ATOVAQUONE (BioDeep_00000399126)
Main id: BioDeep_00000006353
natural product
代谢物信息卡片
Atovaquone (Atavaquone)
化学式: C22H19ClO3 (366.1023)
中文名称: 阿托伐醌
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1([C@@H]2CC[C@H](CC2)C3=CC=C(C=C3)Cl)C(C4=C(C(C=1O)=O)C=CC=C4)=O
InChI: InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,24H,5-8H2
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D004791 - Enzyme Inhibitors
同义名列表
3 个代谢物同义名
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:575568
- ChEBI: CHEBI:95346
- KEGG: C06835
- KEGGdrug: D00236
- PubChem: 74989
- DrugBank: DB01117
- ChEMBL: CHEMBL519462
- ChEMBL: CHEMBL222334
- ChEMBL: CHEMBL471792
- MeSH: Atovaquone
- CAS: 1329792-63-3
- CAS: 137732-39-9
- CAS: 94015-53-9
- CAS: 95233-18-4
- MoNA: CCMSLIB00000078570
- PubChem: 9053
- PDB-CCD: AOQ
- NIKKAJI: J389.528I
- RefMet: Atovaquone
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qingyu Lu, Wenhao Gao, Zhenzhen Chen, Zhihong Liu, Jie Wang, Lingjun Zeng, Xiaomu Hu, Enqin Zheng, Qian Zhang, Hongtao Song. Co-delivery of Paclitaxel/Atovaquone/Quercetin to regulate energy metabolism to reverse multidrug resistance in ovarian cancer by PLGA-PEG nanoparticles.
International journal of pharmaceutics.
2024 Apr; 655(?):124028. doi:
10.1016/j.ijpharm.2024.124028. [PMID: 38518871] - Tian-Jiao Zhou, Meng-Meng Zhang, Dan-Meng Liu, Li-Ling Huang, Hai-Qing Yu, Yi Wang, Lei Xing, Hu-Lin Jiang. Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer.
Biomaterials.
2024 Mar; 305(?):122447. doi:
10.1016/j.biomaterials.2023.122447. [PMID: 38154441] - Thomas D Horvath, Sridevi Devaraj. Liquid Chromatography-Tandem Mass Spectrometry-Based Therapeutic Monitoring of Plasma Atovaquone Concentrations in Pediatric Patients.
Methods in molecular biology (Clifton, N.J.).
2024; 2737(?):67-77. doi:
10.1007/978-1-0716-3541-4_7. [PMID: 38036811] - Stephan Chalon, M Farouk Chughlay, Nada Abla, Andre Marie Tchouatieu, Amina Haouala, Ben Hutter, Ulrike Lorch, Fiona Macintyre. Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.
Clinical pharmacology and therapeutics.
2022 04; 111(4):867-877. doi:
10.1002/cpt.2404. [PMID: 34453327] - Bruno A Rodriguez-Rodriguez, Maria G Noval, Maria E Kaczmarek, Kyung Ku Jang, Sara A Thannickal, Angelica Cifuentes Kottkamp, Rebecca S Brown, Margaret Kielian, Ken Cadwell, Kenneth A Stapleford. Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro.
Viruses.
2021 12; 13(12):. doi:
10.3390/v13122437. [PMID: 34960706] - Jeremy W Jacobs, Alexa J Siddon. Concurrent COVID-19 and babesiosis in an older, splenectomized patient.
Blood.
2021 11; 138(21):2154. doi:
10.1182/blood.2021013947. [PMID: 34821934] - Dyhia Amrane, Nicolas Primas, Christophe-Sébastien Arnold, Sébastien Hutter, Béatrice Louis, Julen Sanz-Serrano, Amaya Azqueta, Nadia Amanzougaghene, Shahin Tajeri, Dominique Mazier, Pierre Verhaeghe, Nadine Azas, Cyrille Botté, Patrice Vanelle. Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum.
European journal of medicinal chemistry.
2021 Nov; 224(?):113722. doi:
10.1016/j.ejmech.2021.113722. [PMID: 34364164] - Madalina Elena Carter-Timofte, Rozanne Arulanandam, Naziia Kurmasheva, Kathy Fu, Geneviève Laroche, Zaid Taha, Demi van der Horst, Lena Cassin, Renée M van der Sluis, Enrico Palermo, Daniele Di Carlo, David Jacobs, Glib Maznyi, Taha Azad, Ragunath Singaravelu, Fanghui Ren, Anne Louise Hansen, Manja Idorn, Christian K Holm, Martin R Jakobsen, Julien van Grevenynghe, John Hiscott, Søren R Paludan, John C Bell, Jean Seguin, Luc A Sabourin, Marceline Côté, Jean-Simon Diallo, Tommy Alain, David Olagnier. Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern.
ACS infectious diseases.
2021 11; 7(11):3034-3051. doi:
10.1021/acsinfecdis.1c00278. [PMID: 34658235] - Shigehiro Enkai, Hirokazu Kouguchi, Daniel Ken Inaoka, Takao Irie, Kinpei Yagi, Kiyoshi Kita. In vivo efficacy of combination therapy with albendazole and atovaquone against primary hydatid cysts in mice.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2021 Sep; 40(9):1815-1820. doi:
10.1007/s10096-021-04230-5. [PMID: 33770336] - Chané Erasmus, Janine Aucamp, Frans J Smit, Ronnett Seldon, Audrey Jordaan, Digby F Warner, David D N'Da. Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone.
Bioorganic chemistry.
2021 09; 114(?):105118. doi:
10.1016/j.bioorg.2021.105118. [PMID: 34216896] - Melanie T Cushion, Parag Kumar, Ruying Lu, Alan Ashbaugh, Lilian W Adeojo, Raul Alfaro, Raphael Mannino, Edmund Tramont, Joseph A Kovacs. A Novel Encochleated Formulation Improves Atovaquone Activity in a Murine Model of Pneumocystis Pneumonia.
The Journal of infectious diseases.
2021 07; 224(2):326-331. doi:
10.1093/infdis/jiaa731. [PMID: 33245345] - Prashanth Chowdary, Shraddha Shetty, John Booth, Muhammad Arslan Khurram, Magdi Yaqoob, Ismail Heyder Mohamed. Experience of SARS-CoV-2 infection in two kidney transplant recipients living with HIV-1 infection.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Apr; 23(2):e13500. doi:
10.1111/tid.13500. [PMID: 33174284] - Lorna Chebon-Bore, Taremekedzwa Allan Sanyanga, Colleen Varaidzo Manyumwa, Afrah Khairallah, Özlem Tastan Bishop. Decoding the Molecular Effects of Atovaquone Linked Resistant Mutations on Plasmodium falciparum Cytb-ISP Complex in the Phospholipid Bilayer Membrane.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22042138. [PMID: 33670016] - Maria Fernanda Alves do Nascimento, Tatiane Freitas Borgati, Larissa Camila Ribeiro de Souza, Carlos Alberto Tagliati, Alaíde Braga de Oliveira. In silico, in vitro and in vivo evaluation of natural Bignoniaceous naphthoquinones in comparison with atovaquone targeting the selection of potential antimalarial candidates.
Toxicology and applied pharmacology.
2020 08; 401(?):115074. doi:
10.1016/j.taap.2020.115074. [PMID: 32464218] - Gaber El-Saber Batiha, Amany Magdy Beshbishy, Oluyomi Stephen Adeyemi, Eman Nadwa, Eman Rashwan, Naoaki Yokoyama, Ikuo Igarashi. Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.
PloS one.
2020; 15(2):e0228996. doi:
10.1371/journal.pone.0228996. [PMID: 32053698] - Christopher Evernden, Michelle Dowhan, Rosy Dabas, Ahsan Chaudhry, Amit Kalra, Poonam Dharmani-Khan, Daniel Gregson, Andrew Johnson, Jennifer Jupp, Victor Jimenez-Zepeda, Kareem Jamani, Peter Duggan, Jason Tay, Faisal Khan, Andrew Daly, Jan Storek. High incidence of Pneumocystis jirovecii pneumonia in allogeneic hematopoietic cell transplant recipients in the modern era.
Cytotherapy.
2020 01; 22(1):27-34. doi:
10.1016/j.jcyt.2019.11.002. [PMID: 31889628] - Alexandra M Stevens, Michael Xiang, Lisa N Heppler, Isidora Tošić, Kevin Jiang, Jaime O Munoz, Amos S Gaikwad, Terzah M Horton, Xin Long, Padmini Narayanan, Elizabeth L Seashore, Maci C Terrell, Raushan Rashid, Michael J Krueger, Alicia E Mangubat-Medina, Zachary T Ball, Pavel Sumazin, Sarah R Walker, Yoshimasa Hamada, Seiichi Oyadomari, Michele S Redell, David A Frank. Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.
Blood advances.
2019 12; 3(24):4215-4227. doi:
10.1182/bloodadvances.2019000499. [PMID: 31856268] - Xiaofeng Zhao, Edward J Yoon, Massa Zantah, Mohamed Alsammak. Discoloration of plasma associated with Atovaquone in therapeutic plasma exchange.
Journal of clinical apheresis.
2019 08; 34(4):480-481. doi:
10.1002/jca.21682. [PMID: 30597613] - Mamdouh M Hegazy, Manar S Elmehankar, Manar S Azab, Nora L El-Tantawy, Azza Abdel-Aziz. Sex dichotomy in the course of experimental latent toxoplasmosis.
Experimental parasitology.
2019 Jul; 202(?):15-21. doi:
10.1016/j.exppara.2019.05.003. [PMID: 31078550] - Ryohkan Funakoshi, Yukana Tomoda, Toshiyuki Kudo, Kenichi Furihata, Hiroyuki Kusuhara, Kiyomi Ito. Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers.
British journal of clinical pharmacology.
2019 07; 85(7):1454-1463. doi:
10.1111/bcp.13914. [PMID: 30845361] - Harini Bejjanki, Olanrewaju A Olaoye, Alfonso H Santos, Abhilash Koratala. Liver transplant, toxoplasmosis and kidney stones: connecting the dots.
BMJ case reports.
2019 Feb; 12(2):. doi:
10.1136/bcr-2019-229197. [PMID: 30772835] - Yuan Sun, Hai Xu, Xinju Chen, Xiaodong Li, Baoping Luo. Inhibition of mitochondrial respiration overcomes hepatocellular carcinoma chemoresistance.
Biochemical and biophysical research communications.
2019 01; 508(2):626-632. doi:
10.1016/j.bbrc.2018.11.182. [PMID: 30522865] - Dehong Chen, Xiaosong Sun, Xuejun Zhang, Jun Cao. Targeting mitochondria by anthelmintic drug atovaquone sensitizes renal cell carcinoma to chemotherapy and immunotherapy.
Journal of biochemical and molecular toxicology.
2018 Sep; 32(9):e22195. doi:
10.1002/jbt.22195. [PMID: 30004155] - Nicolas Argy, Solène Le Gal, Romain Coppée, Zehua Song, William Vindrios, Laurent Massias, Wei-Chun Kao, Carola Hunte, Yazdan Yazdanpanah, Jean-Christophe Lucet, Sandrine Houzé, Jérôme Clain, Gilles Nevez. Pneumocystis Cytochrome b Mutants Associated With Atovaquone Prophylaxis Failure as the Cause of Pneumocystis Infection Outbreak Among Heart Transplant Recipients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2018 08; 67(6):913-919. doi:
10.1093/cid/ciy154. [PMID: 29514207] - Mitesh Patel, Marta Johnson, Caroline J Sychterz, Gareth J Lewis, Cory Watson, Harma Ellens, Joseph W Polli, Maciej J Zamek-Gliszczynski. Hepatobiliary Disposition of Atovaquone: A Case of Mechanistically Unusual Biliary Clearance.
The Journal of pharmacology and experimental therapeutics.
2018 07; 366(1):37-45. doi:
10.1124/jpet.117.247254. [PMID: 29653960] - Tresa Reena Mascarenhas, Randi S Silibovsky, Pooja Singh, Katherine A Belden. Tick-borne illness after transplantation: Case and review.
Transplant infectious disease : an official journal of the Transplantation Society.
2018 Apr; 20(2):e12830. doi:
10.1111/tid.12830. [PMID: 29277955] - Azirwan Guswanto, Arifin Budiman Nugraha, Bumduuren Tuvshintulga, Dickson Stuart Tayebwa, Mohamed Abdo Rizk, Gaber El-Saber Batiha, Sambuu Gantuya, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi. 17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice.
International journal for parasitology. Drugs and drug resistance.
2018 04; 8(1):104-111. doi:
10.1016/j.ijpddr.2018.02.005. [PMID: 29499568] - Rahul P Bakshi, Lee M Tatham, Alison C Savage, Abhai K Tripathi, Godfree Mlambo, Matthew M Ippolito, Elizabeth Nenortas, Steve P Rannard, Andrew Owen, Theresa A Shapiro. Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.
Nature communications.
2018 01; 9(1):315. doi:
10.1038/s41467-017-02603-z. [PMID: 29358624] - Milena M McLaughlin, Audrey Galal, Chad L Richardson, Sarah H Sutton, Viktorija O Barr, Niketa Patel, Porntiwa Mitchell, Valentina Stosor. Switch to atovaquone and subsequent re-challenge with trimethoprim-sulfamethoxazole for Pneumocystis prophylaxis in a kidney transplant population.
Transplant infectious disease : an official journal of the Transplantation Society.
2017 Dec; 19(6):. doi:
10.1111/tid.12769. [PMID: 28833985] - Christine Robin, Minh Patrick Lê, Giovanna Melica, Laurent Massias, Rabah Redjoul, Nihel Khoudour, Mathieu Leclerc, Florence Beckerich, Sébastien Maury, Anne Hulin, Catherine Cordonnier. Plasma concentrations of atovaquone given to immunocompromised patients to prevent Pneumocystis jirovecii.
The Journal of antimicrobial chemotherapy.
2017 09; 72(9):2602-2606. doi:
10.1093/jac/dkx198. [PMID: 28651341] - Susann H Krake, Pablo David G Martinez, Jenna McLaren, Eileen Ryan, Gong Chen, Karen White, Susan A Charman, Simon Campbell, Paul Willis, Luiz Carlos Dias. Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans.
European journal of medicinal chemistry.
2017 Jan; 126(?):929-936. doi:
10.1016/j.ejmech.2016.12.024. [PMID: 28002775] - Michael Xiang, Haesook Kim, Vincent T Ho, Sarah R Walker, Michal Bar-Natan, Melodi Anahtar, Suhu Liu, Patricia A Toniolo, Yasmin Kroll, Nichole Jones, Zachary T Giaccone, Lisa N Heppler, Darwin Q Ye, Jason J Marineau, Daniel Shaw, James E Bradner, Traci Blonquist, Donna Neuberg, Claudio Hetz, Richard M Stone, Robert J Soiffer, David A Frank. Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.
Blood.
2016 10; 128(14):1845-1853. doi:
10.1182/blood-2015-07-660506. [PMID: 27531676] - Fabrice Bruneel, Florence Tubach, Jean-Paul Mira, Sandrine Houze, Sebastien Gibot, Marie-Genevieve Huisse, Bruno Megarbane, Christophe Choquet, Philippe Corne, Eric Peytel, Daniel Villers, Christophe Camus, Olivier Bouchaud, Eric Caumes, Pierre-Marie Girard, Fabrice Simon, Antoine Kalloumeh, Carine Roy, Remy Durand, Jacques Le Bras, Sophie Matheron, Michel Wolff. Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study.
Intensive care medicine.
2016 Oct; 42(10):1588-1596. doi:
10.1007/s00134-016-4356-x. [PMID: 27169586] - Marco Fiorillo, Rebecca Lamb, Herbert B Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti. Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells.
Oncotarget.
2016 Jun; 7(23):34084-99. doi:
10.18632/oncotarget.9122. [PMID: 27136895] - Mónica M Calderón, Scott R Penzak, Alice K Pau, Parag Kumar, Maryellen McManus, Raul M Alfaro, Joseph A Kovacs. Efavirenz but Not Atazanavir/Ritonavir Significantly Reduces Atovaquone Concentrations in HIV-Infected Subjects.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2016 Apr; 62(8):1036-1042. doi:
10.1093/cid/ciw028. [PMID: 26797214] - Domagoj Dinter, Goran Gajski, Ana-Marija Domijan, Vera Garaj-Vrhovac. Cytogenetic and oxidative status of human lymphocytes after exposure to clinically relevant concentrations of antimalarial drugs atovaquone and proguanil hydrochloride in vitro.
Fundamental & clinical pharmacology.
2015 Dec; 29(6):575-85. doi:
10.1111/fcp.12153. [PMID: 26434663] - Zehua Song, Jérôme Clain, Bogdan I Iorga, Zhou Yi, Nicholas Fisher, Brigitte Meunier. Saccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.
Antimicrobial agents and chemotherapy.
2015 Jul; 59(7):4053-8. doi:
10.1128/aac.00710-15. [PMID: 25918152] - Brett D Schwartz, Tina S Skinner-Adams, Katherine T Andrews, Mark J Coster, Michael D Edstein, Donna MacKenzie, Susan A Charman, Maria Koltun, Scott Blundell, Anna Campbell, Rebecca H Pouwer, Ronald J Quinn, Karren D Beattie, Peter C Healy, Rohan A Davis. Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold.
Organic & biomolecular chemistry.
2015 Feb; 13(5):1558-70. doi:
10.1039/c4ob01849d. [PMID: 25490858] - Andrea K Boggild, Rachel Lau, Denis Reynaud, Kevin C Kain, Marvin Gerson. Failure of atovaquone-proguanil malaria chemoprophylaxis in a traveler to Ghana.
Travel medicine and infectious disease.
2015 Jan; 13(1):89-93. doi:
10.1016/j.tmaid.2014.12.010. [PMID: 25582377] - Neşe Sönmez, Ozden Büyükbaba Boral, Kamber Kaşali, Fatma Tekeli. [Effects of atovaquone and astragalus combination on the treatment and IL-2, IL-12, IFN-γ levels on mouse models of acute toxoplasmosis].
Mikrobiyoloji bulteni.
2014 Oct; 48(4):639-51. doi:
10.5578/mb.8025. [PMID: 25492659] - Sanna R Rijpma, Jeroen J M W van den Heuvel, Maarten van der Velden, Robert W Sauerwein, Frans G M Russel, Jan B Koenderink. Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.
Malaria journal.
2014 Sep; 13(?):359. doi:
10.1186/1475-2875-13-359. [PMID: 25218605] - Aiko Iguchi, Nobuyuki Shiranaga, Aya Matsuu, Yoshiaki Hikasa. Efficacy of Malarone(®) in dogs naturally infected with Babesia gibsoni.
The Journal of veterinary medical science.
2014 Sep; 76(9):1291-5. doi:
10.1292/jvms.14-0139. [PMID: 24909969] - Qigui Li, Shon Remich, Scott R Miller, Bernhards Ogutu, Walter Otieno, Victor Melendez, Paktiya Teja-Isavadharm, Peter J Weina, Mark R Hickman, Bryan Smith, Mark Polhemus. Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study.
Malaria journal.
2014 Jul; 13(?):281. doi:
10.1186/1475-2875-13-281. [PMID: 25047305] - Carmelina Calitri, Silvia Garazzino, Roberta Camilla, Licia Peruzzi, Alessandro Amore, Pier-Angelo Tovo. 'Collateral' effect of artemether in an atypical kidney involvement by Plasmodium falciparum malaria: a case report.
Journal of vector borne diseases.
2014 Jun; 51(2):147-8. doi:
NULL. [PMID: 24947225] - Vivek Borhade, Sulabha Pathak, Shobhona Sharma, Vandana Patravale. Formulation and characterization of atovaquone nanosuspension for improved oral delivery in the treatment of malaria.
Nanomedicine (London, England).
2014 Apr; 9(5):649-66. doi:
10.2217/nnm.13.61. [PMID: 23927590] - Camille Desgrouas, Jérôme Dormoi, Charles Chapus, Evelyne Ollivier, Daniel Parzy, Nicolas Taudon. In vitro and in vivo combination of cepharanthine with anti-malarial drugs.
Malaria journal.
2014 Mar; 13(?):90. doi:
10.1186/1475-2875-13-90. [PMID: 24618129] - Domagoj Dinter, Goran Gajski, Vera Garaj-Vrhovac. An alkaline comet assay study on the antimalarial drug atovaquone in human peripheral blood lymphocytes: a study based on clinically relevant concentrations.
Journal of applied toxicology : JAT.
2013 Jan; 33(1):56-62. doi:
10.1002/jat.1711. [PMID: 21735454] - Eleri Wallace, Charlene M Y Ong, Charles M Heard. Delivery of atovaquone and proguanil across sublingual membranes, in vitro.
Pharmaceutical development and technology.
2012 Nov; 17(6):770-6. doi:
10.3109/10837450.2011.580760. [PMID: 21612571] - Helieh S Oz, Thomas Tobin. Atovaquone ameliorate gastrointestinal toxoplasmosis complications in a pregnancy model.
Medical science monitor : international medical journal of experimental and clinical research.
2012 Sep; 18(9):BR337-45. doi:
10.12659/msm.883342. [PMID: 22936182] - Kesinee Chotivanich, Mathirut Mungthin, Ronnatrai Ruengweerayuth, Rachanee Udomsangpetch, Arjen M Dondorp, Pratap Singhasivanon, Sasithon Pukrittayakamee, Nicholas J White. The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum.
Malaria journal.
2012 May; 11(?):177. doi:
10.1186/1475-2875-11-177. [PMID: 22640826] - Steven Gabardi, Peter Millen, Shelley Hurwitz, Spencer Martin, Keri Roberts, Anil Chandraker. Atovaquone versus trimethoprim-sulfamethoxazole as Pneumocystis jirovecii pneumonia prophylaxis following renal transplantation.
Clinical transplantation.
2012 May; 26(3):E184-90. doi:
10.1111/j.1399-0012.2012.01624.x. [PMID: 22487221] - M Cella, F Kloprogge, M Danhof, O Della Pasqua. Dosing rationale for fixed-dose combinations in children: shooting from the hip?.
Clinical pharmacology and therapeutics.
2012 Apr; 91(4):718-25. doi:
10.1038/clpt.2011.297. [PMID: 22398964] - Dennis J Slade, George E Lees, Brian R Berridge, Fred J Clubb, Leslie A Kuczynski, Meryl P Littman. Resolution of a proteinuric nephropathy associated with Babesia gibsoni infection in a dog.
Journal of the American Animal Hospital Association.
2011 Nov; 47(6):e138-44. doi:
10.5326/jaaha-ms-5576. [PMID: 22058361] - Ramesh Gujjar, Farah El Mazouni, Karen L White, John White, Sharon Creason, David M Shackleford, Xiaoyi Deng, William N Charman, Ian Bathurst, Jeremy Burrows, David M Floyd, David Matthews, Frederick S Buckner, Susan A Charman, Margaret A Phillips, Pradipsinh K Rathod. Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
Journal of medicinal chemistry.
2011 Jun; 54(11):3935-49. doi:
10.1021/jm200265b. [PMID: 21517059] - Chiara Tommasi, Rita Bellagamba, Massimo Tempestilli, Antonio D'Avolio, Anna L Gallo, Jelena Ivanovic, Emanuele Nicastri, Leopoldo P Pucillo, Pasquale Narciso. Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.
Malaria journal.
2011 May; 10(?):141. doi:
10.1186/1475-2875-10-141. [PMID: 21600016] - Kathleen Hidalgo, Adraine Lyles, Stacey R Dean. A potential interaction between warfarin and atovaquone.
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