective uric acid reduction with probenecid and febuxostat in a patient with chronic kidney disease.
BMJ case reports.
2018 Jan; 2018(?):. doi:
10.1136/bcr-2017-222845. [PMID: 29386212] - Yugo Hamada, Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda. Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers.
Pharmacology.
2018; 101(3-4):176-183. doi:
10.1159/000485920. [PMID: 29353278] - Gerald Levy, Jiaxiao M Shi, T Craig Cheetham, Nazia Rashid. Urate-Lowering Therapy in Moderate to Severe Chronic Kidney Disease.
The Permanente journal.
2018; 22(?):17-142. doi:
10.7812/tpp/17-142. [PMID: 30201087] - Duk-Hee Kang. Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells.
Contributions to nephrology.
2018; 192(?):48-55. doi:
10.1159/000484278. [PMID: 29393109] - Novera Alam, Mia G Angeli, David J Greenblatt. Mechanism of in-vitro inhibition of UGT1A1 by paritaprevir.
The Journal of pharmacy and pharmacology.
2017 Dec; 69(12):1794-1801. doi:
10.1111/jphp.12821. [PMID: 28990653] - Laura Kervezee, Robin Hartman, Dirk-Jan van den Berg, Johanna H Meijer, Elizabeth C M de Lange. Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Nov; 109S(?):S132-S139. doi:
10.1016/j.ejps.2017.05.048. [PMID: 28558980] - Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa. Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess.
Molecular and cellular biochemistry.
2017 Nov; 435(1-2):97-108. doi:
10.1007/s11010-017-3060-7. [PMID: 28534121] - Katia Sayyed, Marc Le Vee, Ziad Abdel-Razzak, Olivier Fardel. Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Oct; 44(?):27-35. doi:
10.1016/j.tiv.2017.06.014. [PMID: 28629854] - Kathryn Ball, Tanguy Jamier, Yannick Parmentier, Claire Denizot, Agnes Mallier, Marylore Chenel. Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Aug; 106(?):122-132. doi:
10.1016/j.ejps.2017.05.055. [PMID: 28552429] - Takuya Matsumoto, Yui Ishizaki, Keika Mochizuki, Mitsuru Aoyagi, Yoshiharu Mitoma, Shoichiro Ishizaki, Yuji Nagashima. Urinary Excretion of Tetrodotoxin Modeled in a Porcine Renal Proximal Tubule Epithelial Cell Line, LLC-PK₁.
Marine drugs.
2017 Jul; 15(7):. doi:
10.3390/md15070225. [PMID: 28714912] - Katiria Flores, José E Manautou, J Larry Renfro. Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus.
Toxicology.
2017 07; 386(?):84-92. doi:
10.1016/j.tox.2017.05.019. [PMID: 28587784] - Elizabeth J M Corbett, Peta Pentony, Neil W McGill. Achieving serum urate targets in gout: an audit in a gout-oriented rheumatology practice.
International journal of rheumatic diseases.
2017 Jul; 20(7):894-897. doi:
10.1111/1756-185x.13032. [PMID: 28205336] - Ciaran J McMullan, Lea Borgi, Naomi Fisher, Gary Curhan, John Forman. Effect of Uric Acid Lowering on Renin-Angiotensin-System Activation and Ambulatory BP: A Randomized Controlled Trial.
Clinical journal of the American Society of Nephrology : CJASN.
2017 May; 12(5):807-816. doi:
10.2215/cjn.10771016. [PMID: 28320765] - Kerstin Römermann, Maren Fedrowitz, Philip Hampel, Edith Kaczmarek, Kathrin Töllner, Thomas Erker, Douglas H Sweet, Wolfgang Löscher. Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain.
Neuropharmacology.
2017 05; 117(?):182-194. doi:
10.1016/j.neuropharm.2017.02.006. [PMID: 28192112] - Sumathy Mathialagan, Mary A Piotrowski, David A Tess, Bo Feng, John Litchfield, Manthena V Varma. Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach.
Drug metabolism and disposition: the biological fate of chemicals.
2017 04; 45(4):409-417. doi:
10.1124/dmd.116.074294. [PMID: 28179375] - Fanuel T Hagos, Monica J Daood, Jacob A Ocque, Thomas D Nolin, Hulya Bayir, Samuel M Poloyac, Patrick M Kochanek, Robert S B Clark, Philip E Empey. Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Apr; 47(4):346-353. doi:
10.1080/00498254.2016.1187777. [PMID: 27278858] - G S Baturina, L E Katkova, E I Solenov, L N Ivanova. Role of the low-selective organic anion transport in regulation of osmotic balance of renal collecting duct principal cells under hypo-osmotic conditions.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections.
2017 Mar; 473(1):43-45. doi:
10.1134/s0012496617020090. [PMID: 28508198] - Tetsuya Taniguchi, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga. Enhancement of pharmacological effects of uricosuric agents by concomitant treatment with pyrazinamide in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Mar; 390(3):253-260. doi:
10.1007/s00210-016-1324-5. [PMID: 27933340] - Lisa K Stamp. Major unanswered questions in the clinical gout field.
Current opinion in rheumatology.
2017 03; 29(2):171-177. doi:
10.1097/bor.0000000000000367. [PMID: 27926541] - Lea Borgi, Ciaran McMullan, Ann Wohlhueter, Gary C Curhan, Naomi D Fisher, John P Forman. Effect of Uric Acid-Lowering Agents on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial.
Hypertension (Dallas, Tex. : 1979).
2017 02; 69(2):243-248. doi:
10.1161/hypertensionaha.116.08488. [PMID: 28028194] - Lisa Stamp, Nicola Dalbeth. Urate-lowering therapy for asymptomatic hyperuricaemia: A need for caution.
Seminars in arthritis and rheumatism.
2017 02; 46(4):457-464. doi:
10.1016/j.semarthrit.2016.07.015. [PMID: 27591828] - Pil Sung Gu, Minho Moon, Jin Gyu Choi, Myung Sook Oh. Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model.
The Journal of nutritional biochemistry.
2017 01; 39(?):15-21. doi:
10.1016/j.jnutbio.2016.08.014. [PMID: 27741433] - Giane Favretto, Lauro M Souza, Paulo C Gregório, Regiane S Cunha, Rayana A P Maciel, Guilherme L Sassaki, Maria G Toledo, Roberto Pecoits-Filho, Wesley M Souza, Andréa E M Stinghen. Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.
Journal of vascular research.
2017; 54(3):170-179. doi:
10.1159/000468542. [PMID: 28472795] - Xin He, Zi-Jing Song, Cui-Ping Jiang, Chun-Feng Zhang. Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat.
The American journal of Chinese medicine.
2017; 45(8):1745-1759. doi:
10.1142/s0192415x1750094x. [PMID: 29121796] - Robert S B Clark, Philip E Empey, Hülya Bayır, Bedda L Rosario, Samuel M Poloyac, Patrick M Kochanek, Thomas D Nolin, Alicia K Au, Christopher M Horvat, Stephen R Wisniewski, Michael J Bell. Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children.
PloS one.
2017; 12(7):e0180280. doi:
10.1371/journal.pone.0180280. [PMID: 28686657] - Wei Wang, Yue Li, Jessica Y Zhu, Dongdong Fang, Han-Fei Ding, Zheng Dong, Qing Jing, Shi-Bing Su, Shuang Huang. Triple negative breast cancer development can be selectively suppressed by sustaining an elevated level of cellular cyclic AMP through simultaneously blocking its efflux and decomposition.
Oncotarget.
2016 Dec; 7(52):87232-87245. doi:
10.18632/oncotarget.13601. [PMID: 27901486] - Yuri Tsuruya, Koji Kato, Yamato Sano, Yuichiro Imamura, Kazuya Maeda, Yuji Kumagai, Yuichi Sugiyama, Hiroyuki Kusuhara. Investigation of Endogenous Compounds Applicable to Drug-Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans.
Drug metabolism and disposition: the biological fate of chemicals.
2016 12; 44(12):1925-1933. doi:
10.1124/dmd.116.071472. [PMID: 27638508] - Philip K Tan, Traci M Ostertag, Jeffrey N Miner. Mechanism of high affinity inhibition of the human urate transporter URAT1.
Scientific reports.
2016 10; 6(?):34995. doi:
10.1038/srep34995. [PMID: 27713539] - Christopher C Coss, Amanda Jones, James T Dalton. Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin.
Investigational new drugs.
2016 08; 34(4):458-67. doi:
10.1007/s10637-016-0353-8. [PMID: 27105861] - Mingli Chen, Huancai Yin, Pengli Bai, Peng Miao, Xudong Deng, Yingxue Xu, Jun Hu, Jian Yin. ABC transporters affect the elimination and toxicity of CdTe quantum dots in liver and kidney cells.
Toxicology and applied pharmacology.
2016 07; 303(?):11-20. doi:
10.1016/j.taap.2016.04.017. [PMID: 27131644] - Yoshikazu Abe, Yuki Nakano, Toru Kanazawa, Takao Furihata, Takuro Endo, Mamoru Kobayashi. Investigation of Drug-Drug Interactions Between Ritobegron, a Selective β3 -Adrenoceptor Agonist, With Probenecid in Healthy Men.
Clinical pharmacology in drug development.
2016 May; 5(3):201-7. doi:
10.1002/cpdd.212. [PMID: 27163499] - Febbie Sangkop, Geeta Singh, Ely Rodrigues, Elspeth Gold, Andrew Bahn. Uric acid: a modulator of prostate cells and activin sensitivity.
Molecular and cellular biochemistry.
2016 Mar; 414(1-2):187-99. doi:
10.1007/s11010-016-2671-8. [PMID: 26910779] - Yi-Fan Zhang, Xiao-Jian Dai, Yong Yang, Xiao-Yan Chen, Ting Wang, Yun-Biao Tang, Cheng-Yuan Tsai, Li-Wen Chang, Yu-Ting Chang, Da-Fang Zhong. Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers.
Drug design, development and therapy.
2016; 10(?):357-70. doi:
10.2147/dddt.s95934. [PMID: 26855561] - Akiko Ohashi, Yusuke Saeki, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa. Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats.
PloS one.
2016; 11(10):e0164305. doi:
10.1371/journal.pone.0164305. [PMID: 27711248] - Tetsuya Taniguchi, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga, Kazuhiro Saitoh. Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor.
The Journal of pharmacy and pharmacology.
2016 Jan; 68(1):76-83. doi:
10.1111/jphp.12490. [PMID: 26589240] - Emanuele Bernardinelli, Roberta Costa, Charity Nofziger, Markus Paulmichl, Silvia Dossena. Effect of Known Inhibitors of Ion Transport on Pendrin (SLC26A4) Activity in a Human Kidney Cell Line.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(5):1984-98. doi:
10.1159/000445559. [PMID: 27161422] - Yuli Qian, Ahmad Sherbini, Bahar Matin, Yanli Zhao, John Castellot, David J Greenblatt. Inhibition of 2-methoxyestradiol glucuronidation by probenecid.
The Journal of pharmacy and pharmacology.
2015 Nov; 67(11):1585-92. doi:
10.1111/jphp.12462. [PMID: 26272356] - Chih-Yuan Lin, Yu-Juei Hsu, Shih-Che Hsu, Ying Chen, Herng-Sheng Lee, Shih-Hua Lin, Shih-Ming Huang, Chien-Sung Tsai, Chun-Che Shih. CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia.
Journal of molecular and cellular cardiology.
2015 Aug; 85(?):249-61. doi:
10.1016/j.yjmcc.2015.06.010. [PMID: 26093151] - Ryutaro Tanizaki, Takeshi Nishijima, Takahiro Aoki, Katsuji Teruya, Yoshimi Kikuchi, Shinichi Oka, Hiroyuki Gatanaga. High-dose oral amoxicillin plus probenecid is highly effective for syphilis in patients with HIV infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2015 Jul; 61(2):177-83. doi:
10.1093/cid/civ270. [PMID: 25829004] - Yuki Mori, Daichi Tomonaga, Anastasia Kalashnikova, Fumihiko Furuya, Nozomi Akimoto, Masataka Ifuku, Yuko Okuno, Kaoru Beppu, Kyota Fujita, Toshihiko Katafuchi, Hiroki Shimura, Leonid P Churilov, Mami Noda. Effects of 3,3',5-triiodothyronine on microglial functions.
Glia.
2015 May; 63(5):906-20. doi:
10.1002/glia.22792. [PMID: 25643925] - Zhixia Qiu, Lei Wang, Yu Dai, Weichao Ren, Wenwen Jiang, Xijing Chen, Ning Li. The potential drug-drug interactions of ginkgolide B mediated by renal transporters.
Phytotherapy research : PTR.
2015 May; 29(5):662-7. doi:
10.1002/ptr.5294. [PMID: 25589475] - Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E Olaleye, Jiajia Dong, Chuan Li. Renal tubular secretion of tanshinol: molecular mechanisms, impact on its systemic exposure, and propensity for dose-related nephrotoxicity and for renal herb-drug interactions.
Drug metabolism and disposition: the biological fate of chemicals.
2015 May; 43(5):669-78. doi:
10.1124/dmd.114.062000. [PMID: 25710938]